In the last few years the study of germinal centers of the lymphoid tissue has progressed at an accelerated pace. Questions about their role and their significance in immune responses that could not be answered, mainly because of tedmicallimitations, are presently approached experimentally from many different directions. Hypotheses, some more than half a century old, receive renewed attention. At this time, members of the Biology Division, Oak Ridge National Laboratory, U.S.A., and of the Institute of Pathology, University of Bern, Switzerland, decided to bring together workers interested in the field. The Conference was held in Bern, June 22-24, 1966, and included fifty-seven contributions which were discussed at length. The range of interest extended from phylogenesis and anatomy to studies on cell proliferation, immunohistochemistry, cancer research and radiobiology. The aim of this broad coverage was to combine all available information on the role of germinal centers in immune responses in a single package, instead of leaving it scattered around in reports dealing with divergent immunological problems. This attempt is reflected in the present book. A rather large space has been devoted to the lively discussions which followed the reports, the volume of most of which had been voluntarily limited. The discussions are not reported verbatim but care has been taken to insure neutrality and objectivity in the necessary adaptation of the shortened transcription. We have been very fortunate indeed, to have Drs.
Adams challenges various stereotypes to present a view of World War II that avoids the simplistic extremes of both glorification and vilification. The Best War Ever charts the complex diplomatic problems of the 1930s and reveals the realities of ground combat. Adams exposes the myth that the home front was fully united behind the war effort, demonstrating how class, race, gender, and age divisions split Americans."--Page [4] of cover.
In the last few years the study of germinal centers of the lymphoid tissue has progressed at an accelerated pace. Questions about their role and their significance in immune responses that could not be answered, mainly because of tedmicallimitations, are presently approached experimentally from many different directions. Hypotheses, some more than half a century old, receive renewed attention. At this time, members of the Biology Division, Oak Ridge National Laboratory, U.S.A., and of the Institute of Pathology, University of Bern, Switzerland, decided to bring together workers interested in the field. The Conference was held in Bern, June 22-24, 1966, and included fifty-seven contributions which were discussed at length. The range of interest extended from phylogenesis and anatomy to studies on cell proliferation, immunohistochemistry, cancer research and radiobiology. The aim of this broad coverage was to combine all available information on the role of germinal centers in immune responses in a single package, instead of leaving it scattered around in reports dealing with divergent immunological problems. This attempt is reflected in the present book. A rather large space has been devoted to the lively discussions which followed the reports, the volume of most of which had been voluntarily limited. The discussions are not reported verbatim but care has been taken to insure neutrality and objectivity in the necessary adaptation of the shortened transcription. We have been very fortunate indeed, to have Drs.
Organ transplantation has almost disappeared from headlines in the daily press, possibly because it failed to fulfill exaggerated expectations. Transplanta tion pathology has become more and more important, not only with relation to therapeutic transplantations but even more in its fundamental theories. There is some analogy here to the development in space science where spectacular achievements were followed by sobering frustrations and where, for the time being, the effect on technology is more fruitful than the outcome of the original far-reaching projects. That transplant rejection was defined, in most of its stages, as an immunologic process, has given many new impulses to immunology in general. Transplantation assays have become a pet experiment in immunobiology and an abundant source of general information and knowledge. The implications of such a development could not be predicted when the present volume was outlined and planned. In accordance with the concept of WILLI MASSHOFF, general transplantion pathology was given a central position as a fundamental science, while the chapters on the transplantation of various tissues are of a more paradigmatic character. It was MASSHOFF who invited competent authors and who managed to balance their articles, despite some overlapping, so as to draw a comprehensive picture of contemporary transplanta tion pathology. WILLI MASSHOFF died while he was editing the first manuscripts. As co-editors we have undertaken to complete the publication that we began together.
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