Alone in a world she doesn't know, a stranger offers kindness and protection. He killed to save her and as a vampire he will kill again. Though vampires don't scare her, the men chasing her do. Does she risk it and go with him? Risking her life and his? He's hiding many secrets from prying eyes. But when he stumbles upon a sleeping beauty covered in blood he can't walk away. It's not her blood he's drawn to, though his mouth is watering, she gives off something that pulls at his protective instincts. He must protect her at all costs. Neither of them plan what comes next. Will they be able to last with everyone out to pull them apart?
Hypertension is defined by an increase in systemic blood pressure above limits considered normal, currently set at 140 mmHg for systolic and 90 mmHg for diastolic pressure. Assuming central venous pressure to be near zero, mean arterial pressure is determined by the product of total peripheral resistance and cardiac output. In most cases of essential hypertension, as well as in animal models of hypertension, cardiac output and its main determinants, stroke volume and heart rate, are normal, whereas total peripheral resistance is increased. Total peripheral resistance is influenced by a number of factors described by the Poiseuille’s law, the most significant of which by far is the diameter of blood vessels of the arterial tree. Since blood vessel diameter is a reflection of both vascular structure and active regulation of vascular tone through mechanisms of vasoconstriction and vasodilatation, it is generally considered that alterations in total peripheral resistance are directly determined by alterations in vascular smooth muscle structure and/or function. Thus, complex blood pressure regulation systems, including renal, nervous, endocrine, immune, and others, in their turn influenced by genetic or environmental factors, converge upon the same molecular mechanisms that control the structure and function of vascular smooth muscle. In this work, rather than providing the exhaustive list of modifications in the blood pressure regulating systems that ultimately affect the vasculature in hypertension, we will focus on the structural and functional alterations of vascular smooth muscle per se during hypertension.
Comprised of the papers presented at the eighth, and latest, International Conference Simulation in Risk Analysis and Hazard Mitigation, this book covers a topic of increasing importance. Scientific knowledge is essential to our better understanding of risk. Natural hazards such as floods, earthquakes, landslides, fires and others, have always affected human societies. Man-made hazards, however, played a comparatively small role until the industrial revolution when the risk of catastrophic events started to increase due to the rapid growth of new technologies and the urbanisation of populations. The interaction of natural and anthropogenic risks adds to the complexity of the problem.Due to advances in computational methods and the ability to model systems more precisely we can now quantify hazards, simulate their effects and calculate risk with greater accuracy, enabling us to manage risk much more effectively. These developments are particularly relevant to environmental issues, where substantial risks are involved. Governments, and their publics, now place a high priority on effective risk management and the mitigation of possible hazards. Covering topics such as: Estimation of Risk; Risk Management; Vulnerability; Geomorphologic Risk; Network Systems; Climate Change Risks; Hazard Prevention; Management and Control; Security and Public Safety; Transportation Safety; Safe Ship Operations; Early Warning Systems; Food Safety; Risk Perception; Natural Hazards; Technological Risk, the book will be of interest to planners, emergency managers, environmentalists, engineers, policy makers and other government officials, researchers and academics involved in the field of risk and disaster management.
This book explores the technical, social and cultural implications of the emerging Information and communication technologies, addressing the technological and scientific development within education, commerce, governance, and security with a special emphasis on the impact on individuals, culture and society. Bringing together papers from the Second International Conference on Advances in Education, Commerce & Governance: Technology's Impact on Individuals, Culture and Society, the text will be of interest to researchers and academics working in areas related to the social, psychological and cultural impact of information communications technology (ICT). Specifically the book addresses a wide range of topics as diverse as: E-Commerce and E-Governance; Data and Information Privacy; Psychology; Gender; Culture; New Learning.
“[A] fascinating read... Contrary to what the title might suggest, this is an upbeat exploration of suicide with a positive message.” --Jeanine Connor, Therapy Today, December, 2018 This thought-provoking volume offers a distinctly human evolutionary analysis of a distinctly human phenomenon: suicide. Its ‘pain and brain’ model posits animal adaptations as the motivator for suicidal escape, and specific human cognitive adaptations as supplying the means , while also providing a plausible explanation for why only a relatively small number of humans actually take their own lives. The author hypothesizes two types of anti-suicide responses, active and reactive mechanisms prompted by the brain as suicide deterrents. Proposed as well is the intriguing prospect that mental disorders such as depression and addiction, long associated with suicidality, may serve as survival measures. Among the topics covered: · Suicide as an evolutionary puzzle. · The protection against suicide afforded to animals and young children. · Suicide as a by-product of pain and human cognition. · Why psychodynamic defenses regulate the experiencing of painful events. · Links between suicidality and positive psychology. · The anti-suicide role of spiritual and religious belief. In raising and considering key questions regarding this most controversial act, The Evolution of Suicide will appeal to researchers across a range of behavioral science disciplines. At the same time, the book’s implications for clinical intervention and prevention will make it useful among mental health professionals and those involved with mental health policy.
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