The book addresses the most recent developments in structural and functional proteomics underlying the recent contributions given in these areas by our laboratory to the instrumentations, the methods and the procedures as mutuated from the nanoscale sciences and technologies. These developments introduced in the last few years make now possible protein massive identification (mass spectrometry and biomolecular arrays down to nanoamounts) and protein structural characterization in solution and in crystals down to the atomic scale to an extent and to a degree so far unmatched. Emphasis is placed in the growth by nanobiofilm template of protein crystals of any type and size from millimeter to micron, leading in combination with microfocus synchrotron technology and atomic force microscopy to the definition of a new field called nanocrystallography. The few useful examples being shown, concerning yet structurally unsolved proteins, point this very promising approach nanotechnology-based in structural proteomics using highly focused X-rays. This has not to be confused with the important study of nanocrystals, both organic and inorganic, and novel diamond like nanocomposite materials and devices having 3D protein crystals as matrices to be equilibrated with nanoparticles/gold/silver to be utilized in the most diversified electronic applications here also summarized. vii Acknowledgments We are particularly grateful to Giuseppe Zanotti at the University of Padova for his fundamental collaboration during all the crystallographic studies.
As optical fiber communication systems have moved out of the laboratory and into commercial use over the past several years, the general field of guided wave and coherent optics has undergone a radical transformation. Research in optical communication has turned heavily towards single-mode technology and, totally new phenomena and applications of the existing technology, outside the communication field, have begun to proliferate. It was for this reason that we decided to organize a NATO Advanced Study Institute assembling the leading workers in this new domain, in order to define the state of the art, and, develop an idea of the new directions the field might take. The lectures and seminars presented at this Advanced Study Institute form the basis for this book. The subjects treated can be roughly grouped as : - New phenomena in optical fibers such as non-linear effects, soliton propagation and polarization conservation. - New applications of fibers, to measurements of rotation pressure, temperature etc ... and medical uses. - Advanced and exploratory work on single-mode fiber communica tion systems including the use of coherent transmission schemes and optical amplification. - Recent developments of optical information treatment based on four-wave mixing. - Integrated optical devices and technologies including bistable devices, parametric oscillators, and optical logic. In addition to these major topics, a number of national reviews and specialized seminars treating new guided wave structures and materials are included. The co-editors admit being rather pleased with the result.
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