Lung function assessment is the central pillar of modern respiratory diagnosis, providing invaluable information to assist in clinical decision making and management strategies.Interpreting Lung Function Tests: A Step-by Step Guide is a practical “how-to” training manual, which provides the reader with the necessary skills to interpret lung function test results, and to write a concise and informative report on the outcome. Interpreting Lung Function Tests: A Step-by Step Guide provides unique guidance on the reporting of pulmonary function tests, including illustrative cases and sample reports. utilizes the many references available on interpretation of lung function and provides a teaching/reference tool for report writing of lung function results routinely performed in clinical practice. provides the reader with the skill to interpret and write a concise, yet informative report provides examples of results and written reports (with commentary where necessary as further explanation). focuses primarily on tests performed as part of routine clinical testing: spirometry, static lung volumes, gas transfer, bronchial provocation tests, and maximal respiratory pressures. Interpreting Lung Function Tests: A Step-by Step Guideis a superb new resource to educate medical students, junior doctors, family physicians, as well as advanced trainee physicians specializing in respiratory medicine, respiratory scientists, and respiratory physicians
The most comprehensive, multi-disciplinary text in the field, Cummings Otolaryngology: Head and Neck Surgery, 7th Edition, provides detailed, practical answers and easily accessible clinical content on the complex issues that arise for otolaryngologists at all levels, across all subspecialties. This award-winning text is a one-stop reference for all stages of your career—from residency and board certification through the challenges faced in daily clinical practice. Updated content, new otology editor Dr. Howard W. Francis, and new chapters and videos ensure that this 7th Edition remains the definitive reference in today's otolaryngology. - Brings you up to date with the latest minimally invasive procedures, recent changes in rhinology, and new techniques and technologies that are shaping patient outcomes. - Contains 12 new chapters, including Chronic Rhinosinusitis, Facial Pain, Geriatric Otology, Middle Ear Endoscopic Surgery, Pediatric Speech Disorders, Pediatric Cochlear Implantation, Tongue-Ties and Lip Ties, Laryngotracheal Clefts, and more. - Covers recent advances and new approaches such as the Draf III procedure for CRS affecting the frontal recess, endoscopic vidian and posterior nasal neurectomy for non-allergic rhinitis, and endoscopic approaches for sinonasal and orbital tumors, both extra- and intraconal. - Provides access to 70 key indicator (Accreditation Council for Graduate Medical Education Key Indicator Procedures), and surgical videos – an increase of 43% over the previous edition. - Offers outstanding visual support with 4,000 high-quality images and hundreds of quick-reference tables and boxes. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Second Edition of this single-authored volume integrates multiple disciplines of basic and clinical research to help clinicians further develop the best possible care for the rehabilitation of patients with neurologic diseases. From the readable descriptions of the structures and functions of pathways for movement and cognition, the reader comes to understand the potential for training induced, pharmacologic, and near-future biologic interventions to enhance recovery. Dr. Dobkin shows how functional neuroimaging serves as a marker for whether physical, cognitive, and neuromodulating therapies work and how they sculpt the plasticity of the brain. Themes, such as how the manipulation of sensory experience can serve as a formidable tool for rehabilitation, run throughout the text, built from the level of the synapse to behaviors such as grasping, walking, and thinking. From illustrating how we may one day repair the brain and spinal cord to how to retrain spared and new pathways, Dr. Dobkin draws insights from a broad swath of fundamental research to give clinicians tools they can translate into bedside practices. The book treats the medical complications and therapeutic approaches to neurologic diseases as an interconnected matrix. The management of common medical issues, impairments, and disabilities are described across diseases. Special problems posed by patients with stroke, myelopathies, brain injury, multiple sclerosis, degenerative diseases, and motor unit disorders receive individual comment. Short-term and delayed pulse interventions for patients, along with clinical trials, are dissected and put into perspective. The First Edition of this book was titled Neurologic Rehabilitation. The title has been changed to reflect Dr. Dobkin's sense that fundamental research now drives the field of neurologic rehabilitation even more than it could in 1996 when the First Edition was published. The Second Edition features entirely new chapters on functional neuroimaging of recovery; neurostimulators and neuroprosteses; integration into the book of many new clinical and neuroscientific observations relevant to the clinician; and extensive updating and expansion of all chapters. Readers, whether clinicians serving the rehabilitation team, or students or researchers in neuroscience, neurology, physical medicine, allied health, or bioengineering, will acquire new insights and tools for creative pursuits that aim to lessen the disabilities of patients.
Encyclopedic, definitive, and state-of-the-art in the field of vascular disease and its medical, surgical, and interventional management, Rutherford's Vascular Surgery and Endovascular Therapy offers authoritative guidance from the most respected and innovative global thought leaders and clinical and basic science experts of our time. The thoroughly revised 10th Edition, published in association with the Society for Vascular Surgery and authored by multidisciplinary and international contributors, is an outstanding reference for vascular surgeons, vascular medicine specialists, interventional radiologists and cardiologists, and their trainees who depend upon Rutherford's in their practice. Under the expert editorial guidance of Drs. Anton N. Sidawy and Bruce A. Perler, it is quite simply the most complete and most reliable resource available on the art and science of circulatory diseases. - Incorporates fundamental vascular biology, diagnostic techniques, and decision making as well as medical, endovascular, and surgical treatment of vascular disease. - Features numerous concise and comprehensive diagnostic and therapeutic algorithms vital to patient evaluation and management. - Covers all vascular imaging techniques, offering a non-invasive evaluation of both the morphology and hemodynamics of the vascular system. - Employs a full-color layout, images and online videos, so readers can view clinical and physical findings and operative techniques more vividly. - Contains fully updated and more concise chapters with a focused format and summary for each that provides a quick access to key information—ideal for consultation as well as daily practice. - Includes expanded coverage of the business of vascular surgery, including a new section on the use of technology platforms and social media, and new chapters on telemedicine, the development and operation of outpatient dialysis centers and multispecialty cardiovascular centers, vascular information on the internet, and much more. - Provides new content on key topics such as endovascular treatment of complex aortic disease, acute vascular occlusion in the pediatric population, outpatient vascular care, and anatomic surgical exposures for open surgical reconstructions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This book is written for a diverse audience of educators from many disciplines, curriculum designers, researchers, and administrators. While this book establishes both a new approach to learning design and an associated research agenda, it is also intended to be practical." "In this book you will find many examples of how people experience information use as they go about learning in different contexts.' --From the preface.
Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.
Now in its 6th edition, Cummings Otolaryngology remains the world's most detailed and trusted source for superb guidance on all facets of head and neck surgery. Completely updated with the latest minimally invasive procedures, new clinical photographs, and line drawings, this latest edition equips you to implement all the newest discoveries, techniques, and technologies that are shaping patient outcomes. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Overcome virtually any clinical challenge with detailed, expert coverage of every area of head and neck surgery, authored by hundreds of leading luminaries in the field. Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes approximately 3,200 images and over 40 high quality procedural videos. Get truly diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors and editors comprised of the world’s leading experts. Glean all essential, up-to-date, need-to-know information. All chapters have been meticulously updated; several extensively revised with new images, references, and content. Stay at the forefront of your field with the most updated information on minimally-invasive surgical approaches to the entire skull base, vestibular implants and vestibular management involving intratympanic and physical therapy-based approaches, radiosurgical treatment of posterior fossa and skull base neoplasms, and intraoperative monitoring of cranial nerve and CNS function. Apply the latest treatment options in pediatric care with new chapters on pediatric sleep disorders, pediatric infectious disease, and evaluation and management of the infant airway. Find what you need faster through a streamlined format, reorganized chapters, and a color design that expedites reference. Manage many of the most common disorders with treatment options derived from their genetic basis. Assess real-world effectiveness and costs associated with emergent technologies and surgical approaches introduced to OHNS over the past 10 years. Incorporate recent findings about endoscopic, microscopic, laser, surgically-implantable, radiosurgical, neurophysiological monitoring, MR- and CT-imaging, and other timely topics that now define contemporary operative OHNS. Take it with you anywhere! With Expert Consult, you'll have access the full text, video clips, and more online, and as an eBook - at no additional cost!
Integrative Theology is designed to help graduate students in a pluralistic world utilize a standard method of fruitful research. Each chapter on a major doctrine: (1) states a classic issue of ultimate concern, (2) surveys alternative past and present answers and (3) tests those proposals by their congruence with information on the subject progressively revealed from Genesis to Revelation. Then the chapter (4) formulates a doctrinal conclusion that consistently fits the many lines of biblical data, (5) defends that conviction respectfully, and finally (6) explores the conclusion’s relevance to a person’s spiritual birth, growth and service to others, all for the glory of God. Why the title Integrative Theology? In each chapter, steps 2-6 integrate the disciplines of historical, biblical, systematic, apologetic and practical theology.
Unlike the contrast between the sacred and the taboo, the opposition of "comic" and "tragic" is not a way of categorizing experience that we find in cultures all over the world or even at different periods in Western civilization. Though medieval writers and readers distinguished stories with happy endings from stories with unhappy endings, it was not until the sixteenth and seventeenth centuries--fifteen hundred years after Sophocles, Euripides, Plautus, and Terence had last been performed in the theaters of the Roman Empire--that tragedy and comedy regained their ancient importance as ways of giving dramatic coherence to human events. Ancient Scripts and Modern Experience on the English Stage charts that rediscovery, not in the pages of scholars' books, but on the stages of England's schools, colleges, inns of court, and royal court, and finally in the public theaters of sixteenth-and seventeenth-century London. In bringing to imaginative life the scripts, eyewitness accounts, and financial records of these productions, Bruce Smith turns to the structuralist models that anthropologists have used to explain how human beings as social creatures organize and systematize experience. He sets in place the critical, physical, and social structures in which sixteenth-and seventeenth-century Englishmen watched productions of classical comedy and classical tragedy. Seen in these three contexts, these productions play out a conflict between classical and medieval ways of understanding and experiencing comedy's interplay between satiric and romantic impulses and tragedy's clash between individuals and society. Originally published in 1988. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
With its consistent, practical organization and succinct bulleted format, Atlas of Head and Neck Pathology, 4th Edition, is an ideal resource for pathologists in training and in practice. High-quality illustrations with extensive figure legends depict the histological, immunohistochemical, cytologic and diagnostic imaging appearances of every type of head and neck pathology, while the user-friendly format allows for quick access to information. From cover to cover, this comprehensive reference is designed to help you effectively and accurately diagnose a wide range of head and neck disorders, improve your turnaround time when diagnosing a specimen, and facilitate clear reports on prognosis and therapeutic management options to surgical and medical colleagues. - Uses a templated approach with standard headings in each chapter, as well as bulleted text for fast retrieval of information. - Explores each entity's clinical features, pathologic features, ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. - Covers recent advances in molecular diagnostic testing, including capabilities, limitations, and targeted/personalized medicine. - Includes clinical information on treatment and prognosis for a better understanding of the clinical implications of diagnosis. - Incorporates the most current WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. - Shares the knowledge and expertise of new co-author Dr. Juan C. Hernandez-Prera. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Effective process safety programs consist of three interrelated foundations—safety culture and leadership, process safety systems, and operational discipline—designed to prevent serious injuries and incidents resulting from toxic releases, fires, explosions, and uncontrolled reactions. Each of these foundations is important and one missing element can cause poor process safety performance. Process Safety: Key Concepts and Practical Approaches takes a systemic approach to the traditional process safety elements that have been identified for effective process safety programs. More effective process safety risk reduction efforts are achieved when these process safety systems, based on desired activities and results rather than by specific elements, are integrated and organized in a systems framework. This book provides key concepts, practical approaches, and tools for establishing and maintaining effective process safety programs to successfully identify, evaluate, and manage process hazards. It introduces process safety systems in a way that helps readers understand the purpose, design, and everyday use of overall process safety system requirements. Understanding what the systems are intended to achieve, understanding why they have been designed and implemented in a specific way, and understanding how they should function day-to-day is essential to ensure continued safe and reliable operations.
Livable Streets 2.0 offers a thorough examination of the struggle between automobiles, residents, pedestrians and other users of streets, along with evidence-based, practical strategies for redesigning city street networks that support urban livability. In 1981, when Donald Appleyard's Livable Streets was published, it was globally recognized as a groundbreaking work, one of the most influential urban design books of its time. Unfortunately, he was killed a year later by a speeding drunk driver. This latest update, Livable Streets 2.0, revisited by his son Bruce, updates the topic with the latest research, new case studies, and best human-centered practices for creating more livable streets for all. It is essential reading for those who influence future directions in city and transportation planning, urban design, and community regeneration, and placemaking. - Incorporates the most current empirical research on urban transportation and land use practices that support the need for more livable communities - Includes recent case studies from around the world on successful projects, campaigns, programs, and other efforts - Contains new coverage of vulnerable populations
Produced amidst the still rippling effects of a pandemic and as the world experiences the increasing burden of global warming and a rapidly changing biosphere, the second edition of Parasitology: A Conceptual Approach offers a timely overview of the eukaryotic parasites affecting human health and the health of domestic and wild animals and plants. The book offers a broadly encompassing, integrative view of the phenomenon of parasitism and of the remarkable diversity of the world’s parasites. This second edition has been thoroughly updated on all aspects of parasitism, including expanded sections on parasite biodiversity, parasite genomes, the interface between parasitology and disease ecology, and applications of new techniques like CRISPR and gene drives for parasite control. Key selling features: Emphasis on a distinctive integrative and conceptual approach rather than the taxon-by-taxon approach used in most parasitology books A concise, handy Rogues Gallery section that summarizes the basic biology for the most important eukaryotic parasites of humans and domestic animals, one a reader is repeatedly directed to throughout the chapters Outstanding full-color illustrations and photographs to reinforce key points The use of text boxes to set apart important topics or ideas that deserve special emphasis Provision of end-of-chapter summaries, questions to test understanding and key references for those wishing to seek further information Reference to particular URLs to highlight recent developments that often pose new and distinctive problems awaiting solution Parasitology: A Conceptual Approach is designed for an upper-level undergraduate audience, but its readability and careful explanation of underlying scientific concepts and terminology makes it appropriate for anyone seeking a broader understanding of the impact of infectious organisms on our well-being and the changes underway in the modern world.
Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an enriched view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. The interfaces between the study of parasitism and prominent biological disciplines such as biodiversity, immunology, ecology, evolution, conservation biology, and disease control are highlighted. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix which provides a concise overview of the biology of important human and veterinary parasites. End-of-chapter questions are provided, as is an instructor manual.
Offering expert, comprehensive guidance on the basic science, diagnosis, and treatment of acute musculoskeletal injuries and post-traumatic reconstructive problems, Skeletal Trauma, 6th Edition, brings you fully up to date with current approaches in this challenging specialty. This revised edition is designed to meet the needs of orthopaedic surgeons, residents, fellows, and traumatologists, as well as emergency physicians who treat patients with musculoskeletal trauma. International thought leaders incorporate the latest peer-reviewed literature, technological advances, and practical advice with the goal of optimizing patient outcomes for the full range of traumatic musculoskeletal injuries. - Offers complete coverage of relevant anatomy and biomechanics, mechanisms of injury, diagnostic approaches, treatment options, and associated complications. - Includes eight new chapters dedicated to advances in technology and addressing key problems and procedures, such as Initial Evaluation of the Spine in Trauma Patients, Management of Perioperative Pain Associated with Trauma and Surgery, Chronic Pain Management (fully addressing the opioid epidemic), Understanding and Treating Chronic Osteomyelitis, and more. - Features a complimentary one-year subscription to OrthoEvidence, a global online platform that provides high-quality, peer-reviewed and timely orthopaedic evidence-based summaries of the latest and most relevant literature. Contains unique, critical information on mass casualty incidents and war injuries, with contributions from active duty military surgeons and physicians in collaboration with civilian authors to address injuries caused by road traffic, armed conflict, civil wars, and insurgencies throughout the world. - Features important call out boxes summarizing key points, pearls and pitfalls, and outcomes. - Provides access to nearly 130 instructional videos that demonstrate principles of care and outline detailed surgical procedures. - Contains a wealth of high-quality illustrations, full-color photographs, and diagnostic images. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The small ears of corn once grown by Native Americans have now become row upon row of cornflakes on supermarket shelves. The immense seas of grass and herds of animals that supported indigenous people have turned into industrial agricultural operations with regular rows of soybeans, corn, and wheat that feed the world. But how did this happen and why? In A Rich and Fertile Land, Bruce Kraig investigates the history of food in America, uncovering where it comes from and how it has changed over time. From the first Native Americans to modern industrial farmers, Kraig takes us on a journey to reveal how people have shaped the North American continent and its climate based on the foods they craved and the crops and animals that they raised. He analyzes the ideas that Americans have about themselves and the world around them, and how these ideas have been shaped by interactions with their environments. He details the impact of technical innovation and industrialization, which have in turn created modern American food systems. Drawing upon recent evidence from the fields of science, archaeology, and technology, A Rich and Fertile Land is a unique and valuable history of the geography, climate, and food of the United States.
A CONCISE YET THOROUGH OVERVIEW OF THE MEDICATIONS AND APPROACHES USED IN CANCER CARE--BACKED BY THE AUTHORITY OF HARRISON'S Harrison's Manual of Oncology is a carry-anywhere guide to the care of patients with cancer. Enhanced by the latest published results, this valuable clinical companion features numerous tables and succinct, outline-style text that puts important information at your fingertips. You will find content that goes beyond the treatment of primary or metastatic disease to encompass the treatment of all therapeutic complications. The opening sections of Harrison's Manual of Oncology are devoted to the classes of agents used to treat cancer and reviews their pharmacology and mechanisms of action. This section is followed by a detailed discussion of the diagnosis, staging, and treatment of all major types of cancer. There is a strong focus on symptom management and complications of treatment, including pain, nausea and vomiting, anemia, febrile neutropenia, metabolic emergencies, thrombosis, psychological issues, and end-of-life care.
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