Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.
Covering the full spectrum of clinical issues and options in anesthesiology, Barash, Cullen, and Stoelting’s Clinical Anesthesia, Ninth Edition, edited by Drs. Bruce F. Cullen, M. Christine Stock, Rafael Ortega, Sam R. Sharar, Natalie F. Holt, Christopher W. Connor, and Naveen Nathan, provides insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This award-winning text delivers state-of-the-art content unparalleled in clarity and depth of coverage that equip you to effectively apply today’s standards of care and make optimal clinical decisions on behalf of your patients.
Drawing on numerous diaries, journals, and reminiscences, Richard Bruce Winders presents the daily life of soldiers at war; links the army to the society that produced it; shares his impressions of the soldiers he "met" along the way; and concludes that American participants in the Mexican War shared a common experience, no matter their rank or place of service. Taking a "new" military history approach, Mr. Polk's Army: The American Military Experience in the Mexican War examines the cultural, social, and political aspects of the regular and volunteer forces that made up the army of 1846-48, presents the organizational framework of the army, and introduces the different styles of leadership exhibited by Zachary Taylor and Winfield Scott.
Click on the Supplements tab above for further details on the different versions of SPSS programs. The canonical Handbook is completely updated with more student-friendly features The Handbook of Social Work Research Methods is a cutting-edge volume that covers all the major topics that are relevant for Social Work Research methods. Edited by Bruce Thyer and containing contributions by leading authorities, this Handbook covers both qualitative and quantitative approaches as well as a section that delves into more general issues such as evidence based practice, ethics, gender, ethnicity, International Issues, integrating both approaches, and applying for grants. New to this Edition More content on qualitative methods and mixed methods More coverage of evidence-based practice More support to help students effectively use the Internet A companion Web site at www.sagepub.com/thyerhdbk2e containing a test bank and PowerPoint slides for instructors and relevant SAGE journal articles for students. This Handbook serves as a primary text in the methods courses in MSW programs and doctoral level programs. It can also be used as a reference and research design tool for anyone doing scholarly research in social work or human services.
There should not be a practitioner who does not have a copy ... highly recommended." —Arbitration When first published, The Arbitration Act 1996: A Commentary was described by Lord Bingham as "intensely practical and admirably user-friendly". It remains the most readable, useful, practical and user-friendly guide to the Arbitration Act 1996. The courts – particularly the Commercial and the Technology & Construction Courts – continue to grapple with many questions relating to the Act, with many judgments reported since the previous edition was published. While many of these do not add to the wisdom on this legislation, for the fifth edition the authors have considered some 330 new cases, resulting in extensive changes throughout much of the commentary. Many of the cases going to court concern challenges to awards and as a result the commentary on the relevant sections of the Act (ss. 67, 68, 70 and 72) has been subject to very substantial revision indeed. The details of all of these changes are of great importance to practitioners, whether lawyers or arbitrators. In addition there have been some significant changes to the Model Law since publication of the previous edition, which are fully documented and commented upon. Alterations to the CPR, the new UNCITRAL Rules (2010), the new ICC Rules (2012) and the new ICE Arbitration Procedure (2010) are also covered. Written by three practising arbitrators, the fifth edition continues to be the essential handbook for all concerned with English arbitration.
Obtain the best outcomes from the latest techniques with help from a "who's who" of orthopaedic trauma experts. The updated edition of Skeletal Trauma: Basic Science, Management, and Reconstruction is dedicated to conveying today's most comprehensive information on the basic science, diagnosis, and treatment of acute musculoskeletal injuries and post-traumatic reconstructive problems. You'll be equipped with all of the knowledge needed to manage any type of traumatic injury in adults. Confidently approach every form of traumatic injury with current coverage of relevant anatomy and biomechanics, mechanisms of injury, diagnostic approaches, treatment options, and associated complications. Access critical information concerning mass casualty incidents and war injuries. Sixteen active-duty military surgeons and physicians from various branches of the U.S. Military have collaborated with civilian authors to address injuries caused by road traffic, armed conflicts, civil wars, and insurgencies throughout the world. Learn from many brand-new chapters including Principles of Internal Fixation; Gunshot Wounds and Blast Injuries; New Concepts in Management of Thoracolumbar Fractures; Surgical Treatment of Acetabular Fractures; Diaphyseal Fractures of the Forearm; Fractures of the Distal Femur; Tibial Plateau Fractures; and Amputations in Trauma. Take advantage of guidance from expert editors, two brand new to this edition, and a host of new authors who provide fresh insights on current trends and approaches in the specialty. Know what to look for and how to proceed with a fully updated art program that features full-color intraoperative images and crisp, new figures. Handle the most challenging cases of latent or post-operative nonunions, malunions, and more with extensive coverage of post-traumatic reconstruction. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
In 1988, Judge Joe O'Kicki was regarded by his peers as one of the most brilliant legal minds in the United States. He was newly re-married, sworn in as the president judge of a Pennsylvania county and on the fast track to a federal bench.... Silently, however, a state police vice unit was in the midst of covert operation into O'Kicki's personal affairs. The judge would be accused of soliciting bribes, frequenting brothels and running the county as if he were a "battleship commander." Later he'd concoct a plan to flee the country and exact revenge on his enemies. Set in the aftermath of the 1977 Johnstown flood and including courtroom testimony, the memos of whistleblowers, contemporary interviews and excerpts from O'Kicki's unfinished tell-all memoir, "Jailing the Johnstown Judge" is a fresh examination of the extraordinary Western Pennsylvania case that attained international infamy.
This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.
Journeying into the sound-worlds of Shakespeare's contemporaries, this text explores the physical aspects of human speech and the surrounding environment, as well as social and political structures.
The Aqueous Chemistry of Oxides is a single-volume text that encapsulates all of the critical issues associated with how oxide materials interact with aqueous solutions. It serves as a central reference for academics working with oxides in the contexts of geology, various types of inorganic chemistry, and materials science. The text also has utility for professionals working with industrial applications in which oxides are either prepared or must perform in aqueous environments. The volume is organized into five key sections. Part One features two introductory chapters, intended to introduce the mutual interests of engineers, chemists, geologists, and industrial scientists in the physical and chemical properties of oxide materials. Part Two provides the essential and fundamental principles that are critical to understanding most of the major reactions between water and oxides. Part Three deals with the synthesis of oxide materials in aqueous media. Part Four deals with oxide-water reactions and their environmental and technological impacts, and Part Five is devoted to other types of relevant reactions. The Aqueous Chemistry of Oxides is the first book that provides a comprehensive summary of all of the critical reactions between oxides and water in a single volume. As such, it ties together a wide range of existing books and literature into a central location that provides a key reference for understanding and accessing a broad range of more specialized topics. The book contain over 300 figures and tables.
Combining legal and social history, Bruce Mann explores the relationship between law and society from the mid-seventeenth century to the eve of the Revolution. Analyzing a sample of more than five thousand civil cases from the records of local courts in Connecticut, he shows how once-neighborly modes of disputing yielded to a legal system that treated neighbors and strangers alike. During the colonial period population growth, immigration, economic development, war, and religious revival transformed the nature and context of official and economic relations in Connecticut. Towns lost the insularity and homogeneity that made them the embodiment of community. Debt litigation was transformed from a communal model of disputing in which procedures were based on the individual disagreements to a system of mechanical rules that homogenized law. Pleading grew more technical, and the civil jury faded from predominance to comparative insignificance. Arbitration and church disciplinary proceedings, the usual alternatives to legal process, became more formal and legalistic and, ultimately, less communal. Using a computer-assisted analysis of court records and insights drawn from anthropology and sociology, Mann concludes that changes in the law and its applications were tied to the growing commercialization of the economy. They also can be attributed to the fledgling legal profession's approach to law as an autonomous system rather than as a communal process. These changes marked the advent of a legal system that valued predictability and uniformity of legal relations more than responsiveness to individual communities. Mann shows that by the eve of the Revolution colonial law had become less identified with community and more closely associated with society.
As the human population grows from seven billion toward an inevitable nine or 10 billion, the demands on the limited supply of soils will grow and intensify. Soils are essential for the sustenance of almost all plants and animals, including humans, but soils are virtually infinitely variable. Clays are the most reactive and interactive inorganic compounds in soils. Clays in soils often differ from pure clay minerals of geological origin. They provide a template for most of the reactive organic matter in soils. They directly affect plant nutrients, soil temperature and pH, aggregate sizes and strength, porosity and water-holding capacities. This book aims to help improve predictions of important properties of soils through a modern understanding of their highly reactive clay minerals as they are formed and occur in soils worldwide. It examines how clays occur in soils and the role of soil clays in disparate applications including plant nutrition, soil structure, and water-holding capacity, soil quality, soil shrinkage and swelling, carbon sequestration, pollution control and remediation, medicine, forensic investigation, and deciphering human and environmental histories. Features: Provides information on the conditions that lead to the formation of clay minerals in soils Distinguishes soil clays and types of clay minerals Describes clay mineral structures and their origins Describes occurrences and associations of clays in soil Details roles of clays in applications of soils Heavily illustrated with photos, diagrams, and electron micrographs Includes user-friendly description of a new method of identification To know soil clays is to enable their use toward achieving improvements in the management of soils for enhancing their performance in one or more of their three main functions of enabling plant growth, regulating water flow to plants, and buffering environmental changes. This book provides an easily-read and extensively-illustrated description of the nature, formation, identification, occurrence and associations, measurement, reactivities, and applications of clays in soils.
Impact cratering is an important geological process on all solid planetary bodies, and, in the case of Earth, may have had major climatic and biological effects. Most terrestrial impact craters have been erased or modified beyond recognition. However, major impacts throw ejecta over large areas of the Earth's surface. Recognition of these impact ejecta layers can help fill in the gaps in the terrestrial cratering record and at the same time provide direct correlation between major impacts and other geological events, such as climatic changes and mass extinctions. This book provides the first summary of known distal impact ejecta layers
1858" explores the events and personalities of the year that would send the America's North and South on a collision course culminating in the slaughter of 630,000 of the nation's young men, a greater number than died in any other American conflict.
By reprinting over 400 items from contemporary newspapers, magazines, and trade journals, this book reveals Taylor's life in Hollywood--from his arrival as a minor actor in 1912 until his death in 1922 as one of Hollywood's top directors.
Summary: "Along with sixty full-color illustrations of the light and airy baths themselves, The Japanese Bath, delves into the aesthetic of bathing Japanese style and the innate beauty of the steps surrounding the process. The authors explain how to create a Japanese bath in your own home."--Publisher description.
Report into the Loss of the SS Titanic is a complete re-evaluation of the loss of Titanic based on evidence that has come to light since the discovery of the wreck in 1985. This collective undertaking is compiled by eleven of the world's foremost Titanic researchers – experts who have spent many years examining the wealth of information that has arisen since 1912. Following the basic layout of the 1912 Wreck Commission Report, this modern report provides fascinating insights into the ship itself, the American and British inquiries, the passengers and crew, the fateful journey and ice warnings received, the damage and sinking, rescue of survivors, the circumstances in connection with the SS Californian and SS Mount Temple, and the aftermath and ramifications that followed the disaster. The book seeks to answer controversial questions, such as whether steerage passengers were detained behind gates, and also reveals the names and aliases of all passengers and crew who sailed on Titanic's maiden voyage. Containing the most extensively referenced chronology of the voyage ever assembled and featuring a wealth of explanatory charts and diagrams, as well as archive photographs, this comprehensive volume is the definitive 'go-to' reference book for this ill-fated ship.
DeLisa’s Physical Medicine and Rehabilitation, Principles and Practice presents the most comprehensive review of the state of the art, evidence-based clinical recommendations for physiatric management of disorders affecting the brain, spinal cord, nerves, bones, joints, ligaments, muscles, and tendons.
From Europe to India and America, Britain's Colonial Wars relates empire to the fortunes of war. In less than a century, between the Glorious Revolution of 1688 and the settlement following the War of the American Revolution, the modern British state was born. This penetrating new analysis questions the centrality of the colonial enterprise to Westminster policy-makers obsessed with European issues, and explains how the impact of their strategies necessarily shaped the destiny of a multi-national and incoherent empire beyond the shores of Europe.
The lived experience of murder - those who kill, those whose loved ones are killed, and those who investigate and who participate in the legal disposition of homicide - is the subject of this work. As part of a continuing series with the Foundation of Thanatology, this volume comprises twenty-eight essays which address such topics as the military, euthanasia, terrorism, gun control, and capital punishment. The Human Side of Homicide incorporates legal and public health perspectives on homicide and presents work drawn from a wide range of related professions. Material is organized in three sections. "The Human Side of Homicide" profiles those who kill; "The Killers and the Victims" discusses specific types of homicide; and "Law and Justice" examines germane legal issues. Few texts have encompassed analyses of such range and insight. This new volume will be of special interest to those already followin the research of the Foundation of Thanatology. However, The Human Side of Homicide will also prove to be an inexhaustible resource for doctors, psychologists, psychiatrists, social workers, and sociologist, as well as students and teachers of criminal law, and the police administration. -- from dust jacket.
In the hollows of Lewis County, Tennessee, Mormon missionaries baptized nearly fifty members of a large extended family. But their initial success was marred by false accusations of salacious behavior. A few influential citizens were disturbed by the rumors and by the missionaries' apparent popularity. On August 10th 1884, tensions erupted into violence and bloodshed. Two of the Utah missionaries, two young Tennessean converts, and one vigilante were shot dead. At least one other member of the congregation was wounded and never fully recovered. Much has been written about the two missionaries killed, but the real story is much deeper. Step into the lives of these proud Tennesseans, the earnest converts, the fearsome gunmen, and those stuck in between. See how their families intertwined in the years before and after the shooting. Its a snapshot of post-bellum rural Tennessee you won't soon forget.
Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science.
The use of genetics for the resolution of legal conflicts has recently been gaining a higher profile, largely as a result of scientific and technological advancements and the substantial broadening of applications. The theoretical framework underlying forensic genetics is the same irrespective of the materials and technology involved, however a great divide still exists in the manner and processes related to human and non-human analyses.This advanced handbook intends to overcome the historical barriers between the scientific fields of legal medicine, biodiversity and conservation, and food analysis by presenting a unifying, global perspective on the implications of genetic analyses on forensic affairs. This global perspective is presented in three parts: modes of inheritance and reproduction and taxonomic implications; current technological approaches and future perspectives; and a comprehensive systematization of the types of applications and organisms. Finally, a critical revision of the current investigative/expert systems and future perspectives is undertaken.This book provides a collection of international research, thereby constituting a reference platform for the forensic community and an advanced textbook for graduate students. It encompasses the theoretical bases of the field, and presents in the context of both perspectives of forensic action — probative and investigative — a comprehensive coverage of the current applications and technological state of the art.
Many humanitarian interventions led and supported by the United States go beyond simple disaster relief and include such difficult tasks as protecting refugees, securing humanitarian aid, and restoring civil order. The U.S. Air Force often plays an important role in such complex contingency operations. This book explores how the military might improve coordination with relief agencies and with European allies in such operations. It examines the dynamics of complex contingency operations, provides an overview of the relief community, delineates barriers to better cooperation, discusses the European contribution, and recommends steps the military might take to improve coordination in future crises. Steps include improving military familiarization with key relief organizations, perhaps appointing a humanitarian advisor, establishing more "centers of excellence," and bringing relief organizations into the planning process. The military should encourage information sharing with relief organizations, improve procedures for managing the flow of aid, and leverage European capabilities.
Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity
A high-quality, exam-focused resource to facilitate passage through ICU Fellowship examinations. This is the first publication to specifically meet the goals of an examination guide for ICM trainees.
This book integrates the most current research findings on the economic, demographic, fiscal, and social consequences of rapid growth in rural communities and offers strategies that can be used to mitigate the often disruptive impact of that growth. While working extensively with government officials and citizens in rural communities, Drs. Weber and Howell became aware of the need for a compilation and synthesis of the research on rural growth; they subsequently invited scholars working in selected topic areas to contribute to that effort. The resulting papers were refined during a meeting sponsored by the Western Rural Development Center, edited, and brought together in this volume. Incorporating 1980 census data, the book outlines the spectrum of changes associated with rapid growth in rural areas, presents specific options for managing rapid growth, and suggests a model that communities can use for impact assessment and for monitoring the effectiveness of various management strategies.
In 1988, Judge Joe O'Kicki was regarded by his peers as one of the most brilliant legal minds in the United States. He was newly re-married, sworn in as the president judge of a Pennsylvania county and on the fast track to a federal bench.... Silently, however, a state police vice unit was in the midst of covert operation into O'Kicki's personal affairs. The judge would be accused of soliciting bribes, frequenting brothels and running the county as if he were a "battleship commander." Later he'd concoct a plan to flee the country and exact revenge on his enemies. strongSet in the aftermath of the 1977 Johnstown flood and including courtroom testimony, the memos of whistleblowers, contemporary interviews and excerpts from O'Kicki's unfinished tell-all memoir, "Jailing the Johnstown Judge" is a fresh examination of the extraordinary Western Pennsylvania case that attained international infamy.
‘An insightful and gripping account that will take you into the dark but fascinating world of a Victorian executioner.’ – Stewart P. Evans Between 1884 and 1905 James Billington and his three sons, Thomas, William and John, were responsible for 235 executions in Victorian Great Britain and Ireland. They hanged many notorious murderers, but equally fascinating is the story of the family. Did James really feel he served society and justice, or did this position satisfy something more personal? Billington: Victorian Executioner provides a complete account of the stories behind James Billington’s executions, as well as the real man behind the rope – a man whose business was death. This enthralling biography is an exciting addition to any true crime bookshelf.
Yellowstone National Park is one of the most crowded parks in the country, and for good reason: breathtaking scenery, amazing wildlife, and for anglers, great fishing. Yet, even a short hike from the road or trailhead into the backcountry of the park and the surrounding area can put anglers into even better fishing, often in solitude. This guidebook focuses on backcountry fishing opportunities in Yellowstone Park and surrounding areas in Wyoming, Montana, and Idaho (Greater Yellowstone Area). In addition to full color photographs of the destinations, the author includes essential information for each stream or lake, including maps and written directions, flies, gear, and timing. Waters Covered Yellowstone Park Fall River Basin Beula Lake Boundary Creek Cascade Creek Hering Lake Mountain Ash Creek Robinson Creek Lewis River Drainage Moose Creek Polecat Creek Gallatin River Drainage Madison River Drainage “Beaver Meadows” of the Madison River Duck Creek Gneiss Creek Yellowstone River Drainage Blacktail Ponds Blacktail Deer Creek Cascade Lake Grizzly Lake McBride Lake Riddle Lake Tower Creek West of Yellowstone Park (Montana) “Waters to the West” Centennial Valley Red Rock Creek Odell Creek Elk Lake Elk Spring Creek Hidden Lake Graben Lakes Cliff Lake Wade Lake Madison River Drainage Between Highway 191 and Hebgen Lake Quake Lake Smith Lake South Fork Madison River West Fork Madison River Ruby River Upper River F. North of Yellowstone Park Gallatin River Taylor Fork Yellowstone River Drainage G. East of Yellowstone Park North Fork Shoshone River Drainage Clark’s Fork Drainage Sunlight Creek H. South of Yellowstone (Idaho and Wyoming) “Waters to the South” Snake River Drainage Grand Teton Park Waters Fish Creek Flat Creek Pacific Creek Upper Gros Ventre River Hoback River Drainage Willow Creek (Wyoming) Granite Creek Grey’s River Drainage Salt River Drainage Beaver Ponds Idaho Tributaries Swift Creek Willow Creek (Idaho) Drainage Beaver Ponds Henry’s Fork Drainage Teton River and Bitch Creek Fall River Blackfoot River Fish Lake Harriman Fish Pond Henry’s Lake Outlet Horseshoe Lake Warm River and Robinson Creek Wind River Drainage Brooks Lake Upper Wind River Warm Springs Creek
Curtis discusses census making as a political project, investigating its place in and impact on party politics and ethnic, religious, and sectional struggles.
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