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Transformation of Human Diploid Fibroblasts

Molecular and Genetic Mechanisms

By: George E. Milo,Bruce C. Casto

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Transformation of Human Diploid Fibroblasts

Molecular and Genetic Mechanisms

By: George E. Milo,Bruce C. Casto

This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.

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Page Count

306

Publisher

CRC Press

Published Date

ISBN 10

0849349567

ISBN 13

9780849349560

Transformation of Human Epithelial Cells (1992)

Molecular and Oncogenetic Mechanisms

By: George E Milo,Bruce C Casto,Charles F Shuler

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Transformation of Human Epithelial Cells (1992)

Molecular and Oncogenetic Mechanisms

By: George E Milo,Bruce C Casto,Charles F Shuler

This book offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the progression of tumors from different organ sites. The fate of the modification of adducts is discussed at the molecular level. The role that modifications in hot spots in oncogenes and supressor genes play at the molecular level and how these molecular modifications can lead to an explanation of molecular control in the formation of tumor phenotypes is also examined. Researchers in cell biology and toxicology, applied pharmacology, carcinogenesis, teratogenesis, mutagenesis, and molecular toxicology will find the book useful, interesting reading.

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Page Count

393

Publisher

CRC Press

Published Date

ISBN 10

135135597X

ISBN 13

9781351355971