Pulsed Field Gel Electrophoresis: A Practical Guide is the first laboratory manual to describe the theory and practice of this technique. Based on the authors' experience developing pulsed field gel instruments and teaching procedures, this book provides everything a researcher or student needs to know in order to understand and carry out pulsed field gel experiments. Clear, well-tested protocols assume only that users have a basic familiarity with molecular biology. Thorough coverage of useful data, theory, and applications ensures that this book is also a lasting resource for more advanced practitioners of pulsed field gels. - Reviews all types of pulsed field gel electrophoresis - Describes all commercially available systems and summarizes advantages and limitations of each - Includes step-by-step protocols for sample preparation and analysis - Illustrated with photographs that depict - How to run gels: What the results should look like - What they look like when they go wrong - Covers applications to a wide range of organisms - Includes bibliography of over 900 publications and cross-referenced by topic, application, and organism
A New York Times bestseller! A pioneering and timely study of how to navigate life's biggest transitions with meaning, purpose, and skill Bruce Feiler, author of the New York Times bestsellers The Secrets of Happy Families and Council of Dads, has long explored the stories that give our lives meaning. Galvanized by a personal crisis, he spent the last few years crisscrossing the country, collecting hundreds of life stories in all fifty states from Americans who’d been through major life changes—from losing jobs to losing loved ones; from changing careers to changing relationships; from getting sober to getting healthy to simply looking for a fresh start. He then spent a year coding these stories, identifying patterns and takeaways that can help all of us survive and thrive in times of change. What Feiler discovered was a world in which transitions are becoming more plentiful and mastering the skills to manage them is more urgent for all of us. The idea that we’ll have one job, one relationship, one source of happiness is hopelessly outdated. We all feel unnerved by this upheaval. We’re concerned that our lives are not what we expected, that we’ve veered off course, living life out of order. But we’re not alone. Life Is in the Transitions introduces the fresh, illuminating vision of the nonlinear life, in which each of us faces dozens of disruptors. One in ten of those becomes what Feiler calls a lifequake, a massive change that leads to a life transition. The average length of these transitions is five years. The upshot: We all spend half our lives in this unsettled state. You or someone you know is going through one now. The most exciting thing Feiler identified is a powerful new tool kit for navigating these pivotal times. Drawing on his extraordinary trove of insights, he lays out specific strategies each of us can use to reimagine and rebuild our lives, often stronger than before. From a master storyteller with an essential message, Life Is in the Transitions can move readers of any age to think deeply about times of change and how to transform them into periods of creativity and growth.
The ubiquity of computer-generated imagery around us, in movies, advertising or on the Internet is already being taken for granted and what impresses most people is the photorealistic quality of the images. Pictures, as we have often been told, are worth a thousand words and the information transported by an image can take many different forms. Man
This book on Health and Social Care for Advanced GNVQ matches the six mandatory units with key skills sign-posting throughout. Realistic case studies are given as well as emphasis given to the skills necessary for further studies or a career in the care sector. Key information is easily identifiable within the text and revision is aided with review questions at the end of each unit.
Focusing on individual patient needs, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Seventh Edition, provides thorough, comprehensive information from Drs. Bruce A. Chabner, Dan L. Longo, and an authoritative team of clinicians and scientists working at renowned cancer centers across the globe. It covers fundamental information about mechanism of action, pharmacokinetics, clinical toxicity, and drug interactions, all essential to the safe and effective use of the drug.
This simple and manageable guide to user interface design is written for the professional in industry working on product development and the decision process. It is directed not only to the human factors specialists, but also to technicians, designers, marketing and product managers and students. The book presents guidelines for user interface d
A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features: Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.
The use of genetics for the resolution of legal conflicts has recently been gaining a higher profile, largely as a result of scientific and technological advancements and the substantial broadening of applications. The theoretical framework underlying forensic genetics is the same irrespective of the materials and technology involved, however a great divide still exists in the manner and processes related to human and non-human analyses.This advanced handbook intends to overcome the historical barriers between the scientific fields of legal medicine, biodiversity and conservation, and food analysis by presenting a unifying, global perspective on the implications of genetic analyses on forensic affairs. This global perspective is presented in three parts: modes of inheritance and reproduction and taxonomic implications; current technological approaches and future perspectives; and a comprehensive systematization of the types of applications and organisms. Finally, a critical revision of the current investigative/expert systems and future perspectives is undertaken.This book provides a collection of international research, thereby constituting a reference platform for the forensic community and an advanced textbook for graduate students. It encompasses the theoretical bases of the field, and presents in the context of both perspectives of forensic action — probative and investigative — a comprehensive coverage of the current applications and technological state of the art.
The profession of social work has a long and admirable history of attending to issues related to diversity and oppression. This new edition continues to examine the disciplinary attention regarding the provision of services to clientele who were most often marginalized by mainstream society. By understanding certain aspects of the culture experienced by a client, a social worker is better equipped to be of service, to assess, to plan, to cooperate, and to intervene. The goal of this book is to bridge the gaps and to present to readers, in one source, a wealth of practice-relevant information a.
The intellectual and cultural battles now raging over theism and atheism, conservatism and secular progressivism, dualism and monism, realism and antirealism, and transcendent reality versus material reality extend even into the scientific disciplines. This stunning new volume captures this titanic clash of worldviews among those who have thought most deeply about the nature of science and of the universe itself. Unmatched in its breadth and scope, The Nature of Nature brings together some of the most influential scientists, scholars, and public intellectuals—including three Nobel laureates—across a wide spectrum of disciplines and schools of thought. Here they grapple with a perennial question that has been made all the more pressing by recent advances in the natural sciences: Is the fundamental explanatory principle of the universe, life, and self-conscious awareness to be found in inanimate matter or immaterial mind? The answers found in this book have profound implications for what it means to do science, what it means to be human, and what the future holds for all of us.
During the 1970s and 1980s prescription and over-the-counter drugs had come to play a major role in the health care of older people. Originally published in 1986, this book reviews the historical background to this development and explores its social and pharmacological implications. The main aim of the study was to provide a critical perspective on drug use together with a framework for developing effective prescribing policies. The authors do not, in developing their arguments, reject the enormous value of drugs in the treatment of many illnesses affecting older people; they do, however, criticise excessive as well as inappropriate prescribing. The intention was to provide some practical illustrations of how the harmful effects of drug use can be curtailed. This book was aimed, in particular, at workers in the health services, for example: doctors, health visitors, district nurses, pharmacists, the professions allied to medicine. However, it should also be of interest to other groups such as social workers, carers, support groups and older people themselves.
Livable Streets 2.0 offers a thorough examination of the struggle between automobiles, residents, pedestrians and other users of streets, along with evidence-based, practical strategies for redesigning city street networks that support urban livability. In 1981, when Donald Appleyard's Livable Streets was published, it was globally recognized as a groundbreaking work, one of the most influential urban design books of its time. Unfortunately, he was killed a year later by a speeding drunk driver. This latest update, Livable Streets 2.0, revisited by his son Bruce, updates the topic with the latest research, new case studies, and best human-centered practices for creating more livable streets for all. It is essential reading for those who influence future directions in city and transportation planning, urban design, and community regeneration, and placemaking. - Incorporates the most current empirical research on urban transportation and land use practices that support the need for more livable communities - Includes recent case studies from around the world on successful projects, campaigns, programs, and other efforts - Contains new coverage of vulnerable populations
Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
This book and the accompanying Volume B (Lanark-Wigton plus General Retours) are composed from the three volumes together called Inquisitionum ad Capellam Domini Regis Retornatarum, quae in Publicis Archivis Scotiae Adhuc Servantur (Inquiries Retourned to the Chancery of our Lord the King which are Held in the Archives of Scotland) from 1544 to 1699. These records, informally known as Retours of Services of Heirs, represent possibly the greatest unused resource for Scottish genealogy and land history, but are not widely available and thus largely unknown. Essentially, they are abbreviated abstracts of the records of inheritance, the continuity of heritable possession of land and certain associated rights and responsibilities. The original Retours themselves are often long and complicated, and mostly in Latin, but they were indexed and abbreviated into the form presented here. The Retours can be searched by County, then by surname and placename. With additional material and a Latin glossary by Dr. Bruce Durie
Specialists combine efforts to present an overall picture of current thinking and research on sex roles, sex differences, and sex role development. With its emphasis on psychological antecedents and concomitants underlying sex roles and sex typing, this volume will definitely appeal to developmental and educational psychologists. Those involved in women's studies, sociology, and anthropology will also find it useful.
This unique book is designed to help unlock the power of memory for people whose ability to remember has begun to fade. Among Drs. Thorsheim and Roberts's ideas are using objects to help people reminisce, as well as a study of what can be done in group settings.
Addresses the full range of reproductive endocrinology and infertility (REI) issues, from the fundamentals of reproductive medicine through disorders of the endocrine system, infertility, contraception, and menopause. Clinically focused and logically organized, the book is designed to reflect how the clinician should approach the REI patient.
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