Genome-wide interaction studies is an extremely challenging problem in statistics, in which conventional methods are often inadequate in terms of both power and computational efficiency. An exhaustive search for genome-wide gene–gene interactions becomes feasible with modern cluster computing run on graphics processing units. However, the large number of tests accompanying the search raises a serious multiple testing problem. A way to overcome these limits is to apply a filtering step prior to the combinatorial method and to analyze only interesting single nucleotide polymorphisms selected based on a priori (defined by statistical evidence, genetic impact, or biological plausibility). The advantage of the filter approach is speed, and the disadvantage is that attributes with poor quality scores are disregarded. Genome-wide gene–environment interaction is less problematic computational demand compared with pairwise genome-wide gene–gene interaction. Accounting for gene–gene and gene–environment interactions is important for future strategies of diagnosis, prognosis, and management of human diseases and will bring new data regarding pathogenetic mechanisms for human complex diseases.
This book introduces the tailor-made design of detection probes as well as schemes from a top-down perspective according to the unique characteristics of cellular functional molecules.
This book addresses the fundamental theory and key technologies of narrowband and broadband mobile communication systems specifically for railways. It describes novel relaying schemes that meet the different design criteria for railways and discusses the applications of signal classification techniques as well as offline resource scheduling as a way of advancing rail practice. Further, it introduces Novel Long Term Evolution for Railway (LTE-R) network architecture, the Quality of Service (QoS) requirement of LTE-R and its performance evaluation and discusses in detail security technologies for rail-dedicated mobile communication systems. The advanced research findings presented in the book are all based on high-speed railway measurement data, which offer insights into the propagation mechanisms and corresponding modeling theory and approaches in unique railway scenarios.It is a valuable resource for researchers, engineers and graduate students in the fields of rail traffic systems, telecommunication and information systems.
The King of Mercenaries, Zhang Xiaobin, returned to the city and became a waiter in a small bar. Not only did he take away the top quality beauty, the boss, but he also managed to fool the beautiful female police. Even the beautiful maid Zhang Xiaobin, the peerless female assassin, and the beautiful widow fell in love with him.
The King of Mercenaries, Zhang Xiaobin, returned to the city and became a waiter in a small bar. Not only did he take away the top quality beauty, the boss, but he also managed to fool the beautiful female police. Even the beautiful maid Zhang Xiaobin, the peerless female assassin, and the beautiful widow fell in love with him.
The King of Mercenaries, Zhang Xiaobin, returned to the city and became a waiter in a small bar. Not only did he take away the top quality beauty, the boss, but he also managed to fool the beautiful female police. Even the beautiful maid Zhang Xiaobin, the peerless female assassin, and the beautiful widow fell in love with him.
The King of Mercenaries, Zhang Xiaobin, returned to the city and became a waiter in a small bar. Not only did he take away the top quality beauty, the boss, but he also managed to fool the beautiful female police. Even the beautiful maid Zhang Xiaobin, the peerless female assassin, and the beautiful widow fell in love with him.
In this book, control and filtering problems for several classes of stochastic networked systems are discussed. In each chapter, the stability, robustness, reliability, consensus performance, and/or disturbance attenuation levels are investigated within a unified theoretical framework. The aim is to derive the sufficient conditions such that the resulting systems achieve the prescribed design requirements despite all the network-induced phenomena. Further, novel notions such as randomly occurring sensor failures and consensus in probability are discussed. Finally, the theories/techniques developed are applied to emerging research areas. Key Features Unifies existing and emerging concepts concerning stochastic control/filtering and distributed control/filtering with an emphasis on a variety of network-induced complexities Includes concepts like randomly occurring sensor failures and consensus in probability (with respect to time-varying stochastic multi-agent systems) Exploits the recursive linear matrix inequality approach, completing the square method, Hamilton-Jacobi inequality approach, and parameter-dependent matrix inequality approach to handle the emerging mathematical/computational challenges Captures recent advances of theories, techniques, and applications of stochastic control as well as filtering from an engineering-oriented perspective Gives simulation examples in each chapter to reflect the engineering practice
China's Elite Politics provides a new theoretical perspective on elite politics in China and uses this theoretical perspective to explain power transfer from Jiang Zemin to Hu Jintao and political dynamics between different factional groups since the Sixteenth Party Congress of November 2002. It explains the transition in structural terms, presents characteristics of China's political elites, and analyzes the balance of power among formal institutions as well as among factional groups. It also examines political interactions between Jiang Zemin and his cronies on the one side and Hu Jintao and his allies on the other over a number of issues: the epidemic of severe acute respiratory syndrome (SARS); ideological institutionalization; the politics over economic overheating; Jiang Zemin's complete retirement; and Hu Jintao's power consolidation in both ideological and personnel terms. /a
They were twins, but they had very different personalities. This fake death had caused all the survivors to live in a dislocated position. Since then, she has become a substitute for honorifics. But her little sister followed behind her boyfriend all day long. All she could do was wait for the truth to be revealed ...
This book systematically studies the feedback control and filtering problems for nonlinear plants with limited communication channels based on T-S fuzzy models. By fully considering different network-induced phenomena, such as signal quantizations, time-delays, data packet dropouts, communication protocols, cyber attacks, and so on, some significant strategies are provided for various performance analysis and different controller/filter synthesis of fuzzy systems. The event-triggered mechanism is also mentioned to save the communication resource. Moreover, some results are extended to the fault detection and fault-tolerant control. The book provides some new methodologies in analysis and synthesis of fuzzy systems under communication channels, and can serve as a valuable reference material for researchers wishing to explore the area of control and filtering of fuzzy systems and networked systems.
Bo Bengtson is regarded today as the foremost international authority on dog shows past and present, and his definitive volume Best in Show: The World of Show Dogs and Dog Shows has become an "instant classic," hailed by critics around the world as the most important book ever written about the sport of dogs. Richard G. Beauchamp, a revered judge and author, praises Best in Show: "At long last a factual and meticulously researched history of the purebred dog scene. It's an everything-you-ever-wanted-to know book about the fascinating world of show dogs;" Best in Show spans the history of dog shows from its beginnings in England to the present-day, highlighting the most important dogs, shows, judges, handlers, breeders, and more in 656 pages overflowing with over 700 full-color and historical black-and-white images.Bengtson is at once a student of dog-show history, an accomplished scholar, a highly regarded international judge, a breeder of champions, and, as Kerrin Winter-Churchill surmises, "the greatest living dog writer of our times." His ultimate achievement, the award-winning Best in Show begins with a history of the dog sport, "How Dog Shows Began," a chapter that talks about the development of pure breeds, the beginnings of the dog fancy, and the first dog shows. To understand the essence of dog shows, it's critical to understand what show judges are looking for, a topic that Bengtson covers in the chapter "The Breed Standards." "Without breed standards, dog shows could not exist. It would be impossible to conduct any meaningful comparison of dogs without universally accepted descriptions of each breed;. At their best, the standards;give a vivid, colorful word picture of the image each breed represents, in motion and standing, when alert and at rest." With illustrations from early and modern breed standards, this chapter discusses the evolution of the standards and addresses the variations in certain breed standards from country to country.The third chapter is devoted to dog shows and highlights the most important shows in Britain and the United States. A detailed discussion of England's most famous dog show, Crufts, begins with the origins of the show and traces its development through the 21st century. (A complete roster of the winners of Crufts is presented in the appendix of the book.) America's most highly regarded show, the Westminster Kennel Club is discussed, accompanied by many photographs of the show and its Best in Show winners. (Roster of WKC winners can also be found in the appendix.) Bengtson also discusses other premiere shows in the U.S. including Santa Barbara, Morris & Essex, AKC/Eukanuba as well as the Fdration Cynologique Internationale's annual event, the World Dog Show. The following chapter discusses specialty shows (shows for one breed or one group), addressing the importance and purpose of specialty shows as well as some of the anomalies of certain breed events. The chapter also highlights some top winners as well as America's most famous group specialty show, the Montgomery County Kennel Club's terrier classic.Separate chapters are dedicated to the judges, breeders, and handlers who have made their mark on the sport of purebred dogs. International in scope, each chapter highlights the most accomplished individuals in the sport, summarizing their accomplishments and their special areas of expertise. The chapters also explain what's required to become a professional in the sport. The historical photographs in these chapters do a splendid job of spotlighting the careers of some of the pillars of the sport, including Anne Rogers Clark, Geraldine Rockefeller Dodge, Anna H. Whitney, Alva Rosenberg, Louis Murr, Anna Katherine Nicholas, Percy Roberts, Robert and Jane Forsyth as well as many contemporary greats such as Peter Green, Maxine Beam, Corky Vroom, Patricia Craige-Trotter, Jimmy Moses, David Fitzpatrick, Sylvia Hammarström, Roger Rechler, Julia Gasow, and dozens of others.The author devotes individual chapters to the greatest dogs from Britain, the United States of America, and the international scene. It is in these insightful, detailed chapters that the interplay of breeders, handlers, and dogs takes focus and the complex picture of the purebred dog scene is exposed. From studying thousands of show records and breed books and from his five decades' experience in the sport, Bengtson is able to put the sport of dog showing into perspective. He highlights important kennels, breeders, and leading dogs in each country and manages to weave all of these individual threads into an elaborate quilt that depicts the history of the sport. Each chapter chronologically presents the dogs and breeds that had the greatest impact on the show world. In the chapter "The Best of Britain," the author traces the nation's history beginning with early Best in Show winners, the emergence of the Collie and Fox Terrier as leading breeds, how other terrier breeds came to the fore in the 1920s, as well as Cocker Spaniels, Great Danes, Irish Wolfhounds, and Irish Setters. In post-war Britain, the focus shifts to Chow Chows and Poodles and then to Toy breeds, like the Pekingese, Pomeranian, and Yorkshire Terrier. The depth and breadth of each chapter, accomplished through insightful, detailed information and exhilarating photography, must be experienced to be truly appreciated.The chapter "Tops in America" is a detailed 150-page chapter;a book in itself;retells the stories of America's most beloved and accomplished show dogs. Readers will feel bolstered by the amount of information and great photography on offer here, as they meet such iconic greats as the Boxer Ch. Bang Away of Sirrah Crest, arguably the most famous show dog in history and the first to win 100 Best in Show awards; Ch. Warren Remedy, the Wire Fox Terrier whose claim to fame is three consecutive Best in Show victories at the Westminster Kennel Club; the Afghan Hound Ch. Tryst of Grandeur; the German Shepherds Ch. Covy-Tucker Hill's Manhattan and Ch. Altana's Mystique, two top-winning dogs that each won over 200 Bests in Show; the famous English Setter Ch. Rock Fall's Colonel, Bang Away's rival and also the winner of 100 Best in Shows; plus the many great winners of the Westminster Kennel Club and other important shows.The author walks the reader through the decades in America, highlighting the breeds that made the greatest impact in the show rings, from the German Shepherds and Sealyham Terriers of the 1920s, the Wire and Smooth Fox Terriers of 1920s and 1930s, the English Setters and Cocker Spaniels of the 1940s and 1950s, to the Boxers, Doberman Pinschers, Pointers, and Poodles that later dominated the scene. Afghan Hound, English Springer Spaniel, and German Shepherd greats of the modern age are also featured in photography and great detail.The international chapter "On Top Around the World" offers a perspective on the greatest show dogs of Canada, Europe, Scandinavia, South Africa, Australia, New Zealand, Russia and Asia. An archivist and journalist for the international dog scene, Bengtson, himself a Swedish import to the United States, has remained extremely well informed for decades, and he remains uniquely qualified to present the kind of global overview on offer in this chapter.
This is a teacher’s resource book tailor-made for EFL teachers who want to bring Shakespeare into their classes. It includes forty innovative lesson plans with ready-to-use worksheets, hands-on games and student-oriented activities that help EFL learners achieve higher levels of English proficiency and cultural sensitivity. By introducing the plots, characters, and language arts employed in Macbeth, Romeo and Juliet, The Taming of the Shrew, and The Merchant of Venice, the book conveys English grammatical rules and aspects like a walk in the garden; complicated rhetorical features such as stress, meter, rhyme, homonymy, irony, simile, metaphor, euphemism, parallelism, unusual word order, etc. are taught through meaning-driven games and exercises. Besides developing EFL learners’ English language skills, it also includes practical extended tasks that enhance higher-order thinking skills, encouraging reflection on the central themes in Shakespeare’s plays.
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