The explosion of research activity in the field of neuropeptides has led to the idenfication of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
Social welfare has a three-thousand-year history in Western society. Th is book off ers a sociological framework that provides conceptual order to the countless details of that history, while highlighting its essentials. Social welfare in all its forms is based on one central concept-help. But there are many versions of help and multiple debates about those versions. Th e outcomes of some debates have led to withholding help, and these outcomes are an inescapable part of this domain, in the past and in the present. Th e major versions, their development, and the debates are carefully examined in this volume.
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