Sisters Kim and Kathy Hodges are born sixteen months apart in a middle-class existence parented by Linda and David Hodges of Houston, Texas. The happy couple welcomes their “lucky daughter” Kim, who is physically and mentally advanced. Following several miscarriages, Linda delivers “unlucky” Kathy at twenty-nine weeks, ensuring a life of cognitive and physical disabilities. Kathy enters public school as a special education student, while Kim is recognized as gifted. Both sisters face life and death decisions as Houston is caught in the rip current of Hurricane Harvey. Kim learns the capricious nature of luck, while Kathy continues to make her own luck, surviving Hurricane Harvey, as she has survived all undertows with the ethereal courage of the resolute. Sisters of the Undertow examines the connotations of lucky and unlucky, the complexities of sibling rivalry, and the hand fate delivers without reason.
Why are philosophers, as opposed to, say, linguists and psychologists, puzzled by language? How should we attempt to shed philosophical light on the phenomenon of language? "How to Understand Language" frames its discussion by these two questions. The book begins by thinking about the reasons that language is hard to understand from a philosophical point of view and, armed with the fruits of that discussion, begins searching for an approach to these questions. After finding fault with approaches based on philosophical analysis and on translation it undertakes an extended investigation of the programme of constructing a theory of meaning. Donald Davidson's advocacy of that approach becomes pivotal; though, the book endorses his broad approach, it argues strongly against the roles both of truth theory and of radical interpretation.
There are many short stories and books written with an inspirational storyline. Which also includes the Holy Bible They are hard to believe written so that the reader follows the guidelines like an educational premise. Thus, the belief of the reader only last a certain amount of time, leaving them with a cycle of disappointment. Falling Through The Cracks is a fiction trilogy dealing with events of characters during their daily lives. The book is based on a female main character in her 50's who fights sobriety over a five year period after her husband dies from a heart attack. She is surrounded by friends who try to help her. She follows their lead off and on for several months, then goes into relapse. Finally she falls in love with her husband's best friend and they plan their marriage.
Gracey Reiter confronts a painful past and an intimidating future with the approaching death of her father, Henry Mueller, the self-described “last Mohican” from the chaotic gene pool known as the Walsh-Mueller family. The present holds the answer, and the last opportunity for Gracey to understand her father’s alcoholism, her mother’s infidelity, and her siblings’ version of the truth. The voices of the past give Gracey the courage to find her voice. Using biting humor and gut-level truths for the first time in her life, Gracey walks across the land mines created by a crippling family legacy. Henry’s funeral and the Irish wedding of Therese Mueller, Gracey’s and her husband Mark Mueller’s daughter, coincide by a few weeks and serve as a completion of the family circle. With the closing of one door, and the opening of the future, Gracey finds forgiveness by realizing six generations of the Walsh-Mueller family, saints and sinners, criminals and heroes, the abandoned and the celebrated, are forever family, forever bound by blood and the dreams of an Irish girl, Patricia Walsh Mueller. A Good Girl examines the numbing work of raising children and burying parents through six generations.
Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
The scientist Roithamer has dedicated the last six years of his life to “the Cone,” an edifice of mathematically exact construction that he has erected in the center of his family’s estate in honor of his beloved sister. Not long after its completion, he takes his own life. As an unnamed friend pieces together—literally, from thousands of slips of papers and one troubling manuscript—the puzzle of Rotheimer’s breakdown, what emerges is the story of a genius ceaselessly compelled to correct and refine his perceptions until the only logical conclusion is the negation of his own soul. Considered by many critics to be Thomas Bernhard’s masterpiece, Correction is a cunningly crafted and unforgettable meditation on the tension between the desire for perfection and the knowledge that it is unattainable.
Visual Computing for Medicine, Second Edition, offers cutting-edge visualization techniques and their applications in medical diagnosis, education, and treatment. The book includes algorithms, applications, and ideas on achieving reliability of results and clinical evaluation of the techniques covered. Preim and Botha illustrate visualization techniques from research, but also cover the information required to solve practical clinical problems. They base the book on several years of combined teaching and research experience. This new edition includes six new chapters on treatment planning, guidance and training; an updated appendix on software support for visual computing for medicine; and a new global structure that better classifies and explains the major lines of work in the field. - Complete guide to visual computing in medicine, fully revamped and updated with new developments in the field - Illustrated in full color - Includes a companion website offering additional content for professors, source code, algorithms, tutorials, videos, exercises, lessons, and more
In our everyday thought and talk, we put things into categories in order to generalize about them: 'Lions have manes', 'Ravens are black'. Bernhard Nickel presents a theory of generic sentences and the modes of thought they express, integrating compositional semantics with metaphysics to solve the problems of what they mean and how they work.
INTERNATIONAL BESTSELLER • Hailed for its coiled eroticism and the moral claims it makes upon the reader, this mesmerizing novel is a story of love and secrets, horror and compassion, unfolding against the haunted landscape of postwar Germany. "A formally beautiful, disturbing and finally morally devastating novel." —Los Angeles Times When he falls ill on his way home from school, fifteen-year-old Michael Berg is rescued by Hanna, a woman twice his age. In time she becomes his lover—then she inexplicably disappears. When Michael next sees her, he is a young law student, and she is on trial for a hideous crime. As he watches her refuse to defend her innocence, Michael gradually realizes that Hanna may be guarding a secret she considers more shameful than murder.
Financial Risk Modelling and Portfolio Optimization with R, 2nd Edition Bernhard Pfaff, Invesco Global Asset Allocation, Germany A must have text for risk modelling and portfolio optimization using R. This book introduces the latest techniques advocated for measuring financial market risk and portfolio optimization, and provides a plethora of R code examples that enable the reader to replicate the results featured throughout the book. This edition has been extensively revised to include new topics on risk surfaces and probabilistic utility optimization as well as an extended introduction to R language. Financial Risk Modelling and Portfolio Optimization with R: Demonstrates techniques in modelling financial risks and applying portfolio optimization techniques as well as recent advances in the field. Introduces stylized facts, loss function and risk measures, conditional and unconditional modelling of risk; extreme value theory, generalized hyperbolic distribution, volatility modelling and concepts for capturing dependencies. Explores portfolio risk concepts and optimization with risk constraints. Is accompanied by a supporting website featuring examples and case studies in R. Includes updated list of R packages for enabling the reader to replicate the results in the book. Graduate and postgraduate students in finance, economics, risk management as well as practitioners in finance and portfolio optimization will find this book beneficial. It also serves well as an accompanying text in computer-lab classes and is therefore suitable for self-study.
The danger to British democracy in the interwar period came from a different source to that which has thus far been assumed. It came from a network of radical conservatives who challenged the political system and sought to replace it with an authoritarian corporate state. In this book, Bernhard Dietz provides the first systematic analysis of this network and its members, which are called Neo-Tories. With strong links to the European right, yet a minority back home, this group of British conservatives are all the more fascinating today because it is on their ultimate failure that the success of British democracy rested.
LeopardologyTM – the art of Positive Predatory Thinking. Critical business strategy, gleaned from the hunt of the African leopard. Critical business thinking and strategy, gleaned from the hunting habits and techniques of the African leopard, perhaps the most successful predator on earth! Using the hunting habits and techniques of Africa’s most successful predator, Leopardology TM draws metaphors of personal and business success that will simply leave you spellbound! Having the “lion's share” of market territories and clients, to which corporations have been accustomed, is no longer the case. Competitor predators are continually on the prowl for your market share and profit. On the plains of the African savannah, deficiencies of vision, strategy, trust and change-management are often the indicators that lead alert predators to easy prey. Not unlike the world of commerce, in the bushlands of Africa, if one is not hunting to survive, one will simply survive to be hunted!
This self-contained textbook covers fundamental aspects of sequence analysis with special emphasis on evolutionary biology, including sequence alignment, exact matching, phylogeny reconstruction, and coalescent simulation. It addresses these topics through a series of over 800 computer problems, ranging from elementary to research level, to enable learning by doing. Students solve the problems in the same computational environment used for decades in science – the Unix command line. This is available on all four major operating systems for PCs: Windows, macOS, chromeOS, and Linux. To learn using this powerful system, students analyze sample sequence data by applying generic tools, bioinformatics software, and over 50 programs specifically written for this course and available via GitHub. The solutions for all problems are included, making the book ideal for self-study. Problems are grouped into sections headed by an introduction and a list of new terms. By using practical computing to explore sequence data in an evolutionary context, the book enables readers to tackle their own computational problems.
Technological change is a central feature of modern societies and a powerful source for social change. There is an urgent task to direct these new technologies towards sustainability, but society lacks perspectives, instruments and policies to accomplish this. There is no blueprint for a sustainable future, and it is necessary to experiment with alternative paths that seem promising. Various new transport technologies promise to bring sustainability benefits. But as this book shows, important lessons are often overlooked because the experiments are not designed to challenge the basic assumptions about established patterns of transport choices. Learning how to organise the process of innovation implementation is essential if the maximum impact is to be achieved - it is here that strategic niche management offers new perspectives. The book uses a series of eight recent experiments with electric vehicles, carsharing schemes, bicycle pools and fleet management to illustrate the means by which technological change must be closely linked to social change if successful implementation is to take place. The basic divide between proponents of technological fixes and those in favour of behavioural change needs to be bridged, perhaps indicating a third way.
This study focuses on the problems and prospects of the automobile and the steel industries contributing to Brazilian economy in the international division of labour. It gives insights on importance of the competing hypotheses on the manufactured export performance of these industries.
Now a popular Netflix series! The #1 international bestseller hailed as "one of the most arresting thrillers" (#1 New York Times bestselling author Lisa Gardner), Woman of the Dead is the darkly riveting tale of Brünhilde Blum, a successful undertaker whose happiness is struck by tragedy that sets her on the path for revenge. For the past eight years, Blum has had a good life—a life that masks the terrible secrets of her past. She is a successful undertaker, a doting mother, and the loving wife of a decorated police officer. Then in one devastating moment, a hit-and-run changes everything. As Blum’s grief over the death of her husband, Mark, overwhelms her, only her two little girls can drag her back to the land of the living. Time passes quietly until while packing up Mark’s office, Blum discovers a recorded conversation from a case he was investigating. She soon learns Mark’s death was no accident—it was murder—and Blum dives headfirst into the abyss to find out why and have her revenge. Woman of the Dead, the first book in a trilogy, is an unforgettable thriller about the lengths one passionate woman will go to for vengeance and the tug-of-war between good and evil that exists in all of us. Vivid, tense, and written with breakneck narration, this novel introduces Bernhard Aichner as a rising star in crime fiction.
Biophysical models have been used in biology for decades, but they have been limited in scope and size. In this book, Bernhard Ø. Palsson shows how network reconstructions that are based on genomic and bibliomic data, and take the form of established stoichiometric matrices, can be converted into dynamic models using metabolomic and fluxomic data. The Mass Action Stoichiometric Simulation (MASS) procedure can be used for any cellular process for which data is available and allows a scalable step-by-step approach to the practical construction of network models. Specifically, it can treat integrated processes that need explicit accounting of small molecules and protein, which allows simulation at the molecular level. The material has been class-tested by the author at both the undergraduate and graduate level. All computations in the text are available online in MATLAB® and Mathematica® workbooks, allowing hands-on practice with the material.
A brand-new edition of the best-selling classic with added and updated practices. In 2001, Toni Bernhard got sick and, to her and her partner’s bewilderment, stayed that way. As they faced the confusion, frustration, and despair of a life with sudden limitations—a life that was vastly different from the one they’d thought they’d have together—Toni had to learn how to be sick. In spite of her many physical and energetic restrictions (and sometimes, because of them), Toni learned how to live a life of equanimity, compassion, and joy. This book reminds us that our own inner freedom is limitless, regardless of our external circumstances. Updated with new insights and practices hard-won from Toni’s own ongoing life experience, this is a must-read for anyone who is—or who might one day be—sick or in pain.
In this paper the authors apply their results on the geometry of polygons in infinitesimal symmetric spaces and symmetric spaces and buildings to four problems in algebraic group theory. Two of these problems are generalizations of the problems of finding the constraints on the eigenvalues (resp. singular values) of a sum (resp. product) when the eigenvalues (singular values) of each summand (factor) are fixed. The other two problems are related to the nonvanishing of the structure constants of the (spherical) Hecke and representation rings associated with a split reductive algebraic group over $\mathbb{Q}$ and its complex Langlands' dual. The authors give a new proof of the Saturation Conjecture for $GL(\ell)$ as a consequence of their solution of the corresponding saturation problem for the Hecke structure constants for all split reductive algebraic groups over $\mathbb{Q}$.
Intimately and without jargon, How to Wake Up: A Buddhist-Inspired Guide to Navigating Joy and Sorrow describes the path to peace amid all of life's ups and downs. Using step by step instructions, the author illustrates how to be fully present in the moment without clinging to joy or resisting sorrow. This opens the door to a kind of wellness that goes beyond circumstances. Actively engaging life as it is in this fashion holds the potential for awakening to a peace and well-being that are not dependent on whether a particular experience is joyful or sorrowful. This is a practical book, containing dozens of exercises and practices, all of which are illustrated with easy-to-relate to personal stories from the author's experience.
This book is devoted to one of the fastest developing fields in modern control theory - the so-called H-infinity optimal control theory. The book can be used for a second or third year graduate level course in the subject, and researchers working in the area will find the book useful as a standard reference. Based mostly on recent work of the authors, the book is written on a good mathematical level. Many results in it are original, interesting, and inspirational. The topic is central to modern control and hence this definitive book is highly recommended to anyone who wishes to catch up with important theoretical developments in applied mathematics and control.
Fifty-year-old Karen Anders, a high school English teacher and the adoptive mother of Tiffany, comes to terms with being a single-parent and a clumsy drunk in the multicultural melting pot of Houston, Texas, as she forges an unlikely friendship with Leona Supak, a WWII Hungarian refugee, who inspires Karen to change her views on motherhood, drinking, and men. Karen’s teaching job provides an ongoing challenge with low scoring students and a lack of support from school administrators. Meanwhile, Tiffany moves to Austin to attend the University of Texas, but soon neglects her academic life when she meets a gamer boyfriend and begins a job at the Ink & Juice, a tattoo parlor-juicing bar. Tiffany hides the truth of her new life from Karen through a text-only relationship. Feeling rejected, Karen explores the paradox of romance for the middle-aged. Despite the challenges, a family unit comes together inspired by strangers and second chances in How We Came to Be.
Tremendous strides in decoding the human genome have been made over the last ten years. Large, chromosome-scale, genome-scale EST-sequencing and mapping techniques have dramatically expanded the base of identified genes and sequenced DNA. Gene isolation and cloning techniques that emerged earlier on, however, still remain effective mainstays for constructing dense transcript maps to isolate coding sequences and disease-associated genes contained within a specific chromosomal region. Positional Cloning by Exon Trapping and cDNA Selection examines two powerful methods for locating the coding region of a given gene by isolating gene fragments from individual clones or pools of genomic clones. This comprehensive guide details the exon-trapping and cDNA selection processes step by step-from isolating genomic templates and nuclear splicing, to verifying generated clones and sequenced data, to analyzing exon libraries and cDNA sublibraries. Procedures covered include: * Exon-trapping systems and descriptions of pSPL1 and pSPL3 vectors. * Exon amplification protocols for preparing vectors for cloning; subcloning genomic DNA into vectors; transformation, analysis, and transfection of sublibraries; RNA transcription; and PCR amplification and PCR product cloning. * Evaluation of exon libraries by PCR colony testing, identifying artifactual clones using Southern blot, and sequencing and mapping back candidate exons. * Isolation of genomic templates, such as COSMID-, P1-, PAC, and YAC DNA. * cDNA selection experiment protocols including cDNA screening, hybridization, and biotinylation; preparation of genomic and cDNA sources; and PCR cloning. * Clone analysis and analysis by hybridization. Positional Cloning by Exon Trapping and cDNA Selection offers researchers, scientists, and graduate students an invaluable tool for probing gene distribution and molecular organization. Most importantly, it provides a critical approach to isolating specific disease genes within a targeted genomic area.
Social ontology, conventionally defined, is not primarily about us. Rather, it is about the social world (or worlds), about social reality (or realities), or about the domain(s) of social facts. Social ontology aims at providing an inventory of the basic kinds of entities that make up the social world(s) - items such as norms, institutions, social practices, status positions, power structures, and artifacts. It is the study of the basic kinds of properties of these entities, and of how the social world exists, how it is constituted, or constructed"--
Joining insights from social science and philosophy, this book offers a nuanced view on the discourse of evil, which has been on the rise in the West in recent years. Exploring the famous ‘Pear Theft’ episode in St Augustine’s Confessions, it looks beyond the theological implications of the event to focus instead on the secular insights that it offers when the event is placed in the context of social thought. With attention to Augustine’s lengthy reflections on a seemingly marginal episode, the author contends that it is possible to discern the elements of a convincing account of intentional evil action, the Pear Theft representing a case of joint radical improvisation that lacks collective deliberation. As such, a new perspective emerges on familiar and more intuitive forms of evil in joint action that involve group identification and institutional action. Evil in Joint Action will appeal to scholars of sociology, social theory and philosophy with interests in ethics, collective action and concepts of evil.
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