Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.
Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.
How does chance enter our world? And why is so much not predictable? In an understandable, exciting and amusing narrative, the author takes us into the world of chemistry, quantum physics and biology. Touching on astronomy and philosophy, we witness a rewarding journey of discovery. In the process, he develops a completely new view of chance based on the laws of nature. Here, the omnipresent non-equilibrium plays an extremely decisive role, because it generates the complex structures in our world. Finally, on this basis, he presents an equally simple and captivating hypothesis on the nature of time. This non-fiction book provides a deep insight into the fascination of research, the agonizing search for fundamental understanding, and the struggle for scientific knowledge.
What social security rights are there for illegal workers? To what extent can health care services be refused by the beneficary, and to what extent can coverageof health care services be refused by social security bodies? This casebook is composed of two main parts. The first gives an overview of the ways related cases were decided by national courts in a number of European contries. In the second part the reader finds the crucial parts of the court decisions in about sixty cases. The decisions are published in their original language with a summary in English.
Visualization, Visual Analytics and Virtual Reality in Medicine: State-of-the-art Techniques and Applications describes important techniques and applications that show an understanding of actual user needs as well as technological possibilities. The book includes user research, for example, task and requirement analysis, visualization design and algorithmic ideas without going into the details of implementation. This reference will be suitable for researchers and students in visualization and visual analytics in medicine and healthcare, medical image analysis scientists and biomedical engineers in general. Visualization and visual analytics have become prevalent in public health and clinical medicine, medical flow visualization, multimodal medical visualization and virtual reality in medical education and rehabilitation. Relevant applications now include digital pathology, virtual anatomy and computer-assisted radiation treatment planning. Combines visualization, virtual reality and analytics Written by leading researchers in the field Gives the latest state-of-the-art techniques and applications
Now in its second edition, this comprehensive history of the Celts draws on archaeological, historical, literary and linguistic evidence to provide a comprehensive and colourful overview from origins to the present. Divided into three parts, the first covers the continental Celts in prehistory and antiquity, complete with accounts of the Celts in Germany, France, Italy, Iberia and Asia Minor. Part Two follows the Celts from the departure of the Romans to the late Middle Ages, including the migrations to and settlements in Ireland, Wales, Scotland and Brittany. This section also includes discussions of the Celtic kingdoms and the significance of Christianisation. Part Three brings the history of the Celts up to the present, covering the assimilation of the Celts within the national cultures of Great Britain, France and Ireland. Included in this consideration are the suppression of Gaelic, the declines, revivals and survivals of languages and literatures, and the histories of Celtic culture. The book concludes with a discussion of the recent history of the meaning of 'Celtic' and an examination of the cultural legacy of the Celts in the modern era.
-- Tips from the authors of Gentleman's Guide: To Grooming and Style -- An indispensable guide for every fashion aficionado -- Dress for self-confidence and success -- How to combine fabrics, patterns, accessories and jewelry -- Look great on a tiny budget without compromising style -- From "casual" to "evening dress
Design today is a global instrument. Bernhard Bürdek traces the progress of design from its beginnings in the late 19th century, through the most significant movements of the 20th century up to those recent developments in biological engineering which will shape the 21st century. Design is now a discipline in its own right and its expertise can be incorporated within interdisciplinary processes. The most important fundamental principles of design theory and methodology are presented, looking in particular at the communicative function of products and highlighting aspects such as corporate and service design, design management, strategic design, interface/interaction design and human design.
This book focuses on advances in imaging and mapping strategies to study the brain's structure, function and the relationship between both, from the whole brain to the molecular and cellular tissue level in order to improve the understanding of normal and disease processes. Studies of intact living organisms may be at the human, animal, cellular or molecular level, which advance our understanding of biological events in living systems and how these events relate to normal and pathological processes. Imaging modalities include nuclear medicine techniques (SPECT and PET) and non-nuclear techniques such as MRI, MRS, CT, ultrasound, intravital microscopy, optical imaging, diffuse optical tomography, electromagnetic tomography and other methods which elucidate molecular and cellular mechanisms, accelerate the understanding of biology, test the efficacy of therapeutic interventions in intact living systems and assess the therapeutic outcomes.
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