Invertebrate Zoology: A Tree of Life Approach is a comprehensive and authoritative textbook adopting an explicitly phylogenetic organization. Most of the classical anatomical and morphological work has not been changed – it established the foundation of Invertebrate Zoology. With the explosion of Next-Generation Sequencing approaches, there has been a sea-change in the recognized phylogenetic relationships among and between invertebrate lineages. In addition, the merger of evolutionary and developmental biology (evo-devo) has dramatically contributed to changes in the understanding of invertebrate biology. Synthesizing these three approaches (classical morphology, sequencing data, and evo-devo studies) offers students an entirely unique perspective of invertebrate diversity. Key Features One of the first textbooks to combine classical morphological approaches and newer evo-devo and Next-Generation Sequencing approaches to address Invertebrate Zoology Organized along taxonomic lines in accord with the latest understanding of invertebrate phylogeny Will provide background in basic systematic analysis useful within any study of biodiversity A wealth of ancillary materials for students and teachers, including downloadable figures, lecture slides, web links, and phylogenetic data matrices
The European Commission is a detailed and comprehensive guide to the workings of the European Commission. This straightforward and accessible new title de-mystifies procedures, practices and policies, which, up until now, have been perceived by many as baffling and oblique.Written in a style that is both uncomplicated and user-friendly, the authors equip readers with all the information about the background of the Commission; its administrative structure; its policies; external relations; and general and internal services.Packed with numerous handy tables and figures, The European Commission will serve to help readers to gain a full understanding of how the machinery of the Commission functions and how the daily work processes are carried out. This is both an essential and fascinating handbook for all those working in the political arena.
Explores the roots of the Christmas tree tradition, tracing customs from the Middle Ages to the present day to reveal how it first became part of mainstream American culture and has since become popular worldwide.
Dieses Lehrbuch betrachtet ganzheitlich den Bereich Umwelttechnik, baut dabei auf grundlegende Prinzipien der Umweltchemie auf und konzentriert sich auf innovative und nachhaltige Technologien im Rahmen internationaler Regelungen.
Despite considerable investments in health facilities worldwide, little systematic evidence is available on how to plan, design and build new facilities that maximize health gain and ensure that services are responsive to the legitimate expectations of users. This book brings together current knowledge about key dimensions of capital investment in the health sector.
The modern welfare state is indeed one of the greatest achievements of the post-war 20th century. With its key aims of eradicating the five giant social ills of Want, Ignorance, Disease, Squalor and Idleness, it aimed to providing a minimum standard of living, with all people of working age paying a weekly contribution; in return, benefits would be paid to anyone who was sick, unemployed, retired or widowed. The modern welfare state, therefore, is about maintaining a delicate equilibrium between dependent social groups on the one hand and the active working classes on the other. In the case of old-age security, this balance is being achieved (or not) by the so-called Generation Contract. This social pact is more of an implicit, unwritten and unspecified social contract. This ground-breaking book demonstrates how countries are addressing population-ageing challenges in depth, using the case study of Austria to gain the required complexity and differentiation in a comparative European framework of empirical evidence. This is a broad social science study in political economy and sociology, not an economic analysis. Though focusing on pensions, it centres on the (im)balance between work and non-work, issues of health, work ability, employability, and benefit receipt from old-age security to disability allowance. It will be required reading for all sociologists and social policy experts and academics working within this area.
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging. In short, this book covers all aspects of drug analysis.
Hermann Haken (born 1927) is one of the “fathers” of the quantum-mechanical laser theory, formulated between 1962 and 1966, in strong competition with American researchers. Later on, he created Synergetics, the science of cooperation in multicomponent systems. The book concentrates on the development of his scientific work during the first thirty-five years of his career. In 1970 he and his doctoral student Robert Graham were able to show that the laser is an example of a nonlinear system far from thermal equilibrium that shows a phase-transition like behavior. Subsequently, this insight opened the way for the formulation of Synergetics. Synergetics is able to explain, how very large systems show the phenomenon of self-organization that can be mathematically described by only very few order parameters. The results of Haken’s research were published in two seminal books Synergetics (1977) and Advanced Synergetics (1983). After the year 1985 Haken concentrated his research on the macroscopic foundation of Synergetics. This led him towards the application of synergetic principles in medicine, cognitive research and, finally, in psychology. A comprehensive bibliography of Hermann Haken’s publications (nearly 600 numbers) is included in the book.
Alginates: Biology and Applications" provides an overview of the state of art of alginate material properties, genetics and the molecular mechanisms underlying alginate biosynthesis as well as applications of tailor-made alginates in medicine, food and biotechnology. Topics treated are: material properties of alginates, alginate production: precursor biosynthesis, polymerization and secretion, bacterial system for alginate uptake and degradation, enzymatic alginate modification, alginate gene regulation, role of alginate in bacterial biofilms, microbial production of alginates: physiology and process aspects, alginate-based blends and nano/microbeads, applications of alginates in food, alginate and its comonomer mannuronic acid: medical relevance as drugs.
Microbial polysaccharides represent an attractive alternative to those from plants or macro algae. They can be produced from renewable sources including lignocellulosic waste streams. Their production does not depend on geographical constraints and/or seasonal limitations. Additionally the manipulation of biosynthetic pathways to enhance productivity or to influence the chemical polysaccharide composition is comparatively easy in bacteria. Microbial exopolysaccharides represents a valuable resource of biogenic and biodegradable polymers, suitable to replace petro based polymers in various technical applications. Furthermore, biocompatible exopolysaccharides are very attractive in medical applications, such as drug delivery systems, use as vaccines or nanoparticles. This research topic will depict the status quo, as well as the future needs in the field of EPS and biofilm research. Starting from the unexplored diversity of microbial polysaccharide producers to production processes and possibilities for modifications, to enhance the already high number of functionalities based on the chemical structures. An overview of the recent and future applications will be given, and the necessity in unravelling the biosynthesis of microbial exopolysaccharide producers is depicted, highlighting the future trend of tailor made polymers. Constraints in structure analysis of these highly complex biogenic polymers are described and different approaches to solve the restrictions in imaging and NMR analysis will be given. Therefore; this research topic comprises the whole process from genes to applications.
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