This book presents a Two-Stage Anaerobic Digestion (TSAD) technique for producing hydrogen and methane, following a step-by-step approach in order to guide readers through the experimental verification of the related hypothesis. In the first stage of AD, the reaction conditions are optimized to obtain the maximum amount of hydrogen, while in the second the liquid residue from the first phase is used as a substrate to produce fuel-methane. AD has traditionally been used to reduce the organic content of waste; this results in a biogas that is primarily constituted of CH4 and CO2. Over the last few decades, the conversion of organic matter into hydrogen by means of AD and selecting Hydrogen Producing Bacteria (HPB) has matured into a viable and sustainable technology among the pallet of H2 generation technologies. The combined bio-production of hydrogen and methane from Organic Waste Materials (OWM) is considered to be an ideal way of utilizing waste, and can increase energy efficiency (the substrate Heat Value converted into H2 and CH4 fuel) to roughly 80%, since the energy efficiency of H2-production alone (15%) is not energetically competitive. The two gas streams can be used either separately or in combination (Hytane®), be supplied as civilian gas or used for transportation purposes. All the aspects of this sustainable technology are taken into account, from the basic biochemical implications to engineering aspects, establishing the design criteria and the scale-up procedures for full-scale application. The sustainability of the TSAD method is assessed by applying EROI (Energy Return On Investment) and EPT (Energy Payback Time) criteria, and both the general approach and application to the field of Anaerobic Digestion are illustrated.
This book presents a Two-Stage Anaerobic Digestion (TSAD) technique for producing hydrogen and methane, following a step-by-step approach in order to guide readers through the experimental verification of the related hypothesis. In the first stage of AD, the reaction conditions are optimized to obtain the maximum amount of hydrogen, while in the second the liquid residue from the first phase is used as a substrate to produce fuel-methane. AD has traditionally been used to reduce the organic content of waste; this results in a biogas that is primarily constituted of CH4 and CO2. Over the last few decades, the conversion of organic matter into hydrogen by means of AD and selecting Hydrogen Producing Bacteria (HPB) has matured into a viable and sustainable technology among the pallet of H2 generation technologies. The combined bio-production of hydrogen and methane from Organic Waste Materials (OWM) is considered to be an ideal way of utilizing waste, and can increase energy efficiency (the substrate Heat Value converted into H2 and CH4 fuel) to roughly 80%, since the energy efficiency of H2-production alone (15%) is not energetically competitive. The two gas streams can be used either separately or in combination (Hytane®), be supplied as civilian gas or used for transportation purposes. All the aspects of this sustainable technology are taken into account, from the basic biochemical implications to engineering aspects, establishing the design criteria and the scale-up procedures for full-scale application. The sustainability of the TSAD method is assessed by applying EROI (Energy Return On Investment) and EPT (Energy Payback Time) criteria, and both the general approach and application to the field of Anaerobic Digestion are illustrated.
Bayesian analysis is today understood to be an extremely powerful method of statistical analysis, as well an approach to statistics that is particularly transparent and intuitive. It is thus being extensively and increasingly utilized in virtually every area of science and society that involves analysis of data.A widespread misconception is that Bayesian analysis is a more subjective theory of statistical inference than what is now called classical statistics. This is true neither historically nor in practice. Indeed, objective Bayesian analysis dominated the statistical landscape from roughly 1780 to 1930, long before 'classical' statistics or subjective Bayesian analysis were developed. It has been a subject of intense interest to a multitude of statisticians, mathematicians, philosophers, and scientists. The book, while primarily focusing on the latest and most prominent objective Bayesian methodology, does present much of this fascinating history.The book is written for four different audiences. First, it provides an introduction to objective Bayesian inference for non-statisticians; no previous exposure to Bayesian analysis is needed. Second, the book provides an overview of the development and current state of objective Bayesian analysis and its relationship to other statistical approaches, for those with interest in the philosophy of learning from data. Third, the book presents a careful development of the particular objective Bayesian approach that we recommend, the reference prior approach. Finally, the book presents as much practical objective Bayesian methodology as possible for statisticians and scientists primarily interested in practical applications.
Since its first description (1841) the identity of West syndrome was deeply investigated and is now recognized as an epileptic syndrome in infancy (ILAE Task Force, 1989). West syndrome has become a paradigmatic model of an epileptic syndrome causing neurological deterioration (epileptic encephalopathy) and the object of a number of studies aimed at understanding the complex relationships between an epileptic disorder and neurodevelopment. Although the symptomatic triad (peculiar electrographic findings named hypsarrhythmia, brief tonic spasms, and arrest of psychomotor development) that characterizes the syndrome suggests a unique pathogenetic mechanism, causal heterogeneity heavily influences syndrome variability in terms of neurodevelopment, treatment choices, management and, possibly, electroclinical semiology. Important insights may arise for that might help developing models of epileptic encephalopathies in the basic sciences. However, a more immediate benefit may arise for clinicians in everyday practice. A group of clinical researchers recently met in Rome to discuss hot points concerning infantile spasms and West syndrome. Their contributions were collected and are presented in this book that we hope will contribute to the progress of knowledge of this paradigmatic epileptic disorder.
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