Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Few side effects of cancer treatment are more feared by patients than nausea and vomiting. Failure to control these symptoms on the first day of chemotherapy increases the risk of them occurring on subsequent days and in subsequent cycles of chemotherapy, and can often result in patients refusing further cancer treatment. Very effective antiemetics are available to prevent this from happening, but do you know how best to use them? 'Fast Facts: Chemotherapy-Induced Nausea and Vomiting' presents the evidence for the clinical agents that can prevent CINV, along with the recommendations for their use in various clinical settings using recently established international guidelines. Correct administration of prophylactic antiemetics in relation to the emetogenicity of the chemotherapy being given not only improves patients’ quality of life during treatment but also adherence to subsequent cancer treatments, thus improving overall outcomes. This refreshingly readable handbook is therefore a must-read resource for all health professionals in a position to make this kind of a difference. Contents: • Definitions and pathophysiology • Types of CINV and risk factors • Antiemetic agents • Prevention and management of acute and delayed CINV • Treatment of breakthrough, refractory and anticipatory CINV • Prevention and treatment of chemotherapy-induced nausea • Barriers and opportunities in CINV management
Fast Facts: Managing Immune-Related Adverse Events in Oncology, 2nd edition, provides an overview of immuno-oncology and an update on immune checkpoint inhibitors and their associated toxicities, alongside the principles of diagnosing and managing immune-related adverse events, important nursing care considerations and a set of convenient management summaries for quick reference. As such, it is essential reading for all members of the cancer care team. Table of Contents: • Immunotherapy and its side effects: an overview • Gastrointestinal and hepatic adverse events • Dermatologic adverse events • Endocrine-related adverse events • Pulmonary adverse events • Less frequent adverse events • Optimizing patient care and early recognition of irAEs • Management summaries
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