Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
Unravelling the Mystery of the Atomic Nucleus is a history of atomic and nuclear physics. It begins in 1896 with the discovery of radioactivity, which leads to the discovery of the nucleus at the center of the atom. It follows the experimental discoveries and the theoretical developments up to the end of the Fifties. Unlike previous books regarding on history of nuclear physics, this book methodically describes how advances in technology enabled physicists to probe the physical properties of nuclei as well as how the physical laws which govern these microscopic systems were progressively discovered. The reader will gain a clear understanding of how theory is inextricably intertwined with the progress of technology. Unravelling the Mystery of the Atomic Nucleus will be of interest to physicists and to historians of physics, as well as those interested development of science.
These essays take Baudelaire seriously as a thinker. Bernard Howells explores the problematics surrounding individualism and history in a number of prose texts, and situates Baudelaire within the broader contexts of nineteenth-century historical, cultural and artistic speculation, represented by Emerson, Carlyle, Joseph de Maistre, Giuseppe Ferrari and Eugene Chevreul.
The international publishing sensation is now available in the United States—two brilliant, controversial authors confront each other and their enemies in an unforgettable exchange of letters. In one corner, Bernard-Henri Lévy, creator of the classic Barbarism with a Human Face, dismissed by the media as a wealthy, self-promoting, arrogant do-gooder. In the other, Michel Houellebecq, bestselling author of The Elementary Particles, widely derided as a sex-obsessed racist and misogynist. What began as a secret correspondence between bitter enemies evolved into a remarkable joint personal meditation by France’s premier literary and political live wires. An instant international bestseller, Public Enemies has now been translated into English for all lovers of superb insights, scandalous opinions, and iconoclastic ideas. In wicked, wide-ranging, and freewheeling letters, the two self-described “whipping boys” debate whether they crave disgrace or secretly have an insane desire to please. Lévy extols heroism in the face of tyranny; Houellebecq sees himself as one who would “fight little and badly.” Lévy says “life does not ‘live’” unless he can write; Houellebecq bemoans work as leaving him in such “a state of nervous exhaustion that it takes several bottles of alcohol to get out.” There are also touching and intimate exchanges on the existence of God and about their own families. Dazzling, delightful, and provocative, Public Enemies is a death match between literary lions, remarkable men who find common ground, confident that, in the end (as Lévy puts it), “it is we who will come out on top.”
This 1975 text is a survey of French Catholic thought during a period of marked spiritual and intellectual revival, delimited roughly by the Napoleonic Concordat with the Vatican in 1802 and the Separation Law of 1905. The author studies many diverse writers in detail and analyses in characteristically lucid manner the distinctive contribution to French intellectual life in this 'second grand siècle'. Dr Reardon examines too the major trends in French Catholic thought, and concludes that in the nineteenth century there was a recurring tension between liberalism and tradition; between the poles of a secular and even agnostic humanism, and a rigid ultramontanism. The approach is non-technical, an the book will be of considerable interest to a wide variety of readers, both general and specialist. It was the first book in English to cover the development of Catholic thought in France through the whole of the nineteenth century.
Djerassi est le journal d'une résidence menée en 1996 aux environs de San Francisco par le poète Bernard Heidsieck, constitué d'un ensemble de soixante collages chargés d'écriture manuscrite. L'auteur s'est contraint chaque jour à inventer des nouvelles formes, avec ses fameuses amorces de bandes magnétiques, créant un projet à la fois littéraire et plastique. L'artiste a produit ainsi une série en hommage, notamment, aux nombreux artistes cinétiques et poètes Beat, connus de lui.
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