The focus of this chapter is on the development of miRNA diagnostics and the process for miRNA biomarker development. We discuss pancreatic cancer as a model for the application of miRNA-based tests in different clinical biopsy specimen types. Asuragen’s miRInform® Pancreas test illustrates the development of a laboratory developed test (LDT) that was validated in compliance with Clinical Laboratory Improvement Amendments (CLIA) and College of American Pathologists (CAP) regulations. We provide an overview of work on miRNA-based signatures which is focused on resolving clinical dilemmas in solid and cystic pancreatic lesions. We also review some of the promising miRNA candidates identified in biofluids from other cancer types. These studies highlight the emergence of miRNA-based diagnostic tools which have the potential to impact the clinical management of cancer by guiding early diagnosis, aiding in the assessment of patients’ prognosis, and enabling the identification of novel, more effective therapeutic targets.
Bernard Bolzano (1781-1848, Prague) was an outstanding thinker and reformer, far ahead of his times in many areas, including philosophy, ethics, politics, logic, theology and physics, and mathematics. Aimed at historians of mathematics, philosophy, ethics and logic, this volume contains the first English translations of some of his most significant mathematical writings, which contain the details of many celebrated insights and anticipations: clear topological definitions of various geometric extensions, an effective statement and use of the Cauchy convergence before it appears in Cauchy's work, remarkable results on measurable numbers (a version of real numbers), on functions (the construction of a continuous, non-differentiable function around 1830) and on infinite collections.
This book is about strategic performance management for the Twenty-First Century organization. In a practical step-by-step approach it navigates readers though the identification, measurement, and management of the strategic value drivers as enables of superior performance. Using many real life case examples this book outlines how organizations can visualize their value creation, design relevant and meaningful performance indicators to assess performance, and then use them to extract real management insights and improve everyday strategic decision making as well as organizational learning. A key focus of the book is the important issue of creating value from intangible assets. Much has been written about the importance of intangible assets such as knowledge, skills, relationships, culture, practices, routines, and intellectual property as levers for organisational success. However, little has been published that tells managers how to do that. This book moves beyond just raising awareness and provides practical tools and templates, gathered in many extensive case studies with world-leading organizations. The key issues the book addresses are: • How do we identify the strategic value drives, especially the intangibles, in our organisations? • How do we understand their strategic value using the powerful mapping tools? • How do we then measure the business performance? • How do we use performance indicators to improve decision making and organisational learning? • How do we align performance reviews and risk management with our strategy? Well grounded in theory and packed with case studies from around the world, this book will function as a guide for managers as well as a reference work for students and researchers. The tools described in this book are not only suitable for leading international corporations, but have been designed to be equally appropriate for not-for-profit organizations, central and local government institutions, small and medium sized businesses, and even departments and business units. The ideas, tools, and templates provided allow managers to apply them straight away and transform the way they manage strategic performance at all levels of their organization.
In 2008, the mainstream media crossed a line. It's not the same old liberal bias we've seen for years; the media deified Obama, making conservatives blasphemers and liberals gullible fools. What did it mean, and what will the consequences be?
We Are Charleston not only recounts the events of that terrible day but also offers a history lesson that reveals a deeper look at the suffering, triumph, and even the ongoing rage of the people who formed Mother Emanuel A.M.E. church and the wider denominational movement. On June 17, 2015, at 9:05 p.m., a young man with a handgun opened fire on a prayer meeting at the Mother Emanuel African Methodist Episcopal (AME) Church in Charleston, South Carolina, killing nine members of the congregation. The captured shooter, twenty-one-year-old Dylan Roof, a white supremacist, was charged with their murders. Two days after the shooting, while Roof’s court hearing was held on video conference, some of the families of his nine victims, one by one, appeared on the screen—forgiving the killer. The “Emanuel Nine” set a profound example for their families, their city, their nation, and indeed the world. In many ways, this church’s story is America’s story—the oldest A.M.E. church in the Deep South fighting for freedom and civil rights but also fighting for grace and understanding. Fighting to transcend bigotry, fraud, hatred, racism, poverty, and misery. The shootings in June 2015, opened up a deep wound of racism that still permeates Southern institutions and remains part of American society. We Are Charleston tells the story of a people, continually beaten down, who seem to continually triumph over the worst of adversity. Exploring the storied history of the A.M.E. Church may be a way of explaining the price and power of forgiveness, a way of revealing God’s mercy in the midst of tremendous pain. We Are Charleston may help us discover what can be right in a world that so often has gone wrong.
Tom Brady marching the team upfield in the final minute of the 2001 Super Bowl. Troy Brown playing offense, defense, and special teams. The Tuck Rule. A rogue groundskeeper plowing a path for kicker John Smith at the end of a scoreless, snowy game. Gino Cappelletti setting the AFL record for points in a game against the Houston Oilers. These are the moments Patriots fans love to remember, now retold by the players who lived them. Once a top team in the AFL in the 1960s, the Patriots have returned to glory as one of the NFL's best franchises during the past decade, and enthusiasm for them has never been higher. Sportswriters Jim Baker and Bernard M. Corbett relive the evolution of the team, getting war stories from players like Cappelletti, John Hannah, and Steve Grogan. Moving through the team's biggest games, they put a fresh spin on the stories all Pats fans love, with detail and color from the players who were there, on the field, making history. The Most Memorable Games in Patriots History is a perfect gift for the serious fan-not just a collectible, but the kind of book you can hunker down and enjoy.
A fiery crash at a remote air force base in the Azores archipelago takes the lives of five USAF airmen and a civilian farmer. Captain Jim Welch joins the ensuing accident investigation. After a finding of pilot error, it is determined that the crash was no accident. Absent a logical explanation, a criminal investigation begins. Several suspects surface each having motive, means and opportunity. A briefcase found at the crash scene leads Welch and Alberto Zagame, an irascible local lawyer, through a complex web of evidence and relationships as the investigation unfolds on two continents. An apparent suicide is thought to provide answers, but an autopsy reveals that death also to be murder. The protagonist grasps the connection, and is certain he knows who the killer is, but not that he can prove it. He is very nearly another murder victim before the truth is revealed in a confrontation with the killer. The main characters are introduced in the early chapters, and flash backs examine their personas. Relationships are rooted in the aerial combat arena of WW II and the culture of pre war America. As the criminal investigation winds to its climax, a penetrating overview of the military justice system of the era is offered. History, mystery and romance along with an introduction to the islands beauty and Portuguese culture are all captured in this saga.
A Noted Psychologist Shows You How to...'Embrace Your Passion?Maximize Your Courage to Create?Identify and Overcome Personal Barriers?Awaken Your Natural Curiosity?Increase Your Emotional Intelligence to Create?Prepare to Be InspiredBernard Golden has provided a comprehensive manual of cognitive behavioral therapy for alleviating creative block. This book is a must-read for all students of creativity, as well as for writers, artists, inventors, and all individuals who feel their creative powers percolating just out of reach. It will become required reading for my course.-SHELLEY H. CARSON, Ph.D., HARVARD UNIVERSITY, Lecturer and Assistant Head Tutor, Psychology Instructor for the course Creativity: Madmen, Geniuses, and Harvard StudentsCreativity is one of life's great sources of fulfillment, whether it is expressed in the arts, science, business, or sheer entertainment. When we are at our creative best, we experience emotions of joy, excitement, anticipation, hope, and deep satisfaction. Unfortunately, for many people such moments of uninhibited creative drive are all too rare. Often, when we try to be creative, we also experience the inhibiting emotions of anxiety, self-doubt, judgmental attitudes, or even shame, guilt, and physical discomfort.Psychologist Bernard Golden helps us to be our authentic selves by pursuing our individual creative paths in this motivational guide. Filled with the insights and practical techniques culled from his almost thirty years as a psychotherapist, Unlock Your Creative Genius gives you the tools to unleash your creative imagination and manage the tension and negative mind-body reactions that often impede the creative flow.Golden first offers a variety of strategies that help the reader become aware of the often-unconscious obstacles to creative fulfillment. Among these are fear of failure; survivor's guilt, when friends or loved ones are ill or have died; the shame of failing to meet our own or others' unrealistic expectations; grandiose fantasies; problems with self-discipline; a pattern of dependency that impedes self-motivation; and an aversion to being alone even though creative expression usually demands time by ourselves.To counter these negative reactions, Golden provides guidelines to enhance positive emotions such as openness to change, trust, and the commitment essential for creativity. He also stresses the need to promote physical calm to offset tension and the importance of developing self-compassion, a vital resource in dealing with fear, shame, and guilt.This inspiring, helpful, and very practical book offers readers the freedom to live authentically as they access, accept, and act on their creative genius.Bernard Golden, Ph.D. (Chicago, IL), a clinical psychologist since 1977, is the author of Healthy Anger: How to Help Children and Teens Manage Their Anger and the coauthor (with Jan Fawcett, MD, and Nancy Rosenfeld) of New Hope for People with Bipolar Disorder.
Performance management is at the top of agendas in most government and public organizations, as well as many not-for-profit organizations. In this follow up to his successful book, Strategic Performance Management, the author focuses on the unique challenges public sector organizations face when tackling the issues of strategic performance management. Drawing on his extensive experience of working with numerous government, public sector, and not-for-profit organizations over the author covers: * The context of decision making in the public sector * The significance of the use of budgeting for performance management, and the impact of performance measurements on budgets * A huge range of underpinning cases and examples from the public sector, including cases on the Home Office and the NHS in the UK, and the US Air Force For senior executives in the public sector and government, and for faculty and students in the field this is the authoritative strategic level treatment of this fast-growing area.
In the ancient world, writings were read aloud, heard, and remembered. But modern exegesis assumes a silent text. According to Margaret Lee & Brandon Scott, the disjuncture between ancient and modern approaches to literature obscures the beauty and meaning in writings such as the New Testament. Further, the structure of an ancient Greek composition derives first from its sounds and not from the meaning of its words. They argue that sound analysis, analysis of the signifier and its audible dimension, is crucial to interpretation. Sound Mapping the New Testament explores writing technology in the Greco-Roman world, then turns to ancient Greek literary criticism for descriptions of grammar as a science of sound and literary composition as a woven fabric of speech. Based on these perspectives and a close analysis of writings from the four gospels, Paul, and Q, Sound Mapping the New Testament advances a theory of sound analysis that will enable modern readers to hear the New Testament afresh. The second edition reprints the first edition with a new introduction that reviews a decade of sound mapping scholarship and argues for the continued necessity of sound mapping for New Testament interpretation.
Completely revised and updated, with more than 3,000 listings honoring a variety of cultural traditions, this authoritative, painstakingly researched compendium is one of the most-used references in libraries and schools nationwide.
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