Preaching is a relational act. This book explores the relationship between the preacher and the assembly as a spousal relationship. Written by a parish pastor with a doctorate in preaching and rooted in the Roman Catholic notion of the priest as bridegroom of the church, this work examines characteristics of the spousal relationship between husband and wife and then provides an analysis of the ministerial priesthood through this nuptial lens. This nuptial reflection on the ministerial priesthood is then applied to preaching. This book presents a nuptial hermeneutic or vision for preaching and the implications of this vision for the assembly, the preacher, the homily, and the homiletical method. The appendices include a one-page strategy for preaching summarizing the homiletical method, a rubric for homily evaluation by members of the assembly, and two sample homilies.
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Intensive Care Unit Manual is a practical, hands-on, how-to manual that covers the full spectrum of conditions encountered in the ICU, guiding you step-by-step from your initial approach to the patient through diagnosis and treatment. Compact, affordable, and comprehensive, the ICU Manual puts all the critical care information you need right at your fingertips! Stay at the forefront of critical care with a practice-oriented, relevant, and well-illustrated account of the pathophysiology of critical disease, presented in a highly readable format. Gain valuable insight into the recognition, evaluation, and management of critical conditions such as respiratory, hemodynamic, and infectious diseases; management of ICU patients with special clinical conditions; cardiovascular, hematologic, and neurological disorders; poisoning and overdoses; trauma and burns; and much more! Grasp the latest developments in critical care with extensive updates and revisions to several key chapters, as well as brand-new chapters on Alcohol Withdrawal Syndromes; Acute Heart Failure Syndromes; Noninvasive Ventilation; and more ICU conditions. Understand and apply the most important ICU practices, including management of acute respiratory failure, mechanical ventilation, invasive hemodynamic monitoring, and the care of patients with special needs, AIDS, end-stage renal disease, or end-stage liver disease. Get convenient access to the full text and image library online at Expert Consult, in addition to online-only text, figures, and tables from the Alcohol Withdrawal Syndromes and Acute Heart Failure Syndromes chapters.
The nature of olfaction; its importance for understanding perennial issues of philosophy of mind, perception, and consciousness; and its implications for cognitive neuroscience. What are smells? Despite the best efforts of philosophy and the chemosciences, the question remains vexing—but no more perplexing than the historical lapse of the past centuries to seriously consider a sense that has a key place in philosophy of mind and perception. Stinking Philosophy! is Benjamin Young’s answer to this critical lapse. Drawing together more than a decade's research on olfactory philosophy, the book offers a clear, comprehensive look at the nature of odors—how we perceive smells, how we cognitively represent odors, how we communicate about them as categories, and what they can tell us about consciousness. In Stinking Philosophy! Young presents a methodology for addressing the philosophical and conceptual issues raised by the sense of smell. Then, in an exacting and coherent fashion, he explores how the philosophy of smell contributes to—and advances—a wide range of debates within philosophy of mind, perception, and cognitive neuroscience. Ultimately, his work demonstrates how empirically informed philosophy can have a significant impact on interdisciplinary research on smell across philosophy, the chemosciences, and neuroscience.
Hundreds of changes and additions to state symbols since the 1987 volume, four new chapters, and expanded coverage beyond the 50 states--including the District of Columbia and the five U.S. territories--make this revised edition essential for students and library reference collections. The only single documented source for historical information and color illustrations of all state and territory symbols includes new chapters on state and territory legal holidays and observances, automobile license plates, festivals and fairs, and selected U.S. postage stamps issued in honor of the states and territories. Color illustrations of official state and territory seals, flags, flowers, trees, birds, license plates, and postage stamps complement the text. This revised edition of the only single reference source for information about state symbols updates and doubles the coverage of the original 1987 volume. New chapters on state and territory fairs and festivals and legal holidays and observances offer not only essential information, but also fascinating sidelights and unusual facts about the states and territories that are a treasure trove of information for students. The work features chapters on official state and territory names and nicknames, mottoes, seals, flags, capitols, flowers, trees, birds, songs, legal holidays and observances, license plates, miscellaneous designations, and fairs and festivals. A bibliography and subject index complete the work.
By integrating complementary and alternative medicine (CAM) with traditional medical treatment, this volume represents the next generation in the evolving field of integrative medicine. Features a unique approach and case studies immediately applicable to clinical practice. Far more than a review of CAM modalities, this is an evidence-based and clinically authoritative guide for family medicine and primary care providers.
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