Numerous epidemiological studies report that birth weight is inversely associated with blood pressure, suggesting that slow growth during fetal life programs hypertension and increased risk for cardiovascular disease in later life. Different experimental models are used to provide proof of concept for the theory of developmental programming of cardiovascular disease, and studies in these different animal models are providing insight into the etiology of chronic disease programmed by an imbalance in nutrition during early life or exposure to maternal complications during pregnancy. Alterations in the regulatory systems key to the long-term control of blood pressure are implicated in the etiology of hypertension that results from adverse exposures during early development. Epigenetic processes are also implicated in the increased risk for programmed cardiovascular disease and the passage of programmed cardiovascular risk to the next generation. Sex, age, and early postnatal growth impact later programmed risk; programmed risk is also amplified in response to a secondary challenge that includes normal physiological processes such as pregnancy. Thus, this book will highlight how events during early life impact later cardiovascular health in a manner that is sex- and age-dependent and can be transmitted to the next generation. Table of Contents: Introduction / Historical Perspective / Epidemiological Studies / Experimental Models of Developmental Programming / Mechanisms of Developmental Programming / Birth Weight and Clinical Considerations / Birth Weight and Cardiovascular Disease: Translational Considerations / Summary and Conclusions / References / Author Biography
The open access publication of this book has been published with the support of the Swiss National Science Foundation. This book offers a comprehensive analysis of the right to citizenship in international and regional human rights law. It critically reflects on the limitations of state sovereignty in nationality matters and situates the right to citizenship within the existing human rights framework. It identifies the scope and content of the right to citizenship by looking not only at statelessness, deprivation of citizenship or dual citizenship, but more broadly at acquisition, loss and enjoyment of citizenship in a migration context. Exploring the intersection of international migration, human rights law and belonging, the book provides a timely argument for recognizing a right to the citizenship of a specific state on the basis of one’s effective connections to that state according to the principle of jus nexi.
2021 Outstanding Academic Title, Choice Magazine How globalization is undermining sustainable social environments for children This book uses the ecological model of child development together with ethnographic and comparative studies of two small villages, in Italy and the United States, as its framework for examining the well-being of children in the aftermath of the Great Recession. Global forces, far from being distant and abstract, are revealed as wreaking havoc in children’s environments even in economically advanced countries. Falling birth rates, deteriorating labor conditions, fraying safety nets, rising rates of child poverty, and a surge in racism and populism in Europe and the United States are explored in the petri dish of the village. Globalism’s discontents—unrestrained capitalism and technological change, rising inequality, mass migration, and the juggernaut of climate change—are rapidly destabilizing and degrading the social and physical environments necessary to our collective survival and well-being. This crisis demands a radical restructuring of our macrosystemic value systems. Woodhouse proposes an ecogenerist theory that asks whether our policies and politics foster environments in which children and families can flourish. It proposes, as a benchmark, the family-supportive human-rights principles of the UN Convention on the Rights of the Child. The book closes by highlighting ways in which individuals can engage at the local and regional levels in creating more just and sustainable worlds that are truly fit for children.
Psychodynamic Perspectives on Asylum Seekers and the Asylum-Seeking Process looks at the psychosocial assessment of asylum seekers from three perspectives: forensic, psychodynamic, and political and then attempts to better understand, from a psychodynamic perspective, differences in the historical/motivational routes of asylum seekers themselves. Barbara Eisold begins in Chapter One by exploring the unique evaluation relationship of psychosocial assessment and the striking will to survive of the asylum seekers that it puts into focus, using a psychodynamic lens. The forensic value of psychosocial assessment and its potential as both a political and a therapeutic tool are then described. Chapter Two describes individuals, who, by background and personal characteristics, shared a profound desire to protest, gravely compromising their survival at home and forcing them to seek asylum elsewhere. Chapter Three discusses women who have suffered female genital mutilation and includes a discussion of the development of strong personal agency in one case. Chapter Four describes abused women from Central America forced to flee from femicide. The evolution of femicide is explored, including the development of honor-bound machismo and the wide-spread disregard of law. The hold men have on women is then examined from a psychodynamic perspective. Psychodynamic Perspectives on Asylum Seekers and the Asylum-Seeking Process will be of great interest to psychoanalysts, psychoanalytic psychotherapists, and all mental health professionals working with asylum seekers.
Winner, Book Prize in Latin American Studies, Colonial Section of Latin American Studies Association (LASA), 2016 ALAA Book Award, Association for Latin American Art/Arvey Foundation, 2016 The capital of the Aztec empire, Tenochtitlan, was, in its era, one of the largest cities in the world. Built on an island in the middle of a shallow lake, its population numbered perhaps 150,000, with another 350,000 people in the urban network clustered around the lake shores. In 1521, at the height of Tenochtitlan's power, which extended over much of Central Mexico, Hernando Cortés and his followers conquered the city. Cortés boasted to King Charles V of Spain that Tenochtitlan was "destroyed and razed to the ground." But was it? Drawing on period representations of the city in sculptures, texts, and maps, The Death of Aztec Tenochtitlan, the Life of Mexico City builds a convincing case that this global capital remained, through the sixteenth century, very much an Amerindian city. Barbara E. Mundy foregrounds the role the city's indigenous peoples, the Nahua, played in shaping Mexico City through the construction of permanent architecture and engagement in ceremonial actions. She demonstrates that the Aztec ruling elites, who retained power even after the conquest, were instrumental in building and then rebuilding the city. Mundy shows how the Nahua entered into mutually advantageous alliances with the Franciscans to maintain the city's sacred nodes. She also focuses on the practical and symbolic role of the city's extraordinary waterworks—the product of a massive ecological manipulation begun in the fifteenth century—to reveal how the Nahua struggled to maintain control of water resources in early Mexico City.
New York Times bestselling author Barbara Delinsky has written her most complex and emotionally rewarding novel yet: a story of two women, a generation apart, each of whose dream becomes bound with the other's. To her family, Natalie Seebring is a woman who prizes appearances: exquisitely mannered, a supportive wife, and head of a successful wine-producing enterprise. So when she announces plans to marry a vineyard employee mere months after the death of her husband of fifty-eight years, her son and daughter are stunned. Faced with their disapproval, Natalie decides to write a memoir. Olivia Jones is a dreamer, living vicariously through the old photographs she restores. She and her daughter, Tess, cling to the fantasy that a big, happy family is out there just waiting for them. When Natalie hires Olivia to help with her memoir, a summer at Natalie's vineyard by the sea seems the perfect opportunity to live out that fantasy, but all is not as it seems. As the illusion of an idyllic existence comes crashing headlong into reality, the lives of these two women, parallel in so many ways, become a powerful and moving story.
An omnibus collection of three favorites by the best-selling author of 'A Woman of Substance' includes complete copies of 'Hold the Dream', 'To Be the Best', and 'Act of Will' in one romantic volume.
At a time when women could not vote and very few were involved in the world outside the home, Annie Montague Alexander (1867–1950) was an intrepid explorer, amateur naturalist, skilled markswoman, philanthropist, farmer, and founder and patron of two natural history museums at the University of California, Berkeley. Barbara R. Stein presents a luminous portrait of this remarkable woman, a pioneer who helped shape the world of science in California, yet whose name has been little known until now. Alexander's father founded a Hawaiian sugar empire, and his great wealth afforded his adventurous daughter the opportunity to pursue her many interests. Stein portrays Alexander as a complex, intelligent, woman who--despite her frail appearance--was determined to achieve something with her life. Along with Louise Kellogg, her partner of forty years, Alexander collected thousands of animal, plant, and fossil specimens throughout western North America. Their collections serve as an invaluable record of the flora and fauna that were beginning to disappear as the West succumbed to spiraling population growth, urbanization, and agricultural development. Today at least seventeen taxa are named for Alexander, and several others honor Kellogg, who continued to make field trips after Alexander's death. Alexander's dealings with scientists and her encouragement--and funding--of women to do field research earned her much admiration, even from those with whom she clashed. Stein's extensive use of archival material, including excerpts from correspondence and diaries, allows us to see Annie Alexander as a keen observer of human nature who loved women and believed in their capabilities. Her legacy endures in the fields of zoology and paleontology and also in the lives of women who seek to follow their own star to the fullest degree possible.
A young woman inherits a business empire in this sequel to A Woman of Substance, book two in the #1 New York Times–bestselling author’s Harte Family Saga. Nearing retirement, Emma Harte is preparing to leave her retail empire, Harte Enterprises, to her favorite grandchild, Paula McGill Fairley. She has only one request of Paula: “I charge you to hold my dream.” Now Paula must navigate the cutthroat corporate waters of the business world while steering her course toward the happiness she longs for, and the legacy she herself will build. Emotionally rich and splendidly detailed, this sequel continues the story of the Hartes in magnificent style. “Few novelists are as consummate as Barbara Taylor Bradford at keeping the reader turning the page.” —The Guardian “Another instant bestseller.” —The Philadelphia Inquirer
Lydia’s life felt like it ended when Tristan died. Sure, they had their problems and he could be a little...intense at times. But he’d promised to love her forever... When her parents propose a summer across the country with a music teacher who runs an inn, Lydia agrees. But it’s different from what she expected. There’s a presence there she can’t quite reconcile—and it feels like it’s hunting her. It seems Tristan’s promise followed her...and may have graver consequences than she could have known. Then there’s Michael Malone, the one light spot in an otherwise dark existence. Lydia can’t help but be drawn to him, and as they try to uncover the evil plaguing the inn, they grow closer. But guilt over Tristan’s death still consumes her. Can she and Michael uncover what evil lurks in the inn before it takes another victim?
If you thought Junie B. Jones was funny—catch more laughs from New York Times bestselling author Barbara Park with the hilarious sequel to Skinnybones—just right for fans of Diary of a Wimpy Kid and I Funny! And the award goes to…Alex Frankovitch! Roll out the red carpet! Alex “Skinnybones” Frankovitch is about to become a HUGE star—in his very own TV commercial! But Alex’s plans for stardom go HORRIBLY wrong. Forget fame and fortune—his friends think he’s a FLOP! And his fan club only has two members—a cat and a drooling toddler. Can Alex figure out another way to get his name in lights? Or is this star going to crash and burn? “Skinnybones equals tickled funny bones.” —Booklist “Young Alex ‘Skinnybones’ Frankovitch finally gets his chance to become a Big Celebrity…in this amusing follow-up to Skinnybones.” —Publishers Weekly “Once again demonstrating her remarkable ear for dialogue, [Barbara Park] also shows a good sense of timing in this fast-paced outing.” —School Library Journal
The most comprehensive text available on the use of evidence-based medication therapies for optimal patient outcomes – updated with the latest breakthroughs and guidelines A Doody's Core Title for 2019! Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations. This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health. Here’s why this is the perfect learning tool for students, patient-focused pharmacists, and other health care providers: • All chapters have been updated to provide the most current, reliable, and relevant information possible • Key Concepts at the beginning of each chapter • Clinical Presentation Tables summarize disease signs and symptoms • Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy • Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways • Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.
The landmark text that has served generations of obstetrician-gynecologists—fully updated with the most current perspectives of the field A Doody's Core Title for 2023! Williams Obstetrics has defined the discipline for generations of obstetrician-gynecologists. Written by authors from the nationally renowned University of Texas Southwestern Medical Center and Parkland Hospital, the new edition of this authoritative, evidence-based work maintains its trademark comprehensive coverage and applicability at the bedside, while offering the most current information and insights. The culmination of a century of clinical thought, Williams Obstetrics, 26th Edition delivers expert coverage of obstetrical complications, such as preterm labor, pregnancy-related hypertension, infection, and hemorrhage. It additionally offers foundational content on reproductive anatomy, physiology, and prenatal care. The authors have enhanced this edition with 1,000+ full-color illustrations, plus an increased emphasis on the fast-growing subspecialty of Maternal-Fetal Medicine. No other text matches the long-established scientific rigor and accessibility of Williams Obstetrics. With its state-of-the-art design and review of the newest advances and protocols, this not-be-missed clinical companion brings positive outcomes within reach. New and updated content includes: Increased focus on Maternal-Fetal Medicine Greater coverage of hypertension and hemorrhage Deeper insights into in-utero complications Expanded fetal t section includes cutting-edge fetal imaging, genetics, prenatal diagnosis, and fetal disorders and therapy Basic science, physiology of labor, preterm labor updated with contemporaneous publications in the literature More obstetrical sonography figures Eye-catching illustrations, including updated graphs, sonograms, MRIs, photographs, and photomicrographs
The fur trade was the impetus for much of the exploration and discovery of North America. The essays in Dark Storm Moving West trace three phases of westward exploration: naval and fur trade ventures on the Pacific coast; traders progress along interior rivers and lakes; and the transcontinental Lewis and Clark expedition, which used maps based on fur trade surveys. Author Barbara Belyea poses challenging questions about the rapid expansion, its effects on Native populations, European versus Native cartography, cultural definitions of space, and communication of traditions.
The time is December 1999. Millennial fever holds the world in its grip—stirring ancient and terrible fears that the apocalypse is at hand. In the Sinai desert, archeologist Catherine Alexander just unearthed a cache of six ancient papyrus scrolls that point to the millennium's most transforming secret. Discovered inside the legendary Well of Miriam, a site named after the ancient prophetess who was the sister of Moses, the scrolls reveal a hidden history of the world and its religions—a series of shattering revelations that governments will do anything to suppress, and that an enigmatic billionaire named Miles Havers will do anything to possess. But there is more: a seventh scroll that contains a secret of almost unimaginable power. It is a secret that may cost Catherine her life as she dodges government agents, Vatican operatives, and cyberspace perils in her race to translate the scrolls and release their powers to the world. Aided by two very different and compelling men, Dr. Julius Voss and Father Michael Garibaldi, Catherine finds herself caught up in the adventure of a lifetime and a struggle that she must win.
Paula O'Neill has taken over her grandmother Emma Harte's elegant chain of department stores. Her ambition begins to override all other considerations when an opportunity to expand occurs.
Betrayals' is a murder mystery novel set in a fictional small city in Canada. It features the sexual exploitation of a fourteen year-old immigrant boy by his female language teacher. The novel examines the personal and psychological factors which led to this distortion of the teacher-student relationship. However, the teacher is murdered. A police investigation follows'with startling revelations involving a series of suspects, each with a motive to kill. Murder touches and maims the lives of all who come near it. The reader is plunged into the world of drug dealing, a string of burglaries, the betrayal of lovers, and the result of the flight of an immigrant family to Canada to escape an abusive father. The novel ends with a tragic twist of fate.
A Minute to Smile Fans of Barbara Freethy, Susan Mallery, and Robyn Carr will love this powerful, full length contemporary romance novel by award-winning Barbara Samuel. How had single mother Esther Lucas become the fix-it lady? Bandaging her sons' scraped knees was on thing; hoping to heal the handsome widower's broken heart was quite another. But Alexander Stone brought out much more than just Esther's maternal instincts. And she knew that loving the tall, dark loner would make her need a fix-it person of her own -- Alexander Stone didn't know if he agreed with that old saying about having loved and lost --he just knew he'd never love again. But how could he resist a warm, sexy woman who always had a minute to smile and two little boys who made him remember what it was like to laugh -- or to long for a family to call his own?
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