Barbara Carlson--an on-air cross between Rush Limbaugh and Howard Stern--was hired by KSTP in Minneapolis to shock listeners into listening some more. Now this convent-educated, pill-popping socialite-turned-radio-host tells her raucous life story with lusty humor, remaining remarkably candid, wonderfully entertaining, and always true to herself. photo insert.
In 1872, Jesup W. Scott donated 160 acres of land to serve as an endowment for the Toledo University of Arts and Trades. Unfortunately, the university failed in its early years but was resurrected in 1884 by Scott's three sons, who gave the remaining assets to the City of Toledo to create a manual training school. By 1909, the institution was becoming a full-fledged university but struggled financially and did not have a permanent home. That changed in 1931 with the construction of the Bancroft Street campus, including the iconic University Hall, built in the Collegiate Gothic style. The University of Toledo remained a municipally supported university until 1967, when it joined Ohio's higher education system. In 2006, the University of Toledo merged with the former Medical College of Ohio, a state-supported institution founded in 1964. Today, the University of Toledo serves 20,000 students in degree programs as varied as medicine, law, engineering, business, education, pharmacy, nursing, and liberal arts.
Barbara W. Tuchman won her second Pulitzer Prize for this nonfiction masterpiece—an authoritative work of history that recounts the birth of modern China through the eyes of one extraordinary American. General Joseph W. Stilwell was a man who loved China deeply and knew its people as few Americans ever have. Barbara W. Tuchman’s groundbreaking narrative follows Stilwell from the time he arrived in China during the Revolution of 1911, through his tours of duty in Peking and Tientsin in the 1920s and ’30s, to his return as theater commander in World War II, when the Nationalist government faced attack from both Japanese invaders and Communist insurgents. Peopled by warlords, ambassadors, and missionaries, this classic biography of the cantankerous but level-headed “Vinegar Joe” sparkles with Tuchman’s genius for animating the people who shaped history. Praise for Stilwell and the American Experience in China “Tuchman’s best book . . . so large in scope, so crammed with information, so clear in exposition, so assured in tone that one is tempted to say it is not a book but an education.”—The New Yorker “The most interesting and informative book on U.S.–China relations . . . a brilliant, lucid and authentic account.”—The Nation “A fantastic and complex story finely told.”—The New York Times Book Review
Organizations turn to multistakeholder partnerships (MSPs) to meet challenges that they cannot handle alone. By tapping the resources of diverse stakeholders, MSPs develop the capability to address complex issues and problems, such as health care delivery, poverty, human rights, watershed management, education, sustainability, and innovation. This book provides a comprehensive understanding of MSPs, why they are needed, the challenges partners face in working together and how to design them effectively. Through the process of collaboration partners combine their differing strengths, vantage points and expertise to craft innovative responses to pressing societal concerns. The book offers valuable advice for leaders about how to design and scale up effective partnerships and how to address potential obstacles that partners may face. Drawing on three comprehensive cases and countless shorter examples from around the world, the book offers both practical advice for organization embarking on an MSP as well as a theoretical understanding of how partnerships function. Using an institutional theory lens, it explains how partnerships can effect change in institutional fields by reducing turbulence and negotiating a common set of norms and routines to govern partners' future interactions within the field of concern.
Shadowing offers an array of techniques to study people on the move, and the book is addressed to all social scientists interested in fieldwork as a way of grasping phenomena typical of late modernity. The book's starting point is that present times require different metaphors than static "cultures," "organizations," or even "societies." It is time to start constructing a mobile ethnology that is knowledge about people, objects, and ideas that circulate globally. The present text offers suggestions concerning the ways such construction may take.
Willard and Spackman’s Occupational Therapy, Twelfth Edition, continues in the tradition of excellent coverage of critical concepts and practices that have long made this text the leading resource for Occupational Therapy students. Students using this text will learn how to apply client-centered, occupational, evidence based approach across the full spectrum of practice settings. Peppered with first-person narratives, which offer a unique perspective on the lives of those living with disease, this new edition has been fully updated with a visually enticing full color design, and even more photos and illustrations. Vital pedagogical features, including case studies, Practice Dilemmas, and Provocative questions, help position students in the real-world of occupational therapy practice to help prepare them to react appropriately.
The untimely deaths of Amy Winehouse (2011) and Whitney Houston (2012), and the ’resurrection’ of Tupac Shakur for a performance at the Coachella music festival in April 2012, have focused the media spotlight on the relationship between popular music, fame and death. If the phrase ’sex, drugs and rock’n’roll’ ever qualified a lifestyle, it has left many casualties in its wake, and with the ranks of dead musicians growing over time, so the types of death involved and the reactions to them have diversified. Conversely, as many artists who fronted the rock’n’roll revolution of the 1950s and 1960s continue to age, the idea of dying young and leaving a beautiful corpse (which gave rise, for instance, to the myth of the ’27 Club’) no longer carries the same resonance that it once might have done. This edited collection explores the reception of dead rock stars, ’rock’ being taken in the widest sense as the artists discussed belong to the genres of rock’n’roll (Elvis Presley), disco (Donna Summer), pop and pop-rock (Michael Jackson, Whitney Houston, Amy Winehouse), punk and post-punk (GG Allin, Ian Curtis), rap (Tupac Shakur), folk (the Dutchman André Hazes) and ’world’ music (Fela Kuti). When music artists die, their fellow musicians, producers, fans and the media react differently, and this book brings together their intertwining modalities of reception. The commercial impact of death on record sales, copyrights, and print media is considered, and the different justifications by living artists for being involved with the dead, through covers, sampling and tributes. The cultural representation of dead singers is investigated through obituaries, biographies and biopics, observing that posthumous fame provides coping mechanisms for fans, and consumers of popular culture more generally, to deal with the knowledge of their own mortality. Examining the contrasting ways in which male and female dead singers are portrayed in the media, the book
This text provides an overview of the field of aggression. It presents an account of both theoretical and applied issues and explores strategies designed to control, reduce and prevent aggression on both an individual and societal level.
1. 1 OBJECTIVES The main objective of this joint work is to bring together some ideas that have played central roles in two disparate theoretical traditions in order to con tribute to a better understanding of the relationship between focus and the syn tactic and semantic structure of sentences. Within the Prague School tradition and the branch of its contemporary development represented by Hajicova and Sgall (HS in the sequel), topic-focus articulation has long been a central object of study, and it has long been a tenet of Prague school linguistics that topic-focus structure has systematic relevance to meaning. Within the formal semantics tradition represented by Partee (BHP in the sequel), focus has much more recently become an area of concerted investigation, but a number of the semantic phenomena to which focus is relevant have been extensively investi gated and given explicit compositional semantic-analyses. The emergence of 'tripartite structures' (see Chapter 2) in formal semantics and the partial simi larities that can be readily observed between some aspects of tripartite structures and some aspects of Praguian topic-focus articulation have led us to expect that a closer investigation of the similarities and differences in these different theoretical constructs would be a rewarding undertaking with mutual benefits for the further development of our respective theories and potential benefit for the study of semantic effects of focus in other theories as well.
This book is a "must read" for anyone interested in parish nursing. It offers practical guidance for many life challenges, utilizing extensive examples from a successful parish nursing practice.
Through her books, articles, and periodicals, Barbara Brabec has been showing people how to profit from their creative talents and know-how for over twenty-five years.
The action was intense and kept me on the edge of my seat! Barbara Freethy is an amazing writer who captures the reader's attention from the very first sentence, so much so, I read this book in one sitting." 5 Stars! Booklover's Anonymous He didn't just break her heart, he broke her soul… When a bomb exploded at her college, Caitlyn Carlson's life changed in an instant. Ten years later, she's no longer a vulnerable, trusting girl, but a tough, ruthless, FBI agent. But her hard exterior covers a deep, aching hole in her heart. Quinn Kelly has changed his life, too, trying to make up for the horrific mistakes of his youth. But some mistakes can't be outrun or forgiven. Some feelings don't stay buried, no matter how hard you try. An explosion at a local university takes them back to the past, to the one place they never wanted to go again…and to each other. They barely survived loving each other the first time around. The secrets and lies almost killed them. Will this be their second chance, or will this be the end of everything? A shattered love story, a fatal explosion, and a web of secrets and lies await in this exciting tale of ecoterrorism from #1 New York Times Bestselling Author Barbara Freethy! For fans of Susan Stoker, Meli Raine, Nora Roberts, Karin Slaughter, Mary Burton, and Melinda Leigh. Note: THE FBI SERIES takes readers on thrilling, romantic, and suspenseful adventures! Every story stands completely on its own and there are no cliffhangers! The books feature complex and exciting storylines ranging from kidnapping to organized crime, terrorism, and espionage. Personal stories often play out against a bigger, broader storyline, and surprising twists will keep you up all night. Start reading today! Also Available in the Off The Grid: FBI Series Perilous Trust #1 Reckless Whisper #2 Desperate Play #3 Elusive Promise #4 Dangerous Choice #5 Ruthless Cross #6 Critical Doubt #7 Fearless Pursuit #8 Daring Deception #9 Risky Bargain #10 Perfect Target #11 Fatal Betrayal #12 What the readers are saying… "Daring Deception paints a thrilling picture of a dangerous love story. Brodie and Caitlyn pull emotions into a maze that is powerful, intriguing and never ending. With Freethy there is always a twist to tie emotions up in knots and leave readers feeling breathless." Isha – Goodreads "There were a lot of twists and turns in this series that kept me guessing about what was going to happen next, and I definitely did not see the ending coming! This book was the perfect mix of romance and suspense, a page turner from beginning to end! Kate – Bookbub "A story that builds on revenge, kidnapping, and forgiveness. DARING DECEPTION is a definite winner in this series." Ellen - Goodreads "Just finished this gem by Barbara Freethy...I can honestly say it was one of the best books I have read this year. This author is a genius at creating authentic characters!" Claire – Goodreads on Daring Deception "Barbara Freethy knows how to write a beautiful, believable love story....with just the right amount of heat." Trude – Goodreads on Daring Deception "Wow! Every time I think I can’t enjoy a book in this Off The Grid series any more than the ones I’ve already read, Barbara Freethy proves me wrong. DARING DECEPTION is full of twists and turns and two great main characters." Mary - Goodreads
This book presents the most important problems of reference and considers their solution. It presupposes no technical knowledge, presents analyses from first principles, illustrates every stage with examples, and is written with verve and clarity. This is the ideal introduction to reference for students of linguistics and philosophy of language.
Emma Harte’s legacy lives on in a “lushly detailed” novel following A Woman of Substance and Hold the Dream from the #1 New York Times–bestselling author (Rave Reviews). The heiress to Emma Harte’s international retail empire, Paula McGill O’Neill has grown to fill her legendary grandmother’s shoes and become the woman she has always wanted to be. Coming into her own, she now keeps her grandmother’s vision alive with firm, confident control. But unbeknownst to her, Paula faces threats from every side. Two families watch her carefully, each hoping for their own chance at the reins of power, and an old enemy lurks in the shadows, alert to any sign of weakness. When Paula’s unscrupulous cousin Jonathan returns, even more determined than ever to wrest away everything Paula has fought for, she must marshal all her strength and fortitude to defend her fortune and her family. “A compulsive read.” —Daily Mail “Will keep you up till all hours reading just one more chapter before you can bear to turn out the bedside light.” —Prima “A host of dramatic subplots continues the amorous, sorrowful and shady doings of the O’Neills and the Kallinskis, two families whose fortunes are entwined with the Hartes.” —Publishers Weekly “Readers will happily re-acquaint themselves with the sprawling Harte clan . . . A more than satisfactory sequel to the previous segments of this generational tale, with an ending that promises still more to come.” —Library Journal
Costume defines the superhero, disguising and distinguishing him or her from the civilian alter ego. The often garish garb expresses a hero's otherness and empowers its wearers to seek a primal form of justice. This book provides the first interdisciplinary analysis of the superhero costume and investigates wide-ranging issues such as identity, otherness, ritual dress and disguise. Analysis focuses on the implications of wearing superhero costume, exploring interpretations of the costumed hero and the extent to which the costume defines his or her role. Using examples across various media (comic books, film, and television) with case studies including The X-Men, Watchmen, real-life superheroes such as Phoenix Jones and Pussy Riot, and audience activities such as cosplay, The Superhero Costume presents new perspectives on the increasingly popular genre. A lively and thorough account of superhero fashions throughout history, The Superhero Costume will be essential reading for students of visual culture, popular culture, fashion and cultural studies.
The position Frances Burney (1752-1840) holds as a novelist, journalist, and letterwriter is now undisputed, thanks to reevaluations of the canon in recent years. Yet Burney was always intrigued by, and wrote for, the stage. Though only one of Burney's dramas was performed in her lifetime, Barbara Darby places the plays in the context of performance and feminist theory, challenging past assertions about Burney that were based entirely on her novels and journals. Darby maintains that in exposing the failure of such practices and institutions as courtship, marriage, family, government, and the church, Burney's dramas often exceed her novels in the depth of their social commentary. In her four comedies and four tragedies, Burney uses stage space, dialogue, blocking, and gesture to highlight the ways power is distributed among society's members. According to Darby, these plays show that the eighteenth-century female experience was dominated by physical, psychic, and emotional regulation that included bodily punishment and the limitation of personal choice. Placing Burney alongside other prominent female playwrights of the period, Darby brings to light a substantial body of work, revealing that Burney's drama was not a casual sideline to her novel writing. Frances Burney, Dramatist, expands our appreciation of the extent to which eighteenth-century women playwrights used the stage as a forum.
Discover new approaches to promote a viable forest industry while protecting non-timber values!Frontiers of Forest Biology: Proceedings of the 1998 Joint Meeting of the North American Forest Biology Workshop and the Western Forest Genetics Association gives you significant new insights on current initiatives in forest biology. Because the field is changing rapidly, you need to keep aware of current trends, as the emphasis in forest research shifts from productivity-based goals to sustainable development of forest resources. In this volume, you will find a comprehensive summary of the state of the art of forest science in North America. Whether your focus is on genetics or on the environmental aspects of forest science, plant physiology, or silviculture, you will find helpful chapters by practitioners as well as cutting-edge research by scientists. This integrated approach is unique in the field. Based on the 1998 Joint Meeting of the North American Forest Biology Workshop and the Western Forest Genetics Association, Frontiers of Forest Biology addresses changing priorities in forest resource management. This important book contains fascinating research studies, complete with tables and diagrams, on topics such as biodiversity research, the productivity of commercial species, conserving adaptive variation in forest ecosystems, and the effect of harvesting trees on nutrient leaching.The book maps the frontiers of this fast-changing science with chapters on: the social, biological, and industrial context of forest biology new directions for research into genetics, physiology, plant silviculture, and conservation the impact of genetics on sustainable forestry the effects of cold and disease on plant physiology regeneration of various species after logging new species adapted for agroforestry the impact and management of exotic weeds Frontiers of Forest Biology offers solid information on a broad spectrum of topics and suggests fresh avenues for your investigations in all aspects of forest biology.
A NEW YORK TIMES BESTSELLER An urgent, comprehensive explanation of the ways disinformation is impacting democracy, and practical solutions that can be pursued to strengthen the public, media, and truth-based politics MSNBC's legal expert breaks down the ways disinformation has become a tool to drive voters to extremes, disempower our legal structures, and consolidate power in the hands of the few. "One of the most acute observers of our time shares . . . a compelling work about a challenge that—left unexamined and left unchecked—could undermine our democracy." —Eric H. Holder Jr, 82nd Attorney General of the United States American society is more polarized than ever before. We are strategically being pushed apart by disinformation—the deliberate spreading of lies disguised as truth—and it comes at us from all sides: opportunists on the far right, Russian misinformed social media influencers, among others. It's endangering our democracy and causing havoc in our electoral system, schools, hospitals, workplaces, and in our Capitol. Advances in technology including rapid developments in artificial intelligence threaten to make the problems even worse by amplifying false claims and manufacturing credibility. In Attack from Within, legal scholar and analyst Barbara McQuade, shows us how to identify the ways disinformation is seeping into all facets of our society and how we can fight against it. The book includes: The authoritarian playbook: a brief history of disinformation from Mussolini and Hitler to Bolsonaro and Trump, chronicles the ways in which authoritarians have used disinformation to seize and retain power. Disinformation tactics—like demonizing the other, seducing with nostalgia, silencing critics, muzzling the media, condemning the courts; stoking violence—and reasons why they work. An explanation of why America is particularly vulnerable to disinformation and how it exploits our First Amendment Freedoms, sparks threats and violence, and destabilizes social structures. Real, accessible solutions for countering disinformation and maintaining the rule of law such as making domestic terrorism a federal crime, increasing media literacy in schools, criminalizing doxxing, and much more. Disinformation is designed to evoke a strong emotional response to push us toward more extreme views, unable to find common ground with others. The false claims that led to the breathtaking attack on our Capitol in 2021 may have been only a dress rehearsal. Attack from Within shows us how to prevent it from happening again, thus preserving our country’s hard-won democracy.
Alice Hamilton (1869-1970), a pioneer in the study of diseases of the workplace, a founder of industrial toxicology in the United States, and Harvard's first woman professor, led a long and interesting life. Always a consummate professional, she was also a prominent social reformer whose interest in the environmental causes of disease and in promoting equitable living conditions developed during her years as a resident at Jane Addams's Hull-House. This legendary figure now comes to life in an integrated work of biography and letters that reveals the personal as well as the professional woman. In documenting Hamilton's evolution from a childhood of privilege to a life of social advocacy, the volume opens a window on women reformers and their role in Progressive Era politics and reform. Because Hamilton was a keen observer and vivid writer, her letters--more than 100 are included here--bring an unmatched freshness and immediacy to a range of subjects, such as medical education; personal relationships and daily life at Hull House; the women's peace movement; struggles for the protection of workers' health; academic life at Harvard; politics and civil liberties during the cold war; and the process of growing old. Her story takes the reader from the Gilded Age to the Vietnam War.
OUR SCANDINAVIAN HERITAGE is a collection of true stories by members of The Norden Clubs, Jamestown, NY, stories of themselves and/or their ancestors their adventures, customs, and the sacrifices they made to come to America, a land where streets were paved in gold, as one young girl was told. Included is a history of the emigration from Scandinavia to America and to Jamestown, NY, in the late 1800s and early 1900s. The Norden Clubs are pleased to permanently record these memories as part of history, particularly the Scandinavian influence in America.
Compositionality in Formal Semantics is a collection of Barbara Partee’s papers that have been influential in the field but are not readily available and includes a new introductory essay in which Partee reflects on how her thinking and the field of semantics have developed over the past 35 years. Brings together, in one volume, influential but difficult to find papers by one of the most important researchers in formal semantics. Includes a new introductory essay in which Partee reflects on how her research and the field of semantics have developed over the past 35 years. Discusses critical themes in semantic theory.
Using Biographical Methods in Social Research provides an informative, comprehensive, accessible and practical guide to the nature and use of biographical methods, combining a consideration of theoretical issues with practical guidance as well as reflections on the personal experience of doing research. Barbara Merrill and Linden West consider important questions about who and what research is for and what makes it valid, alongside the practical business of interviewing, transcribing, analyzing and writing up of biographical data. The authors draw on their sociological and psychological orientations to provide a truly interdisciplinary approach to the subject, and provide numerous examples of biographical research across the social sciences. This book will equip students with all the skills necessary to undertake biographical research as well as to fully understand what they are doing and the assumptions they make about the nature of truth, knowledge, story telling and being human. It will be useful for students and researchers using biographical methods in a range of disciplines, including sociology, social policy, social psychology, health care and education.
The lively ghosts found on this magical, mysterious Massachusetts island include a pirate, a preacher, a witch, a whaling captain, and a sea captain's wife. The area's history stretches back to the Indians of thousands of years ago, to the Vikings, to the Pilgrims, until the present day. This book highlights the most interesting stories, featuring such sites as a haunted rare-books store, several inns, a guesthouse, a tavern, and a theater.
This book explores the impact of artistic experiments in inspiring people to turn away from current food consumerism and take an active role in preserving, sustaining, and protecting the environment. As artists are expanding their practice into social justice and community concerns, erasing traditional forms of expression and integrating others, the culture around food and its production has been added to a new vocabulary of experiential art. The authors measure the impact of such experiments on local food consumption and production, focusing on education and youth, both in the surrounding community and culture at large. They suggest how these projects can be up-scaled to further encourage sustainable solutions for our environment and communities. The book explores the reflections and motivations of case study practitioners in urban and rural areas and, through interviews, engages with artists who are pioneering a new trend to create hubs of activity away from traditional art spaces in cities to follow a non-hierarchal practice that is de-centralized and communally based. This book will be of great interest to academic readers concerned with issues related to environmental aesthetics, eco-design, eco-criticism, culture, heritage, memory, and identity, and those interested in the current debates on the place of aesthetics and culture in sustainability.
The COVID-19 pandemic will forever be remembered as a pivotal event in American history. Written by one of the world's foremost experts on leadership and followership, this book centers on the first six months of the pandemic and the crises that ran rampant. The chapters focus less on the former president, Donald Trump, than on his followers: on people complicit in his miserable mismanagement of the crisis in public health. Barbara Kellerman provides clear and compelling evidence that Trump was not entirely to blame for everything that went wrong. Many others were responsible including his base, party, administration, inner circle, Republican elites, members of the media, and even medical experts. Far too many surrendered to the president's demands, despite it being obvious his leadership was fatally flawed. The book testifies to the importance of speaking truth to power, and a willingness to take risks properly to serve the public interest.
A hard-hitting, groundbreaking exploration of the new mating conditions that are changing the face of love, commitment, and marriage as we know it. A double revolution is at work in modern American love: A revolution in higher education has created the most professionally accomplished and independent generation of young women in history, and a revolution in mating has created a prolonged and perplexing search for Mr. Right. Based on extensive research and interviews, Why There Are No Good Men Left explores the romantic plight of this high-status woman with findings that are sure to rouse debate. Cultural historian, Barbara Dafoe Whitehead documents the new social climate in which the demands of work, the epidemic of cohabitation, the disappearance of courtship, and the exacting standards of educated women are leading them to stay single longer–and to find the search for a mate even harder when the time is right. From the frontlines of college, where dating is dead, to the trenches of corporate solitude, Whitehead reports on a wholesale shift that has stacked the marriage deck against the best and brightest women. The thirty-something, perplexed single woman is today’s new cultural icon. Why There Are No Good Men Left is the first book to take a serious approach to analyzing where she came from and to ask how she can realize her dreams of lasting love.
One of the most important African American leaders of the twentieth century and perhaps the most influential woman in the civil rights movement, Ella Baker (1903–1986) was an activist whose remarkable career spanned fifty years and touched thousands of lives. A gifted grassroots organizer, Baker shunned the spotlight in favor of vital behind-the-scenes work that helped power the Black freedom struggle. Making her way in predominantly male circles while maintaining relationships with a vibrant group of women, students, and activists, Baker was a national officer and key figure in the NAACP, a founder of the Southern Christian Leadership Conference, and a prime mover in the creation of the Student Nonviolent Coordinating Committee. In this definitive biography, Barbara Ransby chronicles Baker's long and rich career, revealing her complexity, radical democratic worldview, and enduring influence on group-centered, grassroots activism. Beyond documenting an extraordinary life, Ransby paints a vivid picture of the African American fight for justice and its intersections with other progressive struggles worldwide throughout the twentieth century.
Based on a novel by acclaimed Christian fiction author Barbara Cameron, Her Restless Heart is the story of an Amish woman caught between the traditions of her faith and the pull of a different life. This six-session Bible study explores the heart’s longing for love and acceptance and the Bible’s answer to this universal human need. The study equips women as they seek to know God’s plan for their lives and find satisfaction and fulfillment. The Leader Guide contains six session guides plus leader helps. Her Restless Heart is the second study in the Faith and Fiction Bible study series that uses Christian fiction as a backdrop for exploring biblical themes.
Health Economics: An International Perspective is the only textbook to provide a truly international, comparative treatment of health economics. Offering an analysis of health systems across borders, the fourth edition of this key text has been updated and revised to take account of changes in a host of countries. This edition features an expanded introduction, providing better grounding for many of the examples that come in subsequent chapters and making it easier for non-health care experts to see the links between the theory, the examples and the health care system components. It also boasts a restructured format, dividing the book into two broad sections: the first focuses on ideas and principles, along with evidence on their applications in the health sector, whereas the second focuses on introducing core tools and techniques used in applied health economics research. Further updates to this edition include: two new chapters on applied econometrics; a new chapter on equity, focusing on equity in access to health care, paying particular attention to how access and need for health care are defined and measured in applied research; a new chapter on emerging issues for health systems that are emanating from a series of global transitions both within (e.g. demographic change, epidemiological change, the global resolution on universal health coverage) and without the health sector (e.g. economic transitions). Throughout the text, examples and illustrations are taken from a wide range of settings and world regions, providing a unique overview of the performance of different health systems.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
This 1990 volume was written to re-examine the long-standing controversy about consistency in personality from a social psychological perspective. Barbara Krahé reconsiders the concept of consistency in terms of the systematic coherence of situation cognition and behaviour across situations. In the first part of the volume she undertakes an examination of social psychological models of situation cognition for their ability to clarify the principles underlying the perception of situational similarities. She then advances an individual-centred methodology in which nomothetic hypotheses about cross-situational coherence are tested on the basis of idiographic measurement of situation cognition and behaviour. In the second part of the volume, a series of empirical studies is reported which apply the individual-centred framework to the analysis of cross-situational coherence in the domain of anxiety-provoking situations. These studies are distinctive in that they extend over several months and use free-response data.
“A true-crime masterpiece written by a cold-case-cracking master. Barbara Rae-Venter’s investigative DNA work has revolutionized the way law enforcement hunts serial killers.”—John Douglas, New York Times bestselling co-author of Mindhunter “Barbara Rae-Venter isn’t just the genealogy expert who helped capture the Golden State Killer—she’s an unsung hero who has given murdered women and children their faces and names back, recognizing that their lives mattered.”—Maureen Callahan, New York Times bestselling author of American Predator For twelve years the Golden State Killer terrorized California, stalking victims and killing without remorse. Then he simply disappeared, for the next forty-four years, until an amateur DNA sleuth opened her laptop. In I Know Who You Are, Barbara Rae-Venter reveals how she went from researching her family history as a retiree to hunting for a notorious serial killer—and how she became the nation’s leading authority on investigative genetic genealogy, the most dazzling new crime-fighting weapon to appear in decades. Rae-Venter leads readers on a vivid journey through the many cases she tackled, often starting with little more than a DNA sample. From the first criminal case she ever solved—uncovering the long-lost identity of a child abductee—to the heartbreaking story of the Billboard Boy, whose skeletal remains were discovered along a highway, to the search for the Golden State Killer, Rae-Venter shares haunting, often thrilling accounts of how she helped solve some of America’s most chilling cold cases in the span of just three years. For each investigation, Rae-Venter brings readers inside her unique “grasshopper mind” as she analyzes DNA data and pores through obituaries, marriage records, and old newspaper articles. Readers join in on urgent calls with sheriffs, FBI agents, and district attorneys as she details the struggle to obtain usable crime scene DNA samples, until, finally, a critical piece of the puzzle tumbles into place. I Know Who You Are captures both the exhilaration of the moment of discovery and the sheer depth of emotion that lingers around cold cases, informing Rae-Venter’s careful approach to her work. It is a story of relentless curiosity, of constant invention and reinvention, and of human beings striving to answer the most elemental questions about themselves: What defines identity? Where do we belong? And are we truly who we think we are?
A revelation of Bill and Hillary Clinton's last days as the First Family discusses President Clinton's controversial pardons and his relationship with fugitive Marc Rich, and Hillary's solicitation of gifts and partaking of the White House china.
The twelve stories in Curtain Calls are about love, loss, aloneness and self-discovery told from the view of the very young to the elderly. No matter how heart-tugging the stories may be, there is always the redeeming element of humor. A widow meets her lover during a bank robbery; a nine-year-old confesses to the parish priest her fear she is going to murder someone; a man in his 80's learns that his buddy in assisted living is planning his wife's mercy killing; after hitting a deer, a woman's car catapults into a dark parkway where no one can hear her cries for help; a bored, stay-at-home young mother plots to attract her neighbor, a soldier recently back from the battlefield; a middle-aged bride's obsessions come vicariously close to spoiling her honeymoon in Portugal. In the last story, "Curtain Calls" a once-glamourous Pop singer faces her nineties without her lover, a man who had lived life to the fullest.
Barbara Kleine-Kalmer analyses the impact of branding in social networks and introduces the construct of brand page attachment. On the basis of a comprehensive quantitative study she validates the construct as relevant for user behavior and investigates which instruments and antecedents influence brand page attachment. Through these conceptually and empirically profound analyses, the author detects interesting implications for the management of brands in the context of social media.
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