Don't Stop Believin' pays tribute to the glorious mash-up of music, comedy, drama and social commentary that has put Glee and its band of misfits in the spotlight"--Page 4 of cover
This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.
Balser examines the Working Women's Assc. of 1868, Union WAGE of the 1970s, and the Coalition of Labor Union Women to answer questions about organizing around gender and work issues.
Tackling a challenge faced by millions of business professionals every day, this handy guide shows how to create effective, visually appealing PowerPoint slides. In contrast to other books on the topic that focus on the wrong skills or read like boring technical manuals, this lighthearted book avoids jargon and provides useful information about the practical realities of creating materials in this popular application. It addresses common user concerns, such as turning facts and data into compelling visual images, generating concise project updates, creating presentation decks to be emailed or reviewed over the phone, and finding useful PowerPoint examples with minimal research. With accessible language and 50 color illustrations, the book efficiently explains how to translate ideas into sleek presentations.
Symbolic execution is an intuitive strategy to verify sequential programs, which can be automated to a large extent. We have successfully carried over this method of proof to the interactive verification of concurrent systems. The resulting strategy can be applied to the verification of complex parallel programs and arbitrary (linear) temporal formulas. Our underlying logic is defined such that operators for parallel programs and temporal logic can be arbitrarily nested. We support interleaving with explicit blocking, nondeterministic choice, and others. Most important, the semantics of all of the operators are compositional. Thus, systems can be abstracted and proofs can be decomposed. This ensures that our strategy of proof can be applied to the verification of large, concurrent systems.
Don't Stop Believin' pays tribute to the glorious mash-up of music, comedy, drama and social commentary that has put Glee and its band of misfits in the spotlight"--Page 4 of cover
Can the teachings of Judaism provide a sacred framework for repairing the world? In this groundbreaking volume, leading rabbis, intellectuals, and activists explore the relationship between Judaism and social justice, drawing on ancient and modern sources of wisdom. The contributors argue that American Jewry must move beyond “mitzvah days” and other occasional service programs, and dedicate itself to systemic change in the United States, Israel, and throughout the world. These provocative essays concentrate on specific justice issues such as eradicating war, global warming, health care, gay rights and domestic violence, offering practical ways to transform theory into practice, and ideas into advocacy. Rich and passionate, these expressions will inspire you to consider your obligations as a Jew, as an American and as a global citizen, while challenging you to take thoughtful and effective action in the world. Contributors: Martha Ackelsberg, PhD • Rabbi Rebecca Alpert, PhD • Diane Balser, PhD • Jeremy Benstein, PhD • Rabbi Phyllis Berman • Ellen Bernstein • Marla Brettschneider, PhD • Rabbi Sharon Brous • Aryeh Cohen, PhD • Stephen P. Cohen, PhD • Rabbi Elliot N. Dorff, PhD • Aaron Dorfman • Jacob Feinspan • Rabbi Marla Feldman • Sandra M. Fox, LCSW • Julia Greenberg • Mark Hanis • Rabbi Jill Jacobs • Rabbi Jane Kanarek, PhD • Rabbi Elliot Rose Kukla • Joshua Seth Ladon • Arieh Lebowitz • Rabbi Michael Lerner, PhD • Shaul Magid, PhD • Rabbi Natan Margalit, PhD • Ruth Messinger • Jay Michaelson • Rabbi Micha Odenheimer • Rabbi Jonah Dov Pesner • Judith Plaskow, PhD • Judith Rosenbaum, PhD • April Rosenblum • Adam Rubin, PhD • Danya Ruttenberg • Rabbi David Saperstein • Joel Schalit • Rabbi Sidney Schwarz, PhD • Martin I. Seltman, MD • Dara Silverman • Daniel Sokatch • Shana Starobin • Naomi Tucker • Abigail Uhrman • Rabbi Arthur Waskow, PhD • Rabbi Melissa Weintraub
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