The bestselling guide to the medical management of common genetic syndromes —now fully revised and expanded A review in the American Journal of Medical Genetics heralded the first edition of Management of Genetic Syndromes as an "unparalleled collection of knowledge." Since publication of the first edition, improvements in the molecular diagnostic testing of genetic conditions have greatly facilitated the identification of affected individuals. This thorough revision of the critically acclaimed bestseller offers original insights into the medical management of sixty common genetic syndromes seen in children and adults, and incorporates new research findings and the latest advances in diagnosis and treatment of these disorders. Expanded to cover five new syndromes, this comprehensive new edition also features updates of chapters from the previous editions. Each chapter is written by an expert with extensive direct professional experience with that disorder and incorporates thoroughly updated material on new genetic findings, consensus diagnostic criteria, and management strategies. Edited by two of the field's most highly esteemed experts, this landmark volume provides: A precise reference of the physical manifestations of common genetic syndromes, clearly written for professionals and families Extensive updates, particularly in sections on diagnostic criteria and diagnostic testing, pathogenesis, and management A tried-and-tested, user-friendly format, with each chapter including information on incidence, etiology and pathogenesis, diagnostic criteria and testing, and differential diagnosis Up-to-date and well-written summaries of the manifestations followed by comprehensive management guidelines, with specific advice on evaluation and treatment for each system affected, including references to original studies and reviews A list of family support organizations and resources for professionals and families Management of Genetic Syndromes, Third Edition is a premier source to guide family physicians, pediatricians, internists, medical geneticists, and genetic counselors in the clinical evaluation and treatment of syndromes. It is also the reference of choice for ancillary health professionals, educators, and families of affected individuals looking to understand appropriate guidelines for the management of these disorders. From a review of the first edition: "An unparalleled collection of knowledge . . . unique, offering a gold mine of information." —American Journal of Medical Genetics
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders.
In honor of the bicentennial of Abraham Lincoln's birth comes this sequel to the enormously successful "Lincoln: An Illustrated Biography." This work picks up where the previous book left off, and examines how the 16th president's legend came into being.
Psychology is of interest to academics from many fields, as well as to the thousands of academic and clinical psychologists and general public who can't help but be interested in learning more about why humans think and behave as they do. This award-winning twelve-volume reference covers every aspect of the ever-fascinating discipline of psychology and represents the most current knowledge in the field. This ten-year revision now covers discoveries based in neuroscience, clinical psychology's new interest in evidence-based practice and mindfulness, and new findings in social, developmental, and forensic psychology.
Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.
Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.
A study of African-American workers empowered and partly liberated by their skills. At Buffalo Forge, an extensive ironmaking and farming enterprise in Virginia before the Civil War, a unique treasury of materials yields an "engrossing, often surprising record of everyday life on an estate in the antebellum South" (Kirkus Reviews).
Slow Fade to Black completes Richard B. Jewell’s richly detailed two-part history of the RKO film studio, which began with RKO Radio Pictures: A Titan Is Born, published in 2012. This second volume charts the studio’s fortunes, which peaked during World War II, declined in the postwar period, and finally collapsed in the 1950s. Drawing on hard-to-access archival materials, Jewell chronicles the period from 1942 to the company’s demise in 1957. Towering figures associated with the studio included Howard Hughes, Orson Welles, Charles Koerner, Val Lewton, Jane Russell, and Robert Mitchum. In addition to featuring an extraordinary cast of characters, the RKO story describes key aspects of entertainment history: Hollywood’s collaboration with Washington, film noir, censorship, HUAC, the rise of independent film production, and the impact of television on film. Taken as a whole, Jewell’s two-volume study represents the most substantial and insightful exploration of the Hollywood studio system to date.
The definitive account of the crash of 1987, a cautionary tale of how the U.S. financial system nearly collapsed--from the bestselling author of The Wizard of Lies Monday, October 19, 1987, was by far the worst day in Wall Street history. The market fell 22.6 percent – almost twice as bad as the worst day of 1929 – equal to a one-day loss of nearly 5,000 points today. Black Monday was more than seven years in the making and threatened nearly every U.S. financial institution. Drawing on superlative archival research and dozens of original interviews Diana B. Henriques weaves a tale of missed opportunities, market delusions, and destructive actions that stretched from the “silver crisis” of 1980 to turf battles in Washington, a poisonous rivalry between the New York Stock Exchange and the Chicago Mercantile Exchange, and the almost-fatal success of two California professors whose idea for reducing market risk spun terribly out of control. As the story hurtles forward, the players struggle to forestall a looming market meltdown and unexpected heroes step in to avert total disaster. For thirty years, investors, regulators, and bankers have failed to heed the lessons of 1987, even as the same patterns have resurfaced, most spectacularly in the financial crisis of 2008. A First-Class Catastrophe offers a new way of looking not only at the past, but at our financial future as well.
The revised edition of A Handbook on Stuttering continues its remarkable role as the authoritative, first-line resource for researchers and clinicians who work in the field of fluency and stuttering. Now in its seventh edition, this unique book goes beyond merely updating the text to include coverage of roughly 1,000 articles related to stuttering research and practice that have been published since 2008. This extended coverage integrates the more traditional body of research with evolving views of stuttering as a multi-factorial, dynamic disorder. Comprehensive, clear, and accurate, this text provides evidence-based, practical information critical to understanding stuttering. By thoroughly examining the intricacies of the disorder, A Handbook on Stuttering, Seventh Edition lays the foundation needed before considering assessment and treatment. New to the Seventh Edition: * A completely reorganized table of contents, including two new chapters. * The deletion of approximately 1,000 non-peer-reviewed references from the previous edition to assure discussion of the highest quality evidence on stuttering. * New content on the development of stuttering across the lifespan and assessment. * Given the Handbook’s historic role as a primary reference for allied professionals, a new chapter that addresses myths and misconceptions about stuttering * Expanded coverage on the role of temperament in childhood stuttering * Expanded coverage of brain-based research, genetics, and treatment findings. * A thoroughly updated chapter on conditions under which stuttering fluctuates * Brief tutorial overviews of critical concepts in genetics, neuroimaging, language analysis and other relevant constructs, to better enable reader appreciation of research findings. * A greater selection of conceptual illustrations of basic concepts and findings than in prior editions * Integrated cross-referencing to content across chapters
A great deal of research has been carried out on this important class of compounds in the last ten years. To ensure that scientists are kept up to date, the editors of the First Edition of The Lipid Handbook have completely reviewed and extensively revised their highly successful original work. The Lipid Handbook: Second Edition is an indispensable resource for anyone working with oils, fats, and related substances.
This book provides a new direction in electronics research with the invention of a new material tuPOY, which changes our perception of developing electronics. Evolving on a relatively underplayed phenomenon of static electricity in scientific exploration and application, tuPOY upholds the potential to rival both silicon and metals as electronics of the future. Devices made of tuPOY present a new emblem to the technological world, where we could envision our electronic paraphernalia from a completely different perspective. A computer the size of a big wall, which could be neatly folded and kept in our pockets when not in use and laundered on a regular basis, can be imagined possible with this invention. The concept, manufacturing process, physics and uses of tuPOY as the next generation material of electronics is described in this book. The book covers the production process of tuPOY and goes on to conceptual advancement from manipulating the sensing, radiating and processing properties of tuPOY. Theoretical modelling of tuPOY is characterized by steady-state equations exploiting interchanges based on the lattice kinetics, which mathematizes an Interchange Phenomenon in tuPOY. The numerical manifestations calibrate mathematically, tuPOY’s response to any external physical impetus such as charge, heat or energy flow. The book validates the sensing properties and theoretical model by designing a tuPOY sensor which can be used in a plethora of applications. A novel microstrip antenna is designed by amalgamation of tuPOY, raw silk and polynylon composites to experimentally verify the radiation properties of the new material. The conduction properties are verified by drawing fibres of tuPOY and using them as wires and connectors in electronics. A Power Generating Unit (PGU) is designed with tuPOY as its primary element. This is a first of its kind PGU that scavenges power from thermal energy presenting a new dimension in operational power dynamics. Overall this book should be of interest to a wide range of readers ranging from researchers, scientists, developers, manufacturers, engineers, graduate students and anyone who has satiety to think differently.
Few who appreciate the visual arts or the American Southwest can behold the masterpieces Sangre de Cristo Mountains or Haystack, Taos Valley, 1927 or Bend in the River, 1941 and come away without a vivid image burned into memory. The creator of these and many other depictions of the Southwest and its people was Ernest L. Blumenschein, cofounder of the famous Taos art colony. This insightful, comprehensive biography examines the character and life experiences that made Blumenschein one of the foremost artists of the twentieth century. Robert W. Larson and Carole B. Larson begin their life of “Blumy” with his Ohio childhood and trace his development as an artist from early study in Cincinnati, New York City, and Paris through his first career as a book and magazine illustrator. Blumenschein and artist Bert G. Phillips discovered the budding art community of Taos, New Mexico, in 1898. In 1915 the two along with Joseph Henry Sharp, E. Irving Couse, and other like-minded artists organized the Taos Society of Artists, famous for preferring American subjects over European themes popular at the time. Leaving illustration work behind, Blumenschein sought a distinctive place in his American homeland and in fine-art painting. He moved with his family to Taos in 1919 and began his long career as a figurative and landscape painter, becoming prominent among American artists for his Pueblo Indian figures and stunning southwestern landscapes. Robert Larson calls Blumenschein a “transformational artist,” trained classically but drawing to a limited degree on abstract representation. Placing Blumy’s life in the context of World War I, the Great Depression, and other national and world events, the authors show how an artistic genius turned a fascination with the people, light, and color of New Mexico into a body of work of lasting significance to the international art world.
Upon his retirement from active service as a Justice of the Supreme Court of Virginia in 2011, Justice Koontz had completed more than four decades of service to citizens of the Commonwealth of Virginia. In order to recognize that service and help preserve Justice Koontz legacy as one of the outstanding jurists in Virginia and the United States, the Salem/Roanoke County Bar Association instituted this project to collect all of Justice Koontz's published opinions, both from his tenure as a Justice of the Supreme Court and as an inaugural member of the Court of Appeals of Virginia. The fifth volume to be produced by the Opinions Project includes opinions, concurrences and dissents authored by Justice Koontz during the middle years of his service as a Justice of the Supreme Court of Virginia. It is dedicated to the honor of Harry Lee Carrico, the long-time Chief Justice of the Court who retired during the time of the reports contained in the volume.
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