Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.
Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.
A courageous, comprehensive and no-holds-barred account, by a veteran journalist, of a 66-year-old nation that is still trying to find its identity and fighting its own demons Beginning with the ‘genetic defect’ that Pakistan was born with, Babar Ayaz highlights the numerous problems faced by Pakistan today that have arisen as a result of the country’s foundation being based on religion. What Quaid-e-Azam Muhammad Ali Jinnah managed to achieve as a separate homeland in August 1947 is today being consumed by religious fanaticism. Ayaz attributes such a state of affairs to the Islamization of Pakistani laws, which are in conflict with the twenty-first century value systems. The author next pinpoints how Jinnah failed to recognize the ethno-linguistic diversity of the Pakistan he had created, which needed proper distribution of power between the Centre and the states in the then-existent West Pakistan and East Pakistan. He describes how the centralization of power and the imposition of a single language for both wings of the country led to the dismemberment of Pakistan and the creation of Bangladesh in 1971. The book also analyzes the ‘unwritten national security policy’ of Pakistan and how it has dictated its foreign policy. Relations with the US, India, China, Saudi Arabia, Iran and Afghanistan are discussed vis-à-vis the overall national security policy. The author contends that the rise of fundamentalism is a global phenomenon, but in Pakistan, it has given birth to a plethora of Islamic militant groups covertly supported by the Pakistani intelligence services. Pakistan has been branded as ‘the most dangerous state of the world’ and the ‘epicentre of terrorism’. He laments the fact that attempts to present the peaceful side of Islam are extremely feeble because of the dominance of the pro-jihad elements, which are pushing the country into a civil war-like situation. In spite of several years of attempts at indoctrination of the people through mass media and educational institutions, in Pakistan, the anti-Indian feelings and extreme stands on Kashmir have been limited. Ayaz believes that India and the developed world would have to help by being more accommodating and understanding, so that the people of Pakistan can re-invent their country. Without moving towards secularism, the author warns, Pakistan will remain at war with itself as it is torn between the twenty-first century and medieval religious value systems.
“He is exactly what this age needs, a real voice of universal spirituality. His appeal is urgent, human and sacred.” DAN CRUSEY Sidney, Ohio “Each era has its own prophet poets. Russia has been praying and is praying poems by Pushkin, a holy name for every Russian. Ayaz seems to touch us with that sensitivity, inspiring and changing the rhythm of our breathing.” SEBARITA KAKHOVSKAYA Ukraine “His words transform you through a subtle Alchemy process, and; you suddenly travel from a Neophyte to the Connoisseur of Mysteries. His poetry is a gateway to the stars!” ELLURA ZURIA Rhön, Germany “Reading Ayaz is akin to a journey into the mysterious ‘East’ where tradition and values are interwoven intricately into grand imagery. His words capture one’s heart in a time capsule, holding it there to ache for more.” CHERRY ANDAYA POLISTICO Bacoor, Philippines “It so opens the windows of our hearts, that the walls appear as mere illusion.” JANET LIA AWE Studio, Seattle “A fresh breath of cosmic air. Full of wisdom – earthly and esoteric.” ISRAEL BERGER Rehovot, Israel “A journey into the heart of existence. I read, and meet the Beloved everywhere along!” MEIKE SCHÜTT Tyagarah, NSW, Australia “He has challenged my perspective on life and love.” PAUL BOHANNON Fort Bragg, California "It reads and feels like a new Upanishad." Sharon Rea Swansea, United Kingdom “Glistening in the Sun – A Diamond, Ruby, and Rose Quartz ALL in ONE!” Elyse Simon Narragansett, Rhode Island “Ayaz brings us water – a drop, a cup, a waterfall. It depends upon the size of your vessel. Words are weapons, or merely pointing pathways. He will point you home. You are Home!” GENEVIEVE G. JONES Melbourne, Australia
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