Avital Schurr's Books

Cerebral Ischemia and Resuscitation

By: Avital Schurr,Benjamin M. Rigor

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Cerebral Ischemia and Resuscitation

By: Avital Schurr,Benjamin M. Rigor

This fascinating monograph is filled with information formerly found only in periodicals and symposia proceedings. Chapters discuss the different models of cerebral ischemia in use today, including their advantages and disadvantages. This one-of-a-kind resource also contains essential chapters on cellular mechanisms of ion and acid-base homeostases, and energy metabolism of the ischemic brain. It reviews the possible role of lipids, free fatty acids, and free radicals. Four chapters are devoted to neurotransmitters and neuroregulators in cerebral ischemia. This extraordinary work also covers aspects of protection against and resuscitation from cerebral ischemia. An extremely informative volume, this book is an absolute must for every student in the field of cerebral ischemia, as well as the clinician or scientist who is already involved with this worldwide problem.

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Page Count

456

Publisher

CRC Press

Published Date

ISBN 10

0849367158

ISBN 13

9780849367151

Brain Slices in Basic and Clinical Research

By: Avital Schurr,Benjamin M. Rigor

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Brain Slices in Basic and Clinical Research

By: Avital Schurr,Benjamin M. Rigor

Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following: Mechanisms of synaptic plasticity as the basis of memory processes Chaos and synaptic variability Brain calcium currents Glutamate receptors Pathophysiology of excitotoxins Cerebral hypoxia-ischemia Neuronal injury Free radicals Optical methods of measuring brain metabolism Voltammetry in brain slices Calcium imaging Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices Intracellular double labeling of various neuronal populations Use of brain slices in teaching neurophysiological methods Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.

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355

Publisher

CRC Press

Published Date

ISBN 10

1000714357

ISBN 13

9781000714357

Cerebral Ischemia and Resuscitation

By: Avital Schurr,Benjamin M. Rigor

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Cerebral Ischemia and Resuscitation

By: Avital Schurr,Benjamin M. Rigor

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N/A

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Solve jigsaw puzzle

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Page Count

456

Publisher

CRC Press

Published Date

ISBN 10

0849367158

ISBN 13

9780849367151

Glycolysis at 75: Is it Time to Tweak the First Elucidated Metabolic Pathway in History?

By: Avital Schurr,Evelyne Gozal

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Glycolysis at 75: Is it Time to Tweak the First Elucidated Metabolic Pathway in History?

By: Avital Schurr,Evelyne Gozal

Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. Accordingly, two outcomes of this pathway were proposed, an aerobic glycolysis, with pyruvate as its final product, and an anaerobic glycolysis, identical to the aerobic one, except for an additional reaction, where pyruvate is reduced to lactate. Several studies in the 1980s have shown that both muscle and brain tissues can oxidize and utilize lactate as an energy substrate, challenging this monocarboxylate’s reputation as a useless end-product of anaerobic glycolysis. These findings were met with great skepticism about the idea that lactate could be playing a role in bioenergetics. In the past quarter of a century monocarboxylate transporters (MCTs) were identified and localized in both cellular and mitochondrial membranes. A lactate receptor has been identified. Direct and indirect evidence now indicate that the enzyme lactate dehydrogenase (LDH) resides not only in the cytosol, as part of the glycolytic pathway machinery, but also in the mitochondrial outer membrane. The mitochondrial form of the enzyme oxidizes lactate to pyruvate and concomitantly produces the reducing agent NADH. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway i.e., its inability to regenerate NAD+, as opposed to anaerobic glycolysis that features the cyclical ability of regenerating NAD+ upon pyruvate reduction to lactate by the cytosolic form of LDH. The malate-aspartate shuttle (MAS), a major redox shuttle in the brain, was proposed as an alternative pathway for NAD+ generation for aerobic glycolysis. Nonetheless, would MAS really be necessary for that function if glycolysis always proceeds to the end-products, lactate and NAD+? An additional dilemma the originally proposed aerobic glycolysis presents has to do with the glycolytic pathway of erythrocytes, which despite its highly aerobic environment, always produces lactate as its end-product. It is time to reexamine the original, dogmatic separation of glycolysis into two distinct pathways and put to test the hypothesis of a unified, singular pathway, the end-product of which is lactate, the real substrate of the mitochondrial TCA cycle.

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Page Count

128

Publisher

Frontiers Media SA

Published Date

ISBN 10

2889195864

ISBN 13

9782889195862

Brain Slices in Basic and Clinical Research

By: Avital Schurr,Benjamin M. Rigor

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Brain Slices in Basic and Clinical Research

By: Avital Schurr,Benjamin M. Rigor

Average ratings

N/A

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Solve jigsaw puzzle

Age

Page Count

355

Publisher

CRC Press

Published Date

ISBN 10

1000714357

ISBN 13

9781000714357

Book's by Avital Schurr

Cerebral Ischemia and Resuscitation

Cerebral Ischemia and Resuscitation

Brain Slices in Basic and Clinical Research

Brain Slices in Basic and Clinical Research

Cerebral Ischemia and Resuscitation

Cerebral Ischemia and Resuscitation

Glycolysis at 75: Is it Time to Tweak the First Elucidated Metabolic Pathway in History?

Glycolysis at 75: Is it Time to Tweak the First Elucidated Metabolic Pathway in History?

Brain Slices in Basic and Clinical Research

Brain Slices in Basic and Clinical Research

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