Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
To reduce the emissions of greenhouse gasses and maintain environmental sustainability, electric vehicles play a vital role in a modern energy-efficient environment. Permanent magnet synchronous motors (PMSMs) are widely employed in electric vehicle technology due to their high dynamic response, better torque-speed characteristics, noiseless operation, high power density, high efficiency and power factor as compared to other conventional motor drives. This book demonstrates the development of various control strategies and illustrates the dynamic performance intensification of a PMSM drive. To ensure the faster dynamic behaviour and flexibility in control under various operating conditions, the performance of a PMSM drive has been explained. Finally, control strategies have been executed through mathematical modelling and illustration of several case studies for optimal operation. Features: Introduces performance indicators in a self-controlled PMSM machine to justify the dynamic behaviour Discusses comparative performance study and optimization of the drive performance Provides a detailed comparative performance analysis between classical and fuzzy logic controllers in a PMSM drive Includes illustrations and case studies using mathematical modelling and real-time test results Discusses the state of the art in solar-powered energy-efficient PMSM drives with various issues This book is aimed at researchers, graduate students and libraries in electrical engineering with specialization in electric vehicles.
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