Arthur Horwich's Books

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

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Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

By: Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a 'clamp' or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

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Page Count

328

Publisher

World Scientific

Published Date

ISBN 10

9814749346

ISBN 13

9789814749343

The Constitutive A Priori

Developing and Extending an Epistemological Framework

By: Arthur Sullivan

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The Constitutive A Priori

Developing and Extending an Epistemological Framework

By: Arthur Sullivan

The question of the a priori—can an adequate epistemology be developed without appeal to a non-empirical source of justification?—is a core issue running throughout the history of philosophy, and recent decades have seen some provocative and potentially epochal work on the issue. Arthur Sullivan provides a clear-headed evaluation of the upshot of these developments. He argues that the notion of the constitutive a priori provides the best means, all things considered, of accommodating these recent developments into a coherent, compelling view. The constitutive a priori is most commonly known as a position within the philosophy of science, holding that one of Kant’s signature moves provides the means to incorporate unforeseen drastic shocks into existing theory. This book shows that this notion of the constitutive a priori provides not merely a satisfactory epistemological framework, but, further, a compelling way to accommodate and integrate some of the most significant lessons learned in twentieth century philosophy. Its distinctive contribution lies in the case it builds for taking this constitutive a priori orientation as a good means of integrating and consolidating certain epochal insights of Wittgenstein, Carnap, Quine, Kripke, and Kaplan.

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Page Count

203

Publisher

Lexington Books

Published Date

ISBN 10

1498547125

ISBN 13

9781498547123

Historical Directory of Trade Unions

Volume 4, Including Unions in Cotton, Wood and Worsted, Linen and Jute, Silk, Elastic Web, Lace and Net, Hosiery and Knitwear, Textile Finishing, Tailors and Garment Workers, Hat and Cap, Carpets and Textile Engineering

By: Arthur Marsh,Victoria Ryan

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Historical Directory of Trade Unions

By: Arthur Marsh,Victoria Ryan

Despite widespread interest in the trade union movement and its history, it has never been easy to trace the development of individual unions, especially those now defunct, or where name changes or mergers have confused the trail. In this respect the standard histories and industrial studies tend to stimulate curiosity rather than satisfy it. When was a union founded? When did it merge or dissolve itself, or simply disappear? What records survive and where can further details of its history be found? These are the kinds of question the Directory sets out to answer. Each entry is arranged according to a standard plan, as follows: 1. Name of union; 2. Foundation date: Name changes (if any) and relevant dates. Any amalgamation or transfer of engagements. Cessation, winding up or disappearance, with date and reasons where appropriate and available; 3. Characteristics of: membership, leadership, policy, outstanding events, membership (numbers). 4. Sources of information: books, articles, minutes etc; location of documentation.

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Page Count

572

Publisher

Taylor & Francis

Published Date

ISBN 10

1040289509

ISBN 13

9781040289501

The Shaky Game

Einstein Realisn and the Quantum Theory

By: Arthur Fine

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The Shaky Game

Einstein Realisn and the Quantum Theory

By: Arthur Fine

In this new edition, Arthur Fine looks at Einstein's philosophy of science and develops his own views on realism. A new Afterword discusses the reaction to Fine's own theory. "What really led Einstein . . . to renounce the new quantum order? For those interested in this question, this book is compulsory reading."—Harvey R. Brown, American Journal of Physics "Fine has successfully combined a historical account of Einstein's philosophical views on quantum mechanics and a discussion of some of the philosophical problems associated with the interpretation of quantum theory with a discussion of some of the contemporary questions concerning realism and antirealism. . . . Clear, thoughtful, [and] well-written."—Allan Franklin, Annals of Science "Attempts, from Einstein's published works and unpublished correspondence, to piece together a coherent picture of 'Einstein realism.' Especially illuminating are the letters between Einstein and fellow realist Schrödinger, as the latter was composing his famous 'Schrödinger-Cat' paper."—Nick Herbert, New Scientist "Beautifully clear. . . . Fine's analysis is penetrating, his own results original and important. . . . The book is a splendid combination of new ways to think about quantum mechanics, about realism, and about Einstein's views of both."—Nancy Cartwright, Isis

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Page Count

233

Publisher

University of Chicago Press

Published Date

ISBN 10

0226923266

ISBN 13

9780226923260

Sensory Neuropathies

By: Arthur K. Asbury

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Sensory Neuropathies

By: Arthur K. Asbury

While motor neuropathies and neuronopathies and mixed sensory-motor neuropathies have been met with adequate interest by clinical and basic researchers and physicians, pure sensory neuropathies and neuro nopathies have received comparably less attention, despite of the consider able morbidity they may cause in the individual patient. This prompted us to organize an International Symposium on Sensory Neuropathies which was held in Vienna, September 22-24,1990, as satellite to the International Neuromuscular Congress held one week earlier in Munich, Germany. We were fortunate to have a faculty of experienced authorities in the field as participants. This volume is the proceedings of the symposium. Due to factors which were beyond our control, publication of this volume was significantly delayed. Despite the enormous progress of biomedicine in recent years, most prominently in molecular biology, we feel that the contributions of this volume still represent a valuable reference for clinical, physiological, biochemical and pathomorphological studies on the sensory nervous system for which similarly comprehensive data are difficult to locate. November 1994 Arthur K Asbury Herbert Budka ElJriede Sluga Contents Contributors 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 IX 1.

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Page Count

228

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3211826424

ISBN 13

9783211826423

Reference and Structure in the Philosophy of Language

A Defense of the Russellian Orthodoxy

By: Arthur Sullivan

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Reference and Structure in the Philosophy of Language

A Defense of the Russellian Orthodoxy

By: Arthur Sullivan

This volume investigates the precise contours of the connections between two foundational concepts: reference (the means of semantically expressing singular or object-dependent information) and structure (the having or lacking of meaningful sub-parts). Sullivan shows that the notion of structure, properly excavated, underlies and grounds various important points in the theory of reference. As such, this work builds on and further develops work by Bertrand Russell, Saul Kripke, David Kaplan, and Stephen Neale - principally, among many others. Sullivan aims to clearly establish the intrinsic connections between structure and reference, which brings into focus informative and explanatory connections underlying otherwise disparate debates about various aspects of linguistic communication. The overall result is a simple, comprehensive lens that can help to clarify a wide range of semantic phenomena.

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Page Count

169

Publisher

Routledge

Published Date

ISBN 10

0415634008

ISBN 13

9780415634007

The Reality of Time Flow

Local Becoming in Modern Physics

By: Richard T. W. Arthur

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The Reality of Time Flow

Local Becoming in Modern Physics

By: Richard T. W. Arthur

It is commonly held that there is no place for the 'now’ in physics, and also that the passing of time is something subjective, having to do with the way reality is experienced but not with the way reality is. Indeed, the majority of modern theoretical physicists and philosophers of physics contend that the passing of time is incompatible with modern physical theory, and excluded in a fundamental description of physical reality. This book provides a forceful rebuttal of such claims. In successive chapters the author explains the historical precedents of the modern opposition to time flow, giving careful expositions of matters relevant to becoming in classical physics, the special and general theories of relativity, and quantum theory, without presupposing prior expertise in these subjects. Analysing the arguments of thinkers ranging from Aristotle, Russell, and Bergson to the proponents of quantum gravity, he contends that the passage of time, understood as a local becoming of events out of those in their past at varying rates, is not only compatible with the theories of modern physics, but implicit in them.

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Page Count

294

Publisher

Springer

Published Date

ISBN 10

3030159485

ISBN 13

9783030159481

Protein NMR Spectroscopy

Principles and Practice

By: John Cavanagh,Wayne J. Fairbrother,Arthur G. Palmer III,Nicholas J. Skelton

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Protein NMR Spectroscopy

Principles and Practice

By: John Cavanagh,Wayne J. Fairbrother,Arthur G. Palmer III,Nicholas J. Skelton

Protein NMR Spectroscopy: Principles and Practice combines a comprehensive theoretical treatment of high resolution NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules. Beginning with simple theoretical models and experimental techniques, Protein NMR Spectroscopy: Principles and Practice develops the complete repertoire of theoretical principals and experimental practices necessary for understanding and implementing the most sophisticated NMR experiments. Protein NMR Spectroscopy: Principles and Practice is written as a graduate-level textbook and will be of particular interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy as a research tool or who wish to remain abreast of the latest developments in this increasingly important area.* Special Features: * First book to combine detailed NMR theory discussions with experimental applications to biomolecules.* All the theory required to understand these experiments and others.* Easy to follow progression from a fundamental level to an advanced level.* Theory of NMR and practical applications for biomolecular investigations presented.* Theory applied to very practical situations.* Comprehensive treatment of different "levels" of theory from simple ideas to density matrix analysis and operator practices.* Comprehensive description of multi dimensional NMR experiments as applied to unlabeled, 15N-labeled and doubly (13C/15N) labeled proteins.

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Page Count

915

Publisher

Elsevier

Published Date

ISBN 10

0080515290

ISBN 13

9780080515298

Whiplash Injuries

The Cervical Acceleration/deceleration Syndrome

By: Stephen M. Foreman,Arthur C. Croft

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Whiplash Injuries

The Cervical Acceleration/deceleration Syndrome

By: Stephen M. Foreman,Arthur C. Croft

Written by two leading chiropractic authorities, this Third Edition helps the reader understand, assess, diagnose, and treat whiplash injuries (cervical acceleration/deceleration syndrome). The text reviews the developmental anatomy and underlying anatomy associated with the syndrome and examines biomechanics related to whiplash. In addition, the book covers assessment techniques including clinical radiographic examinations such as MRI and CT.

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Page Count

616

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

0781726816

ISBN 13

9780781726818

Chemistry

Decade by Decade

By: Arthur Greenberg

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Chemistry

Decade by Decade

By: Arthur Greenberg

Presents a history of chemistry, providing definitions and explanations of related topics, plus brief biographies of scientists of the 20th century.

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Page Count

497

Publisher

Infobase Publishing

Published Date

ISBN 10

1438109784

ISBN 13

9781438109787

Book's by Arthur Horwich

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

Structure And Action Of Molecular Chaperones: Machines That Assist Protein Folding In The Cell

The Constitutive A Priori

The Constitutive A Priori

Historical Directory of Trade Unions

Historical Directory of Trade Unions

The Shaky Game

The Shaky Game

Sensory Neuropathies

Sensory Neuropathies

Reference and Structure in the Philosophy of Language

Reference and Structure in the Philosophy of Language

The Reality of Time Flow

The Reality of Time Flow

Protein NMR Spectroscopy

Protein NMR Spectroscopy

Whiplash Injuries

Whiplash Injuries

Chemistry

Chemistry

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