This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a knock-in mouse that expresses a mutated form of A20 which selectively lacks the deubiquitinase activity. The knock-in mice surprisingly display completely normal NF-κB activation with no accompanying inflammatory phenotype. Given that the presumed role of A20 as a deubiquitinase has been used to support the importance of regulatory K63-linked ubiquitination in NF-kB signaling, this study will help focus future research efforts into alternative target pathways that do not depend on K63 ubiquitination. In fact, the work suggests that it might be important to revisit the role of K63-linked polyubiquitination in cell-signalling. Ubiquitin Chains: Degradation and Beyond is essential reading for anyone conducting research in cell-signalling and immunology. Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted in multiple patents and publications in peer reviewed journals. He presented his findings at the American Peptide Symposium and was awarded the Young Investigator’s Award. He is the author of the book entitled Application of Peptide-Based Prodrug Chemistry in Drug Development, with a foreword written by Professor Jean Martinez (Former President, European Peptide Society) and published in the series SpringerBriefs in Pharmaceutical Science & Drug Development. His research interests lie at the intersection of chemistry and medicine. Besides biomedical research, he is also generally interested in public health policy and general scientific outreach.
Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However it’s short duration of action (half-life of 2 minutes in plasma) precludes its therapeutic use. In this volume, the use of novel therapeutics like GLP1 as an alternative to tradition insulin-based drugs in diabetes is described. Application of Peptide-Based Prodrug Chemistry in Drug Development elucidates the traditional concept of prodrugs as “specialized non-toxic protective groups used in a transient manner to alter or to eliminate certain limiting properties in the parent small molecule” (IUPAC definition). It goes on to provide insight into how prodrugs of peptides (with GLP1 as an example) could be appropriately used to extend the biological half life, broaden the therapeutic index of macromolecules and improve the pharmacodynamics of such drugs. Author explains the logic behind designing peptide prodrugs, synthetic procedures and bioassays to examine the conversion of the prodrug to the drug under therapeutic conditions. The prodrugs described slowly convert to the parent drug at physiological conditions of 37C and pH 7.2 driven by their inherent chemical instability without the need of any enzymatic cleavage. The diketopiperazine and diketomorpholine (DKP and DMP) strategies for prodrug conversion are demonstrated in detail with special emphasis on the chemical flexibility that it offers to develop prodrugs with variable time actions. This book will be of useful to chemists, biochemists, medicinal chemists, biologists and people in the medical profession (doctors). It may be used in undergraduate classes but will certainly help post-graduate students and advanced professionals. The author is grateful to Prof. Richard DiMarchi (Standiford H. Cox Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University) for valuable suggestions. The foreword for the book has been written by Prof. Jean Martinez, (Legion d'Honneur awarded by the French Republic; Professor of Chemistry and Medicinal Chemistry of the University of Montpellier, France; and Chairman of European Peptide Society, 2002-2010).
Thorough Understanding Of Inorganic Chemistry And Also Inorganic Analysis Are Best Achieved Through Rigourous Processes Of Problems And Exercises. This Provides The Students With Clear Concepts Of The Subject Matter In Their Proper Perspective. This New Edition, Thoroughly Recast And Updated, Will Equip The Students With Modern Concepts Of Inorganic Chemistry As Well As Inorganic Analysis, So That They Can Face The Challenges Of The New Century In Shaping Their Future Career In The Best Possible Manner.This Book, In Combination With Its Parent Volume: A Textbook Of Inorganic Chemistry3⁄4A.K. De, 9Th Ed. (2003), New Age International Is Destined To Satisfy The Challenging Requirements Of B.Sc. Hons./Major Students Of Indian Universities And Also Net (Csir-Ugc), Gate (Iits) And Slet Examinees.
The brief is the first to focus exclusively on environmentally friendly delivery of pesticides (controlled-release nanoparticulate formulation of pesticides using biodegradable polymers as carriers). The brief also introduces pesticides like Chlorpyrifos and biodegradable polymers like guar-gum. The brief will be extremely useful to the researchers in the field of agrochemicals and will be equally useful for advanced professionals in the field of biology, chemistry, environmental biology, entomology and horticulture.
It is frequently observed that most decision-making problems involve several objectives, and the aim of the decision makers is to find the best decision by fulfilling the aspiration levels of all the objectives. Multi-objective decision making is especially suitable for the design and planning steps and allows a decision maker to achieve the optimal or aspired goals by considering the various interactions of the given constraints. Multi-Objective Stochastic Programming in Fuzzy Environments discusses optimization problems with fuzzy random variables following several types of probability distributions and different types of fuzzy numbers with different defuzzification processes in probabilistic situations. The content within this publication examines such topics as waste management, agricultural systems, and fuzzy set theory. It is designed for academicians, researchers, and students.
This textbook develops astrophysics from the basics without requiring any previous study in astronomy or astrophysics. Physical concepts,mathematical derivations and observational data are combined in a balanced way to provide a unified treatment"--Provided by publisher.
A good working knowledge of fluid mechanics and plasma physics is essential for the modern astrophysicist. This graduate textbook provides a clear, pedagogical introduction to these core subjects. Assuming an undergraduate background in physics, this book develops fluid mechanics and plasma physics from first principles. This book is unique because it presents neutral fluids and plasmas in a unified scheme, clearly indicating both their similarities and their differences. Also, both the macroscopic (continuum) and microscopic (particle) theories are developed, establishing the connections between them. Throughout, key examples from astrophysics are used, though no previous knowledge of astronomy is assumed. Exercises are included at the end of chapters to test the reader's understanding. This textbook is aimed primarily at astrophysics graduate students. It will also be of interest to advanced students in physics and applied mathematics seeking a unified view of fluid mechanics and plasma physics, encompassing both the microscopic and macroscopic theories.
This book provides the first comprehensive introduction to multi-agent, multi-choice repetitive games, such as the Kolkata Restaurant Problem and the Minority Game. It explains how the tangible formulations of these games, using stochastic strategies developed by statistical physicists employing both classical and quantum physics, have led to very efficient solutions to the problems posed. Further, it includes sufficient introductory notes on information-processing strategies employing both classical statistical physics and quantum mechanics. Games of this nature, in which agents are presented with choices, from among which their goal is to make the minority choice, offer effective means of modeling herd behavior and market dynamics and are highly relevant to assessing systemic risk. Accordingly, this book will be of interest to economists, physicists, and computer scientists alike.
Filling the gap for an up-to-date textbook in this relatively new interdisciplinary research field, this volume provides readers with a thorough and comprehensive introduction. Based on extensive teaching experience, it includes numerous worked examples and highlights in special biographical boxes some of the most outstanding personalities and their contributions to both physics and economics. The whole is rounded off by several appendices containing important background material.
This is the first volume to focus specifically on Rabindranath Tagore’s dramatic literature, visiting translations and adaptations of Tagore’s drama, and cross-cultural encounters in his works. As Asia’s first Nobel Laureate, Tagore’s highly original plays occupy a central position in the Indian theatrescape. Tagore experimented with dance, music, dance drama, and plays, exploring concepts of environment, education, gender and women, postcolonial encounters, romantic idealism, and universality. Tagore’s drama plays a generous host to experimentations with new performance modes, like the writing and staging of an all-women play on stage for the first time, or the use of cross-cultural styles such as Manipuri dance, Thai craft in stage design, or the Baul singing styles. This book is an exciting re-exploration of Tagore’s plays, visiting issues such as his contribution to Indian drama, drama and environment, feminist readings, postcolonial engagements, cross-cultural encounters, drama as performance, translational and adaptation modes, the non-translated or the non-translatable Tagore drama, Tagore drama in the 21st century, and Indian film. The volume serves as a wide-ranging and up-to-date resource on the criticism of Tagore drama, and will appeal to a range of Theatre and Performance scholars as well as those interested in Indian theatre, literature, and film.
IN THIS VOLUME: ‘Sagara Manthan’: Make in India Transition | Lt Gen JS Bajwa “Our vision in next 10 years is to become top defence industry in the world...” | Interview by Danvir Singh Indian Airborne Troops Script History | Danvir Singh Submarine Ahoy – Whither to Bound? | Rear Adm AP Revi Aerospace and Defence News | Priya Tyagi Higher Defence Organisation for India: Towards an Integrated Approach | Maj Gen Rajiv Narayanan Indian Army: Adopting ‘Deep Operations’ Doctrine | Col JK Achuthan The Government’s Burden of Military Security | Lt Gen Gautam Banerjee Global Terrorism: An Analysis of Fault Lines and Risks | Maj Gen SB Asthana Tackling Global Terror | Anil Kumar Tandale Islamic State: The New Brand of Terrorism in India | V Balasubramaniyan India & China Territorial Dispute: The Growing Challenge | Brig Gurmeet Kanwal China-India-Myanmar: The Forgotten Frontier | Air Cmde PC Chopra Myanmar and India: A New Future | Maj Gen Nitin P Gadkari Airfield Security: Lessons for the IAF | Air Marshal Anil Chopra Acoustic Capacity Building in the Indian Ocean Region | Cdr (Dr) Arnab Das & Vice Adm DSP Varma Transportation Infrastructure in the North East | Air Marshal Dhiraj Kukreja Our Forgotten Wars: Victimisation and Survival in Bodoland | Dr Samrat Sinha Women Officers in the Indian Army: A Reality Check | Lt Gen Mukesh Sabharwal Socio Economic Transformation: Through Ex-Servicemen | Lt Gen SK Gadeock & Col Nishant Sharma DPP 2016: A Missed Opportunity | Dr SN Misra Defence Budget 2016: Hits and Misses for the IAF | Air Marshal Anil Chopra Privatisation of the Indian Aerospace Industry: Problems and Prospects | Gp Capt AK Sachdev The Patrol Leader | Sumit Walia
Survey Sampling Theory and Applications offers a comprehensive overview of survey sampling, including the basics of sampling theory and practice, as well as research-based topics and examples of emerging trends. The text is useful for basic and advanced survey sampling courses. Many other books available for graduate students do not contain material on recent developments in the area of survey sampling. The book covers a wide spectrum of topics on the subject, including repetitive sampling over two occasions with varying probabilities, ranked set sampling, Fays method for balanced repeated replications, mirror-match bootstrap, and controlled sampling procedures. Many topics discussed here are not available in other text books. In each section, theories are illustrated with numerical examples. At the end of each chapter theoretical as well as numerical exercises are given which can help graduate students. Covers a wide spectrum of topics on survey sampling and statistics Serves as an ideal text for graduate students and researchers in survey sampling theory and applications Contains material on recent developments in survey sampling not covered in other books Illustrates theories using numerical examples and exercises
Game Science in Hybrid Learning Spaces explores the potential, implications, and impact of game-based approaches and interventions in response to the blurring of boundaries between digital and physical as well as formal and informal learning spaces and contexts. The book delves into the concept, opportunities, and challenges of hybrid learning, which aims to reduce the barriers of time and physical space in teaching and learning practices, fostering seamless, sustained, and measurable learning experience and outcomes beyond the barriers of formal education and physical learning contexts. Based on original research, Game Science in Hybrid Learning Spaces establishes trans-disciplinary and holistic considerations for further conceptual and empirical investigation into this topic, with the dual goals of a better understanding of the role of game-based approaches in a blended environment and of the possible structural and cultural transformation of formal education and lifelong learning. This book is an essential guide for researchers, designers, teachers, learners, and practitioners who want to better understand the relationship between games and learning that merges digital and physical experiences and blends formal and informal instructions.
This book introduces important results and techniques in property testing, where the goal is to design algorithms that decide whether their input satisfies a predetermined property in sublinear time, or even in constant time – that is, time is independent of the input size. This book consists of three parts. The first part provides an introduction to the foundations of property testing. The second part studies the testing of specific properties on strings, graphs, functions, and constraint satisfaction problems. Vectors and matrices over real numbers are also covered. The third part is more advanced and explains general conditions, including full characterizations, under which properties are constant-query testable. The first and second parts of the book are intended for first-year graduate students in computer science. They should also be accessible to undergraduate students with the adequate background. The third part can be used by researchers or ambitious graduate students who want to gain a deeper theoretical understanding of property testing.
The 11-year cycle of sunspots is one of the most intriguing natural cycles known to mankind. This book explores the fascinating science behind these phenomena and gives an insider's view of the history of the field.
Fundamentals of Database Indexing and Searching presents well-known database searching and indexing techniques. It focuses on similarity search queries, showing how to use distance functions to measure the notion of dissimilarity.After defining database queries and similarity search queries, the book organizes the most common and representative ind
This textbook provides a comprehensive one-semester course on advanced electromagnetic theory written from the modern perspective covering all important topics that a professional physicist needs to know. Starting from Maxwell's equations, electrostatics and magnetostatics, this book goes on to discuss such topics as relativistic electrodynamics, emission of electromagnetic radiation and plasma physics. It contains solved examples and exercises for students to highlight the concepts in each chapter.
Back for a second edition, Current Surgical Guidelines has been fully updated to reflect changes in guidelines across the surgical sub-specialities since its first publication. Drawing together printed and digital guidelines from the Scottish Intercollegiate Guidelines Network (SIGN), the National Institute for Health and Clinical Excellence (NICE), and relevant US guidelines, this book acts as a valuable complete and comprehensive reference for those embarking on their surgical training, revising for exams, or for senior staff as an aide-memoire. Guidelines have been distilled into summary tables, and topics are formulated to answer most real-life clinical practice questions with contemporary facts and figures, decision recommendations, and treatment options. New chapters on hernias, skin malignancies, trauma, and medicolegal practice have been added to increase fresh challenges facing the contemporary surgical trainee.
Arnab Dey examines the intersecting role of law, ecology, and agronomy in shaping the history of tea and its plantations in British east India. He suggests that looking afresh at the legal, environmental, and agro-economic aspects of tea production illuminate covert, expedient, and often illegal administrative and commercial dealings that had an immediate and long-term human and environmental impact on the region. Critiquing this imperial commodity's advertised mandate of agrarian modernization in colonial India, Dey points to numerous tea pests, disease ecologies, felled forests, harsh working conditions, wage manipulation, and political resistance as examples of tea's unseemly legacy in the subcontinent. Dey draws together the plant and the plantation in highlighting the ironies of the tea economy and its consequences for the agrarian history of eastern India.
The cybersecurity of connected medical devices is one of the biggest challenges facing healthcare today. The compromise of a medical device can result in severe consequences for both patient health and patient data. Cybersecurity for Connected Medical Devices covers all aspects of medical device cybersecurity, with a focus on cybersecurity capability development and maintenance, system and software threat modeling, secure design of medical devices, vulnerability management, and integrating cybersecurity design aspects into a medical device manufacturer's Quality Management Systems (QMS). This book is geared towards engineers interested in the medical device cybersecurity space, regulatory, quality, and human resources specialists, and organizational leaders interested in building a medical device cybersecurity program. Lays out clear guidelines for how to build a medical device cybersecurity program through the development of capabilities Discusses different regulatory requirements of cybersecurity and how to incorporate them into a Quality Management System Provides a candidate method for system and software threat modelling Provides an overview of cybersecurity risk management for medical devices Presents technical cybersecurity controls for secure design of medical devices Provides an overview of cybersecurity verification and validation for medical devices Presents an approach to logically structure cybersecurity regulatory submissions
Multiscale Modeling for Process Safety Applications is a new reference demonstrating the implementation of multiscale modeling techniques on process safety applications. It is a valuable resource for readers interested in theoretical simulations and/or computer simulations of hazardous scenarios. As multi-scale modeling is a computational technique for solving problems involving multiple scales, such as how a flammable vapor cloud might behave if ignited, this book provides information on the fundamental topics of toxic, fire, and air explosion modeling, as well as modeling jet and pool fires using computational fluid dynamics. The book goes on to cover nanomaterial toxicity, QPSR analysis on relation of chemical structure to flash point, molecular structure and burning velocity, first principle studies of reactive chemicals, water and air reactive chemicals, and dust explosions. Chemical and process safety professionals, as well as faculty and graduate researchers, will benefit from the detailed coverage provided in this book. Provides the only comprehensive source addressing the use of multiscale modeling in the context of process safety Bridges multiscale modeling with process safety, enabling the reader to understand mapping between problem detail and effective usage of resources Presents an overall picture of addressing safety problems in all levels of modeling and the latest approaches to each in the field Features worked out examples, case studies, and a question bank to aid understanding and involvement for the reader
At a time when so many options exist for access to theatrical entertainments, it is no surprise that theatre practitioners and scholars are often preoccupied with the role of the audience. While space undoubtedly impacts the rehearsal and production processes, its greater significance seems to rest in the impact a specific location has on the audience. This volume delves into issues of theatre and space, traversing traditional theatre spaces such as the African Grove Theater discussed by Gregory Carr, Tony Gunn's examination of Edward Gorey's theatrical designs, and George Pate's reflections on Beckett's stage directors. Also highlighted are some decidedly innovative spaces, like those described by J. K. Curry in her examination of "Theatre for One" and modern uses of medieval sacred spaces as detailed by Carla Lahey. Whether positive or negative in scope, meanings generated within theatre spaces are impacted by the cultural context from which they emerge--the ways in which space is conceived, scrutinized, and experiences. As a result, the relationship between space, theatre, and audience is diverse, complex, and ever changing in practice.
This book is the first of its kind offering a materialistic semiotic analysis of a non-Western theatre culture: Bengali group theatre. Arnab Banerji fills two lacunas in contemporary theatre scholarship. First, the materialist semiotic approach to studying a non-Western theatre event allows Banerji to critically examine the material conditions in which theatre is created and seen outside the Euro-American context. And second, by shifting the critical lens onto a contemporary urban theatre phenomenon from India, the book attempts to even out the scholastic imbalance in Indian theatre scholarship which has largely focused on folk and classical traditions. The book shows a refreshing new perspective toward a theatre culture that frequently escapes the critical lens in spite of being one of the largest urban theatre cultures in the world. Theatre events are a sum total of the conditions in which they are built and the conditions in which they are viewed. Studying the event separate from its materialistic beginnings and semiotic effects allow only a partial insight into the performance phenomenon. The materialist semiotic critical framework of this book locates the Bengali group theatre within its performative context and offers a heretofore unexplored insight into this vibrant theatre culture.
Eyelid tumors are commonly encountered by oculoplastic as well as plastic surgeons. The challenge of managing these cases lies not only in performing the surgery in a precise manner in small area, but also in ensuring a visually-appealing cosmetic outcome. This is an innovative and concise portable handbook that guides the surgeons on how to approach and manage these cases in a step-by-step manner. Each chapter of this practical guidebook has outstanding illustrations drawn in full color clearly showing each incision line, flap management, suture placement and its technique and the expected cosmetic outcome. When a lid tumor is excised, there is a tissue defect that needs to be corrected. Ophthalmologists and plastic surgeons will find this work an excellent reference material to solve the jigsaw puzzle of tissue defects in and around the periorbital region. Importantly, they can quickly refer to the images just before starting a procedure. The author has first explained the anatomical aspects and anesthetic techniques for eyelid surgery, followed by review of the benign and malignant tumors, finally describing the flap creation and reconstruction techniques that are currently used in various lid tumors in an organized fashion.
A New Concept for Tuning Design Weights in Survey Sampling: Jackknifing in Theory and Practice introduces the new concept of tuning design weights in survey sampling by presenting three concepts: calibration, jackknifing, and imputing where needed. This new methodology allows survey statisticians to develop statistical software for analyzing data in a more precisely and friendly way than with existing techniques. Explains how to calibrate design weights in survey sampling Discusses how Jackknifing is needed in design weights in survey sampling Describes how design weights are imputed in survey sampling
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