Arabinda Samanta's Books

Cancer Immunotherapy

Chapter 14. Monoclonal Antibodies for Cancer Therapy and Prevention: Paradigm Studies in Targeting the neu/ERBB2/HER2 Oncoprotein

By: Hongtao Zhang,Arabinda Samanta,Yasuhiro Nagai,Hiromichi Tsuchiya,Takuya Ohtani,Zheng Cai,Zhiqiang Zhu,Jing Liu,Mark I. Greene

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Cancer Immunotherapy

Chapter 14. Monoclonal Antibodies for Cancer Therapy and Prevention: Paradigm Studies in Targeting the neu/ERBB2/HER2 Oncoprotein

By: Hongtao Zhang,Arabinda Samanta,Yasuhiro Nagai,Hiromichi Tsuchiya,Takuya Ohtani,Zheng Cai,Zhiqiang Zhu,Jing Liu,Mark I. Greene

The foundation for targeted therapy of cancers driven by members of the ErbB oncoprotein family was established initially by the demonstration that ectodomain binding monoclonal antibodies (mAb) could disable the protein kinase encoded by the HER2/neu oncogene. Homomeric and heteromeric erbB kinases play critical roles in the development of cancer and in the spread of early lesions. In particular, antibodies targeting the p185erbB2/neu receptor provide major clinical benefits in the treatment of breast cancer and also stomach cancer. As suggested by our study with oncogenic neu transgenic mice, anti-p185erbB2/neu antibodies are also effective in preventing the tissue hyperplasia that precedes tumorigenesis, tumor growth and the dissemination of ErbB2/neu kinase-positive cells into other tissues. As a therapeutic principle, “reversion of phenotype” for established tumors and “prevention” of tumorigenesis and spread can explain the basis for the benefits invoked by therapeutic and adjuvant therapies for breast cancer patients after cancers are surgically removed. These emerging principles being enlightened by ongoing studies of monoclonal antibody therapy will continue to provide guidance for the development of new targeted therapies for resistant tumors that arise after treatment.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059109

ISBN 13

9780128059104

Living with Epidemics in Colonial Bengal

By: Arabinda Samanta

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Living with Epidemics in Colonial Bengal

By: Arabinda Samanta

Making epidemics in colonial Bengal as its entry point and drawing heavily on social, cultural and linguistic anthropology to understand the functions of health experiences, distribution of illness, prevention of sickness, social relations of therapeutic intervention and employment of pluralistic medical systems, the book interrogates the social construction of medical knowledge, politics of science, and the changing paradigm of relationship between health of the individual and the prerogatives of larger colonial economic formations. Smallpox, plague, cholera and malaria which visited colonial Bengal with epidemic vengeance, caught the people unaware, killed them in thousands, and changed the society and its demographic structures. The book shows how sometimes through mutual adaptation but more often by cultural contestation, people pulled on with their microbial fellow travellers, and how illness became metaphor for the social dangers of improper code of conduct, to be corrected only through personal expropriation of the sin committed, or by community worship of the deity supposedly responsible for it. As a result, Western medical science was often relegated to the background, and elaborate rites and rituals, supposedly having curative values, came to the forefront and were observed with much community fanfare. Epidemics were also interpreted as outcome of politically incorrect moves made by the ruling power. To right the wrongs, people very often resorted to social protest. The protest by the literati went sometimes muted when its members seem to be beneficiaries of the colonial government, but it turned out to be all the more violent when the people, who had no private axe to grind, took up the cudgel to fight it out.

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129

Publisher

Routledge

Published Date

ISBN 10

1351399659

ISBN 13

9781351399654

Living with Epidemics in Colonial Bengal

By: Arabinda Samanta

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Living with Epidemics in Colonial Bengal

By: Arabinda Samanta

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129

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Routledge

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ISBN 10

1351399659

ISBN 13

9781351399654

Contesting Colonial Authority

Medicine and Indigenous Responses in Nineteenth- and Twentieth-Century India

By: Poonam Bala

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Contesting Colonial Authority

Medicine and Indigenous Responses in Nineteenth- and Twentieth-Century India

By: Poonam Bala

Poonam Bala’s Contesting Colonial Authority explores the interplay of conformity and defiance amongst the plural medical tradition in colonial India. The contributors reveal how Indian elites, nationalists, and the rest of the Indian population participated in the move to revisit and frame a new social character of Indian Medicine. Viewed in the light of the cultural, nationalistic, social, literary and scientific essentials, Contesting Colonial Authority highlights various indigenous interpretations and mechanisms through which Indian sciences and medicine were projected against the cultural background of a rich medical tradition.

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177

Publisher

Lexington Books

Published Date

ISBN 10

0739170244

ISBN 13

9780739170243

Book's by Arabinda Samanta

Cancer Immunotherapy

Cancer Immunotherapy

Living with Epidemics in Colonial Bengal

Living with Epidemics in Colonial Bengal

Living with Epidemics in Colonial Bengal

Living with Epidemics in Colonial Bengal

Contesting Colonial Authority

Contesting Colonial Authority

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