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Diabetes

Chapter 14. Diabetic Nephropathy and Tocotrienol

By: Kanwaljit Chopra,Vipin Arora,Anurag Kuhad

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Diabetes

Chapter 14. Diabetic Nephropathy and Tocotrienol

By: Kanwaljit Chopra,Vipin Arora,Anurag Kuhad

Diabetic nephropathy is a serious complication for patients with diabetes mellitus. Increasing evidence from both experimental and clinical studies suggests that there is a close link between this condition and hyperglycemia and oxidative stress induced inflammatory cascade. Therefore investigations into antioxidant and anti-inflammatory strategies may offer new effective approaches in its treatment. This chapter is an account of the effect of one dietary polyphenolic antioxidant, tocotrienol, on renal function and the renoinflammatory cascade in streptozotocin (STZ)-induced diabetes. Significant alterations in renal function, increased oxidative-nitrosative stress, TNF-α, TGF-β1, caspase-3 activity and NF-κB were observed in these experiments. Tocotrienol was seen to prevent the biochemical and molecular changes associated with diabetes. Moreover, diabetic rats treated with an insulin-tocotrienol combination produced a more pronounced effect on molecular parameters than their respective control groups. The data reveal that tocotrienol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation and apoptosis, and thus exerts a marked renoprotective effect.

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Page Count

29

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128069759

ISBN 13

9780128069752

Diabetes

Chapter 14. Diabetic Nephropathy and Tocotrienol

By: Kanwaljit Chopra,Vipin Arora,Anurag Kuhad

Write a review Read reviews Take a Quiz Solve Book Puzzle

Diabetes

Chapter 14. Diabetic Nephropathy and Tocotrienol

By: Kanwaljit Chopra,Vipin Arora,Anurag Kuhad

Diabetic nephropathy is a serious complication for patients with diabetes mellitus. Increasing evidence from both experimental and clinical studies suggests that there is a close link between this condition and hyperglycemia and oxidative stress induced inflammatory cascade. Therefore investigations into antioxidant and anti-inflammatory strategies may offer new effective approaches in its treatment. This chapter is an account of the effect of one dietary polyphenolic antioxidant, tocotrienol, on renal function and the renoinflammatory cascade in streptozotocin (STZ)-induced diabetes. Significant alterations in renal function, increased oxidative-nitrosative stress, TNF-α, TGF-β1, caspase-3 activity and NF-κB were observed in these experiments. Tocotrienol was seen to prevent the biochemical and molecular changes associated with diabetes. Moreover, diabetic rats treated with an insulin-tocotrienol combination produced a more pronounced effect on molecular parameters than their respective control groups. The data reveal that tocotrienol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation and apoptosis, and thus exerts a marked renoprotective effect.

Average ratings

N/A

5

0%

4

0%

3

0%

2

0%

1

0%

Solve jigsaw puzzle

Age

Page Count

29

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128069759

ISBN 13

9780128069752