This is the first full-length study of the life and career of Brian Simon (1915-2002), leading Marxist intellectual and historian of education in twentieth-century Britain. Using documentary sources that have only recently become publicly available, it reveals the remarkably broad range of Simon’s life as student, soldier and school teacher, Communist Party activist, and educational academic, campaigner and reformer. In a sympathetic biography that yet retains critical distance, the authors analyse Simon’s contribution to Marxism and the CP, explore the influence of both on his work as a historian of education and trace the significance of his Marxist beliefs, political associations and historical approach to the cause of educational reform. In so doing, they consider the full nature and limitations of Simon’s achievements in his struggle for education. Unlike many Marxist scholars he remained loyal to the CP in the 1950s, which damaged his reputation as a public intellectual. Nevertheless, his support for comprehensive education helped to promote egalitarian educational reforms in Britain, although he was later unable to provide sufficient resistance to the 1988 Education Reform Act and to a decline in the position of the comprehensive schools. In all this, the significance of Simon’s family, and especially his relationship with his wife Joan is to the fore. Joan and Brian forged a formidable 60-year partnership, in politics and the CP as well as in life, that lasted until Brian’s death in January 2002.
2014 Runner-Up, MLA Prize in United States Latina and Latino and Chicana and Chicano Literary and Cultural Studies In Unbecoming Blackness, Antonio López uncovers an important, otherwise unrecognized century-long archive of literature and performance that reveals Cuban America as a space of overlapping Cuban and African diasporic experiences. López shows how Afro-Cuban writers and performers in theU.S. align Cuban black and mulatto identities, often subsumed in the mixed-race and postracial Cuban national imaginaries, with the material and symbolic blackness of African Americans and other Afro-Latinas/os. In the works of Alberto O’Farrill, Eusebia Cosme, Rómulo Lachatañeré, and others, Afro-Cubanness articulates the African diasporic experience in ways that deprive negro and mulato configurations of an exclusive link with Cuban nationalism. Instead, what is invoked is an “unbecoming” relationship between Afro-Cubans in the U.S and their domestic black counterparts. The transformations in Cuban racial identity across the hemisphere, represented powerfully in the literary and performance cultures of Afro-Cubans in the U.S., provide the fullest account of a transnational Cuba, one in which the Cuban American emerges as Afro-Cuban-American, and the Latino as Afro-Latino.
At the height of the Cold War, the John F. Kennedy administration designed an ambitious plan for the Middle East-its aim was to seek rapprochement with Nasser's Egypt in order to keep the Arab world neutral and contain the perceived communist threat. In order to offset this approach, Kennedy sought to grow relations with the Kingdom of Saudi Arabia and embrace Israel's defense priorities-a decision which would begin the US-Israeli 'special relationship'. Here, Antonio Perra shows for the first time how new relations with Saudi Arabia and Israel which would come to shape the Middle East for decades were in fact a by-product of Kennedy's efforts at Soviet containment. The Saudi's in particular were increasingly viewed as 'an atavistic regime who would soon disappear' but Kennedy's support for them-which hardened during the Yemen Crisis even as he sought to placate Nasser-had the unintended effect of making them, as today, the US' great pillar of support in the Middle East.
Robert Boyle (1627-1691) was one of the most influential scientific and theological thinkers of his time. This is the first edition of his correspondence, transcribed from the original manuscripts. It is fully annotated, with an introduction and general index. The four volumes cover the time periods of Volume 1: 1936-91, Volume 2: 1662-5, Volume 3: 1666-7 and finally Volume 4 1668 to 77.
Weill Cornell Medicine is a story of continuity and transformation. Throughout its colorful history, Cornell's medical school has been a leader in education, patient care, and research—from its founding as Cornell University Medical College in 1898, to its renaming as Weill Cornell Medical College in 1998, and now in its current incarnation as Weill Cornell Medicine.In this insightful and nuanced book, dean emeritus Antonio M. Gotto Jr., MD, and Jennifer Moon situate the history of Cornell's medical school in the context of the development of modern medicine and health care. The book examines the triumphs, struggles, and controversies the medical college has undergone. It recounts events surrounding the medical school's beginnings as one of the first to accept female students, its pioneering efforts to provide health care to patients in the emerging middle class, wartime and the creation of overseas military hospitals, medical research ranging from the effects of alcohol during Prohibition to classified partnerships with the Central Intelligence Agency, and the impact of the Depression, 1960s counterculture, and the Vietnam War on the institution. The authors describe how the medical school built itself back up after nearing the brink of financial ruin in the late 1970s, with philanthropic support and a renewal of its longstanding commitments to biomedical innovation and discovery.Central to this story is the closely intertwined, and at times tumultuous, relationship between Weill Cornell and its hospital affiliate, now known as New York–Presbyterian. Today the medical school's reach extends from its home base in Manhattan to a branch campus in Qatar and to partnerships with institutions in Houston, Tanzania, and Haiti. As Weill Cornell Medicine relates, the medical college has never been better poised to improve health around the globe than it is now.
This book reconstructs the original and origins of the Rig Veda, (between 5.000 to 2.500 B.C, ) the first Indo-European written document ever to show the origin of cultures and the power of music in the recitation and construction of the original hymns. Here we find the original geometries, original forms, original sacrifice of any form to claim supremacy over the others and the continued movement of human life. This book brings together early humans with modern neurobiological discoveries and shows the origins of multiple centers of knowing (the gods), the movement of the singer and the song in a world that avoids idolatry of substances by insisting in the constant movement of singer, song, and music. If you thought you knew all there is to know about the language you use, read this book and find out the idolatry of its imagery and the possible sacrifice needed for a happy, communal and divine life.
This two volume set is a complete guide to the diagnosis and treatment of paediatric skin conditions. With its first edition having published more than 33 years ago, this reference is renowned amongst clinicians practising in the field of paediatric dermatology. The fifth edition has been thoroughly revised and updated to provide all the latest techniques and therapeutic advances for daily practice. More than 2000 clinical and histologic pictures, the majority new to this edition, illustrate all the skin conditions described in the comprehensive text covering 2500 pages, across the two volumes. Detailed references offer suggestions for further reading. Divided into 22 sections, the book begins with an introduction to basic science and discussion on diagnosis in paediatric dermatology. The following chapters cover a multitude of conditions, from genetic diseases, eczema, and pigmentary disorders, to vascular anomalies, tumours and cysts, skin infections, and many more. The book concludes with a section on the principles of treatment. A complete section is dedicated to neonatal disorders. The book is edited by Madrid-based Antonio Torrelo, with contributions from numerous other experts in the field. The previous edition (9780723435402) published in 2010.
Exploring the many dimensions of Hispanic health issues, this book updates interested readers with recent information and offers a view of the depth, scope, and complementarity of the challenges of providing adequate health care. Accordingly, the book is organized in four sections addressing, first, the conceptual, institutional, and policy element
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Implantable defibrillators as originally conceived by Michel Mirowski were limited to the detection and automatic termination of ventricular fibrillation. In the original "AID" device, the detection algoritlun sought to distinguish sinus rhytlun from ventricular fibrillation by identifying the "more sinusoidal waveform of ventricular fibrillation. " The therapeutic intervention was elicited only once deadly polymorphic rhythms had developed. It was rapidly learned, however, that ventricular fibrillation is usually preceded by ventricular tachycardia. Mirowski recognized the pivotal importance of developing algoritllms based on heart rate. Ventricular tachycardia detection allowed the successful development of interventions for the termination of ventricular tachyarrhythmias before they degenerated into ventricular fibrillation. Current device therapy no longer confines itself to tlle termination of chaotic rhythms but seeks to prevent them. Diagnostic algorithms moved upward along the chain of events leading to catastrophic rhytlulls. Rate smoothing algorithms were developed to prevent postextrasystolic pauses from triggering ventricular and atrial tachyarrhytlmlias. Beyond the renaissance of ectopy-centered strategies, long-term prevention received increasing attention. Multisite pacing therapies provided by "Arrhythmia Management Devices" were designed to reduce the "arrhytlunia burden" and optimize the synergy of cardiac contraction and relaxation. Clinical evidence now suggests that atrial fibrillation prevention by pacing is feasible and tllat biventricular pacing may be of benefit in selected patients with heart failure. However, these applications of device therapy that generally require ventricular defibrillation backup remain investigational and were not considered in this book.
In the closing years of the second century B.C., the ancient world watched as the Roman armies maintained clear superiority over all they surveyed. But, social turmoil prevailed at the heart of her territories, led by an increasing number of dispossessed farmers, too little manpower for the army, and an inevitable conflict with the allies who had fought side by side with the Romans to establish Roman dominion. Storming the Heavens looks at this dramatic history from a variety of angles. What changed most radically, Santosuosso argues, was the behavior of soldiers in the Roman armies. The troops became the enemies within, their pillage and slaughter of fellow citizens indiscriminate, their loyalty not to the Republic but to their leaders, as long as they were ample providers of booty. By opening the military ranks to all, the new army abandoned its role as depository of the values of the upper classes and the propertied. Instead, it became an institution of the poor and drain on the power of the Empire. Santosuosso also investigates other topics, such as the monopoly of military power in the hands of a few, the connection between the armed forces and the cherished values of the state, the manipulation of the lower classes so that they would accept the view of life, control, and power dictated by the oligarchy, and the subjugation and dehumanization of subject peoples, whether they be Gauls, Britons, Germans, Africans, or even the Romans themselves.
Medical Biochemistry is supported by over forty years of teaching experience, providing coverage of basic biochemical concepts, including the structure and physical and chemical properties of hydrocarbons, lipids, proteins, and nucleotides in a straightforward and easy to comprehend language. The book develops these concepts into the more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including particular aspects of metabolism in some organs and tissues, and the biochemical bases of endocrinology, immunity, vitamins, hemostasis, and apoptosis. Integrates basic biochemistry principles with molecular biology and molecular physiology Provides translational relevance to basic biochemical concepts though medical and physiological examples Utilizes a systems approach to understanding biological phenomena
Gain a solid foundation in the structure and function of oral tissues with the definitive text in oral histology! Ten Cate's Oral Histology, 10th Edition covers the latest research and thinking on general embryology, the development of the head (especially the structures in and around the mouth), oral anatomy, the structure of the tooth, salivary glands, the temporomandibular joint, and more. Clear explanations and full-color photos, micrographs, drawings, and charts help you better understand even the most complex topics. Edited by noted educator Dr. Antonio Nanci and written with the collaboration of some notable experts, this renowned text also provides excellent preparation for the histology content in the INDBE exam. - NEW! An eBook version is included with print purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. - NEW! Updated review questions for the INDBE exam are added to the eBook included with print purchase, along with interactive drag-and-drop labelling exercises, providing extra practice for the exam. - A robust art program includes full-color photomicrographs and 3D art, as well as detailed histological and structural images to help differentiate the microanatomy of tissues. - Molecular concepts are integrated to help you understand genes and mechanisms implicated in embryogenesis, development, cell function, and matrix events. - Application of histology content to the clinical setting is emphasized throughout the book. - User-friendly approach emphasizes learning and understanding concepts rather than memorization of detail, and also allows you to use individual chapters or sections independently. - Feature boxes provide a broader context, present new concepts, and discuss topics of clinical relevance.
Cox rings are significant global invariants of algebraic varieties, naturally generalizing homogeneous coordinate rings of projective spaces. This book provides a largely self-contained introduction to Cox rings, with a particular focus on concrete aspects of the theory. Besides the rigorous presentation of the basic concepts, other central topics include the case of finitely generated Cox rings and its relation to toric geometry; various classes of varieties with group actions; the surface case; and applications in arithmetic problems, in particular Manin's conjecture. The introductory chapters require only basic knowledge in algebraic geometry. The more advanced chapters also touch on algebraic groups, surface theory, and arithmetic geometry. Each chapter ends with exercises and problems. These comprise mini-tutorials and examples complementing the text, guided exercises for topics not discussed in the text, and, finally, several open problems of varying difficulty.
Many processes in nature arise from the interaction of periodic phenomena with random phenomena. The results are processes that are not periodic, but whose statistical functions are periodic functions of time. These processes are called cyclostationary and are an appropriate mathematical model for signals encountered in many fields including communications, radar, sonar, telemetry, acoustics, mechanics, econometrics, astronomy, and biology. Cyclostationary Processes and Time Series: Theory, Applications, and Generalizations addresses these issues and includes the following key features. - Presents the foundations and developments of the second- and higher-order theory of cyclostationary signals - Performs signal analysis using both the classical stochastic process approach and the functional approach for time series - Provides applications in signal detection and estimation, filtering, parameter estimation, source location, modulation format classification, and biological signal characterization - Includes algorithms for cyclic spectral analysis along with Matlab/Octave code - Provides generalizations of the classical cyclostationary model in order to account for relative motion between transmitter and receiver and describe irregular statistical cyclicity in the data
In The Focused Organization Antonio Nieto-Rodriguez shows you how fewer, more effectively elected and managed projects are the key to strategic and long-term success. Using his own research and work experience he explains how and why those organizations that focus on just a few key initiatives can perform significantly better than unfocused organizations, not only financially but also in achieving their strategic objectives and motivating their staff. The author introduces a new way of looking at a company through two very different and often conflicting dimensions: running-the-business and changing-the-business. What you add to one dimension you have to subtract from the other one. Finding the right balance between these two dimensions represents one of the major challenges to successful strategy execution. Becoming a focused organization involves a radical change in the way companies are organized and the way they select and manage projects - the creation of a new culture. The Focused Organization discusses the characteristics that comprise a focused organization. It describes key areas where a focused organization builds its levels of maturity; provides examples of focused organizations that outperform the rest; and explains in practical steps how all enterprises can become focused. The book finishes with a unique and inspiring case study that transports us to the early days of the current business world. Through the main character, Benny White, we learn how a business was conducted and how management evolved over decades with the introduction of business theories, including project management.
Bestselling crime writers Peter Edwards and Antonio Nicaso reveal the final years of Canada's top mafia boss, Vito Rizzuto, and his bloody war to avenge his family and control the North American drug trade. Until Vito Rizzuto went to prison in 2006 for his role in a decades-old Brooklyn triple murder, he ruled the Port of Montreal, the northern gateway to the major American drug markets. A master diplomat, he won the respect of rival mafia clans, bikers and street gangs, and criminal business thrived on his turf. His family prospered and his empire grew--until one of North America's true Teflon dons finally lost his veneer. As he watched helplessly from his Colorado prison, the murders of his son and father made international headlines; the killings of his lieutenants and friends filled the pages of Canadian news; and the influence of the 'Ndrangheta, the Calabrian Mafia, spread across Montreal faster than the blood of Rizzuto's crime family. In 2012, Vito Rizzuto emerged from prison, a 66-year-old man who could carefully rebuild his criminal empire or seek bloody revenge and damn the consequences. From the events leading to his imprisonment to his shocking death in December 2013, Business or Blood is the final chapter of Vito's story.
An ambitious and meticulous foray into the nature of being." -- The Boston Globe A landmark exploration of the relationship between emotion and reason Since Descartes famously proclaimed, "I think, therefore I am," science has often overlooked emotions as the source of a person’s true being. Even modern neuroscience has tended, until recently, to concentrate on the cognitive aspects of brain function, disregarding emotions. This attitude began to change with the publication of Descartes’ Error in 1995. Antonio Damasio—"one of the world’s leading neurologists" (The New York Times)—challenged traditional ideas about the connection between emotions and rationality. In this wondrously engaging book, Damasio takes the reader on a journey of scientific discovery through a series of case studies, demonstrating what many of us have long suspected: emotions are not a luxury, they are essential to rational thinking and to normal social behavior.
Skin diseases are highly prevalent among indigenous people, leading to low mortality but greatly impacting their quality of life. Such diseases can be observed in indigenous people; both those living in isolated communities and those who have since been urbanized to some degree share a common characteristic of presenting different clinical patterns than non-indigenous individuals. These specificities necessitate a special approach when diagnosing dermatologic diseases in indigenous people. However, these considerations are rarely discussed in standard dermatology books. This Atlas addresses that gap by providing specific materials for professionals involved in the health of indigenous people, especially with those who live either alone or in remote areas. It offers a comprehensive overview of the most common skin diseases in specific tribes, providing a full clinical guide on the dermatologic signs and symptoms in these individuals. Additionally, the book complements the clinical standpoint with an anthropologic perspective, examining the impact of dermatologic diseases in indigenous people and the different meaning of these diseases in their lives. Most of the material presented in this Atlas was collected in the Xingu Program, a project created in 1965 by the Federal University of São Paulo, Brazil, and devoted to providing medical care to indigenous people from the Upper Xingu region, in the heart of the Amazon rainforest. Thus, the content is primarily applicable to South American indigenous people. However, the common characteristics of the isolation and non-urbanization of these communities, as well as the anthropologic perspective adopted here, allow the content to be extrapolated to other indigenous peoples worldwide. This Atlas will be a novel and valuable resource for health professionals who work with indigenous peoples, especially in geographic areas where dermatologists are not always readily available.
Is Gaia becoming Thanatia, a resource exhausted planet? For how long can our high-tech society be sustained in the light of declining mineral ore grades, heavy dependence on un-recycled critical metals and accelerated material dispersion? These are all root causes of future disruptions that need to be addressed today.This book presents a cradle-to-cradle view of the Earth's abiotic resources through a novel and rigorous approach based on the Second Law of Thermodynamics: heat dissipates and materials deteriorate and disperse. Quality is irreversibly lost. This allows for the assessment of such depletion and can be used to estimate the year where production of the main mineral commodities could reach its zenith. By postulating Thanatia, one acquires a sense of destiny and a concern for a unified global management of the planet's abiotic resource endowment.The book covers the core aspects of geology, geochemistry, mining, metallurgy, economics, the environment, thermodynamics and thermochemistry. It is supported by comprehensive databases related to mineral resources, including detailed compositions of the Earth's layers, thermochemical properties of over 300 substances, historical energy and mineral resource inventories, energy consumption and environmental impacts in the mining and metallurgical sector and world recycling rates of commodities.
The book is aimed at assessing the capabilities of state-of-the-art optical techniques in elucidating the fundamental electronic and structural properties of semiconductor and metal surfaces, interfaces, thin layers, and layer structures, and assessing the usefulness of these techniques for optimization of high quality multilayer samples through feedback control during materials growth and processing. Particular emphasis is placed on the theory of non-linear optics and dynamical processes through the use of pump-probe techniques together with the search for new optical sources. Some new applications of Scanning Probe Microscopy to Material science and biological samples, dried and in vivo, with the use of different laser sources are also presented. Materials of special interest are silicon, semiconductor-metal interfaces, semiconductor and magnetic multi-layers and III-V compound semiconductors.
Principles and applications of SQUIDs serves as a textbook and a multi-author collection of critical reviews. Providing both basic aspects and recent progress in SQUIDs technology, it offers a realistic and stimulating picture of the state of the art. It can also contribute to a further development of the field for commercial applications.
In response to criticism and disappointment from the Left, A Consequential President offers a bold assessment of the lasting successes and major achievements of President Obama. Had he only saved the U.S. economy with his economic recovery act and his program to restore the auto industry, President Obama would have been considered a successful president. He achieved so much more, however, that he can be counted as one of our most consequential presidents. With The Affordable Care Act, he ended the long-running crisis of escalating costs and inadequate access of treatment that had long-threatened the well-being of 50 million Americans. His energy policies drove down the cost of power generated by the sun, the wind, and even fossil fuels. His efforts on climate change produced the Paris Agreement, the first treaty to address global warming in a meaningful way, and his diplomacy produced a dramatic reduction in the nuclear threat posed by Iran. Add the withdrawal of troops from Iraq, the normalization of relations with Cuba, and his “pivot” toward Asia, and President Obama's triumphs abroad match those at home. Most importantly, as the first African-American president, he navigated race relations and a rising tide of bigotry, including some who challenged his citizenship, while also fighting a Republican Party determined to make him one-term president. As a result, Obama's greatest achievement was restoring dignity and ethics to the office of the president, proof that he delivered his campaign promise of hope and change.
The book is interdisciplinary and focuses on the topic of artificial consciousness: from neuroscience to artificial intelligence, from bioengineering to robotics. It provides an overview on the current state of the art of research in the field of artificial consciousness and includes extended and revised versions of the papers presented at the International Workshop on ‘Artificial Consciousness', held in November 2005 at Agrigento (Italy).
In this introduction to theory and method, students of organization will find a comprehensive view of the key theories in their field, combined with a toolkit of guidelines linking these to the different methods available for analyzing and interpreting organizational life. Distinguishing `the external society' and the `internal society', Antonio Strati sheds light on the different contexts that shape organizational life and the different levels of analysis that may be used. By showing the many levels at which organizations function and can be understood this book provides an invaluable introduction to analysis and research for advanced students. Recent concepts such as `the organization as hypertext'; `communities of practi
What exactly is happening when politicians evoke a center space beyond partisan politics to advance what are unmistakably political arguments? Drawing from an analysis of pivotal speeches surrounding Bill Clinton's 1992 presidential campaign and first term in office, Centrist Rhetoric: The Production of Political Transcendence in the Clinton Presidency takes an extended look at this question by showing how the possibility of political transcendence takes form in the rhetoric of the political center. Faced with a divided and shrinking party, and later with a pitched battle against a resurgent conservative movement, Clinton used the image of a political center, a "third way" beyond liberal and conservative orthodoxies, to advance his strategic goals, define his adversaries, and overcome key political challenges. As appeals to the center helped Clinton to achieve these advantages in specific cases, however, they also served to define the means, ends, and very essence of democracy in ambiguous and contradictory ways. Touching on controversies from the early 1990s over the future of the Democratic Party, racial identity in American politics, the threat of rightwing extremism, and the role of government, Antonio de Velasco show how centrist rhetoric's call to transcendence weaved together forms of identification and division, insight and blindness, so as to defy the conventional assessments of both Clinton's supporters and his detractors. Centrist Rhetoric thus offers general insight into the workings of political rhetoric, and a specific appreciation of Clinton's attempts to define and adjust to the political exigencies of a critical period in history of the Democratic Party and politics in the United States.
Cesar Chavez has long been heralded for his personal practice of nonviolent resistance in struggles against social, racial, and labor injustices. However, the works of Gandhi and Martin Luther King Jr. have long overshadowed Chavez's contributions to the theory of nonviolence. José-Antonio Orosco seeks to elevate Chavez as an original thinker, providing an analysis of what Chavez called "the common sense of nonviolence." By engaging Chavez in dialogue with a variety of political theorists and philosophers, Orosco demonstrates how Chavez developed distinct ideas about nonviolent theory that are timely for dealing with today's social and political issues, including racism, sexism, immigration, globalization, and political violence.
Antonio Perez, the brilliant but erratic secretary to Philip II of Spain, became in the years of his exile a political agent in the service of the Earl of Essex, arriving at the Court of Queen Elizabeth in 1593. On behalf of Essex, who valued him as a friend, a partner and a humanist scholar, he cast an intelligence network over Italy; and he made a striking, though dangerous, contribution to the Essex cult.
Global, interdisciplinary, and engaging, this textbook integrates materials from philosophical and biological origins to the historical development of psychology. Its extensive coverage of women, minorities, and psychologists around the world emphasizes psychology as a global phenomenon while looking at both local and worldwide issues. This perspective highlights the relationship between psychology and the environmental context in which the discipline developed. In tracing psychology from its origins in early civilizations, ancient philosophy, and religions to modern science, technology, and applications, this book integrates overarching psychological principles and ideas that have shaped the global history of psychology, keeping an eye toward the future of psychology. Updated and revised throughout, this new edition also includes a new chapter on clinical psychology.
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Economic structuralists use a broad, systemwide approach to understanding development, and this textbook assumes a structuralist perspective in its investigation of why a host of developing countries have failed to grow at 2 percent or more since 1960. Sensitive to the wide range of factors that affect an economy's strength and stability, the authors identify the problems that have long frustrated growth in many parts of the developing world while suggesting new strategies and policies to help improve standards of living. After a survey of structuralist methods and post-World War II trends of global economic growth, the authors discuss the role that patterns in productivity, production structures, and capital accumulation play in the growth dynamics of developing countries. Next, it outlines the evolution of trade patterns and the effect of the terms of trade on economic performance, especially for countries that depend on commodity exports. The authors acknowledge the structural limits of macroeconomic policy, highlighting the negative effects of financial volatility and certain financial structures while recommending policies to better manage external shocks. These policies are then further developed through a discussion of growth and structural improvements, and are evaluated according to which policy options-macro, industrial, or commercial& mdash;best fit within different kinds of developing economies.
Today's European Union is in an identity crisis as it seems to be losing its points of reference. The principles that upheld its creation are being increasingly questioned around the world and within the EU itself. Its chances to survive hinge upon its ability to deliver at home and abroad, without abandoning its values and principles but rather adapting and re-launching them. This volume offers policy options on key questions for the future of the EU: How to scale-up its role abroad? How to benefit from new partners without severing ties with traditional allies such as the US? How to contain Eurosceptic forces by reducing inequalities? And how to reinforce the euro while aiming at more sustainable and balanced growth?
The human urinary bladder is subject to a unique and extraordinarily diverse array of congenital, inflammatory, metaplastic, and neoplastic abnormalities. This book provides contemporary, comprehensive, and evidence-based practice information for pathologists, urologists, oncologists, and other medical professionals. In Bladder Pathology, a full spectrum of pathologic conditions that afflict the bladder and urothelium are described and lavishly illustrated. With its emphasis on diagnostic criteria and differential diagnoses, this book is of particular value to practicing pathologists—assisting in the pathologist’s recognition, understanding, and accurate interpretation of the light microscopic findings in bladder specimens. Features and benefits of this new volume include: • 1,741 high-quality, color illustrations and 112 tables to illustrate the wide range of pathologic and clinical features in the urinary tract • An evidence-based approach to diagnosis and patient management for infectious, nonneoplastic, and neoplastic conditions • Recent advances in the molecular genetics of the urinary bladder with discussion of their current or potential impact on diagnosis and personalized patient care • With emphasis on the scientific validation of current diagnostic methods and their direct application in clinical practice, Bladder Pathology is a cutting-edge resource that not only offers comprehensive research and clinical information for practicing surgical pathologists, urologists, oncologists, and their clinical colleagues, but also captures a genuine sense of excitement about recent advances in this vital, ever-evolving field.
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