Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
This book brings together several contributions from leading experts in the field of nonlinear wave propagation. This field, which during the last three decades has seen important breakthroughs from the theoretical point of view, has recently acquired increased relevance due to advances in the technology of fluids e.g. at microscale or nanoscale and the recognition of crucial applications to the understanding of biological phenomena. Nonlinear wave theory requires the use of disparate approaches, including formal and rigorous asymptotic methods, Lie group theory, energy methods, numerical analysis, and bifurcation theory. This book presents a unique blend in which different aspects of the theory are enlightened and several real-life applications are investigated. The book will be a valuable resource for applied scientists interested in some of the most recent advances in the theory and in the applications of wave propagation, shock formation, nonequilibrium thermodynamics and energy methods.
Human sexuality is a very important subject, especially in a cultural context such as ours, in which social and work transformations offer behavioral models that are characterized by a remarkable sexual indeterminacy. In Transcending Gender Ideology, Antonio Malo tries to rethink sexuality with equilibrium and intellectual rigor, using a philosophical approach, since sexuality does not only affect biological aspects or social conditioning, but above all the same essence of the relationship between man and woman. Malo’s reflections begin with the historical evolution of the concept of sexuality: the naturalistic conception, which sees the difference between man and woman as something biological and absolute, and the postmodern conception, which criticizes it by judging human sexuality as a socio-cultural construction or gender. According to Malo, the limitation of the gender approach is to deny the relationship of human sexuality to the body and to the differences between man and woman. In fact, by rejecting these aspects, they end up sustaining a limitless creativity of freedom, which transforms the body into something that is used at will, and relationships as something fluid. Faced with these extremes, Malo proposes a vision of sexuality as a personal condition or sexed condition, received at the time of birth, but which develops, grows and matures through family models, experiences and relationships. Even if based on an original sexual difference, sexed condition covers many other aspects: physical, psychological, social and cultural, as well as behavioral patterns and, above all, the personal integration of sexuality through the gift of oneself in marriage or in celibacy.
The diagnosis and management of congenital heart defects has rapidly evolved over the decades. This book presents the role that cardiac CT and MRI may play in the management of congenital heart defects.
This two volume set is a complete guide to the diagnosis and treatment of paediatric skin conditions. With its first edition having published more than 33 years ago, this reference is renowned amongst clinicians practising in the field of paediatric dermatology. The fifth edition has been thoroughly revised and updated to provide all the latest techniques and therapeutic advances for daily practice. More than 2000 clinical and histologic pictures, the majority new to this edition, illustrate all the skin conditions described in the comprehensive text covering 2500 pages, across the two volumes. Detailed references offer suggestions for further reading. Divided into 22 sections, the book begins with an introduction to basic science and discussion on diagnosis in paediatric dermatology. The following chapters cover a multitude of conditions, from genetic diseases, eczema, and pigmentary disorders, to vascular anomalies, tumours and cysts, skin infections, and many more. The book concludes with a section on the principles of treatment. A complete section is dedicated to neonatal disorders. The book is edited by Madrid-based Antonio Torrelo, with contributions from numerous other experts in the field. The previous edition (9780723435402) published in 2010.
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