A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists.Key Features* Completely up-to-date* Revised and expanded to include over 70 new entries* More than 200 entries in total, plus additional introductory material* New structural data* New nomenclature for CD and related molecules covered
With unique scholarly analysis and practical discussion, this book provides a comprehensive introduction to the relationship between environmental protection and human rights being formalized into law in many legal systems. This book instructs on environmental techniques and procedures that assist in the protection of human rights. The text provides cogent guidance on a growing international jurisprudence on the promotion and protection of human rights in relation to the environment that has been developed by international and regional human rights bodies and tribunals. It explores a rich body of case law that continues to develop within states on the environmental dimension of the rights to life, to health, and to public participation and access to information. Five compelling contemporary case studies are included that implicate human rights and the environment, ranging from large dam projects to the creation of a new human right to a clean environment.
This second volume in an exciting and detailed series on contact allergens provides monographs of all 181 fragrances and 79 essential oils which have caused contact allergy / allergic contact dermatitis, including the indicators for fragrance allergy (fragrance mixes I and II and Myroxylon pereirae resin [Balsam of Peru]) and non-fragrance allergens in botanical products used in the perfume industry. The monographs present: Identification section; Contact allergy (general population, patients with dermatitis, case reports and case series); Cross-reactions; Patch test sensitization; Presence in products and chemical analyses; Other side effects (irritant contact dermatitis, photosensitivity, immediate-type reactions, systemic side effects) and more. Key Features: Presents monographs of all known fragrance chemicals and essential oils which have caused contact allergy / allergic contact dermatitis Provides a full literature review of relevant topics of allergenic fragrances and essential oils Identifies INCI and IUPAC names, synonyms, CAS and EC numbers, structural formulas, RIFM and Merck Index monographs, SCCS opinions, IFRA and EU restrictions and advises on patch testing Presents an alphabetical list of all synonyms indicating their INCI names Covers an extensive amount of information to benefit dermatologists, allergists, and non-medical professionals involved with the research, development and marketing of fragrances and essential oils
This third volume in an exciting and detailed series on contact allergens provides monographs of all 384 topical drugs which have caused contact allergy/allergic contact dermatitis. The monographs present: Identification section; Contact allergy (general population, patients with dermatitis, case reports and case series); Cross-reactions; Patch test sensitization; Photocontact allergy; and Immediate contact reactions (contact urticaria). Separate chapters present an overview of all aspects of allergic contact dermatitis to topical drugs, contact allergy to non-drug ingredients in topical pharmaceuticals and a preview of delayed-type allergy to systemic drugs (to be discussed in Volume 4). Key Features: Presents monographs of all known topical drugs which have caused contact allergy/allergic contact dermatitis Provides a full literature review of relevant topics of allergenic topical drugs Identifies IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing Presents non-drug allergens in topical pharmaceuticals Covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy
Monographs in Contact Allergy, Volume 1: Non-Fragrance Allergens in Cosmetics (Part 1 and Part 2) is the first 2-part volume in an exciting series on contact allergy. It presents over 500 natural or synthetic chemicals and compounds which have caused allergic contact dermatitis in cosmetic products. Included here are INCI names, synonyms, description/definition, CAS and EU numbers, chemical class, function in cosmetics, molecular formula, structural formula and advice on patch tests. A full literature review is given of patch testing in patients, case reports of cosmetic allergic contact dermatitis, irritant contact dermatitis, photosensitivity, immediate contact reactions and systemic side effects. This text is suitable for anyone with an interest in contact allergy, from university students to professionals, and all readers will find this informative and detailed series an invaluable resource. Key Features: Monographs of all known non-fragrance chemicals and substances which have caused allergic contact dermatitis from their presence in cosmetic products Provides lists of all functional groups (such as antioxidants, preservatives, artificial nail building, emollients, hair dyeing, hair colorants) in both the EU and US formats and all chemicals in these groups which have caused cosmetic allergy Presents an alphabetical list of all synonyms indicating their INCI names Reported cross-reactions, pseudo-cross-reactions and co-reactions, patch test sensitization and presence in cosmetic products (including data from FDA’s Voluntary Cosmetic Registration Program) and chemical analyses are discussed Covers an extensive amount of information to benefit dermatologists, allergists, and non-medical professionals involved with the research, development and marketing of cosmetic products
8. A Matter of Debate: Conceptions of Material Substance in the Scientific Revolution -- 9. War of the Worlds: Cartesian Vortices and Newtonian Gravitation in Eighteenth-Century Astronomy -- 10. Historical Pyrrhonism and Its Discontents -- Conclusion -- Notes -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Y -- Z
Changing Welfare States is is a major new examination of the wave of social reform that has swept across Europe over the past two decades. In a comparative fashion, it analyses reform trajectories and political destinations in an era of rapid socioeconomic restructuring, including the critical impact of the global financial crisis on welfare state futures. The book argues that the overall scope of social reform across the member states of the European Union varies widely. In some cases welfare state change has been accompanied by deep social conflicts, while in other instances unpopular social reforms received broad consent from opposition parties, trade unions and employer organizations. The analysis reveals trajectories of welfare reform in many countries that are more proactive and reconstructive than is often argued in academic research and the media. Alongside retrenchments, there have been deliberate attempts - often given impetus by intensified European (economic) integration - to rebuild social programs and institutions and thereby accommodate welfare policy repertoires to the new economic and social realities of the 21st century. Welfare state change is work in progress, leading to patchwork mixes of old and new policies and institutions, on the lookout, perhaps, for greater coherence. Unsurprisingly, that search process remains incomplete, resulting from the institutionally bounded and contingent adaptation to the challenges of economic globalization, fiscal austerity, family and gender change, adverse demography, and changing political cleavages.
The present volume is the fifth issue of the ‘Evolution’ Yearbook series. Our Yearbooks are designed to present to its readers the widest possible spectrum of subjects and issues: from universal evolutionism to the analysis of particular evolutionary regularities in the development of biological, abiotic, and social systems, culture, cognition, language, etc. The main objective of our Yearbook is the creation of a unified interdisciplinary field of research, within which scientists specializing in different disciplines could work within the framework of unified or similar paradigms, using common terminology and searching for common rules, tendencies and regularities. Global evolution (in connection with the Big History) becomes the main subject of our Yearbook. We strive to arrange each issue in such a way that the line from cosmic evolution to the human future is evident. What is the subject of the present issue of the Yearbook? Similar to the previous issues, it shows some aspects of the evolutionary advance from the earlier phases to the anticipated future of human society. But on the whole, this volume is devoted to different aspects and facts of megaevolution and some universal theories in an attempt to find common ground in the diversity of manifestation of evolution and its forms at different stages of development. So the title of this issue, ‘Evolution and Big History: Dimensions, Trends, and Forecasts’, is fully justified (besides, several papers contribute to the field of Big History). The volume consists of four sections: Dimensions, Trends, and Aspects; Big History's Manifestations; Trends and Forecasts; and Reviews and Information. This Yearbook will be useful both for those who study interdisciplinary macroproblems and for specialists working in focused directions, as well as for those who are interested in evolutionary issues of Cosmology, Biology, History, Anthropology, Economics and other areas of study. More than that, this edition will challenge and excite your vision of your own life and the new discoveries going on around us.
This monograph is devoted to nonlinear dynamics of thin plates and shells with thermosensitive excitation. Because of the variety of sizes and types of mathematical models in current use, there is no prospect of solving them analytically. However, the book emphasizes a rigorous mathematical treatment of the obtained differential equations, since it helps efficiently in further developing of various suitable numerical algorithms to solve the stated problems.
Ia all of history a vast conspiracy? Cosmic joke? Robert Anton Wilson developed the story of the Illuminati, a conspiracy as old as time itself, as a vehicle to amuse and enlighten. His best-selling books, The Illuminati Trilogy and Cosmic Trigger, have delighted readers the world over and made the Illuminati conspiracy the perfect metaphor for our time. In the ILLUMINATI PAPERS, Robert Anton Wilson speaks through characters from his novels and other realities and presents his views on our future way of life. Includes The HEAD Revolution Secrets of Evolution How to Eliminate Stupidity Illuminati Interoffice Memos The Position Papers of Hagbard Celine Economic Liberation The Usual Gang of Lunatics, Mystics, and Characters Clamoring for a New Social Order
For the last 30 years, polyphenols were in the centre of research work worldwide. Silymarin, an extract from a medicinal plant Silybum marianum, also known as milk thistle, has a special place in this group, having been used in human medicine for the management of liver diseases since ancient times. Accumulating scientific evidence indicates that silymarin is characterised by a wide range of protective pharmacological activities and this topic has received tremendous attention in recent years. However, until now there has been no single monograph addressing major questions related to silymarin chemistry, biochemistry and practical applications. The goal of this book is to provide up to date information about silymarin chemistry, biochemistry and molecular mechanisms of protective actions of this phytochemical with a special emphasis to its vitagene- and transcription factor-modulating properties. Silymarin applications in human diseases, including hepatoprotection, neuroprotection, anti-diabetic, anti-arthritis and other protective activities are reviewed. Immunomodulating, anti-inflammatory, anti-toxic protective activities of silymarin are characterised in detail. Practical applications of silymarin in poultry and animal industry with a special emphasis on its protective roles in gut health maintenance are also presented. This book will be of practical importance to medical and pharmaceutical scientists, including medical doctors, pharmacists, consultants, etc. as well as to poultry/animal scientists, poultry producers, nutritionists and vets, as well as to students of medical, biological and agricultural backgrounds. It can also be of interest for researchers in areas related to physiology, biochemistry, nutrition and veterinary medicine.
Over the years of cancer investigation a lot of discoveries in this field were made, and many associations between various biological carcinogens and cancer were revealed. Some of them are credibly determined, thus these infectious agents (human papilloma virus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, human herpes virus 8, human T-cell lymphotropic virus 1, human immunodeficiency virus, Merkel cell polyomavirus, Helicobacter pylori, Opisthorchis viverrini, Clonorchis sinensis, Schistosoma haematobium) are recognized as carcinogens and probable carcinogens by International Agency for Research on Cancer (IARC). The problem is of large importance, since share of infectious agents-related cancer cases is steadily increasing, reaching 25% according to certain estimates. It is worth noting that many of cancer cases are caused by infectious agents other than «conventional ones» like HPV, EBV, HBV, HCV, H.pylori etc. In recent years, a number of significant breakthroughs in the field were performed, such as the discovery of the microbiota role in cancer causation.
Readers will learn in which ways light can be "confined" within a subwavelength region smaller than half a wavelength. Strictly within the focal spot, all degrees of freedom of light interact and manifest themselves in a dramatic way. The size and shape of the focal spot and the magnitude of side-lobes depend on the polarization state alongside phase and amplitude distributions of a light beam. Readers will learn techniques in which inhomogeneously (i.e., azimuthally and radially) polarized optical beams can be focused. In sharp focus, exotic phenomena can occur, including the negative propagation of light and a toroidal optical flow. Throughout the book, the numerical simulation is performed using the rigorous solution of Maxwell’s equations based on a Finite-Difference Time-Domain (FDTD) approach, which makes the results of modeling highly reliable. The photonic components, including optical metasurfaces, discussed in the book have been implemented using state-of-the-art techniques of electron beam writing and reactive ion-beam etching of microrelief. Two chapters are concerned with photonics hot spots, which deal with the control of light by means of optical metasurfaces and the generation of an energy backflow in the region of sharp focus of a laser beam. Another hot topic is diffractive polarization converters implemented as subwavelength diffraction gratings to convert polarization of light. By way of illustration, such converters are shown to perform linear-to-radial or linear-to-azimuthal polarization conversion. The book describes advanced photonic components fabricated by the authors to perform sharp focusing of light, including binary zone plates, binary axicons, a planar photonic crystal lens, diffraction polarization converters, and metalenses. This book is a must-have for individuals and institutions studying cutting edge optics.
Encyclopedic, definitive, and state-of-the-art in the field of vascular disease and its medical, surgical, and interventional management, Rutherford's Vascular Surgery and Endovascular Therapy offers authoritative guidance from the most respected and innovative global thought leaders and clinical and basic science experts of our time. The thoroughly revised 10th Edition, published in association with the Society for Vascular Surgery and authored by multidisciplinary and international contributors, is an outstanding reference for vascular surgeons, vascular medicine specialists, interventional radiologists and cardiologists, and their trainees who depend upon Rutherford's in their practice. Under the expert editorial guidance of Drs. Anton N. Sidawy and Bruce A. Perler, it is quite simply the most complete and most reliable resource available on the art and science of circulatory diseases. - Incorporates fundamental vascular biology, diagnostic techniques, and decision making as well as medical, endovascular, and surgical treatment of vascular disease. - Features numerous concise and comprehensive diagnostic and therapeutic algorithms vital to patient evaluation and management. - Covers all vascular imaging techniques, offering a non-invasive evaluation of both the morphology and hemodynamics of the vascular system. - Employs a full-color layout, images and online videos, so readers can view clinical and physical findings and operative techniques more vividly. - Contains fully updated and more concise chapters with a focused format and summary for each that provides a quick access to key information—ideal for consultation as well as daily practice. - Includes expanded coverage of the business of vascular surgery, including a new section on the use of technology platforms and social media, and new chapters on telemedicine, the development and operation of outpatient dialysis centers and multispecialty cardiovascular centers, vascular information on the internet, and much more. - Provides new content on key topics such as endovascular treatment of complex aortic disease, acute vascular occlusion in the pediatric population, outpatient vascular care, and anatomic surgical exposures for open surgical reconstructions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This is a book about the future of sustainability. Regenerative Business Voices: Values-based Entrepreneurship for Sustainable Enterprises tells the stories of four regenerative organizations and the people who have founded them and guided them towards sustaining futures. Regenerative sustainability recognizes the urgency of transforming organizations to reverse the unsustainable pathways we are currently on. Regenerative businesses do not simply do less harm, or produce zero emissions, or optimize the efficient use of natural resources; they also restore and enhance well-being in social and ecological systems. The stories presented here are analyzed using the business ethics approach called Giving Voice to Values (GVV). Through the application of GVV principles, we uncover the processes involved in how regenerative businesses develop and function, and gain insights into how business leaders voice their deep convictions, overcome silencing rationalizations, normalize their execution of personal choice, discover deep purpose in their work, and draw on their personal histories to create new ways of doing business. We present and analyze these cases to understand how and why expressing values can be so crucial in developing sustainable businesses, and to provide practical examples of how individuals can generate enthusiasm, counter objections, gain allies, and prepare for and practice conversations that help them move forward. The book offers managers and sustainability consultants a new way of understanding some of the central dynamics involved in business ethics and organizational change for sustainability. It will be immensely valuable to educators, business students, and practitioners interested in sustainability, environmental business ethics, and corporate social responsibility topics.
Artificial Intelligence will either be the best or worst thing to happen to humanity. We do not yet know which. – Stephen Hawking As AI becomes more pervasive in every aspect of human life, there is an urgent need to understand it and harness it in a way that benefits mankind. But where do we begin? Will AI Dictate the Future breaks down this complex subject by examining AI’s impact on key sectors of our societies. Each chapter delves into one sector in turn, probing the myriad risks and opportunities brought about by AI: Healthcare Law Manufacturing Cybersecurity Mobility Financial Services Education Satellite Systems Government Written by Dr Anton Ravindran, together with chapters contributed by leading experts in their fields, this invaluable book provides a clear, comprehensive and authoritative look at how AI – managed wisely – can change the world for the better.
This fresh, visual and detailed study of America's best-loved trailing hound by America's most respected Beagle breeders covers origin, history and development, management, breeding, the show ring, and outdoor sports.
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