The seventh edition of Textbook on Administrative Law continues to provide students with an accessible and stimulating guide to the subject. Practical in approach, the authors concentrate on fully analysing core topics, while at the same time setting them within a contextual and thematic framework.
Systems Thinking for a Turbulent World will help practitioners in any field of change engage more effectively in transformative innovation. Such innovation addresses the paradigm shift needed to meet the diverse unfolding global challenges facing us today, often summed up as the Anthropocene. Fragmentation of local and global societies is escalating, and this is aggravating vicious cycles. To heal the rifts, we need to reintroduce the human element into our understandings – whether the context is civic or scientific – and strengthen truth-seeking in decision-making. Aided by appropriate concepts and methods, this healing will enable a switch from reaction to anticipation, even in the face of discontinuous change and high uncertainty. The outcome is to privilege the positive human skills for collaborative navigation through uncertainty over the disjointed rationality of mechanism and artificial intelligence, which increasingly alienates us. The reader in search of new ways of thinking will be introduced to concepts new to systems thinking that integrate systems thinking and futures thinking. The concept of anticipatory present moment (APM) serves as a basis for learning the cognitive skills that better enable navigation through turbulent times. A key personal and team practice is participative repatterning, which is the basis for transformative innovation. This practice is aided by new methods of visual facilitation. The reader is guided through the unfolding of the ideas and practices with a narrative based on the metaphor of search portrayed in the tradition of ox herding, found in traditional Far Eastern consciousness practice.
For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently-available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly-introduced leukotriene modifier drugs; and in the context of frontline research into anti-inflammatory drugs of the future. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in their specialty.
The legacy of ancient Greece and Rome has been imitated, resisted, misunderstood, and reworked by every culture that followed. In this volume, some five hundred articles by a wide range of scholars investigate the afterlife of this rich heritage in the fields of literature, philosophy, art, architecture, history, politics, religion, and science.
The main feature of this work is that it explores criminal behavior from all aspects of Tinbergen's Four Questions. Rather than focusing on a single theoretical point of view, this book examines the neurobiology of crime from a biosocial perspective. It suggests that it is necessary to understand some genetics and neuroscience in order to appreciate and apply relevant concepts to criminological issues. Presenting up-to-date information on the circuitry of the brain, the authors explore and examine a variety of characteristics, traits and behavioral syndromes related to criminal behavior such as ADHD, intelligence, gender, the age-crime curve, schizophrenia, psychopathy, violence and substance abuse. This book brings together the sociological tradition with the latest knowledge the neurosciences have to offer and conveys biological information in an accessible and understanding way. It will be of interest to scholars in the field and to professional criminologists.
Looking at health and health care in a new way, this book examines health risks and benefits as encountered 'on the move' rather than focusing on the risks and benefits incurred at fixed locations. The provision and utilization of health care is also investigated, as produced/delivered and consumed/accessed in mobile settings. Engaging with the contemporary concern with 'mobilities' this book covers many forms of movement and flow, including movements of people, disease, information and health care. The issues and problems which are considered - whether re-emerging infections, displaced persons, or the 'risks' of globalised travel - are of current and ongoing concern. Drawing on three main disciplines, geography, sociology, and epidemiology, author Tony Gatrell makes strong connections between these areas of inquiry, drawing on (for example) social theorising, geographical concepts, and epidemiological methods and data. The book will be of interest to the growing number of geographers working on the geography of health, along with social scientists involved in the mobilities 'turn'. More broadly, as issues of global public health that invariably involve the movements of people, goods, viruses and information continue to hit the headlines, the book is both timely and of policy relevance.
The Encyclopedia of Vaudeville provides a unique record of what was once America's preeminent form of popular entertainment from the late 1800s through the early 1930s. It includes entries not only on the entertainers themselves, but also on those who worked behind the scenes, the theatres, genres, and historical terms. Entries on individual vaudevillians include biographical information, samplings of routines and, often, commentary by the performers. Many former vaudevillians were interviewed for the book, including Milton Berle, Block and Sully, Kitty Doner, Fifi D'Orsay, Nick Lucas, Ken Murray, Fayard Nicholas, Olga Petrova, Rose Marie, Arthur Tracy, and Rudy Vallee. Where appropriate, entries also include bibliographies. The volume concludes with a guide to vaudeville resources and a general bibliography. Aside from its reference value, with its more than five hundred entries, The Encyclopedia of Vaudeville discusses the careers of the famous and the forgotten. Many of the vaudevillians here, including Jack Benny, George Burns and Gracie Allen, Jimmy Durante, W. C. Fields, Bert Lahr, and Mae West, are familiar names today, thanks to their continuing careers on screen. At the same time, and given equal coverage, are forgotten acts: legendary female impersonators Bert Savoy and Jay Brennan, the vulgar Eva Tanguay with her billing as “The I Don't Care Girl,” male impersonator Kitty Doner, and a host of “freak” acts.
Much new data and many new ideas have emerged in the area of oregeology and industrial minerals since publication of the secondedition of this text in 1987. The overriding philosophy behind thisnew edition is the inclusion and integration of this new materialwithin the established framework of the text. The third edition isre-presented in the modern double-column format. Non-metallic deposits of industrial and bulk materials are fullycovered to meet the changing emphasis of courses in appliedgeology. In addition, chapter 1 has been considerably enlarged toinclude a section on mineral economics covering metals, industrialminerals and bulk materials. In this section, the various aspectsof economic exploitation of industrial and bulk materials arecompared with those of metallic deposits. Other major revisions andadditions include a section on fluid inclusions, expansion of thesection on wall rock alteration, expansion of the material onisotope studies, and the inclusion of a section on hydraulicfracturing and seismic pumping.
Have you ever had a question that keeps persisting and for which you cannot find a clear answer? Is the question seemingly so ‘simple that the problem is glossed over in most resources, or skipped entirely?CRC Press/Taylor and Francis is pleased to introduce Commonly Asked Questions in Thermodynamics, the first in a new series of books that addres
Dynamic environments abound, encompassing many real-world problems in fields as diverse as finance, engineering, biology and business. A vibrant research literature has emerged which takes inspiration from evolutionary processes to develop problem-solvers for these environments. 'Foundations in Grammatical Evolution for Dynamic Environments' is a cutting edge volume illustrating current state of the art in applying grammar-based evolutionary computation to solve real-world problems in dynamic environments. The book provides a clear introduction to dynamic environments and the types of change that can occur. This is followed by a detailed description of evolutionary computation, concentrating on the powerful Grammatical Evolution methodology. It continues by addressing fundamental issues facing all Evolutionary Algorithms in dynamic problems, such as how to adapt and generate constants, how to enhance evolvability and maintain diversity. Finally, the developed methods are illustrated with application to the real-world dynamic problem of trading on financial time-series. The book was written to be accessible to a wide audience and should be of interest to practitioners, academics and students, who are seeking to apply grammar-based evolutionary algorithms to solve problems in dynamic environments. 'Foundations in Grammatical Evolution for Dynamic Environments' is the second book dedicated to the topic of Grammatical Evolution.
Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.
Now in its Fifth Edition, Crofton and Douglas's Respiratory Diseases has firmly established itself as the leading clinical textbook on diseases of the chest. Presented, for the first time, as a two-volume set, this classic text has been completely rewritten and greatly expanded. Extensive revisions ensure that these volumes present an up-to-date review of all aspects of lung disease . The contributions of some 18 leading authorities ensure that each area is comprehensively covered and new to this edition are chapters on the genetics of lung disease, smoking, air pollution, sleep apnoea, diving, lung transplantation and medico-legal aspects. The changes in content reflect the pace of change in the areas concerned not only in terms of understanding of the disease processes but also their treatment. The single chapter on asthma that appeared in previous editions, has now been expanded into three chapters covering epidemiology, mechanisms and management, reflecting the enormous research effort currently underway following a marked increase in the incidence of this disease in recent years. This new edition continues to provide an excellent reference both for the trainee and specialist in respiratory medicine, as well as the general physician. It will be extremely useful on the ward and in the office, where clinical problems arise and questions are asked which need clear answers.
This book is written by a leading authority on the subject of magmatic sulfide deposits. An overview of deposit types, accompanied by a summary of the resources of nickel, copper and platinum-group elements in the world’s principal known deposits, is followed by a summary of the relevant physical chemistry. The core of the book comprises a discussion about the geology and geochemistry of each of the deposit types in turn, accompanied by the implications of this data to the origin of the deposits in the light of our understanding of the chemical processes involved. A final chapter focuses on the use of the genetic concepts in exploration.
An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator
This must-have clinical reference, by Drs. Amy S. Paller and Anthony J. Mancini, provides practical, authoritative guidance for identification and management of all types of skin disorders seen in children and adolescents. Hurwitz Clinical Pediatric Dermatology, 5th Edition, is ideal for pediatricians, dermatologists, family practitioners and anyone who sees children with skin disorders – no matter what level of experience you may have. Benefit from the knowledge and expertise of two leaders in the field, who provide a clearly written, consistent approach throughout the text. Stay on the cutting edge of what’s new in pediatric dermatology – from the neonate to the adolescent - with the latest drug developments and disease classifications. Recognize virtually any skin condition you’re likely to see thanks to more than 1,000 high-quality color images, including over 300 brand new to this edition. Find the most appropriate therapy options with updated evidence based guidance. Easily locate the information you need with more quick-reference boxes and summary tables throughout the text.
During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
The 3rd edition of this leading text provides a detailed account of the purposes of judicial review; the nature of the public-private divide in Northern Ireland law; the judicial review procedure; the grounds for review; and remedies. As with the previous editions, the focus is on case law that is unique to Northern Ireland, and the book identifies some important differences between principle and practice in Northern Ireland and England and Wales. These now include differences resulting from the Ireland-Northern Ireland Protocol (as amended by the Windsor Framework), and this edition explains how and when EU law continues to apply in Northern Ireland. It also considers the leading Human Rights Act decisions of the Northern Ireland courts and the House of Lords and UK Supreme Court. The new edition refers to case law from the courts in England and Wales and Scotland; the Court of Justice of the European Union; and the European Court of Human Rights. There is a particular focus on recent rulings of the High Court and Court of Appeal in Northern Ireland and of rulings of the Supreme Court in cases heard on appeal from Northern Ireland. It considers the main points of the Judicial Review Practice Direction 03-2018 and surveys the European Union (Withdrawal) Act 2018 and its implications for Northern Ireland (including the incorporation of the Ireland-Northern Ireland Protocol, as amended by the Windsor Framework). The book will be of use to practitioners in Northern Ireland and the rest of the UK, and also to those involved in the study of judicial reasoning in different jurisdictions (both within the UK and elsewhere).
Written by two leaders in the field of pediatric dermatology, this classic text provides both detailed content for the specialist and easily accessible information for the non-dermatologist and less experienced clinician. Paller and Mancini – Hurwitz Clinical Pediatric Dermatology, 6th Edition, comprehensively covers the full range of skin disorders in children, offering authoritative, practical guidance on diagnosis and treatment in a single volume. This award-winning, evidence-based text has been fully revised and updated, and is an essential resource for anyone who sees children with skin disorders. - Features new content outline boxes for faster navigation, hundreds more clinical images, and authors' tips for the diagnosis and treatment of pediatric skin diseases. - Contains updated, evidence-based guidance and the latest drug developments and disease classifications. - Provides a careful balance of narrative text, useful tables, and 1,300 high-quality clinical photographs, helping you recognize virtually any skin condition you're likely to see. - Includes a greatly expanded discussion of atopic dermatitis and psoriasis and new therapeutic approaches for treating genetic disorders and systemic diseases such as ichthyoses and rheumatologic disorders. - Discusses new tests for subclassifying disease, such as the myositis-specific antibodies of juvenile dermatomyositis, genotyping, and immunophenotypes of inflammatory skin disorders. - Contains new and updated tables on psoriasis co-morbidities, genetic syndrome classifications, acne therapies, pediatric histiocytoses, PHACE syndrome criteria, HSV therapies and juvenile dermatomyositis. - Features updated sections on infections, exanthems, vascular disorders, dermatoses and genodermatoses. - Discusses hot topics such as the use of stem cell and cell therapy, as well as recombinant protein, for treating epidermolysis bullosa; the resurgence of measles; congenital Zika virus infections; and much more.
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