Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.
This book brings genre back to the forefront of the current transmedia trend. Genres are perhaps the most innately transmedial of media constructs, formed as they are from all kinds of industrial, technological and discursive phenomena. Yet, few have considered how genre works in a multiplatform context. This book does precisely that, making a uniquely transmedial contribution to the study of genre in the age of media convergence. The book interrogates how industrial, technological and participatory transformations of digital platforms and emerging technologies reshape workings of genre. The authors consider franchises such as Star Wars, streaming platforms such as Netflix, catch-up services such as ITV Hub, creative technologies such as virtual reality, and beyond. In setting the stage for the revival of genre theory in contemporary transmedia scholarship, this book pushes forward understandings of multiplatform media and the emerging form and function of genre across contemporary culture.
This book shows how the unique characteristics of traditionally differentiated media continue to determine narrative despite the recent digital convergence of media technologies. The author argues that media are now each largely defined by distinctive industrial practices that continue to preserve their identities and condition narrative production. Furthermore, the book demonstrates how a given medium’s variability in institutional and technological contexts influences diverse approaches to storytelling. By connecting US film, television, comic book and video game industries to their popular fictional characters and universes; including Star Wars, Batman, Game of Thrones and Grand Theft Auto; the book identifies how differences in industrial practice between media inform narrative production. This book is a must read for students and scholars interested in transmedia storytelling.
Now in its Fifth Edition, Crofton and Douglas's Respiratory Diseases has firmly established itself as the leading clinical textbook on diseases of the chest. Presented, for the first time, as a two-volume set, this classic text has been completely rewritten and greatly expanded. Extensive revisions ensure that these volumes present an up-to-date review of all aspects of lung disease . The contributions of some 18 leading authorities ensure that each area is comprehensively covered and new to this edition are chapters on the genetics of lung disease, smoking, air pollution, sleep apnoea, diving, lung transplantation and medico-legal aspects. The changes in content reflect the pace of change in the areas concerned not only in terms of understanding of the disease processes but also their treatment. The single chapter on asthma that appeared in previous editions, has now been expanded into three chapters covering epidemiology, mechanisms and management, reflecting the enormous research effort currently underway following a marked increase in the incidence of this disease in recent years. This new edition continues to provide an excellent reference both for the trainee and specialist in respiratory medicine, as well as the general physician. It will be extremely useful on the ward and in the office, where clinical problems arise and questions are asked which need clear answers.
Provides comprehensive coverage of major topics in urban and regional studies Under the guidance of Editor-in-Chief Anthony Orum, this definitive reference work covers central and emergent topics in the field, through an examination of urban and regional conditions and variation across the world. It also provides authoritative entries on the main conceptual tools used by anthropologists, sociologists, geographers, and political scientists in the study of cities and regions. Among such concepts are those of place and space; geographical regions; the nature of power and politics in cities; urban culture; and many others. The Wiley Blackwell Encyclopedia of Urban and Regional Studies captures the character of complex urban and regional dynamics across the globe, including timely entries on Latin America, Africa, India and China. At the same time, it contains illuminating entries on some of the current concepts that seek to grasp the essence of the global world today, such as those of Friedmann and Sassen on ‘global cities’. It also includes discussions of recent economic writings on cities and regions such as those of Richard Florida. Comprised of over 450 entries on the most important topics and from a range of theoretical perspectives Features authoritative entries on topics ranging from gender and the city to biographical profiles of figures like Frank Lloyd Wright Takes a global perspective with entries providing coverage of Latin America and Africa, India and China, and, the US and Europe Includes biographies of central figures in urban and regional studies, such as Doreen Massey, Peter Hall, Neil Smith, and Henri Lefebvre The Wiley Blackwell Encyclopedia of Urban and Regional Studies is an indispensable reference for students and researchers in urban and regional studies, urban sociology, urban geography, and urban anthropology.
The controversial New York Times–bestselling biography of America’s most infamous president written by a master of investigative political reporting. Anthony Summers’s towering biography of Richard Nixon reveals a tormented figure whose criminal behavior did not begin with Watergate. Drawing on more than a thousand interviews and five years of research, Summers traces Nixon’s entire career, revealing a man driven by addiction to power and intrigue. His subversion of democracy during Watergate was the culmination of years of cynical political manipulation. Evidence suggests the former president had problems with alcohol and prescription drugs, was mentally unstable, and was abusive to his wife, Pat. Summers discloses previously unrevealed facts about Nixon’s role in the plots against Fidel Castro and Salvador Allende, his sabotage of the Vietnam peace talks in 1968, and his acceptance of funds from dubious sources. The Arrogance of Power shows how the actions of one tormented man influenced 50 years of American history, in ways still reverberating today. “Summers has done an enormous service. . . . The inescapable conclusion, well body-guarded by meticulous research and footnotes, is that in the Nixon era the United States was in essence a ‘rogue state.’ It had a ruthless, paranoid and unstable leader who did not hesitate to break the laws of his own country.”—Christopher Hitchens, The New York Times Book Review “A superbly researched and documented account—the last word on this dark and devious man.”—Paul Theroux
Providing a description of the state of modelling in global and national economies, this title introduces an approach to modelling that can readily be adopted for use in understanding how economies work and in generating forecasts for decision-makers and policy-makers alike.
Anthony Platt's study, a chronicle of the child-saving movement and the juvenile court, explodes myth after myth about the benign character of both. The movement is described not as an effort to liberate and dignify youth but as a punitive, romantic, and intrusive effort to control the lives of lower-class urban adolescents and to maintain their dependent status. In so doing Platt analyzes early views of criminal behavior, the origins of the reformatory system, the social values of middle-class reformers, and the handling of youthful offenders before and after the creation of separate juvenile jurisdictions. In this second, enlarged edition of The Child Savers, the author has added a new introduction and postscript in which he critically reflects upon his original analysis, suggests new ways of thinking about the child-saving movement, and summarizes recent developments in the juvenile justice system.
As the wine industry has experienced a period of rapid global expansion, there is a renewed emphasis on quality and consistency even within the small winery industry. Written for the small production program, A Complete Guide to Quality in Small-Scale Wine Making is for the novice to intermediate level winemaker seeking foundational information in chemistry and sensory science as they relate to wine quality at a technical level. Drawing from personal experience as well as scientific literature, this book introduces the core concepts of winemaking before delving into methods and analysis to provide practical insights into creating and maintaining quality in the wine product. - Understand the chemistry and sensory science at the foundation of quality wines - Explore real-world examples of key analysis and application of concepts - Practice methods and exercises for hands-on experience
Causal analytics methods can revolutionize the use of data to make effective decisions by revealing how different choices affect probabilities of various outcomes. This book presents and illustrates models, algorithms, principles, and software for deriving causal models from data and for using them to optimize decisions with uncertain outcomes. It discusses how to describe and summarize situations; detect changes; evaluate effects of policies or interventions; learn what works best under different conditions; predict values of as-yet unobserved quantities from available data; and identify the most likely explanations for observed outcomes, including surprises and anomalies. The book resents practical techniques for causal modeling and analytics that practitioners can apply to improve understanding of how choices affect probabilities of consequences and, based on this understanding, to recommend choices that are more likely to accomplish their intended objectives.The book begins with a survey of modern analytics methods, focusing mainly on techniques useful for decision, risk, and policy analysis. Chapter 2 introduces free in-browser software, including the Causal Analytics Toolkit (CAT) software, to enable readers to perform the analyses described and to apply modern analytics methods easily to their own data sets. Chapters 3 through 11 show how to apply causal analytics and risk analytics to practical risk analysis challenges, mainly related to public and occupational health risks from pathogens in food or from pollutants in air. Chapters 12 through 15 turn to broader questions of how to improve risk management decision-making by individuals, groups, organizations, institutions, and multi-generation societies with different cultures and norms for cooperation. These chapters examine organizational learning, community resilience, societal risk management, and intergenerational collaboration and justice in managing risks.
The essential guide to everyday anesthetic practice. In an easy-access, alphabetical format, this manual provides indispensable information about the practices and the management of anesthesia. Includes coverage of commonly used drugs, management of life threatening emergencies, techniques, and more. (Midwest).
The Westmead Anaesthetic Manual has been assisting anaesthetists and other acute-care doctors and nurses to save patient lives and improve patient safety care for the past 15 years. This fourth edition continues to present a step-by-step guide to anaesthetic practice. It has been fully revised and updated to reflect current best practice in the management of almost every type of anaesthetic emergency. Examples include: • the latest cardiac arrest management guidelines from the Australian Resuscitation Council • management of the "Can't Intubate Can't Oxygenate" situation • the most current recommendations for the management of anaphylaxis from the ANZCA Anaesthetic Allergy Group. No other anaesthetic manual on the market is as compact, comprehensive and user friendly as the Westmead Anaesthetic Manual. It is the book you need when dealing with the complex, the unexpected and the dreaded in anaesthetic practice. Anthony P. Padley, MBBS (UNSW), FANZCA, is a Senior Staff Specialist Anaesthetist at Westmead Hospital and a VMO Anaesthetist at Westmead Private Hospital.
Prosodic Features and Prosodic Structure presents an overall view of the nature of prosodic features of language - accent, stress, rhythm, tone, pitch, and intonation - and shows how these connect to sound systems and meaning. It is a work of great scholarship and learning, expressed in way that will be accessible to all linguists from advanced undergraduates to postdoctoral researchers. The last substantial overview was published over 20 years ago. Since then the subject has been transformed by linked advances in phonological and phonetic theory and accoustic technology. This book will interest phonologists, phoneticians, and researchers in related applied fields such as speech pathology and speech synthesis.
The field of natural computing has been the focus of a substantial research effort in recent decades. One particular strand of this research concerns the development of computational algorithms using metaphorical inspiration from systems and phenomena that occur in the natural world. These naturally inspired computing algorithms have proven to be successful problem-solvers across domains as diverse as management science, bioinformatics, finance, marketing, engineering, architecture and design. This book is a comprehensive introduction to natural computing algorithms, suitable for academic and industrial researchers and for undergraduate and graduate courses on natural computing in computer science, engineering and management science.
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