“A comprehensive account of the legendary 1978 heist . . . impressive.” —Kirkus Reviews The crime that inspired the movie Goodfellas. The rest of the story that couldn’t be told—until now. One of the biggest scores in Mafia history, the Lufthansa Airlines heist of 1978 has become the stuff of mafia legend—and a decades-long investigation that continues to this day. Pulitzer Prize-winning reporter Anthony DeStefano sheds new light on this legendary unsolved case using recent evidence from the 2015 trial of eighty-year-old mafioso Vincent Asaro, who for the first time speaks out on his role in the fateful Lufthansa heist. This blistering you-are-there account takes you behind the headlines and inside the ranks of America’s infamous Mafia families—with never-before-told stories, late-breaking news, and bombshell revelations. Praise for Anthony D. DeStefano’s TOP HOODLUM: Frank Costello, Prime Minister of the Underworld “An engrossing chronicle of the life of notorious Mafia boss . . . DeStefano’s canny insight into the don’s mind and motivations set this biography apart from others on Frank Costello.” —Publishers Weekly “DeStefano tells Costello's story well.” —Kirkus Reviews
First released in 2007, the bestselling Transport Revolutions argued that land transport in the first half of the 21st century will feature at least two revolutions. One will involve the use of electric drives rather than internal combustion engines. Another will involve powering many of these drives directly from the electric grid - as trains and trolley buses are powered today - rather than from on-board fuel. Now available for the first time in paperback and updated with the most recent data, it sets out the challenges to our growing dependence on transport fuelled by low-priced oil. These challenges include an early peak in world oil production and profound climate change resulting in part from oil use. It proposes responses to ensure effective, secure movement of people and goods in ways that make the best use of renewable sources of energy while minimizing environmental impacts. Synthesizing engineering, economics, environment, organization, policy and technology in a detailed yet highly readable style, Transport Revolutions is essential reading for anyone working, studying or interested in transport and the environment.
The definitive book on the ultimate mob boss—featuring new FBI revelations, rare family photos, and never-before-published material. To authorities, Frank Costello was “The Prime Minister of the Underworld” and “one of the most powerful and influential Mafia leaders in the U.S.” To friends and associates, he was simply “Uncle Frank.” Pulitzer Prize-winning reporter Anthony M. DeStefano sets out to answer who Frank Costello really was in this definitive portrait of one of the most fascinating figures in the annals of American crime . . . Using newly released FBI files, eyewitness accounts, and family mementos, Top Hoodlum takes you inside the Mafia that Frank Costello helped build from the ground up. These are the riveting stories and stunning revelations that have inspired American crime classics like The Godfather, Casino, Goodfellas, and The Sopranos. This is the man who made the Mafia such a powerful force in our nation’s history. The man who refused to admit his crimes long after he retired. This is Top Hoodlum. Praise for Anthony M. DeStefano and his books on the Mafia “Thrilling American crime writing.” —Jimmy Breslin on King of the Godfatherss “Terrific . . . A fitting end to the murderous story of the 1978 Lufthansa heist.” —Nicholas Pileggi, author of Wiseguy on The Big Heist “The best and last word on the subject . . . DeStefano brings the story to life.” —Jerry Capeci, creator of the website GangLandNews “DeStefano tells Costello’s story well.” —Kirkus Reviews “A master at cutting through the secrecy of the Mafia.” —Publishers Weekly
Pulizter Prize-winning journalist Anthony M. DeStefano’s latest in-depth history of organized crime exposes the truth behind the mafia crew that took down John Gotti. THE BOSS OF BOSSES Pulitzer Prize-winning journalist Anthony M. DeStefano exposes the rise and fall of Vito Genovese in this first comprehensive biography of the legendary mafioso—from his childhood in Naples, Italy, and the beginnings of his bullet-ridden criminal career on lower Manhattan’s mean streets, through his self-exile in the mid-1930s back to his homeland where he ran a black market operation under the fascist regime of Benito Mussolini, and his return to New York where Genovese made a fortune as the head of an illegal narcotics empire. As a member of Giuseppe “Joe the Boss” Masseria’s gang in New York City, Genovese ran rackets before joining forces with Lucky Luciano, Frank Costello, Meyer Lansky, and Bugsy Siegel as bootleggers during Prohibition. He helped orchestrate Masseria’s slaughter on behalf of Brooklyn crime lord Salvatore Maranzano, consolidating his position and power before ensuring Maranzano, too, was knocked off. For the next three decades, Vito Genovese—shrewd, merciless, and utterly savage—killed countless gangsters in his bid to become the capo di tutti i capi—boss of bosses—in the American Mafia. Don Vito would betray some of the mafia’s most notorious bosses, including Albert Anastasia and Frank Costello, to eventually seize control of the Luciano crime family, one that still bears the Genovese name today. Praise for Anthony M. DeStefano’s Gotti’s Boys “DeStefano explores John Gotti’s rise to the head of the Gambino family . . . Aficionados are sure to relish the finer, exhaustively researched details.” —Publishers Weekly “A thrilling ride . . . DeStefano has written another excellent biography of a memorable group of gangsters and an excellent addition to the history of the Teflon Don.” —Booklist
Climate change will be an ecological and humanitarian catastrophe unless we move quickly to eliminate greenhouse gas emissions. Policy experts advise us that we need to make major changes to our lifestyles, and our governments need to agree globally binding treaties and implement market instruments like carbon taxes. This advice is a mistake: it treats technological innovation as being at the periphery of the climate policy challenge, whereas it needs to be at its core; we will phase out emissions when and only when the technologies to replace fossil fuels are good enough, and policies need - quickly - to support these new technologies directly. Anyone with an interest in climate change and energy policy will find this book forward-thinking and invaluable. Professional policy-makers, climate and energy policy researchers, and students of energy and public policy, economics, political science, environmental studies, and geography will find this book especially stimulating.
The updated bestselling biography—based on over six hundred interviews—and the inspiration for the Netflix documentary, The Mystery of Marilyn Monroe. Marilyn Monroe, born in obscurity and deprivation, became an actress and legend of the twentieth century, romantically linked to famous men from Joe DiMaggio to Arthur Miller to John F. Kennedy. But her tragic death at a young age, under suspicious circumstances, left behind a mystery that remains unsolved to this day. Anthony Summers interviewed more than six hundred people, laying bare the truths—sometimes funny, often sad—about this brilliant, troubled woman. The first to gain access to the files of Monroe’s last psychiatrist, Summers uses the documents to explain her tangled psyche and her dangerous addiction to medications. He establishes, after years of mere rumor, that President Kennedy and his brother Robert were both intimately involved with Monroe in life—and in covering up the circumstances of her death. Written and updated by a Pulitzer Prize nominee who has authored works on JFK, J. Edgar Hoover, and the 9/11 attacks, this investigation of an iconic star’s brief life and early death is “remarkable. . . . The ghost of Marilyn Monroe cries out in these pages” (The New York Times). Netflix’s The Mystery of Marilyn Monroe will cement this work as the definitive biography of the unforgettable woman.
These guidelines are designed for decision makers (selection, country commissioners, city planners, preservation officers, contractors, rehabilitation engineers, etc.) to understand the components that are used to make effective decisions about how and when to repair a covered bridge, such as structural integrity, engineering analyses, condition assessments, how to support the bridge during repairs, and more. There are numerous types of covered bridges and ensuring public safety during repairs is a paramount issue for future generations to enjoy. Related products: Find more Renovation & Historic Preservation resources here: https: //bookstore.gpo.gov/catalog/renovation-historic-preservation Bridges & Tunnels resources collection here: https: //bookstore.gpo.gov/catalog/bridges-tunnels Other products published by the U.S. Forest Service are available here: https: //bookstore.gpo.gov/agency/us-forest-service
Even in the 21st Century, the manufacture of leather retains an air of the dark arts, still somewhat shrouded in the mysteries of a millennia old, craft based industry. Despite the best efforts of a few scientists over the last century or so, much of the understanding of the principles of tanning is still based on received wisdom and experience. Leather is made from (usually) the hides and skins of animals - large animals such as cattle have hides, small animals such as sheep have skins. The skin of any animal is largely composed of the protein collagen, so it is the chemistry of this fibrous protein and the properties it confers to the skin with which the tanner is most concerned. In addition, other components of the skin impact on processing, impact on the chemistry of the material and impact on the properties of the product, leather. Therefore, it is useful to understand the relationships between skin structure at the molecular and macro levels, the changes imposed by modifying the chemistry of the material and the eventual properties of the leather. This book aims to contribute to changing the thinking in the industry, to continue building a body of scientific understanding, aimed at enhancing the sustainability of an industry which produces a unique group of materials, derived from a natural source. The Science of Leather is the only current text on tanning science, and addresses the scientific principles which underpin the processes involved in making leather. It is concerned with the chemical modification of collagen, prior to tanning and the tanning reactions in particular. The subject is covered in the following order: collagen chemistry, collagen structure, skin structure, processing to prepare for tanning, the tanning processes and processing after tanning. The aim of the book is to provide leather scientists and technologists with an understanding of how the reactions work, the nature of their outcomes and how the processes can be controlled and changed. The objective is to synthesise a scientific view of leather making and to arrive at an understanding of the nature of tanning - how the wide range of chemistries employed in the art can change the properties of collagen, making leather with different properties, especially conferring different degrees of stabilisation as measured by the hydrothermal stability. Environmental issues are not treated as a separate theme - the impact of leather making on the environment is a thread running through the text, with the assumption that better understanding of the science of leather making will lead to improved processing. The book also reflects on the ways leather technology may develop in the future based on the foundation of understanding the scientific principles which can be exploited. It also includes a subject index, references and a glossary. The book provides the reader with insights into the role science plays in leather technology and provides fundamental understanding, which should be the basis for scientific and technological research and development for the benefit of the global leather industry. The book is aimed at students, leather scientists and technologists, in both academia and industry, in leather production and in chemical supply houses.
A Crazed Killer He dissolved the bodies of some of his victims in acid and poured them down the sewer. He hung grisly souvenirs on nails in his junkyard. La Costra Nostra Charles Carneglia was a stone-cold killer who fell in with the bloodthirsty John Gotti crew. As the infamous crime family rose to power with their murderous trail of sex, jealousy, greed, and revenge, Carneglia rose with them. Mafia, Madness And Murder This is the horrifying story of a misfit who fit perfectly into the New York mafia. In a harrowing journey inside a ruthless criminal underworld, Pulitzer Prize-winning reporter Anthony M. DeStefano chronicles one man's life in a world of depraved acts of violence and the horrors that went with being a member of the Gambino family. "Thrilling American crime writing." -Jimmy Breslin on King of the Godfathers Includes 16 Pages of Shocking Photos
A New York Times–bestselling author’s revealing, “important” biography of the longtime FBI director (The Philadelphia Inquirer). No one exemplified paranoia and secrecy at the heart of American power better than J. Edgar Hoover, the original director of the Federal Bureau of Investigation. For this consummate biography, renowned investigative journalist Anthony Summers interviewed more than eight hundred witnesses and pored through thousands of documents to get at the truth about the man who headed the FBI for fifty years, persecuted political enemies, blackmailed politicians, and lived his own surprising secret life. Ultimately, Summers paints a portrait of a fatally flawed individual who should never have held such power, and for so long.
Networked Graphics equips programmers and designers with a thorough grounding in the techniques used to create truly network-enabled computer graphics and games. Written for graphics/game/VE developers and students, it assumes no prior knowledge of networking.The text offers a broad view of what types of different architectural patterns can be found in current systems, and readers will learn the tradeoffs in achieving system requirements on the Internet. It explains the foundations of networked graphics, then explores real systems in depth, and finally considers standards and extensions.Numerous case studies and examples with working code are featured throughout the text, covering groundbreaking academic research and military simulation systems, as well as industry-leading game designs. - Everything designers need to know when developing networked graphics and games is covered in one volume - no need to consult multiple sources - The many examples throughout the text feature real simulation code in C++ and Java that developers can use in their own design experiments - Case studies describing real-world systems show how requirements and constraints can be managed
Packed with revelations, this is the first complete account of a career built on raw talent, sheer willpower--and criminal connections. Anthony Summers--bestselling author of Goddess: The Secret Lives of Marilyn Monroe--and Robbyn Swan unveil stunning new information about Sinatra’s links to the Mafia, his crowded love life and his tangled relationships with U.S. presidents. Exclusive breakthroughs include the discovery of how the Mafia connection began--in a remote Sicilian village--and moving interviews with his lovers. Never-before-published conversations with Ava Gardner get to the core of the tragic passion that dominated his life, came close to destroying him, and made his best work heartbreakingly personal. Sinatra delivers the full life story of a complex, flawed genius.
Marilyn, JFK, Hoover: Three provocative works of investigative journalism by a New York Times–bestselling author and finalist for the Pulitzer Prize. New York Times–bestselling author Anthony Summers was a finalist for the Pulitzer Prize in 2012 for his acclaimed account of the 9/11 attacks, The Eleventh Day. In these three exposés, Summers uncovers the truth behind the myth-making, cover-ups, and lies surrounding the death of Marilyn Monroe, the assassination of John F. Kennedy, and the career of infamous FBI director J. Edgar Hoover. Goddess: In this “remarkable” New York Times–bestselling biography of the iconic star’s brief life and tragic end, Summers establishes, after years of rumors, that President Kennedy and his brother Robert were both intimately involved with Monroe in life—and in covering up the circumstances of her death (The New York Times). “Convincing evidence of a crude but effective cover-up which was designed to protect Robert Kennedy.” —The Times Literary Supplement Not in Your Lifetime: Updated fifty years after the JFK assassination, Summers’s extensively researched account is comprehensive and candid, shedding new light on Lee Harvey Oswald and Jack Ruby in particular, providing “the closest we have to that literary chimera, a definitive work on the events in Dallas” (The Boston Globe). “Fresh and important . . . We rush on through [Summers’s] narrative as if we were reading an artful thriller.” —The New York Times “An awesome work, with the power of a plea as from Zola for justice.” —Los Angeles Times Official and Confidential: This “enthralling” New York Times–bestselling portrait of J. Edgar Hoover plumbs the depths of a man who possessed—and abused—enormous power as the director of the FBI for fifty years, persecuting political enemies, blackmailing politicians, and living his own surprising secret life, haunted by paranoia (Paul Theroux). “An important book that should give us all pause, especially policy makers.” —The Philadelphia Inquirer “Summers’ book is not just a history of a single hero-sized hypocrite, it is a history of a vast national delusion.” —The Spectator
A KILLER LINE-UP In his bloody reign as the head of the Gambino crime family, John Gotti wracked up a lifetime of charges from gambling, extortion, and tax evasion to racketeering, conspiracy, and five convictions of murder. He didn’t do it alone. Surrounding himself with a rogues gallery of contract killers, fixers, and enforcers, he built one of the richest, most powerful and violent crime empires in modern history. Pulitzer Prize–winning journalist Anthony M. DeStefano takes you inside Gotti’s inner circle to reveal the dark hearts and murderous deeds of the most remorseless and cold-blooded characters in organized crime. Men so vicious even the other Mafia families were terrified of them. Meet Gotti’s Boys . . . * Charles Carneglia * Gene Gotti * Angelo “Quack-Quack” Ruggiero * Tony “Roach” Rampino * “Sammy the Bull” Gravano * Frank DeCicco * Vincent Artuso * Joe “The German” Watts * THE ULTIMATE MURDERER’S ROW “DeStefano explores John Gotti’s rise to the head of the Gambino family . . . Aficionados are sure to relish the finer, exhaustively researched details.” —Publishers Weekly “A thrilling ride . . . DeStefano has written another excellent biography of a memorable group of gangsters and an excellent addition to the history of the Teflon Don.” —Booklist
Italian poet, novelist, literary critic and translator Cesare Pavese (1908-1950) is generally recognized as one of the most important writers of his period. Between the years 1929 and 1933, Pavese enjoyed a rich correspondence with his Italian American friend, the musician and educator Antonio Chiuminatto (1904-1973). The nature of this correspondence is primarily related to Pavese's thirst to learn about American culture, its latest books, its most significant contemporary writers, as well as its slang. This volume presents an annotated edition of Pavese and Chiminatto's complete epistolary exchange. Mark Pietralunga's brilliant introduction provides historical and cultural context for the letters and traces Pavese's early development as a leading Americanist and translator. The volume also includes an appendix of Chiuminatto's detailed annotations and thorough explanations of colloquial American terms and slang, drawn from the works of Sinclair Lewis, Sherwood Anderson, and William Faulkner. A lively and illuminating exchange, this collection ultimately corroborates critical opinion that America was the igniting spark of Pavese's literary beginnings as a writer and translator.
This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. - Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews - Provides researchers with an overview and synthesis of the latest research - Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed - Allows researchers to see at a glance what each chapter will cover - Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation
The Last Of The Old-World Mob Bosses--And The Ultimate Betrayal For more than twenty years, Joseph "Big Joey" Massino ran what was called the largest criminal network in the U.S., employing over two hundred and fifty made men and untold numbers of associates. The Bonanno family was responsible for over thirty murders, even killing a dozen of its own members to enforce discipline and settle scores. He would be brought down by Salvatore "Good Looking Sal" Vitale, the underboss who was not only Massino's closest and most trusted friend, but also his brother-in-law. In the end, facing the death penalty and the prospect of leaving his family penniless, Massino started talking to the FBI--the first Mafia Godfather to break the sacred code of omerta, and the end of a centuries-old tradition. Written by Pulitzer Prize-winning reporter Anthony DeStefano, who interviewed Massino's family and friends as well as law enforcement officials and confidential sources, King of the Godfathers is the story of the brutal mob war that made Massino head of the Bonanno family and the most powerful gangster in America. "The best and last word on the subject." --Jerry Capeci, Gangland News.com and bestselling co-author of Murder Machine With 16 Pages of Revealing Photos! Anthony Destefano was part of the team of New York Newsday reporters who won the 1992 Pulitzer Prize for coverage of the August 1991 subway crash in Manhattan. He covers organized crime for Newsday and was the lead reporter on several major criminal trials, including that of subway gunman Bernhard Goetz. He lives in New Jersey.
Learn, by example, the fundamentals of data analysis as well as several intermediate to advanced methods and techniques ranging from classification and regression to Bayesian methods and MCMC, which can be put to immediate use. Key Features Analyze your data using R – the most powerful statistical programming language Learn how to implement applied statistics using practical use-cases Use popular R packages to work with unstructured and structured data Book Description Frequently the tool of choice for academics, R has spread deep into the private sector and can be found in the production pipelines at some of the most advanced and successful enterprises. The power and domain-specificity of R allows the user to express complex analytics easily, quickly, and succinctly. Starting with the basics of R and statistical reasoning, this book dives into advanced predictive analytics, showing how to apply those techniques to real-world data though with real-world examples. Packed with engaging problems and exercises, this book begins with a review of R and its syntax with packages like Rcpp, ggplot2, and dplyr. From there, get to grips with the fundamentals of applied statistics and build on this knowledge to perform sophisticated and powerful analytics. Solve the difficulties relating to performing data analysis in practice and find solutions to working with messy data, large data, communicating results, and facilitating reproducibility. This book is engineered to be an invaluable resource through many stages of anyone’s career as a data analyst. What you will learn Gain a thorough understanding of statistical reasoning and sampling theory Employ hypothesis testing to draw inferences from your data Learn Bayesian methods for estimating parameters Train regression, classification, and time series models Handle missing data gracefully using multiple imputation Identify and manage problematic data points Learn how to scale your analyses to larger data with Rcpp, data.table, dplyr, and parallelization Put best practices into effect to make your job easier and facilitate reproducibility Who this book is for Budding data scientists and data analysts who are new to the concept of data analysis, or who want to build efficient analytical models in R will find this book to be useful. No prior exposure to data analysis is needed, although a fundamental understanding of the R programming language is required to get the best out of this book.
Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Resistance develops because the bacteria that antibiotics target can evolve ways to defend themselves against these drugs. When antibiotics fail, there is very little else to prevent an infection from spreading. Unnecessary use of antibiotics in both humans and animals accelerates the evolution of drug-resistant bacteria, with potentially catastrophic personal and global consequences. Our best defenses against infectious disease could cease to work, surgical procedures would become deadly, and we might return to a world where even small cuts are life-threatening. The problem of drug resistance already kills over one million people across the world every year and has huge economic costs. Without action, this problem will become significantly worse. Following from their work on the Review on Antimicrobial Resistance, William Hall, Anthony McDonnell, and Jim O’Neill outline the major systematic failures that have led to this growing crisis. They also provide a set of solutions to tackle these global issues that governments, industry, and public health specialists can adopt. In addition to personal behavioral modifications, such as better handwashing regimens, Superbugs argues for mounting an offense against this threat through agricultural policy changes, an industrial research stimulus, and other broad-scale economic and social incentives.
Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.
Market: medical students (18,000/ year); internists (75,000); internal medicine and family medicine residents (30,000), nurse practitioners (50,000), physician assistants (40,000), infectious diseases specialists (15,000); infectious diseases fellows (800) public health education and practice
The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms
Introducing the most dramatically revised edition of Harrison's ever! Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips! MORE THAN TRUSTED, BEYOND ESSENTIAL . . . The #1 selling medical textbook worldwide, Harrison's has defined internal medicine for millions of clinicians and students. The new Seventeenth Edition retains Harrison's acclaimed balance of pathobiology, cardinal signs and manifestations of disease, and best approaches to patient management, yet has been massively updated to give you an innovative array of bold new features and content. If ever there was one must-have resource for clinicians and students - this is it! UNMATCHED EXPERTISE AT YOUR FINGERTIPS As an unprecedented amount of medical information bombards you and your patients, where do you go to sort it out and make sense of it all? When your patients request clarification on something they've “printed off” where do you turn for expert explanations? The same trusted resource physicians and students have turned to for over fifty years: Harrison's Principles of Internal Medicine. Now more than ever, trust Harrison's to filter and clarify the exploding knowledge base, to highlight the breakthroughs, and to deliver a clear, balanced distillation of the best and most current information on which to base clinical decisions. THE MOST EXCITING AND EXTENSIVELY REVISED EDITION EVER! Here are just a few of the reasons why the new 17th Edition of Harrison's is the best edition yet: Bonus companion DVD featuring: 37 new “e-chapters”; over 500 brand-new radiological, laboratory, and clinical images, including complete atlases; state-of-the-art video clips; an Image Bank of nearly all the illustrations contained in the parent text, and much more Expanded, modernized illustration program with more than 800 brand-new, additional illustrations-a 60% increase over the previous edition Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues in Medicine: Patient Safety and Health Quality; Health Disparities: Atlas of EKGs; Clinical Management of Obesity: Atlas of Hematology: Atlases of Chest, Neurological, and Cardiovascular Radiology, and much more! Also included a complete new Section on biological foundations and emerging clinical applications of regenerative medicine! Brand new, reader-friendly text design optimizes the full-color format An expanded, innovative focus on global health NEW Global Advisory Board comprised of 11 prominent medical experts from Asia, India, Europe, and South America Revision of the popular On Line Learning Center, which offers more skill-sharpening self-assessment questions and answers, plus additional case studies for helping you apply Harrison's content to the daily care of patients Harrison's related products are available in a full suite of formats to meet all your educational and clinical needs. Harrison's Practice of Medicine is a complete database of more than 700 clinical topics formatted for use at the point of care. The Harrison's Manual of Medicine is one of the most popular and heavily used handbook-sized resources in internal medicine. The Harrison's Self-Assessment and Board Review features more than 1000 board-type cases and questions and highlights the use of Harrison's as a great board prep resouce.
Learn, by example, the fundamentals of data analysis as well as several intermediate to advanced methods and techniques ranging from classification and regression to Bayesian methods and MCMC, which can be put to immediate use. Key Features Analyze your data using R – the most powerful statistical programming language Learn how to implement applied statistics using practical use-cases Use popular R packages to work with unstructured and structured data Book Description Frequently the tool of choice for academics, R has spread deep into the private sector and can be found in the production pipelines at some of the most advanced and successful enterprises. The power and domain-specificity of R allows the user to express complex analytics easily, quickly, and succinctly. Starting with the basics of R and statistical reasoning, this book dives into advanced predictive analytics, showing how to apply those techniques to real-world data though with real-world examples. Packed with engaging problems and exercises, this book begins with a review of R and its syntax with packages like Rcpp, ggplot2, and dplyr. From there, get to grips with the fundamentals of applied statistics and build on this knowledge to perform sophisticated and powerful analytics. Solve the difficulties relating to performing data analysis in practice and find solutions to working with messy data, large data, communicating results, and facilitating reproducibility. This book is engineered to be an invaluable resource through many stages of anyone’s career as a data analyst. What you will learn Gain a thorough understanding of statistical reasoning and sampling theory Employ hypothesis testing to draw inferences from your data Learn Bayesian methods for estimating parameters Train regression, classification, and time series models Handle missing data gracefully using multiple imputation Identify and manage problematic data points Learn how to scale your analyses to larger data with Rcpp, data.table, dplyr, and parallelization Put best practices into effect to make your job easier and facilitate reproducibility Who this book is for Budding data scientists and data analysts who are new to the concept of data analysis, or who want to build efficient analytical models in R will find this book to be useful. No prior exposure to data analysis is needed, although a fundamental understanding of the R programming language is required to get the best out of this book.
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