Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies
A new and updated version of this best-selling resource! Jones and Bartlett Publisher's 2011 Nurse's Drug Handbook is the most up-to-date, practical, and easy-to-use nursing drug reference! It provides: Accurate, timely facts on hundreds of drugs from abacavir sulfate to Zyvox; Concise, consistently formatted drug entries organized alphabetically; No-nonsense writing style that speaks your language in terms you use everyday; Index of all generic, trade, and alternate drug names for quick reference. It has all the vital information you need at your fingertips: Chemical and therapeutic classes, FDA pregnancy risk category and controlled substance schedule; Indications and dosages, as well as route, onset, peak, and duration information; Incompatibilities, contraindications; interactions with drugs, food, and activities, and adverse reactions; Nursing considerations, including key patient-teaching points; Vital features include mechanism-of-action illustrations showing how drugs at the cellular, tissue, or organ levels and dosage adjustments help individualize care for elderly patients, patients with renal impairment, and others with special needs; Warnings and precautions that keep you informed and alert.
Get the solid foundation you need to practise nursing in Canada! Potter & Perry's Canadian Fundamentals of Nursing, 7th Edition covers the nursing concepts, knowledge, research, and skills that are essential to professional nursing practice in Canada. The text's full-colour, easy-to-use approach addresses the entire scope of nursing care, reflecting Canadian standards, culture, and the latest in evidence-informed care. New to this edition are real-life case studies and a new chapter on practical nursing in Canada. Based on Potter & Perry's respected Fundamentals text and adapted and edited by a team of Canadian nursing experts led by Barbara J. Astle and Wendy Duggleby, this book ensures that you understand Canada's health care system and health care issues as well as national nursing practice guidelines. - More than 50 nursing skills are presented in a clear, two-column format that includes steps and rationales to help you learn how and why each skill is performed. - The five-step nursing process provides a consistent framework for care, and is demonstrated in more than 20 care plans. - Nursing care plans help you understand the relationship between assessment findings and nursing diagnoses, the identification of goals and outcomes, the selection of interventions, and the process for evaluating care. - Planning sections help nurses plan and prioritize care by emphasizing Goals and Outcomes, Setting Priorities, and Teamwork and Collaboration. - More than 20 concept maps show care planning for clients with multiple nursing diagnoses. - UNIQUE! Critical Thinking Model in each clinical chapter shows you how to apply the nursing process and critical thinking to provide the best care for patients. - UNIQUE! Critical Thinking Exercises help you to apply essential content. - Coverage of interprofessional collaboration includes a focus on patient-centered care, Indigenous peoples' health referencing the Truth and Reconciliation Commission (TRC) Report, the CNA Code of Ethics, and Medical Assistance in Dying (MAID) legislation. - Evidence-Informed Practice boxes provide examples of recent state-of-the-science guidelines for nursing practice. - Research Highlight boxes provide abstracts of current nursing research studies and explain the implications for daily practice. - Patient Teaching boxes highlight what and how to teach patients, and how to evaluate learning. - Learning objectives, key concepts, and key terms in each chapter summarize important content for more efficient review and study. - Online glossary provides quick access to definitions for all key terms.
Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies
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