The present outline of astrocytic metabolic pathways involved in glucose and amino acid metabolism provides detailed information about the enzymatic pathways involved, as well as a description of the basic properties of the enzymes including regulatory mechanisms. Hence, the glycolytic pathway and glycogen metabolism are outlined, followed by a detailed account of pyruvate oxidation and its role as a substrate for the tricarboxylic acid (TCA) cycle. Moreover, a detailed description of the main enzymes involved in glutamate metabolism is provided and the role of the glutamate-glutamine cycle is explained. Since this text is primarily covering astrocytic metabolism, an emphasis has been placed on a discussion of the significance of the astrocyte specific enzymes pyruvate carboxylase and glutamine synthetase, which enable these cells to perform a net synthesis of glutamine, the precursor for synthesis of glutamate and γ-aminobutyrate (GABA), the main neurotransmitters of the brain. With this, we have underlined the fundamental importance of astrocytic metabolism for neuronal function with a particular emphasis on the fact that, without continuous support from the astrocytic partners in synaptic function, glutamatergic and GABAergic neurotransmission would not be possible. It is thought provoking that these neurotransmission processes, which account for the vast majority of synaptic activity in the brain, have been made totally dependent on astrocytic metabolic support, particularly with regard to replenishment of the respective neurotransmitters.
For more than 75 years, Grant’s Atlas of Anatomy has maintained a tradition of excellence while continually adapting to meet the needs of each generation of students. The updated 16th edition is a visually stunning reference that delivers the accuracy, pedagogy, and clinical relevance expected of this classic atlas, with new and enhanced features that make it even more practical and user-friendly. Illustrations drawn from real specimens, presented in surface-to-deep dissection sequence, set this book-only version of Grant’s Atlas of Anatomy apart as the most accurate reference available for learning human anatomy. These realistic representations bring structures to life and provide students with the ultimate lab resource.
This collection reviews national policies that critically influence economic performance in developing countries. It describes principles that shape good economic policy and illustrates them with case studies. In an overview that draws together insights from the essays, the volume editor explains why poor countries need sound government policies to offset unfavorable conditions, including scant natural resources, adverse problems that occur with monetary and exchange rate policies and financial sector reform. The basic rules for monetary policy in an open economy are developed along with the different ways in which financial reform and financial repression affect an economy. Practical ways to deal with foreign exchange markets are described. They include such arrangements as multiple exchange rates for commercial transactions and dual rates that separate commercial and financial transactions. Also examined are the ways in which trade liberalization and trade restrictions impede economic development. Advice is given on developing a uniform structure that balances the administration of taxes with the efficiency of a tax structure. The book examines the relationship between budget deficits and money creation and suggests management strategies for developing sound economic policy that include advice on inflation control, international trade, import restrictions, income tax rates, and price and wage controls. Published for the World Bank by Oxford University Press.
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