In humans, the natural history of prostate cancer spans 30–40 years, which makes it a difficult disease to model in rodents. Furthermore, the molecular pathology of prostate cancer responsible for tumor initiation and progression is complex and often redundant. The sequential changes in oncogene and tumor suppressor gene expression during prostate cancer progression have not been fully delineated. Despite these issues, there are model systems, including carefully designed orthotopic xenograft models, that provide robust platforms for drug evaluation and studying the effects of diet and environmental stress on prostate carcinogenesis. Comprehensive transgenic and knockout models have also been developed that recapitulate individual steps in tumor initiation and metastatic progression and highlight the importance of the tumor microenvironment. While very few of the transgenic and knockout systems recapitulate the entire natural history of prostate cancer, individual model systems provide valuable genetic insight into the biological consequences of disrupting prostate homeostasis.
The plain language guide to getting things running smoothly in the world of business Operations management is all about efficiency, and Operations Management For Dummies is all about efficiently teaching you what you need to know about this business hot topic. This book tracks typical operations management MBA courses, and it will help you un-muddle concepts like process mapping, bottlenecks, Lean Production, and supply chain management. Learn to step into a business, see what needs improving, and plug in the latest tools and ideas to shape things up in any industry. This latest edition covers, you guessed it, digital transformation. Technology is completely upending operations management, and Dummies walks you through the latest, so you can stay at the front of the pack. Other new stuff inside: supply chain traceability, ethical sourcing and carbon footprint, business resiliency, and modularizing the supply chain. It’s all here! Optimize operations and increase revenue with strategies and ideas that make businesses run better and cheaper Get easy-to-understand explanations of complex topics and theories in operations management Learn how operations management is affected by digital transformation and sustainability concerns Evaluate, design, improve, and scale all sorts of processes, regardless of business size or area of operation Businesses can't operate successfully without effective operations and supply management. That makes Operations Management For Dummies a must—for MBA students and business professionals alike.
Photo opportunities, ten-second sound bites, talking heads and celebrity anchors: so the world is explained daily to millions of Americans. The result, according to the experts, is an ignorant public, helpless targets of a one-way flow of carefully filtered and orchestrated communication. Common Knowledge shatters this pervasive myth. Reporting on a ground-breaking study, the authors reveal that our shared knowledge and evolving political beliefs are determined largely by how we actively reinterpret the images, fragments, and signals we find in the mass media. For their study, the authors analyzed coverage of 150 television and newspaper stories on five prominent issues—drugs, AIDS, South African apartheid, the Strategic Defense Initiative, and the stock market crash of October 1987. They tested audience responses of more than 1,600 people, and conducted in-depth interviews with a select sample. What emerges is a surprisingly complex picture of people actively and critically interpreting the news, making sense of even the most abstract issues in terms of their own lives, and finding political meaning in a sophisticated interplay of message, medium, and firsthand experience. At every turn, Common Knowledge refutes conventional wisdom. It shows that television is far more effective at raising the saliency of issues and promoting learning than is generally assumed; it also undermines the assumed causal connection between newspaper reading and higher levels of political knowledge. Finally, this book gives a deeply responsible and thoroughly fascinating account of how the news is conveyed to us, and how we in turn convey it to others, making meaning of at once so much and so little. For anyone who makes the news—or tries to make anything of it—Common Knowledge promises uncommon wisdom.
The traditional model of consulting places an emphasis on diagnosing a problem and finding a cure. But in today’s business world of globalized organizations, rapid knowledge proliferation, and the intertwining of economies, that approach is becoming less and less viable; problems are quickly redefined, new knowledge (and ownership of that knowledge) is constantly surfacing and being challenged, and no solution is a permanent solution. Consulting in Uncertainty articulates a model of consulting that addresses the uncertainty and interconnectedness of the world in a post-industrial, knowledge era. Emphasizing outcomes and inquiry over ‘diagnosis’, Brooks and Edwards outline this new consulting model, as well as the skills consultants must bring to the table in any uncertain and dynamic environment. Integrating practical knowledge with scholarship, this book covers skills such as: Relational skills and the consulting relationship Cultural awareness and related skills Contextual analysis Facilitating inquiry Collecting and efficiently analyzing data or information Consultants and students of consulting, as well as managers, teachers, counselors, and even parents, will find this book enlightening and useful in navigating today’s uncertain world.
Updated with new research and insights, the second edition of this foundational guide to the how of differentiation provides the thoughtful strategies teachers need to create and maintain classrooms where each student is recognized and respected and every student thrives. One of the most powerful lessons a teacher must learn is that classroom management is not about control; it's about delivering the support and facilitating the routines that will make the classroom work for each student, and thus, set all students free to be successful learners. In Leading and Managing a Differentiated Classroom, Carol Ann Tomlinson and Marcia B. Imbeau explore the central priorities and mindsets of differentiation and provide practical guidelines for making effective student-centered, academically responsive instruction a reality. Their classroom management approach is based on three critical understandings: 1. When students are engaged, they have no motivation to misbehave. 2. When students understand that their teacher sees them as worthwhile people with significant potential, it opens doors to learning. 3. The classroom can't work for anybody until it works for everybody. Written for K–12 teachers and instructional leaders, this book is packed with strategies for structuring and pacing lessons, organizing learning spaces and materials, starting and stopping class with purpose, setting up and managing routines, and shifting gears if something isn't going well. It also gives teachers the guidance they need to help students, colleagues, and parents understand the goals of differentiated instruction and contribute to its success. Along with examples of recommended practice drawn from real-life classrooms at a variety of grade levels, you will find answers to frequently asked questions and specific advice for balancing content requirements and the needs of learners. You'll gain confidence as a leader for and in your differentiated classroom and be better prepared to teach in a way that's more efficient and rewarding for you and more effective for every student in your care.
The American Teacher is a comprehensive education foundations text with an emphasis on the historical continuity of educational issues that empowers prospective teachers to channel their innate idealism into effective teaching practices.
Media Management: A Casebook Approach provides a detailed look at each of the major areas of responsibility that fall to the managers of media organizations, such as leadership, motivation, planning, marketing, and strategic management. Retaining its core content and case study approach, this third edition draws upon the latest organizational and management research to guide students in the development of their managerial skills. It provides media-based cases that give students the opportunity to develop their critical thinking and problem-solving skills. Updates in this edition include: *research and examples to reflect the current state of the industry; *material on convergence, new media, and international aspects, as well as their influences on leadership and planning; *information and research on new media, the Internet, and their future implications for media managers; *technology and online resource sections; and *examples and information on data used by advertisers and media organizations. This textbook also offers new material on the structure of the Internet, new media, and converged and international media organizations. It is intended for advanced undergraduates and graduate students in media management courses.
The westward migration of nearly half a million Americans in the mid-nineteenth century looms large in U.S. history. Classic images of rugged Euro-Americans traversing the plains in their prairie schooners still stir the popular imagination. But this traditional narrative, no matter how alluring, falls short of the actual—and far more complex—reality of the overland trails. Among the diverse peoples who converged on the western frontier were African American pioneers—men, women, and children. Whether enslaved or free, they too were involved in this transformative movement. Sweet Freedom’s Plains is a powerful retelling of the migration story from their perspective. Tracing the journeys of black overlanders who traveled the Mormon, California, Oregon, and other trails, Shirley Ann Wilson Moore describes in vivid detail what they left behind, what they encountered along the way, and what they expected to find in their new, western homes. She argues that African Americans understood advancement and prosperity in ways unique to their situation as an enslaved and racially persecuted people, even as they shared many of the same hopes and dreams held by their white contemporaries. For African Americans, the journey westward marked the beginning of liberation and transformation. At the same time, black emigrants’ aspirations often came into sharp conflict with real-world conditions in the West. Although many scholars have focused on African Americans who settled in the urban West, their early trailblazing voyages into the Oregon Country, Utah Territory, New Mexico Territory, and California deserve greater attention. Having combed censuses, maps, government documents, and white overlanders’ diaries, along with the few accounts written by black overlanders or passed down orally to their living descendants, Moore gives voice to the countless, mostly anonymous black men and women who trekked the plains and mountains. Sweet Freedom’s Plains places African American overlanders where they belong—at the center of the western migration narrative. Their experiences and perspectives enhance our understanding of this formative period in American history.
The demon is a mob, and the mob is demonic. The Democratic Party activates mobs, depends on mobs, coddles mobs, publicizes and celebrates mobs—it is the mob. Sweeping in its scope and relentless in its argument, Demonic explains the peculiarities of liberals as standard groupthink behavior. To understand mobs is to understand liberals. In her most provocative book to date, Ann Coulter argues that liberals exhibit all the psychological characteristics of a mob, for instance: Liberal Groupthink: “The same mob mentality that leads otherwise law-abiding people to hurl rocks at cops also leads otherwise intelligent people to refuse to believe anything they haven’t heard on NPR.” Liberal Schemes: “No matter how mad the plan is—Fraternité, the ‘New Soviet Man,’ the Master Race, the Great Leap Forward, the Cultural Revolution, Building a New Society, ObamaCare—a mob will believe it.” Liberal Enemies: “Instead of ‘counterrevolutionaries,’ liberals’ opponents are called ‘haters,’ ‘those who seek to divide us,’ ‘tea baggers,’ and ‘right-wing hate groups.’ Meanwhile, conservatives call liberals ‘liberals’—and that makes them testy.” Liberal Justice: “In the world of the liberal, as in the world of Robespierre, there are no crimes, only criminals.” Liberal Violence: “If Charles Manson’s followers hadn’t killed Roman Polanski’s wife, Sharon Tate, Clinton would have pardoned him, too, and he’d probably be teaching at Northwestern University.” Citing the father of mob psychology, Gustave Le Bon, Coulter catalogs the Left’s mob behaviors: the creation of messiahs, the fear of scientific innovation, the mythmaking, the preference for images over words, the lack of morals, and the casual embrace of contradictory ideas. Coulter traces the history of the liberal mob to the French Revolution and Robespierre’s revolutionaries (delineating a clear distinction from America’s founding fathers), who simply proclaimed that they were exercising the “general will” before slaughtering their fellow citizens “for the good of mankind.” Similarly, as Coulter demonstrates, liberal mobs, from student radicals to white-trash racists to anti-war and pro-ObamaCare fanatics today, have consistently used violence to implement their idea of the “general will.” This is not the American tradition; it is the tradition of Stalin, of Hitler, of the guillotine—and the tradition of the American Left. As the heirs of the French Revolution, Democrats have a history that consists of pandering to mobs, time and again, while Republicans, heirs to the American Revolution, have regularly stood for peaceable order. Hoping to muddy this horrifying truth, liberals slanderously accuse conservatives of their own crimes—assassination plots, conspiracy theorizing, political violence, embrace of the Ku Klux Klan. Coulter shows that the truth is the opposite: Political violence—mob violence—is always a Democratic affair. Surveying two centuries of mob movements, Coulter demonstrates that the mob is always destructive. And yet, she argues, beginning with the civil rights movement in the sixties, Americans have lost their natural, inherited aversion to mobs. Indeed, most Americans have no idea what they are even dealing with. Only by recognizing the mobs and their demonic nature can America begin to defend itself.
Around the world, democracies have seen a decline in social and political trust. Australian Social Attitudes IV: The Age of Insecurity is an in-depth look at the economic and geopolitical uncertainty that pervades Australian public discourse. In the decade following the Howard administration, Australian politics has been defined by growing uncertainty, instability, and the emergence of popular disaffection with the political class, similar to what has been seen in the United States and Britain. Featuring contributions from Australia’s leading social scientists, this book explores the connection between insecurities and disaffection, and the ways in which they have manifested – in populist voting patterns, suspicions about climate science, and hostilities to immigration. A fascinating insight into what Australians think about contemporary political and social issues, this book is designed to present the public, media, and policymakers with up-to-date analysis of public opinion about important topics confronting Australian politics and society.
This Brief discusses the adoption of the mixed member proportional (MMP) electoral system in New Zealand and its subsequent effect on representation for women. Concerns about the homogeneity of the legislature under the Single Member Plurality electoral system and the need for increased representativeness and greater proportionality of party preference lead to the changeover in 1996. The book addresses the question of whether an increase in descriptive representation for women in New Zealand’s House of Representatives has translated to policy outcomes that are beneficial to them. It also examines the extent to which female MPs meet the expectation that they will act for members of their groups; pushing minority and gender-friendly legislation and policies into the political arena. Finally, it raises questions about where women are found in New Zealand’s decision making bodies and what influence they might have on policy outcomes. The first book to examine the effects of the MMP system on female descriptive and substantive representation using a case study analysis, this Brief adds to the literature on electoral systems and women’s political representation. This book will be of use to political science students at both the undergraduate and graduate level, particularly those interested in electoral studies, political institutions, politics and gender, and minority representation.
The hottest and most controversial book of the year! Find out who really controls the media in America. “[Ann Coulter] is never in doubt. And that, along with her bright writing, sense of irony and outrage, and her relish at finally hitting back at political opponents (especially in the media) is what makes Slander such refreshing and provocative reading.” —Los Angeles Times “[Ann Coulter] is a fluent polemicist with a gift for Menckenesque invective . . . and she can harness such language to subtle, syllogistic argument.” —Washington Post Book World “The most popular nonfiction book in America.”—New York Times “The real value of Slander . . . is not in the jokes or devastating exposés of liberal politicians and their allies, but the serious and scholarly study of just how entrenched the media prejudice is against anyone whose politics are even faintly conservative.” —New York Sun “Written with a great deal of passion . . . the real source of its strength—and its usefulness—was its painstaking marshalling of evidence . . . More important than [High Crimes and Misdemeanors] because it addresses a much broader issue, and one of lasting significance.”—National Review
“This isn’t a story about black people—it’s a story about the Left’s agenda to patronize blacks and lie to everyone else.” For decades, the Left has been putting on a play with themselves as heroes in an ongoing civil rights movement—which they were mostly absent from at the time. Long after pervasive racial discrimination ended, they kept pretending America was being run by the Klan and that liberals were black America’s only protectors. It took the O. J. Simpson verdict—the race-based acquittal of a spectacularly guilty black celebrity as blacks across America erupted in cheers—to shut down the white guilt bank. But now, fewer than two decades later, our “postracial” president has returned us to the pre-OJ era of nonstop racial posturing. A half-black, half-white Democrat, not descended from American slaves, has brought racial unrest back with a whoop. The Obama candidacy allowed liberals to engage in self-righteousness about race and get a hard-core Leftie in the White House at the same time. In 2008, we were told the only way for the nation to move past race was to elect him as president. And 53 percent of voters fell for it. Now, Ann Coulter fearlessly explains the real history of race relations in this country, including how white liberals twist that history to spring the guilty, accuse the innocent, and engender racial hatreds, all in order to win politically. You’ll learn, for instance, how A U.S. congressman and a New York mayor conspired to protect cop killers who ambushed four police officers in the Rev. Louis Farrakhan’s mosque. The entire Democratic elite, up to the Carter White House, coddled a black cult in San Francisco as hundreds of the cult members marched to their deaths in Guyana. New York City became a maelstrom of racial hatred, with black neighborhoods abandoned to criminals who were ferociously defended by a press that assessed guilt on the basis of race. Preposterous hoax hate crimes were always believed, never questioned. And when they turned out to be frauds the stories would simply disappear from the news. Liberals quickly switched the focus of civil rights laws from the heirs of slavery and Jim Crow to white feminists, illegal immigrants, and gays. Subway vigilante Bernhard Goetz was surprisingly popular in black neighborhoods, despite hysterical denunciations of him by the New York Times. Liberals slander Republicans by endlessly repeating a bizarro-world history in which Democrats defended black America and Republicans appealed to segregationists. The truth has always been exactly the opposite. Going where few authors would dare, Coulter explores the racial demagoguery that has mugged America since the early seventies. She shines the light of truth on cases ranging from Tawana Brawley, Lemrick Nelson, and Howard Beach, NY, to the LA riots and the Duke lacrosse scandal. And she shows how the 2012 Obama campaign is going to inspire the greatest racial guilt mongering of all time.
Resting in one of Western North Carolina's scenic valleys near the continental divide, Hendersonville offers a rich culture and intriguing history in the heart of the Blue Ridge Mountains. Hendersonville was chartered as a city on January 7, 1847, and the coming of the railroad in 1879 sparked its growth. The summer arrival by train of both wealthy and middle-class visitors bolstered Main Street businesses and gave rise to fashionable inns and innumerable boarding houses. The photographs in Images of America: Hendersonville illustrate the history of a town still populated with founding families, seasonal residents, and summer tourists. This volume explores the early pioneer days, the Civil War period, the land boom of the 1920s, the Great Depression, and the growth of this now-thriving city.
American Educator, Activist, and Advocate provides in-depth research into Eleanor Archer's life as one of the first Black public school teachers in Des Moines and presents a gateway for academics to acknowledge the lives and ideas of women during the Jim Crow era, clarifying Black women's standpoint on the segregated South"--
In Creek Indian Medicine Ways, Jordan traces the written accounts of Mvskoke religion from the eighteenth century to the present in order to historically contextualize Lewis's story and knowledge. This book is a collaboration between anthropologist and medicine man that provides a rare glimpse of a living religious tradition and its origins.
Taking risks is how humans learn. It is how humans have always learned. A person sees a problem, takes in the available information, and tries a solution. It is in that process - whether the goal is understanding a Shakespeare play, figuring out an algorithm, or writing a theory of history - that engaged learners make breakthroughs, be those breakthroughs individual, group, or societal. In this book, three experienced practitioners describe how to re-imagine teaching spaces - conventional schools - as learning spaces, spaces where risk is encouraged, celebrated, and actually taught in every area of endeavor: from how, where, or if to sit, to how to find the right pathway to learning. In bringing the stories of a central office Innovation director together with an elementary teacher and administrator and a veteran secondary teacher leader, Education Reimagined: A Space for Risk demonstrates how fundamental change is possible in any school
Fits, trances, visions, speaking in tongues, clairvoyance, out-of-body experiences, possession. Believers have long viewed these and similar involuntary experiences as religious--as manifestations of God, the spirits, or the Christ within. Skeptics, on the other hand, have understood them as symptoms of physical disease, mental disorder, group dynamics, or other natural causes. In this sweeping work of religious and psychological history, Ann Taves explores the myriad ways in which believers and detractors interpreted these complex experiences in Anglo-American culture between the mid-eighteenth and early-twentieth centuries. Taves divides the book into three sections. In the first, ranging from 1740 to 1820, she examines the debate over trances, visions, and other involuntary experiences against the politically charged backdrop of Anglo-American evangelicalism, established churches, Enlightenment thought, and a legacy of religious warfare. In the second part, covering 1820 to 1890, she highlights the interplay between popular psychology--particularly the ideas of "animal magnetism" and mesmerism--and movements in popular religion: the disestablishment of churches, the decline of Calvinist orthodoxy, the expansion of Methodism, and the birth of new religious movements. In the third section, Taves traces the emergence of professional psychology between 1890 and 1910 and explores the implications of new ideas about the subconscious mind, hypnosis, hysteria, and dissociation for the understanding of religious experience. Throughout, Taves follows evolving debates about whether fits, trances, and visions are natural (and therefore not religious) or supernatural (and therefore religious). She pays particular attention to a third interpretation, proposed by such "mediators" as William James, according to which these experiences are natural and religious. Taves shows that ordinary people as well as educated elites debated the meaning of these experiences and reveals the importance of interactions between popular and elite culture in accounting for how people experienced religion and explained experience. Combining rich detail with clear and rigorous argument, this is a major contribution to our understanding of Protestant revivalism and the historical interplay between religion and psychology.
From flammable tap water and sick livestock to the recent onset of hundreds of earthquakes in Oklahoma, the impact of fracking in the United States is far-reaching and deeply felt. In Fractivism Sara Ann Wylie traces the history of fracking and the ways scientists and everyday people are coming together to hold accountable an industry that has managed to evade regulation. Beginning her story in Colorado, Wylie shows how nonprofits, landowners, and community organizers are creating novel digital platforms and databases to track unconventional oil and gas well development and document fracking's environmental and human health impacts. These platforms model alternative approaches for academic and grassroots engagement with the government and the fossil fuel industry. A call to action, Fractivism outlines a way forward for not just the fifteen million Americans who live within a mile of an unconventional oil or gas well, but for the planet as a whole.
Media Management: A Casebook Approach provides a detailed look at the major areas of responsibility that fall to the managers of media organizations, including leadership, motivation, planning, marketing, and strategic management. It provides media-based cases that promote the development of critical thinking and problem-solving skills. Addressing such topics as diversity, group cultures, progressive discipline, training, and market-driven journalism, this casebook provides real-world scenarios that help students anticipate and prepare for experiences in their future careers. Among the additions to this fourth edition are Increased discussions on groups, vision, change, diversity, and management styles; Additional media-sensitive examples within each section of the text; A new chapter on knowledge management; Ethics integrated into law and leadership discussions; A primer in global markets, technology, and policy; In-depth consideration into the aspects of change; and Increased emphasis on analysis. This edition also includes management scenarios in which one or more participant is a new employee or intern, making the material relevant to students while also preparing them to understand the motivations of their future employers. Developed as a media management text for advanced undergraduates and graduate students, Media Management provides realistic scenarios and invaluable insights on working in the media industries.
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