When she was four, Angel Cabrera was a quiet, shy child who loved to dance and make others laugh. But when her parents divorced two years later, Angel’s life suddenly changed direction. As she attempted to find her place in a newly blended family, Angel embarked on a challenging coming-of-age journey; she struggled with depression, self-destructive behavior, and neglect. By the time she was fifteen, Angel had run away from home, tried alcohol and drugs, and shoplifted. Her life was quickly spiraling out-of-control. Disowned and left to fend for herself in a crazy world, Angel details how she walked a dark path with Jerome, a mysterious Jamaican teenager who quickly took advantage of her innocence. As Angel chronicles her new life living with Jerome, she shares how she chose to ignore her intuition that something was wrong and began depending on him for everything, including her financial security. Once Jerome’s true identity was revealed, Angel was led down a dangerous path through crime, hopelessness, and corruption, soon discovering that she could count on nothing. Gangsta to Glory is a true story of redemption as a young woman learns to rely on herself and her faith in God to survive in a tough world.
Why do we need global leaders? The voyage of a pair of blue jeans, from inception to product release, offers a glimpse into the inexorably international--and complex--world of business today: The cotton may be picked from Peruvian or Ugandan fields, shipped to China for finishing, and then sent to Malaysia to be woven into yarn. The yarn goes to Thailand where the fabric is made, and the fabric is cut in Singapore before it is sent to Indonesia for sewing. Labels come from India. Zippers from Hong Kong. Thread from Malaysia. Buttons and rivets from Taiwan. The range of countries and systems involved in this production demonstrates that business in most industries (automotive and electronics, food and pharma) has become inescapably linked across borders. But it's more than mastering geography and culture that makes a leader today a different breed. You must master the complex mindset and competencies needed to lead in today's fully globalized world. No easy task. Enter Angel Cabrera and.
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy.
When she was four, Angel Cabrera was a quiet, shy child who loved to dance and make others laugh. But when her parents divorced two years later, Angels life suddenly changed direction. As she attempted to find her place in a newly blended family, Angel embarked on a challenging coming-of-age journey; she struggled with depression, self-destructive behavior, and neglect. By the time she was fifteen, Angel had run away from home, tried alcohol and drugs, and shoplifted. Her life was quickly spiraling out-of-control. Disowned and left to fend for herself in a crazy world, Angel details how she walked a dark path with Jerome, a mysterious Jamaican teenager who quickly took advantage of her innocence. As Angel chronicles her new life living with Jerome, she shares how she chose to ignore her intuition that something was wrong and began depending on him for everything, including her financial security. Once Jeromes true identity was revealed, Angel was led down a dangerous path through crime, hopelessness, and corruption, soon discovering that she could count on nothing. Gangsta to Glory is a true story of redemption as a young woman learns to rely on herself and her faith in God to survive in a tough world.
Recibida desde su publicaci n en 1946 como una obra maestra, El se or Presidente inaugura en Latinoam rica un g nero que muy pronto dej abundante descendencia: la novela del dictador. Miguel ngel Asturias logr una novela de prosa impecable, de ritmos y atm sferas po ticas, en la que relata el paulatino deterioro moral de un personaje complejo.
An exposé of the controversial friendship between Nobel-prize winning author Gabriel Garcia Marquez and Fidel Castro. Few contemporary writers are more revered by Americans than Gabriel Garcia Marquez, the Nobel prize-winning author of Love in the Time of Cholera and One Hundred Years of Solitude. And few political leaders are more reviled than Fidel Castro. Yet these two seemingly disparate men are close friends. What could possibly unite these two men in friendship? In Fidel and Gabo, Márquez scholars Ángel Esteban and Stéphanie Panichelli examine this strange, intimate, and incredibly controversial friendship between the beloved author and Cuban dictator, exposing facets of their personalities never before revealed to the greater public. For years, Márquez, long fascinated with power, solicited and flattered Castro in hopes of a personal audience, for he viewed Castro’s Cuba as the model on which Latin American would one day build its own brand of socialism. Upon their first meeting, Castro quickly came to regard Márquez as a genius and still calls him his closest friend and confidant. To this day, Márquez still gives Castro “first look” at all his manuscripts and craves his approval. Fidel and Gabo is a vivid and in-depth look at two of the most influential men of the modern era, their worlds, and the effect this friendship has had on their life and works.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.