This book offers a comprehensive overview of Japan's national security institutions and policy today, including a detailed discussion of Japan's regional security environment and its alliance with the United States in the context of the Democratic Party of Japan's rise to power in August 2009. 2010 marks the 50th anniversary of the revision of the U.S.-Japan Security Treaty, making Japan one of the United States's longest and most important military allies. Over 40,000 US troops are based in Japan, as is the only U.S. aircraft carrier based outside the United States, the USS George Washington. Japan possesses one of the world's largest economies and strongest military forces, and as a result, its national security policies and institutions are highly significant—not just to America, but to the rest of the global community as well. This book provides an overview of Japan's transformation into one of the world's most capable military powers over the past 150 years. Particular attention is paid to developments in the past decade, such as the 2009 change in the controlling political party and Japan's responses to new global security threats.
The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions
This is a celebration of the history of the automobile in America from 1907 to 2003 - the best and the worst, the successes and the failures, the classics and the bizarre, the automobiles that America has taken to her heart and that have defined American culture.
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