Callous Disregard is the account of how a doctor confronted first a disease and then the medical system that sought and still seeks to deny that disease, leaving millions of children to suffer and a world at risk. In 1995, Dr. Andrew Wakefield came to a fork in the road. As an academic gastroenterologist at the Royal Free School of Medicine and the University of London, he was confronted by a professional challenge and a moral choice. Previously healthy children were, according to their parents, regressing into autism and developing intestinal problems. Many parents blamed the MMR vaccine. Trusting his medical training, the parental narrative, and, above all, the instinct of mothers for their children?s well-being, he chose what would become a very difficult road. Dr. Wakefield provides the facts and an explanation of the problem that confronted him and his colleagues fifteen years ago. He does this in a detailed forensic analysis of the lies, obfuscation, cover-up, and dystopian science and medicine that panders to commercial interests at the expense of your children.
As the number of children diagnosed with autism spectrum disorders grows each year, new discoveries and controversies arise. Andrew Wakefield explores many of these in his thorough investigation of the recent trial case of the “Arizona 5,” which destroyed an Arizona family. Two parents, with five children on the spectrum, were accused of Munchausen syndrome by proxy—a rare form of child abuse—and were ganged up on by physicians, child protective services, and the courts, who alleged that the parents fabricated medical symptoms in all five children. However, Wakefield now presents ample evidence that was disregarded and that would have proven the parents’ innocence. Families affected by autism suffer great hardship and prejudice, particularly as they navigate the uncertain waters of diagnosis, treatment, and education. The shocking story of the Arizona 5 family delves into the tremendous challenges some parents have to face, especially if their views on how to treat the syndrome don’t align with the medical world’s standards. Wakefield also includes numerous studies and research trials that support the controversial yet significant roles that vaccines and diet play in autism, factors many medical professionals wrongfully dismiss.
Callous Disregard is the account of how a doctor confronted first a disease and then the medical system that sought and still seeks to deny that disease, leaving millions of children to suffer and a world at risk. In 1995, Dr. Andrew Wakefield came to a fork in the road. As an academic gastroenterologist at the Royal Free School of Medicine and the University of London, he was confronted by a professional challenge and a moral choice. Previously healthy children were, according to their parents, regressing into autism and developing intestinal problems. Many parents blamed the MMR vaccine. Trusting his medical training, the parental narrative, and, above all, the instinct of mothers for their children?s well-being, he chose what would become a very difficult road. Dr. Wakefield provides the facts and an explanation of the problem that confronted him and his colleagues fifteen years ago. He does this in a detailed forensic analysis of the lies, obfuscation, cover-up, and dystopian science and medicine that panders to commercial interests at the expense of your children.
Progressively more and more attention has been paid to how location affects health outcomes. The area of disease mapping focusses on these problems, and the Bayesian paradigm has a major role to play in the understanding of the complex interplay of context and individual predisposition in such studies of disease. Using R for Bayesian Spatial and Spatio-Temporal Health Modeling provides a major resource for those interested in applying Bayesian methodology in small area health data studies. Features: Review of R graphics relevant to spatial health data Overview of Bayesian methods and Bayesian hierarchical modeling as applied to spatial data Bayesian Computation and goodness-of-fit Review of basic Bayesian disease mapping models Spatio-temporal modeling with MCMC and INLA Special topics include multivariate models, survival analysis, missing data, measurement error, variable selection, individual event modeling, and infectious disease modeling Software for fitting models based on BRugs, Nimble, CARBayes and INLA Provides code relevant to fitting all examples throughout the book at a supplementary website The book fills a void in the literature and available software, providing a crucial link for students and professionals alike to engage in the analysis of spatial and spatio-temporal health data from a Bayesian perspective using R. The book emphasizes the use of MCMC via Nimble, BRugs, and CARBAyes, but also includes INLA for comparative purposes. In addition, a wide range of packages useful in the analysis of geo-referenced spatial data are employed and code is provided. It will likely become a key reference for researchers and students from biostatistics, epidemiology, public health, and environmental science.
Bayesian statistical methods have become widely used for data analysis and modelling in recent years, and the BUGS software has become the most popular software for Bayesian analysis worldwide. Authored by the team that originally developed this software, The BUGS Book provides a practical introduction to this program and its use. The text presents
Since the publication of the second edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Third Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. In addition to the new material, the book also covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. The target audience for this text is public health specialists, epidemiologists, and biostatisticians who need to work with geo-referenced health data.
Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology. Updated to include a new emphasis on bio-terrorism and disease surveillance. Emphasizes the importance of space-time modelling and outlines the practical application of the method. Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software. Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques. This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.
For nearly 40 years, Oh's Intensive Care Manual has been the quick reference of choice for ICU physicians at all levels of experience. The revised 8th edition maintains this tradition of excellence, providing fast access to practical information needed every day in today's intensive care unit. This bestselling manual covers all aspects of intensive care in sufficient detail for daily practice while keeping you up to date with the latest innovations in the field. - New coverage of the latest developments in ICU imaging techniques, including ultrasound. - New information on the latest advances in ECMO (Extracorporeal Membrane Oxygenation) for cardiac and respiratory failure, ARDS, septic shock, neurologic disorders, muscle function, and hemodynamic therapy. - New co-editor Dr. Jonathan Handy shares his knowledge and expertise on acid-base disturbances during critical illness, critical care transfers, intravenous fluid therapy, cardiovascular physiology, burn management, sepsis, and the immunological impact of surgery and burn injury. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
As the number of children diagnosed with autism spectrum disorders grows each year, new discoveries and controversies arise. Andrew Wakefield explores many of these in his thorough investigation of the recent trial case of the “Arizona 5,” which destroyed an Arizona family. Two parents, with five children on the spectrum, were accused of Munchausen syndrome by proxy—a rare form of child abuse—and were ganged up on by physicians, child protective services, and the courts, who alleged that the parents fabricated medical symptoms in all five children. However, Wakefield now presents ample evidence that was disregarded and that would have proven the parents’ innocence. Families affected by autism suffer great hardship and prejudice, particularly as they navigate the uncertain waters of diagnosis, treatment, and education. The shocking story of the Arizona 5 family delves into the tremendous challenges some parents have to face, especially if their views on how to treat the syndrome don’t align with the medical world’s standards. Wakefield also includes numerous studies and research trials that support the controversial yet significant roles that vaccines and diet play in autism, factors many medical professionals wrongfully dismiss.
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