Müller cells make up just 0.005% of the cells in our central nervous system. They do not belong to the more esteemed family of neuronal cells but to the glia, a family of cells that until recently were seen as mere filling material between the neurons. Now, however, all that has changed. Sharing the insights of more than a quarter century of research into Müller cells, Drs. Andreas Reichenbach and Andreas Bringmann of Leipzig University make a compelling case for the central role Müller cells play. Everyone agrees that the eye is a very special and versatile sense organ, yet it has turned out in recent years that Müller cells are peculiar and multipotent glial cells. In the retina of most vertebrates and even of many mammals, Müller cells are the only type of (macro- ) glial cells; thus, they are responsible for a wealth of neuron-supportive functions that, in the brain, rely upon a division of labour among astrocytes, oligodendrocytes, and ependymal cells. Even beyond such a role in the central nervous system as "model glia", Müller cells are adapted to several exciting roles in support of vision. They deliver the light stimuli to the photoreceptor cells in the inverted vertebrate retina, aid the processing of visual information, and are responsible for the homeostatic maintenance of the retinal extracellular milieu. In Müller Cells in the Healthy and Diseased Retina, aimed not just at neurobiologists but at anyone concerned with retinal degeneration, every angle of Müller cells is covered, from an introduction to their basic properties, through their roles as 'light cables' and 'shock absorbers', to the part they play in diseases and disorders of the eye. Once these have all been covered in detail, the authors move on to discuss the future direction of research into these small but potent cellular phenomena. About the Authors Dr. Andreas Reichenbach was born in 1950 in Leipzig, Germany. He studied medicine and specialized as a physiologist, working on the mammalian retina. Since 1984, he has focused his efforts - and those of a growing number of fellows in his team - on Müller cell research. He has held a professorship at Leipzig University since 1994. After studying biology, Dr. Andreas Bringmann (* 1960) worked in the field of systemic neurophysiology until he was inspired in 1996 by Andreas Reichenbach to research the most interesting cell, the Müller cell. He is now in the Department of Ophthalmology of the University of Leipzig where he is the head of the Basic Research Laboratory
In 1851, Heinrich Müller discovered what he called “radial fibers” and what we now call Müller cells, as the principal glial cells of the vertebrate retina. Later on, other glial cell types were found in the retina, including astrocytes, microglia, and even oligodendrocytes. It turned out that retinal glial cells are essential constituents of the tissue. For instance, Müller cells appear to constitute the “core” of columnar units of clonally and functionally related groups of neurons. Their primary function is to support neuronal functioning by guiding the light towards the photoreceptor cells, removing excess neurotransmitter molecules from extracellular space, and performing efficient clearance of excess extracellular potassium ions. The latter two functions are also crucial for neuronal survival and are coupled to water clearance which is also essential. Müller cells are capable of “sensing” neuronal activity and modifying it by the release of signal substances (gliotransmitters). In cases of retinal injuries the Müller cells become reactive, and all above-mentioned functions are impaired. However, such de-differentiated Müller cells may proliferate, and may even serve as stem cells for the regeneration of a damaged retina. As well as the Müller cells, retinal astrocytes and microglial cells are important players in retinal development and function. This book gives a comprehensive survey of the present knowledge on retinal glia.
Focusing on Gisbertus Voetius’s views on God, freedom, and contingency, Andreas J. Beck offers the first monograph in English that is entirely devoted to the theology of this leading figure of early modern Reformed scholasticism.
No-Point (2022) might be a tighter exploration and continuation of what was explored in No-Point Perspective (2020). Justin Allen and Andreas Müller continue their talks about nothing and still have nothing really to say; even less to say in fact. Allen and Müller are still able to turn something like talking about the weather, or in this case, nothing, into an exploration. The conversations took place from January 24, 2021 to December 21, 2021 and have been transcribed and thoughtfully edited to maintain their casual energy.
The nervous system is particularly fascinating for many biologists because it controls animal characteristics such as movement, behavior, and coordinated thinking. Invertebrate neurobiology has traditionally been studied in specific model organisms, whilst knowledge of the broad diversity of nervous system architecture and its evolution among metazoan animals has received less attention. This is the first major reference work in the field for 50 years, bringing together many leading evolutionary neurobiologists to review the most recent research on the structure of invertebrate nervous systems and provide a comprehensive and authoritative overview for a new generation of researchers. Presented in full colour throughout, Structure and Evolution of Invertebrate Nervous Systems synthesizes and illustrates the numerous new findings that have been made possible with light and electron microscopy. These include the recent introduction of new molecular and optical techniques such as immunohistochemical staining of neuron-specific antigens and fluorescence in-situ-hybridization, combined with visualization by confocal laser scanning microscopy. New approaches to analysing the structure of the nervous system are also included such as micro-computational tomography, cryo-soft X-ray tomography, and various 3-D visualization techniques. The book follows a systematic and phylogenetic structure, covering a broad range of taxa, interspersed with chapters focusing on selected topics in nervous system functioning which are presented as research highlights and perspectives. This comprehensive reference work will be an essential companion for graduate students and researchers alike in the fields of metazoan neurobiology, morphology, zoology, phylogeny and evolution.
Essay from the year 2010 in the subject Business economics - Banking, Stock Exchanges, Insurance, Accounting, grade: 1,7, University of Applied Sciences Stuttgart, language: English, abstract: For the last couple of years the world has been experiencing one of the most severe financial crises ever which has been often compared to the Great Depression from 1929. Starting with the Mortage crisis in the USA in 2007 and the collapse of Lehman Brothers in September 2008, this problem increased to the worst global economic crisis ever. The negative effects of the Global Financial Crisis from 2007-2009 are both financial and real. The financial impact of the crisis resulted in problems in the banking systems of many countries. The real impact was that the economic growth has slowed down. The crisis bought many challenges and questions concerning the ability of the industries in the national economies to survive, the destiny of the employees and the role of the government in current market situation. However, the crisis might create opportunities for some industries if the companies don ́t let themselves to be misled by the general negative moods towards the current state of the market. The following essay gives an overview of the Global Financial Crisis and its challenges and monetary reactions.
Diploma Thesis from the year 2007 in the subject Business economics - Business Management, Corporate Governance, grade: 1,3, Otto Beisheim School of Management Vallendar, 58 entries in the bibliography, language: English, abstract: This paper aims to give an overview of two related human traits that have attracted particularly wide interest, namely overconfidence and overoptimism. The two are closely related to each other, and often used synonymously. Broadly speaking, overconfidence results in underestimation of future risks, e.g. the riskiness of future cash flows, whilst overoptimism leads to an overestimation of future positive outcomes, e.g. the future returns of a company. Besides, the paper wants to deduct suggestions for further research, by systematically identifying uncovered topics in existing literature. This paper also provides a closer look at the empirical methods normally applied in field studies. Although the phenomena are intuitively understandable, empirical researchstill presents itself as a mosaic of fragmented testing rather than a coherent framework. One may assume that this is mainly caused by the difficult measurability of overconfidence and overoptimism: On the one hand, the decision maker, convinced of his own rationality, contributes zero overconfidence or overoptimism to his actions. On the other hand, even a neutral observer cannot specify any degree of biasedness a priori, as stochastic outcomes per definition do not allow for perfect prediction. Therefore, scientists frequently rely on proxy variables that at least allow for measuring a group's average overoptimism or overconfidence. Furthermore, this paper empirically examines several considerations regarding existing research and measurement methods. It particularly aims to connect biasedness with certain personal and economic characteristics, namely participants' gender, industry affiliation, company life cycle, success and risk preferences. Additionally, different methods are e
English summary: Founded by Emil Meynen, edited by Andreas Bittmann in Cooperation with: the German Society for Geography, Austrian IGU-National Committee, and the Swiss Association for Geography/ Association Suisse de G�ographie. For over sixty years and in the 31st edition from Franz Steiner Publishers, the Geographic Pocketbook proves itself as a reference work: the clear list of geographic institutions, administrative authorities, organization and geographers in Germany, Austria and Switzerland makes the handbook indispensible for everything concerning geography. It has been updated and furnished with useful register and serves as a compact and reliable source. German description: Begruendet von Emil Meynen, herausgegeben von Andreas Dittmann im Einvernehmen mit: Deutsche Gesellschaft fuer Geographie, �sterreichisches IGU-Nationalkomitee, Verband Geographie Schweiz / Association Suisse de G�ographie Seit ueber 60 Jahren und in der 31. Ausgabe im Franz Steiner Verlag bew�hrt sich das Geographische Taschenbuch als Nachschlagewerk: die uebersichtliche Auflistung geographischer Institutionen, Beh�rden, Organisationen und Geographen und Geographinnen in Deutschland, �sterreich und der Schweiz machen das Handbuch unentbehrlich fuer alle, die sich mit der Geographie befassen. Wieder aktualisiert und mit nuetzlichen Registern versehen, ist es eine kompakte und zuverl�ssige Quelle.
Diploma Thesis from the year 2007 in the subject Business economics - Business Management, Corporate Governance, grade: 1,3, Otto Beisheim School of Management Vallendar, language: English, abstract: This paper aims to give an overview of two related human traits that have attracted particularly wide interest, namely overconfidence and overoptimism. The two are closely related to each other, and often used synonymously. Broadly speaking, overconfidence results in underestimation of future risks, e.g. the riskiness of future cash flows, whilst overoptimism leads to an overestimation of future positive outcomes, e.g. the future returns of a company. Besides, the paper wants to deduct suggestions for further research, by systematically identifying uncovered topics in existing literature. This paper also provides a closer look at the empirical methods normally applied in field studies. Although the phenomena are intuitively understandable, empirical researchstill presents itself as a mosaic of fragmented testing rather than a coherent framework. One may assume that this is mainly caused by the difficult measurability of overconfidence and overoptimism: On the one hand, the decision maker, convinced of his own rationality, contributes zero overconfidence or overoptimism to his actions. On the other hand, even a neutral observer cannot specify any degree of biasedness a priori, as stochastic outcomes per definition do not allow for perfect prediction. Therefore, scientists frequently rely on proxy variables that at least allow for measuring a group’s average overoptimism or overconfidence. Furthermore, this paper empirically examines several considerations regarding existing research and measurement methods. It particularly aims to connect biasedness with certain personal and economic characteristics, namely participants’ gender, industry affiliation, company life cycle, success and risk preferences. Additionally, different methods are employed for measuring overoptimism. By comparing the strength of bias indicated by each scaling, one gets interesting insights into the influence that question design has on test results.
Medicinal leech therapy has undergone a renaissance in recent years, both in terms of how well the effects of using leeches are understood,and in the discovery of new clinical applications that have resulted in remarkable outcomes. This timely book introduces the basic principles of using leeches in clinical practice, and clearly sets out the methodology and potentialapplications. Emphasis is given to those areas of medicine where scientific studies have already provided firm evidence of success -- treatment of arthrosis and pain is already benefiting from this highly effective therapy.Excellent instructions for the use of leeches cover the full spectrum of possible applications, while the encouraging new developments in research are also addressed. This valuable guide for physicians to this important therapy comes from the acknowledged experts in the field.
Our actions are informed by the consideration of reasons; reasons which constructivism suggests are not simply discovered, but made by us. This book examines this view, elaborating its basic idea into a fully-fledged account of practical reasons, making its theoretical commitments explicit, and defending it against well-known objections.
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