Drawing on the latest research in the field, Systems Biology: Mathematical Modeling and Model Analysis presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are systematically applied in biotechnology. The first part of the book introduces biological basics, such as metabolism, signaling, gene expression, and control as well as mathematical modeling fundamentals, including deterministic models and thermodynamics. The text also discusses linear regression methods, explains the differences between linear and nonlinear regression, and illustrates how to determine input variables to improve estimation accuracy during experimental design. The second part covers intracellular processes, including enzymatic reactions, polymerization processes, and signal transduction. The author highlights the process–function–behavior sequence in cells and shows how modeling and analysis of signal transduction units play a mediating role between process and function. The third part presents theoretical methods that address the dynamics of subsystems and the behavior near a steady state. It covers techniques for determining different time scales, sensitivity analysis, structural kinetic modeling, and theoretical control engineering aspects, including a method for robust control. It also explores frequent patterns (motifs) in biochemical networks, such as the feed-forward loop in the transcriptional network of E. coli. Moving on to models that describe a large number of individual reactions, the last part looks at how these cellular models are used in biotechnology. The book also explains how graphs can illustrate the link between two components in large networks with several interactions.
The technology and engineering behind autonomous driving is advancing at pace. This book presents the latest technical advances and the economic, environmental and social impact driverless cars will have on individuals and the automotive industry.
Motivation for this Book Ontologies have received increasing attention over the last two decades. Their roots can be traced back to the ancient philosophers, who were interested in a c- ceptualization of the world. In the more recent past, ontologies and ontological engineering have evolved in computer science, building on various roots such as logics, knowledge representation, information modeling and management, and (knowledge-based) information systems. Most recently, largely driven by the next generation internet, the so-called Semantic Web, ontological software engineering has developed into a scientific field of its own, which puts particular emphasis on the theoretical foundations of representation and reasoning, and on the methods and tools required for building ontology-based software applications in diverse domains. Though this field is largely dominated by computer science, close re- tionships have been established with its diverse areas of application, where - searchers are interested in exploiting the results of ontological software engine- ing, particularly to build large knowledge-intensive applications at high productivity and low maintenance effort. Consequently, a large number of scientific papers and monographs have been p- lished in the very recent past dealing with the theory and practice of ontological software engineering. So far, the majority of those books are dedicated to the th- retical foundations of ontologies, including philosophical treatises and their re- tionships to established methods in information systems and ontological software engineering.
This richly detailed anthropological account of the policies and practices of Burkina Faso, set against the background of the region's developing economies and ethnic diversity, examines the social, economic and political transformation of Western Africa. Behind the screen of ethnic conflicts, lie vibrant 'concealed economies' that have led to new economic and political practices at almost all levels of national and civil administration.
The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye. - Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea - Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea - Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns - Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure
English summary: Founded by Emil Meynen, edited by Andreas Bittmann in Cooperation with: the German Society for Geography, Austrian IGU-National Committee, and the Swiss Association for Geography/ Association Suisse de G�ographie. For over sixty years and in the 31st edition from Franz Steiner Publishers, the Geographic Pocketbook proves itself as a reference work: the clear list of geographic institutions, administrative authorities, organization and geographers in Germany, Austria and Switzerland makes the handbook indispensible for everything concerning geography. It has been updated and furnished with useful register and serves as a compact and reliable source. German description: Begruendet von Emil Meynen, herausgegeben von Andreas Dittmann im Einvernehmen mit: Deutsche Gesellschaft fuer Geographie, �sterreichisches IGU-Nationalkomitee, Verband Geographie Schweiz / Association Suisse de G�ographie Seit ueber 60 Jahren und in der 31. Ausgabe im Franz Steiner Verlag bew�hrt sich das Geographische Taschenbuch als Nachschlagewerk: die uebersichtliche Auflistung geographischer Institutionen, Beh�rden, Organisationen und Geographen und Geographinnen in Deutschland, �sterreich und der Schweiz machen das Handbuch unentbehrlich fuer alle, die sich mit der Geographie befassen. Wieder aktualisiert und mit nuetzlichen Registern versehen, ist es eine kompakte und zuverl�ssige Quelle.
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