Natural killer (NK) cells are granular lymphocytes that play important roles in immunity against viruses and in the immune surveillance of tumors. In addition to being a potent innate source of IFN-γ, NK cells hold cytoplasmic granula that contain perforin and granzymes involved in cell-mediated cytotoxicity. NK cells express various types of immunoreceptors that are all designed to sense pathological changes of self cells. NK cells differ from lymphocytes of the adaptive immune system, such as T and B cells, because they do not express one major immune recognition receptor generated by recombination of receptor elements. Instead, NK cells express an arsenal of polymorphic inhibitory and activating, germline-encoded immunoreceptors with variegated expression that interact with ligands expressed by self cells. The balance of inhibitory and activating input to an NK cell determines its activation state, and harnessing the power of NK cells by exploiting this polymorphic inhibitory receptor/ligand system has become a constituent of clinical therapies.
Rising temperatures and the rise of the far right. What disasters happen when they meet? In the first study of the far right’s role in the climate crisis, White Skin, Black Fuel presents an eye-opening sweep of a novel political constellation, revealing its deep historical roots. Fossil-fuelled technologies were born steeped in racism. No one loved them more passionately than the classical fascists. Now right-wing forces have risen to the surface, some professing to have the solution—closing borders to save the nation as the climate breaks down. Epic and riveting, White Skin, Black Fuel traces a future of political fronts that can only heat up.
This book offers a new method for aligning brand management and user experience goals. Brand management deals with conveying individual brand values at all marketing contact points, the goal being to reach the target group and boost customer retention. In this regard, it is important to consider the uniqueness of each brand and its identity so as to design pleasurable and high-quality user experiences. Combining insights from science and practice, the authors present a strategy for using interaction patterns, visual appearance, and animations to validate the actual brand values that are experienced by users while interacting with a digital product. Further, they introduce a 'UX identity scale' by assigning brand values to UX related psychological needs. The method applied is subsequently backed by theoretical concepts and illustrated with practical examples and case studies on real-world mobile applications.
Immensely readable...a significant piece of scholarship."—Fred Volkmer, New York Sun He would become one of the most important poets of the twentieth century; she a muse of Europe's fin-de-siècle thinkers and artists. In this collection of letters, a finalist for the PEN USA translation award, the poet Rainer Maria Rilke and Lou Andreas-Salomé, a writer and intellectual fourteen years his senior, pen a relationship that spans thirty years and shifting boundaries: as lovers, as mentor and protégé, and as deep personal and literary allies.
Are pandemics the end of cities? Or, do they present an opportunity for us to reshape cities in ways making us even more innovative, successful and sustainable? Pandemics such as COVID-19 (and comparable disruptions) have caused intense debates over the future of cities. Through a series of investigative studies, Designing Smart and Resilient Cities for a Post-Pandemic World: Metropandemic Revolution seeks to critically discuss and compare different cases, innovations and approaches as to how cities can utilise nascent and future digital technology and/or new strategies in order to build stronger resilience to better tackle comparable large-scale pandemics and/or disruptions in the future. The authors identify ten separate societal areas where future digital technology can impact resilience. These are discussed in individual chapters. Each chapter concludes with a set of proposed "action points" based on the conclusions of each respective study. These serve as solid policy recommendations of what courses of action to take, to help increase the resilience in smart cities for each designated area. Securing resilience and cohesion between each area will bring about the metropandemic revolution. This book features a foreword by Nobel laureate Peter C. Doherty and an afterword by Professor of Urban Technologies, Carlo Ratti. It provides fresh and unique insights on smart cities and futures studies in a pandemic context, offers profound reflections on contemporary societal functions and the needs to build resilience and combines lessons learned from historical pandemics with possibilities offered by future technology.
The nervous system is particularly fascinating for many biologists because it controls animal characteristics such as movement, behavior, and coordinated thinking. Invertebrate neurobiology has traditionally been studied in specific model organisms, whilst knowledge of the broad diversity of nervous system architecture and its evolution among metazoan animals has received less attention. This is the first major reference work in the field for 50 years, bringing together many leading evolutionary neurobiologists to review the most recent research on the structure of invertebrate nervous systems and provide a comprehensive and authoritative overview for a new generation of researchers. Presented in full colour throughout, Structure and Evolution of Invertebrate Nervous Systems synthesizes and illustrates the numerous new findings that have been made possible with light and electron microscopy. These include the recent introduction of new molecular and optical techniques such as immunohistochemical staining of neuron-specific antigens and fluorescence in-situ-hybridization, combined with visualization by confocal laser scanning microscopy. New approaches to analysing the structure of the nervous system are also included such as micro-computational tomography, cryo-soft X-ray tomography, and various 3-D visualization techniques. The book follows a systematic and phylogenetic structure, covering a broad range of taxa, interspersed with chapters focusing on selected topics in nervous system functioning which are presented as research highlights and perspectives. This comprehensive reference work will be an essential companion for graduate students and researchers alike in the fields of metazoan neurobiology, morphology, zoology, phylogeny and evolution.
This study applies discourse analysis to the book of Revelation and offers thus a novel approach to an important biblical text. The object of examination is the last of John's visions in his Apocalypse, Rev. 21:1-22:5, a text famous for its biblical-theological density and for the great problems of literary and exegetical quality revealed by the history of exegesis. The author accurately defines his text concept, explains what he means by discourse analysis of the text and states its phases of application. He evaluates recognized exegetes of the Apocalypse and then moves on to his analysis of the pericope 21:1-22:5. Seven macro-sentences are marked out and explained. The novelty of the method applied yields a fresh and invigorating exegesis through a distinctive adherance to the literary data of the text while observing unusual alertness toward verb tenses.
The world is on the cusp of one and a half degrees of warming - just the rise it has committed itself to avoiding. Heat at such levels would be intolerable. Even before one and a half, seasons of climate disaster have struck with ever more devastating force, and yet a notion has taken hold that the cause is now lost: the intolerable has become unavoidable. The limit will be overshot - perhaps two degrees as well - and the best we can do is cool down the Earth at some later point, towards the end of the century, by means of technologies not yet proven. How did this happen? How could the idea of overshoot gain such traction? What forces are driving us into a climate that people - particularly poor people in the global South - won't be able to cope with? In Overshoot: How the World Surrendered to Climate Breakdown, Andreas Malm and Wim Carton present a history of the present phase of the crisis, likely to extend decades into the future, as the fossil fuel industry swims in the largest profits ever made. Money continues to flow into the construction of pipelines, platforms, terminals, mines - assets that will have to be destroyed for the planet to remain liveable. Too much heat has become officially acceptable because such revolutionary destruction is not. But should the rest of us abide by that priority? Unflinchingly critical of business-as-usual and the calls for surrender to it, sweeping in scope, stirring and sobering, Overshoot lays out the stakes for the climate struggle in the years ahead.
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