Model studies have been performed with individual citrus related aroma compounds such as citral, α-terpineol, α-terpinene, and others, in order to de-couple the complexity of citrus flavors. Degradation pathways and transformation rates have been determined for the most relevant compounds leading to the most prominent off-note compound p-methyl acetophenone. Citral is one of the main precursors. Catechins (flavan-3-ols) are often used as antioxidants for stabilization of flavor mixtures. The reactivity of catechins towards aldehydes is underestimated. In our study, we demonstrate the formation of covalent catechin–citral adducts – a reaction that might influence the aroma stability of citrus flavors in the presence of catechins. As a result, the freshness of citrus flavors and stability of key aroma-active substances can be improved, on the result of this study.
Chapter 55. Discovery and Structure–Activity Studies of Maillard-Modified Guanosine 5′-Monophosphates using Human Sensory Studies and Cell-Based Taste Receptor Assays
Chapter 55. Discovery and Structure–Activity Studies of Maillard-Modified Guanosine 5′-Monophosphates using Human Sensory Studies and Cell-Based Taste Receptor Assays
Activity guided fractionation of a commercially available yeast extract led to the identification of (S)-N2-(1-carboxyethyl)guanosine 5′-monophosphate, a nucleotide exhibiting pronounced umami taste enhancing activity. Applying model reaction systems, this compound was found to be formed upon Maillard reaction of 5′-GMP with short chained carbohydrates. Consequently, systematic studies were undertaken to better understand thermal transformation reactions of the purine ribonucleotide resulting in two structurally diverse groups of Maillard-modified 5′-GMP derivatives which were evaluated with regard to structure–activity relationships in human sensory studies. Results suggested that substitution of the nucleotide’s exocyclic amino function with small, unpolar residues has a beneficial effect on taste enhancement. In addition, selected representatives of the 5′-GMP derivatives were tested in a cell-based taste receptor assay, underlining the human sensory results.
This book provides a comprehensive overview of the current state of knowledge concerning neuropathologies resulting from drug abuse. The first chapters offer readers detailed information on the neurobiological basics of drug abuse and the results of neuroimaging studies in drug abusers. The focus of the book is on neuropathological findings in drug abusers for the predominant substances, which include cannabis, opiates, cocaine, amphetamine, methamphetamine and a broad spectrum of designer drugs. These findings are supported by histological illustrations and discussed in connection with recent scientific publications. A chapter specifically addressing clinicians is also included, and highlights the implications for further therapy. The book is essential reading for neuropathologists, neurologists, neuroradiologists and psychiatrists, as well as other health professionals and scientists interested and engaged in the problem of drug abuse. Although a great deal of data has been derived from animal models and from human neuroimaging studies, little is known about the morphological effects of drug abuse on the human brain. In recent years, fundamental drug-induced effects on the cellular elements of the brain have been detected. These alterations might not only be the substrate of the neuroimaging data but might also have implications for clinical research and therapy. In addition, drug abuse may induce premature neurodegeneration.
The Primeval History (Genesis 1-11) is one of the most complex theological compositions of the Old Testament/the Hebrew Bible. Woven into its multi-layered text one finds reflections on an array of fundamental questions: How did the world come into being? Who is its creator? What role does humankind play in the larger scheme of creation? Why is the world that God made not a perfect one? And finally, is it possible to lead a meaningful and even happy life despite the unpredictabilities of existence? The essays by Andreas Schule assembled in this volume address these and related questions through close readings of Genesis 1-11 and by relating them to kindred textual traditions throughout the Old Testament/the Hebrew Bible.
The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye. - Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea - Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea - Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns - Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure
The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes. Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems. The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.
Radiation can be absorbed and re-emitted many times in atomic vapors before it reaches the boundaries of the container encasing the vapor. This effect is known as radiation trapping. It plays an important role practically everywhere atomic vapors occur, whether in spectroscopy, gas lasers, atomic line filters, the determination of atomic lifetimes, measurements of atomic interaction potentials, or electric discharge lamps. This book is the first to assemble all of the information necessary to handle practical problems related to radiation trapping, and it emphasizes both physical insights and mathematical methods. The introduction reviews resonance radiation and collision processes in atomic vapors. This is followed by detailed explanations of the physical effects and mathematical methods for various types of problems (e.g., with or without saturation, particle diffusion, reflecting cell walls). The last part of the book describes the applications of these methods to a variety of practical problems, such as cross-section measurements and the design of discharge lamps.
Über die Seefahrt, eine der größten Errungenschaften der Menschheit, ist viel geschrieben worden. Dies ist die ganz persönliche Geschichte des Autors Andreas Babillotte. Aber da keine Geschichte ganz und gar real ist und keine ganz und gar fiktiv, reihen sich seine Geschichten und die Schiffstagebuchauszüge aus seinem Seemannsalltag wie Kalenderblätter aneinander, um Sie, werte Leser, darin eintauchen zu lassen.
English summary: Founded by Emil Meynen, edited by Andreas Bittmann in Cooperation with: the German Society for Geography, Austrian IGU-National Committee, and the Swiss Association for Geography/ Association Suisse de G�ographie. For over sixty years and in the 31st edition from Franz Steiner Publishers, the Geographic Pocketbook proves itself as a reference work: the clear list of geographic institutions, administrative authorities, organization and geographers in Germany, Austria and Switzerland makes the handbook indispensible for everything concerning geography. It has been updated and furnished with useful register and serves as a compact and reliable source. German description: Begruendet von Emil Meynen, herausgegeben von Andreas Dittmann im Einvernehmen mit: Deutsche Gesellschaft fuer Geographie, �sterreichisches IGU-Nationalkomitee, Verband Geographie Schweiz / Association Suisse de G�ographie Seit ueber 60 Jahren und in der 31. Ausgabe im Franz Steiner Verlag bew�hrt sich das Geographische Taschenbuch als Nachschlagewerk: die uebersichtliche Auflistung geographischer Institutionen, Beh�rden, Organisationen und Geographen und Geographinnen in Deutschland, �sterreich und der Schweiz machen das Handbuch unentbehrlich fuer alle, die sich mit der Geographie befassen. Wieder aktualisiert und mit nuetzlichen Registern versehen, ist es eine kompakte und zuverl�ssige Quelle.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.