The first years of the 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidence-based assessment of preclinical models, probing their true value in predicting clinical outcomes of human diseases. Likewise, several new approaches, e.g., stem cell-based, diseases-in-a-dish and organs-on-a-chip and lab-on-a-chip technologies have revitalized the domain of alternatives to animal experimentation. In our review, we portray these and other efforts to bring forth relevant and ethically inoffensive models of human diseases.
Clara ist eine Frau, die sich physisch und psychisch krank fühlt. Schmerzen und Traurigkeit umgeben sie. In der Schulmedizin würde man bei ihr Burn out diagnostizieren. In der Hypnose begegnet sie Maira. Clara erfahrt längst vergessene Gefuhle neu zu leben. Sie befreit sich von ihren Fesseln, alten Glaubenssätzen. Der Weg, der Prozess führt sie durch tiefe Täler und Anhöhen. In jedem Tal und auf jeder Anhöhe entdeckt sie immer wieder ihr Leben neu. Es ist ein Weg, der sie spüren lässt, welch großer Schatz in ihr ruht sich selber zu lieben. Aus dieser Liebe heraus kann sie den Schritt der Vergebung gehen und wird frei für ihr Leben.
Bella hat es diesmal wirklich vermasselt. Eigentlich wollte sie sich nach einem anstrengenden Arbeitstag nur zu Hause entspannen. Aber natürlich kam es anders als geplant. Mit einem bewusstlosen Möchtegern-Star im Schlepptau schlittern sie und Maxwell mit Vollgas auf die nächste Katastrophe zu.
Begib dich auf eine inspirierende Reise durch 14 Geschichten, die von der Autorin mit viel Herz und Tiefgang geschrieben wurden. Diese Erzählungen sind eine Ode an Dankbarkeit, Wertschätzung und die tiefe Verbundenheit mit der Natur. Tauche ein in die Welt der Rituale, entdecke die Schönheit im Zyklus des Lebens und lerne, jeden Tag einen Grund zum Lächeln zu finden. Diese Geschichten erinnern uns daran, die kleinen Freuden des Lebens zu schätzen und das Glück in den einfachen Momenten zu entdecken.
Haben sich Ihre Blind-Dates bisher wie eine Begegnung mit der dritten Art erwiesen? Und entpuppte sich der Supermarkt bisher auch nicht als klassischer Heiratsmarkt? Wie schwierig es ist, aus einem Meer an Singles den für sich passenden Partner herauszuangeln, wissen die Hauptfiguren dieses Streifzugs durch den Großstadtdschungel. Begleiten Sie die beiden charmanten Protagonistinnen durch Kneipen, Partys, Chatrooms und finden Sie Ihren Weg zu Mr. Right.
Unglaublich wie ein paar Seiten, dein Leben verändern können. // Leser ___ Anna liebt ihr Leben. Ihren Mann, ihre beiden Teenager und ihre beste Freundin. Ihr Job ist okay und eigentlich gibt es nichts, über dass sie sich beschweren darf. Als sie das vierte Mal 39 wird, fehlt dennoch etwas in ihrem Leben. In der Fußgängerzone trifft sie auf die 23-jährige Straßenmusikerin Grace. Gezogen von Grace‘ Stimme lässt sich Anna dazu überreden, mit ihr zu singen. Dabei entsteht eine Magie, wie Anna sie nie zuvor gespürt hat. Es beginnt eine tiefe musikalische Freundschaft zwischen den beiden Frauen. Eine Verbindung, die so echt und so vertraut ist, dass Anna sich wieder erlaubt zu träumen. Gemeinsam fallen sie in die Liebe zur Musik, der Erfolg baut sich auf und alles scheint leicht und perfekt. Bis zu jenem Moment, in dem Anna die Wahrheit über Grace erfährt. Eine Wahrheit, die es unmöglich macht, dass sie den gemeinsamen Traum bis zum Ziel verfolgen.
A thorough transdisciplinary archaeological study of the ancient Egyptian Theban rock-cut tombs at Sheikh ‘Abd al-Qurna In recent years, archeological research has undergone major changes. The material turn in archaeology and related disciplines prompted the adoption of sophisticated scientific, digital, and technical approaches and methods often conducted on a micro level, enhancing our understanding of depositional processes and of the creation and life of an archeological object. This volume reflects seven seasons of transdisciplinary archaeological research at a cluster of rock-cut tombs in Sheikh 'Abd al-Qurna, an ancient Egyptian hillside cemetery and part of the much larger Theban Necropolis. Organized in twelve main chapters, Life Histories of Theban Tombs presents current investigations in landscape archaeology (including recent excavations at a large debris hill previously covering a tomb), geo- and bioarcheology, the archaeology of tomb construction, burial practices, and domestic uses as well as various epigraphical, visual, and material studies. The last two sections provide additional insight into the applied recording, surveying, and visualization methods and techniques and the database system used for data recording and organization. Contributors’ Affiliations: Martina Aeschlimann-Langer, Basel, Switzerland Zulema Barahona-Mendieta, University of Basel, Switzerland Susanne Bickel, University of Basel, Switzerland Oliver Bruderer, Zurich, SwitzerlandRachael Colldeweih, Nagra, Wettingen, Switzerland Lucía Díaz-Iglesias Llanos, Spanish National Research Council, Madrid, Spain Xavier Droux, Hierakonpolis Expedition, Oxford, England Stéphane Fetler, Université Libre de Bruxelles, Brussels, Belgium Zan Gojcic, Swiss Federal Institute of Technology Zurich (ETH), Switzerland Charlotte Hunkeler, University of Basel, Switzerland Mahmoud Ibrahim, University of Cairo, Egypt Matjaž Kačičnik, Cairo, Egypt Iwona Kozieradzka-Ogunmakin, University of Manchester, England Lara Selina Kurmann, University of Basel, Switzerland Andrea Loprieno-Gnirs, University of Basel, Switzerland Sabrina Meyer, Canton of Zurich, Switzerland Matthias Müller, University of Basel, Switzerland Julianna K. Paksi, University of Basel and École Pratique des Hautes Études, Paris, France Erico Peintner, Cairo, Egypt Matthew A. Perras, York University, Toronto, Canada Lukas Richner, canton of Basel-Landschaft, Switzerland Frank Rühli, University of Zurich, Switzerland Marina Sartori, University of Basel, Switzerland Nadine Schönhütte, Cologne Institute of Conservation Sciences (CICS), Cologne, Germany Roger Seiler, University of Zurich, Switzerland Stephan M. Unter, University of Basel, Switzerland André J. Veldmeijer, American University in Cairo, Egypt Noémi Villars, University of Basel, Switzerland Andreas Wieser, Swiss Federal Institute of Technology Zurich (ETH), Switzerland Andrea Wolter, ETH Engineering Geology Group, Zurich, Switzerland Martin Ziegler, Swiss Federal Institute of Technology Zurich (ETH), Switzerland
Peaceville in Connecticut: Paradies des Friedens und der Nächstenliebe. So wollen es zumindest die Anhänger des Gurus, die sich dort niedergelassen haben. Um den Frieden ist es allerdings geschehen, als der junge Italiener Uto auftaucht. Mit seiner Punkfrisur, der Ledermontur und der Sonnenbrille tritt er gegen das unermüdliche Lächeln der Sinnsucher an – und weckt durch sein mitreißendes Klavierspiel geheime Sehnsüchte...
The first years of the 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidence-based assessment of preclinical models, probing their true value in predicting clinical outcomes of human diseases. Likewise, several new approaches, e.g., stem cell-based, diseases-in-a-dish and organs-on-a-chip and lab-on-a-chip technologies have revitalized the domain of alternatives to animal experimentation. In our review, we portray these and other efforts to bring forth relevant and ethically inoffensive models of human diseases.
A flexible and engaging casebook, Evidence: Cases, Commentary, and Problems focuses on core concepts and central controversies in evidence law, presented through tightly edited cases, stimulating commentary from a wide range of perspectives, and carefully crafted problems. The Fifth Edition, while as streamlined and teachable as its predecessors, includes excerpts from more than fifty new cases and twenty new articles, fresh problems and enhanced editorial material, and three entirely new sections: one on machine-generated proof, one on digital forensics, and one on authenticating electronic evidence. There is new, up-to-date material on sexual assault cases, DNA evidence, social science evidence, privileges, judicial notice, hearsay, confrontation, “other crimes” evidence, and other key topics. New to the Fifth Edition: New sections on machine-generated proof, digital forensics, and authenticating electronic evidence New materials on confrontation and hearsay, character evidence in sexual assault and child molestation cases, DNA evidence, social science evidence, “other crimes” evidence, and other key topics Excerpts from more than 50 new cases and 20 new articles New problems and editorial material throughout Professors and students will benefit from: Flexible structure that allows the book to be taught cover-to-cover in a four-unit, one-semester class, but also can be abridged or rearranged to suit course length and instructor’s preferences. Comprehensive coverage with a wide range of perspectives. Text that is written with clarity and concision and includes well-selected and tightly edited cases. A balanced mix of cases, commentary, and problems covering relevance, hearsay, character evidence, impeachment, privilege, expert testimony, and authentication. Well-written introductory materials that identify key issues, important distinctions, and common sources of confusion.
Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons release the GnRH decapeptide into the portal capillary system leading to the anterior pituitary gland. There, GnRH causes the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn act upon the gonads to stimulate their maturation, and to cause synthesis of sex steroid hormones, estrogen, progesterone and testosterone. Although each of the levels of the hypothalamic-pituitary-gonadal axis is critical for reproductive function, GnRH neurons play the primary role in the control of reproductive maturation and adult reproductive function, and may even play a role in reproductive senescence. Since its discovery in 1970, there has been intense interest in GnRH-producing neurons, with more than 8000 papers and chapters in the last decade alone. Despite this activity of research in basic and clinical science, there has never been a book written specifically on GnRH neurons. GnRH: The Master Molecule of Reproduction aims to bring together the large and diverse literature of both laboratory and applied research that focuses on these unique cells. This book will provide basic background into reproductive neuroendocrinology, as well as specifics regarding the role of GnRH neurons in the control of reproduction. Students studying endocrinology, reproduction, neuroendocrinology or molecular endocrinology will benefit from this book. In addition, this book will take a multi-species approach which will be useful both to basic researchers as well as clinicians. Whenever possible, species differences and similarities will be presented, and if possible, studies on humans, or the clinical relevance of basic research findings to humans will be discussed (such as the treatment of reproductive disorders such as abnormalities in pubertal development, or infertility).
There is a growing awareness of the need to address the psychological distress associated with physical ill health; however, current resources are limited and difficult to access. The best way to tackle the issue is by enhancing the skills of those professionals who have routine contact with them. CBT provides the evidence-based skills that most readily meet these requirements in a time and cost efficient manner. Based on materials prepared for a Cancer Network sponsored training programme and modified to address the needs of a larger client population of people experiencing psychological distress due to physical ill-health, this innovative workbook offers a basic introduction and guide to enable healthcare professionals to build an understanding of the relevance and application of CBT methods in everyday clinical practice.
The Second Edition of Capital Campaigns remains the authoritative work on developing plans, strategies, and tactics that will raise funds for capital projects. It details proven methods of preparing for, launching, and completing a successful project. Step-by-step instructions, along with graphs, charts, checklists, and case studies will help make your campaign run smoothly by outlining the entire process from start to finish.
This book assembles a collection of papers in two different domains: formal syntax and neurolinguistics. Here Moro provides evidence that the two fields are becoming more and more interconnected and that the new fascinating empirical questions and results in the latter field cannot be obtained without the theoretical base provided by the former. The book is organized in two parts: Part 1 focuses on theoretical and empirical issues in a comparative perspective (including the nature of syntactic movement, the theory of locality and a far reaching and influential theory of copular sentences). Part 2 provides the original sources of some innovative and pioneering experiments based on neuroimaging techniques (focusing on the biological nature of recursion and the interpretation of negative sentences). Moro concludes with an assessment of the impact of these perspectives on the theory of the evolution of language. The leading and pervasive idea unifying all the arguments developed here is the role of symmetry (breaking) in syntax and in the relationship between language and the human brain.
The book encodes a vision for the actively sustainable management and development of the built environment by referring to the application of timber-based construction systems as additive solutions for the multi-purpose improvement of existing buildings. It translates this vision into an innovative methodology for the management of the entire building process – from design to production, operation, and maintenance - and the assessment of timber-based construction performances across the whole building life-cycle. This approach is based on a multi-dimensional analysis, which starts from the structure of the Active House (AH) protocol, improved through information-integrated digital environments and multi-criteria evaluation methods, such as BIM and Design Optioneering. During the design stage, indeed, it analyzes and compares different design choices, according to the DO method, until the definition and validation of the “As-Built” step, while in the operational phase, it refers to sensors-retrieved data to show the evolution of the building behaviour, accounting for real users’ interaction, building performances decay and needs of maintenance, defining the digital twin of the building: a real Cognitive Building. Finally, the application of this methodology identifies innovative models of processes, products, and design of wood-based construction technologies, suitable to satisfy the needs of the 2D/3D construction layering for the sustainable transformation of the built environment.
This book examines Jewish writers and intellectuals in Austria, analyzing filmic and electronic media alongside more traditional publication formats over the last 25 years. Beginning with the Waldheim affair and the rhetorical response by the three most prominent members of the survivor generation (Leon Zelman, Simon Wiesenthal and Bruno Kreisky) author Andrea Reiter sets a complicated standard for ‘who is Jewish’ and what constitutes a ‘Jewish response.’ She reformulates the concepts of religious and secular Jewish cultural expression, cutting across gender and Holocaust studies. The work proceeds to questions of enacting or performing identity, especially Jewish identity in the Austrian setting, looking at how these Jewish writers and filmmakers in Austria ‘perform’ their Jewishness not only in their public appearances and engagements but also in their works. By engaging with novels, poems, and films, this volume challenges the dominant claim that Jewish culture in Central Europe is almost exclusively borne by non-Jews and consumed by non-Jewish audiences, establishing a new counter-discourse against resurging anti-Semitism in the media.
The up-dated 2nd edition starts from quantum mechanical and condensed matter foundations and introduces into the necessary theory behind spin electronics. Providing equations of spin diffusion, -evolution and -tunelling the authors give an overview of simulation of spin transport at the atomic scale and discuss devices such as spin valves, memory cells and hard disk heads.
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
This book presents a number of techniques for robustness analysis of uncertain systems. In it, convex relaxations for several robustness problems are derived by exploiting and providing new results on the theory of homogenous polynomial forms.
Cars, single-family houses, fallout shelters, air-conditioned malls—these are only some of the many interiors making up the landscape of American suburbia. Indoor America explores the history of suburbanization through the emergence of such spaces in the postwar years, examining their design, use, and representation. By drawing on a wealth of examples ranging from the built environment to popular culture and film, Andrea Vesentini shows how suburban interiors were devised as a continuous cultural landscape of interconnected and self-sufficient escape capsules. The relocation of most everyday practices into indoor spaces has often been overlooked by suburban historiography; Indoor America uncovers this latent history and contrasts it with the dominant reading of suburbanization as pursuit of open space. Americans did not just flee the city by getting out of it—they did so also by getting inside. Vesentini chronicles this inner-directed flight by describing three separate stages. The encapsulation of the automobile fostered the nuclear segregation of the family from the social fabric and served as a blueprint for all other interiors. Introverted design increasingly turned the focus of the house inward. Finally, through interiorization, the exterior was incorporated into the all-encompassing interior landscape of enclosed malls and projects for indoor cities. In a journey that features tailfin cars and World’s Fair model homes, Richard Neutra’s glass walls and sitcom picture windows, Victor Gruen’s Southdale Center and the Minnesota Experimental City, Indoor America takes the reader into the heart and viscera of America’s urban sprawl.
This practical book offers a guide to finding, choosing, and applying theoretical frameworks to social sciences research, and provides researchers with the scaffolding needed to reflect on their philosophical orientations and better situate their work in the existing landscape of empirical and theoretical knowledge. Using a multifaceted approach, the book provides clear definitions, primary tenets, historical context, highlights of the challenges and contemporary discussion and, perhaps more importantly, concrete and successful examples of studies that have drawn on and incorporated each theoretical framework. The authors define and explain the connections among such concepts as ontology, epistemology, paradigm, theory, theoretical frameworks, conceptual frameworks, and research methodology; describe the process of finding and effectively using theoretical and conceptual frameworks in research; and offer brief overviews of particular theories within the following disciplines: sociology, psychology, education, leadership, public policy, political science, economics, organizational studies, and business. The book also has a dedicated chapter on critical theories, and for each theory, provides a definition, explores how the theory is useful for researchers, discusses the background and foundations, outlines key terms and concepts, presents examples of theoretical applications, and gives an overview of strengths and limitations. This book offers a useful starting point for any researcher interested in better situating their work in existing conceptual and theoretical knowledge, but it will be especially useful for graduate students and early career researchers who are looking for clear definitions of complex terms and concepts, and for an introduction to useful theories across disciplines.
This richly illustrated atlas is entirely devoted to the most modern surgical techniques of the elbow, offering a comprehensive, step-by-step and detailed examination of all the technical aspects of the surgical exposure of this joint. With the help of over 100 original drawings and photographs, it offers readers a unique understanding of elbow anatomy and surgical approaches, providing precise indications and surgical timing for clinical practice. An entire section focuses on the surgical management of the most common diseases of the elbow: the surgical exposures are related to pathologies affecting the lateral medial, anterior and posterior compartments of the elbow. This atlas will be of great value both to trainees and to specialists who manage disorders of the elbow, including orthopedic surgeons, traumatologists, and sports physicians, as well as anatomists.
In recent decades the concept of Mediterranean has been cited with increasing frequency in relation to the study of medieval literatures. And yet, in what sense would Dante’s Comedy be ‘Mediterranean’? Is it because of its Greek-Arabic and Islamic sources? Dante and the Mediterranean Comedy analyzes the ideological function of references to the sea in the study of the Comedy undertaken by Enrico Cerulli, a scholar of Somali-Ethiopian languages, and a colonial governor of ‘Italian East Africa.’ Then it presents novel lines of inquiry on the reception and appropriation of the poem, such as the presence of Islamic sources in early commentaries of the Comedy, and cross-cultural allusions to Dante’s Hell in some graffiti on the walls of the Spanish Inquisition prison in Palermo. The image of the Mediterranean that seeps through the poem and through the history of its circulation is vivid yet hardly idyllic.
An interdisciplinary text on the world's savannas, covering the geography, ecology, economics and politics of savanna regions. Savannas are a distinct vegetation type, covering a third of the world's land surface area and supporting a fifth of the world's population. There has been a wide range of literature on the subject, but the majority of work has focused on the ecology or development of savanna areas, ignoring the wider interdisciplinary issues affecting contemporary savannas. World Savannas aims to buck this trend, providing students with an up-to-date and comprehensive introduction to the global importance of savannas.
With a century of solid theory behind it, tax law confronts a new reality: the weakening of the tenacious link between the sovereignty of states and taxation. Yet it is to the continuity of certain themes and principles inherent in the various national tax systems that tax law scholarship continues to look, even as it develops new principles designed to meet the expanding processes of internationalization. This completely updated collection of essays offers an expert comparative analysis, conducted by a sample of the best international tax law scholars, of the fundamental theory of tax law and of the prospects in the near future of tax legislative systems. The emphasis falls naturally on tax theory, jurisprudence, and legislative development in the Member States of the European Union (particularly in Italy, Germany, and Spain), where the process of tax harmonization has been under way for many years. The effect of these processes, via the relevant tax treaties, on the tax systems of Japan and the United States provides a secondary emphasis. Practitioners and academics in tax law will find in this book an invaluable understanding of the challenges that tax law theory strives to meet at this crucial moment in economic history. The essays present a full and reliable exposition of the current theoretical approaches adopted by the various schools of thought in the field, as well as of the main contributions of jurisprudence.
This work is the first monograph which closely examines the role of the German minority in the American South during the Civil War. In a comparative analysis of German civic leaders, businessmen, militia officers and blockade runners in Charleston, New Orleans and Richmond, it reveals a German immigrant population which not only largely supported slavery, but was also heavily involved in fighting the war. A detailed appendix includes an extensive survey of primary and secondary sources, including tables listing the members of the all-German units in Virginia, South Carolina and Louisiana, with names, place of origin, rank, occupation, income, and number of slaves owned. This book is a highly useful reference work for historians, military scholars and genealogists conducting research on Germans in the American Civil War and the American South.
The point of the technique is to describe the asymptotic behavior of families of minimum problems. This textbook was developed from a lectures series for doctoral students in applied functional analysis to describe all the main features of the convergence to an audience primarily interested in applications but not intending to enter the specialty. Annotation copyrighted by Book News, Inc., Portland, OR
Feminism can reflect the cultural moment, especially as media appropriate and use feminist messaging and agenda to various ends. Yet media can also push boundaries, exposing audiences to ideas they may not be familiar with and advancing public acceptance of concepts once considered taboo. Moreover, audiences are far from passive recipients, especially in the digital age. In Media-Ready Feminism and Everyday Sexism, Andrea L. Press and Francesca Tripodi focus on how audiences across platforms not only consume but also create meanings—sometimes quite transgressive meanings—in engaging with media content. If television shows such as Game of Thrones and Jersey Shore and dating apps such as Tinder are sites of persistent everyday sexism, then so, too, are they sites of what Press and Tripodi call "media-ready feminism." In developing a sociologically based conception of reception that encompasses media's progressive potential, as well as the processes of domestication through which audiences and users revert to more limited cultural schemas, Press and Tripodi make a vital contribution to gender and media studies, and help to illuminate the complexity of our current moment.
This is a very special volume of the Yearbook of Private International Law as it represents the celebration of the 10th anniversary of its first publication! And it will continue to provide you with interesting information on the future development of private international law. - The new Lugano Convention on Jurisdiction and the Recognition and Enforcement of Judgments of 30 October 2007 - Commercial agents under European jurisdiction rules - Grunkin-Paul and beyond - a seminal case in the field of international family law - The new Rome I/Rome II/Brussels I-synergy - Rome I and contracts on intellectual property - Rome I and distribution contracts - Rome I and franchise contracts - Rome I and financial market contracts - Special section on maintenance obligations
Covering every problem encountered in today’s intensive care unit, this leading critical care textbook presents the knowledge and expertise of more than 350 global experts in this fast-changing field. Beginning with the social aspects of medicine, it then discusses monitoring and organ system pathobiology followed by specific diseases states/syndromes. Each chapter begins with immediate concerns and proceeds to broader-based discussions of relevant pathophysiologic and clinical issues.
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