Psychoneuroimmunology is the emerging science devoted to studying the two-way relationship between the nervous and immune systems. Psychoneuroimmunology, Stress, and Infection highlights the latest information concerning microbial infections in both man and animals as related to stress and especially stress hormones. The volume focuses on psychoneuroimmunology as it impacts the immune system in general and also the relationship between neurological events which influence susceptibility and/or resistance to infectious agents such as bacteria, fungi and viruses, as well as parasites. Prominent researchers describe the involvement of the hypothalamus-pituitary-adrenal (HPA) axis on immunity as a function of the nervous system. The text discusses hormones such as prolactin and growth hormone and steroid induced susceptibility to infection and neuropeptides, including vasoactive intestinal peptide, and substance P. The effects of catacholamines on immunity and susceptibility to infection are also covered. This reference also details the involvement of immune cells in the synthesis of neuropeptides, including hormones and endorphins, their effect on the brain as well as the effects of interleukins and tumor necrosis factor on the central nervous system. The book concludes with an interesting look at the relationship between aging, psychoneuroimmunology, and infection. Although there is much new knowledge concerning the nature and mechanism of immune responses, including the mediators involved, Psychoneuroimmunology, Stress, and Infection also presents important discussions and reviews that are long overdue and provide a major contribution to the area of biomedical knowledge in general and psychoneuroimmunology in particular.
With the developing landscape of a European criminal justice sphere comes an increasing imperative for scholars and practitioners to gain some insight into the diversity that exists in the criminal justice systems of European Union Member States. This book explores the mutual admissibility of evidence; a facet of EU criminal justice that is proving difficult to realise. While the Lisbon Treaty places the issue of mutual admissibility of evidence squarely on the agenda, the EU instruments to date have not succeeded in achieving this goal. Andrea Ryan argues that part of the reason for this failure is that while the mutual recognition instruments have focussed on the issue of gathering evidence and safeguarding suspects’ rights, they have not addressed how evidence is to be presented and contested at trial. Drawing upon case studies from Ireland, France and Italy, and adopting a legal cultural perspective, and enriched by the author’s observations of criminal trials, the book presents a detailed analysis of the developments to date in EU criminal justice and evidence law. By examining evidence practices the book asks whether the inquisitorial and accusatorial traditions within the EU systems are too irreconcilable to achieve a system of mutual admissibility of evidence. The book will be of great interest and use to academics and practitioners with an interest in European and comparative criminal justice, criminal procedure, human rights and socio-legal studies.
Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.
This exhaustive text covers all aspects of diagnosis and endovascular treatment of neurological and neurosurgical diseases of the pediatric central nervous system starting from their in utero expression. It also includes the vascular malformations of each district and their endovascular treatment. Besides the "normal" imaging techniques the advanced techniques (spectroscopy, diffusion, perfusion, and functional imaging) are covered in detail. Several topics that are often only superficially dealt with in other books are herewith covered in outstanding detail. The volume is richly illustrated with high-quality neuroradiological images, with pathological correlation where applicable. The rich analytic index makes it an easily usable tool in the everyday clinical practice. The book serves both as a reference for specialists (neuroradiologists, radiologists, neurosurgeons, neurologists, pediatricians) and as a teaching text for residents and fellows-in-training.
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
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