Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.
This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
This text discusses the principal political and constitutional questions that have arisen in the states of Bangladesh, India, Pakistan and Sri Lanka following fifty years of independence. In Sri Lanka the pressing problems have been around the inter-ethnic civil war, experiments with constitutional designs, widespread prevalence of corruption and the recrudescence of Buddhist militancy. In India it has been corruption, Hindu nationalism and general political instability. In Bangladesh and Pakistan it has been the role of the military, the state and religion. A general theme is an analysis of the malaise that is prevalent and how and why this was inherited, despite the colonial legacy of parliamentary democracy, the steel framework of a trained bureaucracy, the independence of the judiciary and the rule of law.
This volume, containing contributions by experts from all over the world, is a collection of 21 articles which present review and research material describing the evolution and recent developments of various pattern recognition methodologies, ranging from statistical, syntactic/linguistic, fuzzy-set-theoretic, neural, genetic-algorithmic and rough-set-theoretic to hybrid soft computing, with significant real-life applications. In addition, the book describes efficient soft machine learning algorithms for data mining and knowledge discovery. With a balanced mixture of theory, algorithms and applications, as well as up-to-date information and an extensive bibliography, Pattern Recognition: From Classical to Modern Approaches is a very useful resource.
The Present Book, Concise Encyclopaedia Of India, Is A Compendium Of Diverse Aspects Of India Which Is One Of The Oldest Civilisations With A Kaleidoscopic Variety, Rich Cultural Heritage And Multifaceted Socio-Economic Progress. The Idea Behind Bringing Out This Book Is To Help One And All In Understanding The Country And Its Unity In Diversity. In Its Three Volumes, The Encyclopaedia Encompasses A Remarkably Wide Range Of Topics Related To India Its History, Physiography, People, Population, National Symbols, National Leaders, Languages And Literatures, Art, Culture, Defence, Education, Economy, Polity, Foreign Policy And Relations, Scientific And Technological Developments, Law And Justice, Sports, Festivals, Transport, Communication And Related Activities. In Addition, A Profile Of All Its 28 States And 7 Union Territories Has Also Been Provided. Furthermore, It Provides An Accessible, Authoritative Account Of The Latest Developments Made In Varied Fields Alongwith The Data From The Central And State Governments, Their Establishments, Constitutional Bodies, Autonomous And Semi-Autonomous Bodies And The Like.The Book Is Comprehensive, Self-Contained And User-Friendly, As The Emphasis Throughout Is On Ensuring That Readers, Particularly Students, Receive Worthwhile, Authentic Information Instead Of Irrelevant And Outdated Details. It Will Definitely Prove An Invaluable Reference Book To Students Of Different Educational Levels And Candidates Preparing For Civil Services Examinations Or Other Competitive Exams And Interviews For Various Jobs. Besides Students, The Researchers, Executives In Government And Private Sector And Also The Common Man Will Find It Highly Informative.
This book describes in detail various aspects of fluoride toxicity in animals. Animals, like human beings, suffer from the toxic effects of excess fluoride intake. They show pathological changes in their teeth and bone, together with a marked reduction in appetite, productive and reproductive potentials, which can result in severe economic losses in the dairy industry. Laboratory and wild animals also suffer from this ailment. Animal suffering and economic losses alike can be minimized through early diagnosis of the problem and by adopting suitable preventive and therapeutic measures. The book details the susceptibility of different animal species, important sources of toxicity, clinical signs and symptoms, pathophysiology, diagnostic methods, preventive and therapeutic approaches. It offers a valuable resource for scientists working in the fields of toxicology, veterinary science, animal nutrition, and environmental science, as well as for public health workers, animal welfare activists, public health veterinarians, field veterinarians, medical professionals and all others interested in the subject.
Abanindranath Tagore (1871-1951) best known outside Bengal for Rajkahini, the valorous tales from Rajasthan, was a versatile writer who redefined the idea of children’s literature. While keeping the core stories intact from the sources in mythology, history and legend, Abanindra added verve by embedding subtle lessons for the young generations. Amita Ray’s translation of Khirer Putul in 2018 found an appreciative audience and opened up the corpus of Abaninindranath to a large English knowing readership. Her present book which translates Shakuntala(1895), Abanindranath’s maiden novella, and Nalak (1916) written much later, are a welcome expansion to the library. Abanindranath Tagore, an innovator like many others in that remarkable family, experiments with form through the twin devices of image and text. In this foreword, I try to relate the stories, and Amita Ray’s translations, to contemporary themes because only then is the reader’s imagination triggered into an awareness of the continuities of a literary heritage.
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