Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercises, and References. New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Each chapter includes a Summary, Exercies, and References Approximately 300 color images Downloadable solutions manual available at www.crcpress.com For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website. Praise for the first edition "This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012
As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
Cluster analysis means the organization of an unlabeled collection of objects or patterns into separate groups based on their similarity. The task of computerized data clustering has been approached from diverse domains of knowledge like graph theory, multivariate analysis, neural networks, fuzzy set theory, and so on. Clustering is often described as an unsupervised learning method but most of the traditional algorithms require a prior specification of the number of clusters in the data for guiding the partitioning process, thus making it not completely unsupervised. Modern data mining tools that predict future trends and behaviors for allowing businesses to make proactive and knowledge-driven decisions, demand fast and fully automatic clustering of very large datasets with minimal or no user intervention. In this volume, we formulate clustering as an optimization problem, where the best partitioning of a given dataset is achieved by minimizing/maximizing one (single-objective clustering) or more (multi-objective clustering) objective functions. Using several real world applications, we illustrate the performance of several metaheuristics, particularly the Differential Evolution algorithm when applied to both single and multi-objective clustering problems, where the number of clusters is not known beforehand and must be determined on the run. This volume comprises of 7 chapters including an introductory chapter giving the fundamental definitions and the last Chapter provides some important research challenges. Academics, scientists as well as engineers engaged in research, development and application of optimization techniques and data mining will find the comprehensive coverage of this book invaluable.
The definitive book on leadership in the digital era: why digital technologies call for leadership that emphasizes creativity, collaboration, and inclusivity. Certain ideas about business leadership are held to be timeless, and certain characteristics of leaders—often including a square jaw, a deep voice, and extroversion—are said to be universal. In Leading in the Digital World, Amit Mukherjee argues that since digital technologies are changing everything else, how could they not change leadership ideologies and styles? As more people worldwide participate equally in business, those assumptions of a leader's ideal profile have become irrelevant. Offering a radical rethinking of leadership, Mukherjee shows why digital technologies call for a new kind of leader—one who emphasizes creativity, collaboration, and inclusivity. Drawing on a global survey of 700 mid-tier to senior executives and interviews with C-level executives from around the world, Mukherjee explains how digital technologies are already reshaping organizations and work and what this means for leaders. For example, globally dispersed businesses can't reserve key leadership roles for people from exclusive groups; leadership must become inclusive, or fail. Leaders must learn to collaborate in a multipolar world of networked organizations, working with co-located and non-co-located colleagues. Leaders must lead for creativity rather than productivity. Focusing on practice, Mukherjee outlines goals and strategies, warns against unthinking assumptions, and explains how leaders can identify the mindsets, behaviors, and actions they need to pursue. With Leading in the Digital World, Mukherjee offers the definitive book on leadership for the digital era.
Parkinsonism is a clinical syndrome characterised by tremor, bradykinesia, rigidity, and postural instability. Parkinsonism shares symptoms found in Parkinson's Disease, from which it is named; but parkinsonism is a symptom complex, and differs from Parkinson's disease which is a progressive neurodegenerative illness. This book is a guide to Parkinsonism for practising neurologists. Beginning with an overview of the condition, the next chapters discuss the differences between Parkinsonism and Parkinson’s Disease. The following sections cover the diagnosis and treatment of various disorders associated with Parkinsonism and both early and advanced Parkinson’s Disease. A complete chapter is dedicated to the use of Botulinum Toxin (Botox) in the management of Parkinsonism. Each chapter is supplemented by clinical cases to assist understanding of the complex condition. Edited by recognised experts in the field, the book is further enhanced by clinical photographs and illustrations. Key points Guide to Parkinsonism detailing differences between the condition and Parkinson’s Disease Covers diagnosis and treatment of disorders associated with both conditions Includes chapter on use of Botulinum Toxin (Botox) in the management of Parkinsonism Each chapter features clinical cases to assist understanding
This book focuses on data and how modern business firms use social data, specifically Online Social Networks (OSNs) incorporated as part of the infrastructure for a number of emerging applications such as personalized recommendation systems, opinion analysis, expertise retrieval, and computational advertising. This book identifies how in such applications, social data offers a plethora of benefits to enhance the decision making process. This book highlights that business intelligence applications are more focused on structured data; however, in order to understand and analyse the social big data, there is a need to aggregate data from various sources and to present it in a plausible format. Big Social Data (BSD) exhibit all the typical properties of big data: wide physical distribution, diversity of formats, non-standard data models, independently-managed and heterogeneous semantics but even further valuable with marketing opportunities. The book provides a review of the current state-of-the-art approaches for big social data analytics as well as to present dissimilar methods to infer value from social data. The book further examines several areas of research that benefits from the propagation of the social data. In particular, the book presents various technical approaches that produce data analytics capable of handling big data features and effective in filtering out unsolicited data and inferring a value. These approaches comprise advanced technical solutions able to capture huge amounts of generated data, scrutinise the collected data to eliminate unwanted data, measure the quality of the inferred data, and transform the amended data for further data analysis. Furthermore, the book presents solutions to derive knowledge and sentiments from BSD and to provide social data classification and prediction. The approaches in this book also incorporate several technologies such as semantic discovery, sentiment analysis, affective computing and machine learning. This book has additional special feature enriched with numerous illustrations such as tables, graphs and charts incorporating advanced visualisation tools in accessible an attractive display.
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