Patients with difficult airways represent a clinical conundrum for anaesthetists. With a wide variety of presentations in both an elective and emergency setting, all anaesthetists need to be prepared to manage such a situation. This book consists of real-life clinical scenarios, describing how these were managed at the time and on reflection how their management could have been improved. Further discussion emphasises how any associated failures and complications could have been mitigated. Using a combination of up-to-date knowledge, advanced technology and clinical expertise, this book provides an invaluable resource for any specialist managing airways in a clinical environment. This book is an indispensable aide-mémoire for postgraduate doctors, physicians practising in the emergency department, intensive care specialists, anaesthesia associates and allied healthcare professionals in managing patients with a difficult airway.
Oxazole, Isoxazole, Benzoxazole Based Drug Discovery offers complete coverage of oxazole and related molecules, both from natural and synthetic origin, with a focus on the reaction mechanisms, and medicinal, pharmacokinetic and computational aspects. New and contemporary methods of synthesis are discussed, with a special focus on green, environment-friendly procedures. Discussion of stereochemical studies, particularly on natural molecules, are included. Computational chemistry has emerged as an integral tool for drug discovery, hence this book explains how the drug candidate is established as suitable for clinical trials with the help of molecular docking and virtual screening modeling. This book offers a broad range of recent developments and detailed coverage of synthesis and biological activities of the drugs, and is an ideal reference guide to researchers working in organic and medicinal chemistry. - Presents detailed coverage of chemical structures and practical synthetic methods of oxazoles, isoxazoles and benzoxazoles in drug discovery - Includes green, environmentally-friendly novel synthetic methods and mechanistic insights - Features biological and computational aspects of the oxazoles family of drugs, including virtual screening and molecular docking
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