Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.
Underwater Cultural Heritage investigates cases of underwater cultural heritage, exploring ethical issues that have never been studied before. A vast cultural heritage lies beneath the sea, including the archaeological remains of more than three million vessels, as well as historic monuments and whole cities. In addition, climate change, population growth and current events around the world mean that new underwater cultural heritage is being created faster than ever before. It is, therefore, essential that the ethical issues related to the management of such heritage are considered now, especially as decisions made now will bestow the heritage with a value and will establish legal frameworks that could be used either to protect or harm underwater heritage in the future. Considering a range of challenges related to underwater cultural heritage - including preservation, management, use, sustainability, valuation, politics, identity, human rights, and intangible heritage - the book presents case studies that both illustrate the key ethical issues and also offer possible solutions to help navigate such challenges. The book will also explore the various legislative instruments protecting underwater cultural heritage and emphasise the importance of revising and updating legal frameworks, whilst also taking into account ethical concerns that may expose cultural heritage to more serious menaces. Underwater Cultural Heritage draws on case studies from around the globe and, as such, should be of great interest to academics, researchers and students working in heritage studies, archaeology, history, politics and sustainability. It should also be appealing to heritage practitioners and policymakers who want to learn more about the issues surrounding not only management of underwater cultural heritage but management of cultural heritage in general.
This second edition explores and accounts for the many changes in the emerging markets of China and the Latin American countries since 2011. Taking account of major developments such as the rapid expansion of the Chinese state and the on-going effects of the global recession, the authors present current case studies and data on both Chinese and Latin American companies, including updates on those included in the first edition and the presentation of new innovative start-ups. Including an international relations perspective alongside business strategy and global markets, The China-Latin America Axis second edition presents the drastic changes in the globalized economy in the past five years.
A guide to the use of transcranial magnetic stimulation to reversibly disrupt cortical functioning as a means of studying perceptual and cognitive functions.
One of the most inspiring and successful global leaders of the early 21st century explains how bold, imaginative leadership can solve even the most intractable problems—and why there is no such thing as a lost cause. It’s one of the great, unexpected turnaround stories in modern history: Just a decade ago, Colombia was regarded as a “failed state,” besieged by megalomaniacal drug kingpins, ruthless terrorist groups, and abominable poverty. But since 2002, it has been dramatically transformed into a far more peaceful, stable modern democracy with a promising future. Now, the man who led the transformation, former Colombian president Alvaro Uribe Velez, offers the untold story of how, at enormous personal risk, he refused to accept Colombia’s perilous status quo. Extremely captivating, No Lost Causes reveals how President Uribe severely weakened the neo-terrorist group, the FARC, which held Colombia captive and caused the brutal murder of his father. It relates the gripping account of how President Uribe staged the daring (and bloodless) jungle rescue of Ingrid Betancourt in 2008, and eventually restored the rule of law across the country. It also explores practical lessons of hands-on management—relevant to both political and business leaders—and provides a thrilling behind-the-scenes look at news-making US foreign affairs and never before discussed details and dealings with various world leaders. Unlike any other presidential memoir, No Lost Causes is not only a compelling story of leadership, but an epic, heart-racing account of how bravery and hope gave a failing nation a brighter future.
This book studies a significant event in US relations with Latin America, shedding light on the role of dependent states and their foreign policy agency in the process by which local concerns become intertwined with the dominant state’s foreign policy. Plan Colombia was a large-scale foreign aid programme through which the US intervened in the internal affairs of Colombia, by invitation. It proved to be one of the major successes of US foreign policy, and has been credited with stemming a potentially catastrophic security failure of the Colombian state. This book discusses the strategies and practices deployed by the Colombian government to influence US foreign policy decision making at the bureaucratic, legislative and executive levels, and is a distinctive contribution to our understanding of the dynamics of small power agency. Giving a clearer insight into the decision making processes in both the US and Colombia, this book founds its argument on solid empirical analysis assembled from interviews of the major players in the events including: Andres Pastrana, President of Colombia; Thomas Pickering, US State Department; Arturo Valenzuela, Senior Director for Inter-American Affairs at the NSA; General Barry McCaffrey, the US ‘Drug Czar’; and Dennis Hastert, Speaker of the US House of Representatives. Approaching the events in question from a bottom-up theoretical perspective that puts the emphasis on the facts of the case, this book will be of great interest to academics, students and policy makers in the field of foreign policy analysis, US foreign policy studies, and Latin American studies.
Three Latin American writers quote, dissect and review this character in a cultural critique that combines analysis with humor and a relentless self-criticism.
Álvaro Mutis’s fantastical, gripping, unnerving tales of the exploits and adventures of Maqroll, the Gaviero, or watchman, an inveterate wanderer both on land and sea, are among the most beloved works of twentieth-century Latin American fiction. Like the stories of Borges, like the novels of Mutis’s great friend García Márquez, they conjure a strange world of their own which also holds up a mirror, disquieting and revelatory, to the everyday world we imagine we know. If Maqroll eventually found his way into prose, he began his career in poetry, and it was as a poet that Mutis first made his name as a writer. This selection of Mutis’s haunting verse, with its evocations, now lush, now stark, of the landscapes of South America, with its prayers to an unknown god, is the first to be published in English. Rendered by Chris Andrews, Edith Grossman, and Alastair Reid, masters of the art of translation, these resonant poems offer a dazzling new entry into the imagination of one of the most original and memorable writers of modern times.
Este libro expone sencilla y amigablemente la forma en que se emplean las radiaciones ionizantes para producir imágenes diagnósticas y la forma en que se emplean dichas radiaciones para atacar y destuir las células cancerosas. Se describe cómo los rayos X se emplean en procedimientos como fluoroscopia, angiografía, mamografía, estudios tomográficos y densitometría ósea. La forma en que las radiaciones nucleares, aparte de ser utilizadas para irradiar células cancerosas, han dado origen a instrumentos tan valiosos coma la gammacámara, SPETC y PET, que por medio de sus imágenes suministran información funcional y documentada de diversos órganos. Finalmente, cómo las radiaciones generadas por el acelerador lineal son utilizados para combatir neoplasias. Aunque el texto está dirigido a médicos, ingenieros, estudiantes y técnicos; por su forma sencilla de presentarlo, puede ser útil a cualquier persona interesada en el tema. Podría ser considerado como el primer contacto con estas modernas tecnologías.
One of the most inspiring and successful global leaders of the early 21st century explains how bold, imaginative leadership can solve even the most intractable problems—and why there is no such thing as a lost cause. It’s one of the great, unexpected turnaround stories in modern history: Just a decade ago, Colombia was regarded as a “failed state,” besieged by megalomaniacal drug kingpins, ruthless terrorist groups, and abominable poverty. But since 2002, it has been dramatically transformed into a far more peaceful, stable modern democracy with a promising future. Now, the man who led the transformation, former Colombian president Alvaro Uribe Velez, offers the untold story of how, at enormous personal risk, he refused to accept Colombia’s perilous status quo. Extremely captivating, No Lost Causes reveals how President Uribe severely weakened the neo-terrorist group, the FARC, which held Colombia captive and caused the brutal murder of his father. It relates the gripping account of how President Uribe staged the daring (and bloodless) jungle rescue of Ingrid Betancourt in 2008, and eventually restored the rule of law across the country. It also explores practical lessons of hands-on management—relevant to both political and business leaders—and provides a thrilling behind-the-scenes look at news-making US foreign affairs and never before discussed details and dealings with various world leaders. Unlike any other presidential memoir, No Lost Causes is not only a compelling story of leadership, but an epic, heart-racing account of how bravery and hope gave a failing nation a brighter future.
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